Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors

Detalhes bibliográficos
Autor(a) principal: Monteiro, Rayan Fidel Martins
Data de Publicação: 2021
Outros Autores: Nascimento, Marcos Vinícius Lebrego, Lima , Klinsmann Thiago, Almeida, José Ramon Gama, Ávila, Paulo Eduardo Santos, Bastos, Gilmara de Nazareth Tavares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/21491
Resumo: In the last decades, the eCB system has been highlighted by its neuro and immunomodulatory effects. Beyond CB1R effects in Central Nervous System (CNS), CB2R target drugs has been showed to be promising to mitigation of neuroinflammatory diseases in mouse models. However, it remains unknow the effects of CB2R target drugs on behavior. Therefore, we review the effects of CB2R on behavior in murine models by Pubmed website, selecting studies between 2001 to 2021. In this sense, many studies has demonstrated the effects of overexpression, lack, activation or antagonization of CB2R on Aggressive behavior, Memory-associated behaviors, Mood disorders and Reward behavior. Similarly, it is not clear yet how the eCB system modulates the behavior through CB2Rs present in neurons. Thus, in mouse models, although the pharmacological treatment with CB2R target drugs seems to be promising for neuroinflammatory diseases, on behavior there are few answers about the pathways of this modulation, as well as, it is fundamental the development and/or the update of behavioral tests that evaluate many parameters, then expose better interpretations in these tests.
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spelling Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptorsSistema endocannabinoide: modulación del comportamiento en modelos murinos por receptores cannabinoides tipo 2Sistema endocanabinóide: modulação comportamental em modelos murinos por receptores de canabinóides tipo 2Receptor canabinóide do tipo 2Sistema endocanabinóideModulação comportamentalTranstornos de HumorDrogas alvo de RCB2Testes comportamentais.Cannabinoid receptor type 2Endocannabinoid systemBehavioral modulationMood disordersCB2R target drugsBehavioral tests.Receptor de cannabinoides tipo 2Sistema endocannabinoideModulación del comportamientoTrastornos del estado de ánimoFármacos diana RCB2Pruebas de comportamiento.In the last decades, the eCB system has been highlighted by its neuro and immunomodulatory effects. Beyond CB1R effects in Central Nervous System (CNS), CB2R target drugs has been showed to be promising to mitigation of neuroinflammatory diseases in mouse models. However, it remains unknow the effects of CB2R target drugs on behavior. Therefore, we review the effects of CB2R on behavior in murine models by Pubmed website, selecting studies between 2001 to 2021. In this sense, many studies has demonstrated the effects of overexpression, lack, activation or antagonization of CB2R on Aggressive behavior, Memory-associated behaviors, Mood disorders and Reward behavior. Similarly, it is not clear yet how the eCB system modulates the behavior through CB2Rs present in neurons. Thus, in mouse models, although the pharmacological treatment with CB2R target drugs seems to be promising for neuroinflammatory diseases, on behavior there are few answers about the pathways of this modulation, as well as, it is fundamental the development and/or the update of behavioral tests that evaluate many parameters, then expose better interpretations in these tests.En las últimas décadas, el sistema eCB se ha destacado por sus efectos neuro e inmunomoduladores. Más allá de los efectos de RCB1 en el Sistema Nervioso Central (SNC), se ha demostrado que los fármacos diana de RCB2 son prometedores para la mitigación de enfermedades neuroinflamatorias en modelos de ratón. Sin embargo, se desconocen los efectos de los fármacos diana RCB2 sobre el comportamiento. Por ello, revisamos los efectos del RCB2 sobre el comportamiento en modelos murinos por la web Pubmed, seleccionando estudios entre 2001 y 2021. En este sentido, numerosos estudios han demostrado los efectos de la sobreexpresión, falta, activación o antagonización del RCB2 sobre el comportamiento agresivo, Memory- comportamientos asociados, trastornos del estado de ánimo y comportamiento de recompensa. Del mismo modo, aún no está claro cómo el sistema eCB modula el comportamiento a través de los RCB2 presentes en las neuronas. Así, en modelos de ratón, aunque el tratamiento farmacológico con fármacos diana RCB2 parece prometedor para las enfermedades neuroinflamatorias, sobre el comportamiento existen pocas respuestas sobre las vías de esta modulación, así como, es fundamental el desarrollo y/o la actualización de pruebas de comportamiento que evalúan muchos parámetros, luego exponen mejores interpretaciones en estas pruebas.Nas últimas décadas, o sistema eCB tem se destacado por seus efeitos neuro e imunomoduladores. Além dos efeitos do RCB1 no Sistema Nervoso Central (SNC), os medicamentos alvo do RCB2 têm se mostrado promissores na mitigação de doenças neuroinflamatórias em modelos de camundongos. No entanto, permanecem desconhecidos os efeitos das drogas alvo do RCB2 no comportamento. Portanto, revisamos os efeitos do RCB2 no comportamento em modelos murinos pelo site Pubmed, selecionando estudos entre 2001 a 2021. Nesse sentido, muitos estudos têm demonstrado os efeitos da superexpressão, falta, ativação ou antagonização do RCB2 no Comportamento agressivo, nos Comportamentos associados à memória, nos Transtornos de humor e no Comportamento de recompensa. Da mesma forma, ainda não está claro como o sistema eCB modula o comportamento por meio dos RCB2s presentes nos neurônios. Assim, em modelos de camundongos, embora o tratamento farmacológico