Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones

Detalhes bibliográficos
Autor(a) principal: Dal Forno, Gonzalo Ogliari
Data de Publicação: 2022
Outros Autores: Romano, Marco Aurélio, Romano, Renata Marino
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/32089
Resumo: The increased consumption of soy-based products may be related to health problems, since the content of isoflavones consumed daily starts to represent levels capable of interfering with body homeostasis, acting as a chemical endocrine disruptor. Interference caused by isoflavones in the hypothalamic-pituitary-thyroid (HHT) axis can affect the production of thyroid hormones by interacting with estrogen receptors located in the thyroid, in addition to influencing the action of deiodases for hormone conversion in peripheral tissues. Thus, the objective of this review was to highlight the possible changes caused by the consumption of isoflavones and their impact on the production of thyroid hormones. For this, search platforms such as PubMed, Science Direct and Google Scholar were used. Search filters limiting the year of publication of the articles used as reference were not applied in this research due to the relevance of initial studies that address the relationship between isoflavones/soy and endocrine disruption. Effects of exposure to soy isoflavones (ISOF) on thyroid functions related to subclinical hypothyroidism were evidenced.
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spelling Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavonesSusceptibilidad del eje hipotálamo-pituitario-tiroideo a las isoflavonas de sojaSusceptibilidade do eixo hipotalâmico-hipofisário-tireoidiano às isoflavonas de sojaIsoflavonesEndocrine disruptorsThyroid glandThyroid hormones.IsoflavonasDisruptores endócrinosHormônios tireóideosGlândula tireoide.IsoflavonasDisruptores endócrinosGlándula tiroidesHormonas tiroideas.The increased consumption of soy-based products may be related to health problems, since the content of isoflavones consumed daily starts to represent levels capable of interfering with body homeostasis, acting as a chemical endocrine disruptor. Interference caused by isoflavones in the hypothalamic-pituitary-thyroid (HHT) axis can affect the production of thyroid hormones by interacting with estrogen receptors located in the thyroid, in addition to influencing the action of deiodases for hormone conversion in peripheral tissues. Thus, the objective of this review was to highlight the possible changes caused by the consumption of isoflavones and their impact on the production of thyroid hormones. For this, search platforms such as PubMed, Science Direct and Google Scholar were used. Search filters limiting the year of publication of the articles used as reference were not applied in this research due to the relevance of initial studies that address the relationship between isoflavones/soy and endocrine disruption. Effects of exposure to soy isoflavones (ISOF) on thyroid functions related to subclinical hypothyroidism were evidenced.El mayor consumo de productos a base de soya puede estar relacionado con problemas de salud, ya que el contenido de isoflavonas consumidas diariamente pasa a representar niveles capaces de interferir con la homeostasis corporal, actuando como un disruptor químico endocrino. La interferencia causada por las isoflavonas en el eje hipotálamo-pituitario-tiroideo (HHT) puede afectar la producción de hormonas tiroideas al interactuar con los receptores de estrógenos ubicados en la tiroides, además de influir en la acción de las desyodasas para la conversión hormonal en los tejidos periféricos. Así, el objetivo de esta revisión fue resaltar los posibles cambios provocados por el consumo de isoflavonas y su impacto en la producción de hormonas tiroideas. Para ello se utilizaron plataformas de búsqueda como PubMed, Science Direct y Google Scholar. Los filtros de búsqueda que limitan el año de publicación de los artículos utilizados como referencia no se aplicaron en esta investigación debido a la relevancia de los estudios iniciales que abordan la relación entre las isoflavonas/soja y la disrupción endocrina. Se evidenciaron los efectos de la exposición a las isoflavonas de soja (ISOF) sobre las funciones tiroideas relacionadas con el hipotiroidismo subclínico.O aumento do consumo de produtos à base de soja pode estar relacionado com problemas de saúde, uma vez que o teor de isoflavonas consumidos diariamente, passa a representar níveis capazes de interferir na homeostase corporal, agindo como um desregulador endócrino químico. A interferência causada pelas isoflavonas no eixo hipotalâmico-hipofisário-tireoideano (HHT) pode afetar a produção dos hormônios tireoidianos ao interagir com receptores de estrógenos localizados na tireoide, além de influenciar na ação das desiodases para a conversão hormonal nos tecidos periféricos. Desta forma, o objetivo desta revisão foi evidenciar as possíveis alterações causadas pelo consumo de isoflavonas e o seu impacto sobre a produção dos hormônios tireoidianos. Para isto foram utilizadas plataformas de busca como PubMed, Science Direct e Google Acadêmico. Filtros de busca limitando o ano de publicação dos artigos utilizados como referência não foram aplicados nesta pesquisa devido a relevância que estudos iniciais que abordam a relação entre isoflavonas/soja e desregulação endócrina apresentam. Foram evidenciados efeitos da exposição as isoflavonas de soja (ISOF), sobre as funções tireoidianas relacionadas ao hipotireoidismo subclínico.Research, Society and Development2022-07-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3208910.33448/rsd-v11i9.32089Research, Society and Development; Vol. 11 No. 9; e47011932089Research, Society and Development; Vol. 11 Núm. 9; e47011932089Research, Society and Development; v. 11 n. 9; e470119320892525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/32089/27330Copyright (c) 2022 Gonzalo Ogliari Dal Forno; Marco Aurélio Romano; Renata Marino Romanohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDal Forno, Gonzalo Ogliari Romano, Marco AurélioRomano, Renata Marino 2022-07-21T12:36:16Zoai:ojs.pkp.sfu.ca:article/32089Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:48:12.119331Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
Susceptibilidad del eje hipotálamo-pituitario-tiroideo a las isoflavonas de soja
Susceptibilidade do eixo hipotalâmico-hipofisário-tireoidiano às isoflavonas de soja
title Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
spellingShingle Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
Dal Forno, Gonzalo Ogliari
Isoflavones
Endocrine disruptors
Thyroid gland
Thyroid hormones.
Isoflavonas
Disruptores endócrinos
Hormônios tireóideos
Glândula tireoide.
Isoflavonas
Disruptores endócrinos
Glándula tiroides
Hormonas tiroideas.
title_short Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
title_full Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
title_fullStr Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
title_full_unstemmed Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
title_sort Susceptibility of the hypothalamic-pituitary-thyroid axis to soy isoflavones
author