com fármacos alvo do RCB2 pareça promissor para doenças neuroinflamatórias, sobre o comportamento existem poucas respostas sobre as vias desta modulação, bem como, é fundamental o desenvolvimento e/ou atualização de testes comportamentais que avaliam muitos parâmetros e, por conseguinte, expõem melhores interpretações nesses testes.Research, Society and Development2021-10-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2149110.33448/rsd-v10i13.21491Research, Society and Development; Vol. 10 No. 13; e356101321491Research, Society and Development; Vol. 10 Núm. 13; e356101321491Research, Society and Development; v. 10 n. 13; e3561013214912525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/21491/18987Copyright (c) 2021 Rayan Fidel Martins Monteiro; Marcos Vinícius Lebrego Nascimento; Klinsmann Thiago Lima ; José Ramon Gama Almeida; Paulo Eduardo Santos Ávila; Gilmara de Nazareth Tavares Bastoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMonteiro, Rayan Fidel MartinsNascimento, Marcos Vinícius LebregoLima , Klinsmann ThiagoAlmeida, José Ramon GamaÁvila, Paulo Eduardo SantosBastos, Gilmara de Nazareth Tavares 2021-11-21T18:26:28Zoai:ojs.pkp.sfu.ca:article/21491Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:40:53.524665Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
Sistema endocannabinoide: modulación del comportamiento en modelos murinos por receptores cannabinoides tipo 2
Sistema endocanabinóide: modulação comportamental em modelos murinos por receptores de canabinóides tipo 2
title Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
spellingShingle Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
Monteiro, Rayan Fidel Martins
Receptor canabinóide do tipo 2
Sistema endocanabinóide
Modulação comportamental
Transtornos de Humor
Drogas alvo de RCB2
Testes comportamentais.
Cannabinoid receptor type 2
Endocannabinoid system
Behavioral modulation
Mood disorders
CB2R target drugs
Behavioral tests.
Receptor de cannabinoides tipo 2
Sistema endocannabinoide
Modulación del comportamiento
Trastornos del estado de ánimo
Fármacos diana RCB2
Pruebas de comportamiento.
title_short Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
title_full Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
title_fullStr Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
title_full_unstemmed Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
title_sort Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors
author Monteiro, Rayan Fidel Martins
author_facet Monteiro, Rayan Fidel Martins
Nascimento, Marcos Vinícius Lebrego
Lima , Klinsmann Thiago
Almeida, José Ramon Gama
Ávila, Paulo Eduardo Santos
Bastos, Gilmara de Nazareth Tavares
author_role author
author2 Nascimento, Marcos Vinícius Lebrego
Lima , Klinsmann Thiago
Almeida, José Ramon Gama
Ávila, Paulo Eduardo Santos
Bastos, Gilmara de Nazareth Tavares
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Monteiro, Rayan Fidel Martins
Nascimento, Marcos Vinícius Lebrego
Lima , Klinsmann Thiago
Almeida, José Ramon Gama
Ávila, Paulo Eduardo Santos
Bastos, Gilmara de Nazareth Tavares
dc.subject.por.fl_str_mv Receptor canabinóide do tipo 2
Sistema endocanabinóide
Modulação comportamental
Transtornos de Humor
Drogas alvo de RCB2
Testes comportamentais.
Cannabinoid receptor type 2
Endocannabinoid system
Behavioral modulation
Mood disorders
CB2R target drugs
Behavioral tests.
Receptor de cannabinoides tipo 2
Sistema endocannabinoide
Modulación del comportamiento
Trastornos del estado de ánimo
Fármacos diana RCB2
Pruebas de comportamiento.
topic Receptor canabinóide do tipo 2
Sistema endocanabinóide
Modulação comportamental
Transtornos de Humor
Drogas alvo de RCB2
Testes comportamentais.
Cannabinoid receptor type 2
Endocannabinoid system
Behavioral modulation
Mood disorders
CB2R target drugs
Behavioral tests.
Receptor de cannabinoides tipo 2
Sistema endocannabinoide
Modulación del comportamiento
Trastornos del estado de ánimo
Fármacos diana RCB2
Pruebas de comportamiento.
description In the last decades, the eCB system has been highlighted by its neuro and immunomodulatory effects. Beyond CB1R effects in Central Nervous System (CNS), CB2R target drugs has been showed to be promising to mitigation of neuroinflammatory diseases in mouse models. However, it remains unknow the effects of CB2R target drugs on behavior. Therefore, we review the effects of CB2R on behavior in murine models by Pubmed website, selecting studies between 2001 to 2021. In this sense, many studies has demonstrated the effects of overexpression, lack, activation or antagonization of CB2R on Aggressive behavior, Memory-associated behaviors, Mood disorders and Reward behavior. Similarly, it is not clear yet how the eCB system modulates the behavior through CB2Rs present in neurons. Thus, in mouse models, although the pharmacological treatment with CB2R target drugs seems to be promising for neuroinflammatory diseases, on behavior there are few answers about the pathways of this modulation, as well as, it is fundamental the development and/or the update of behavioral tests that evaluate many parameters, then expose better interpretations in these tests.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/21491
10.33448/rsd-v10i13.21491
url https://rsdjournal.org/index.php/rsd/article/view/21491
identifier_str_mv 10.33448/rsd-v10i13.21491
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/21491/18987
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 13; e356101321491
Research, Society and Development; Vol. 10 Núm. 13; e356101321491
Research, Society and Development; v. 10 n. 13; e356101321491
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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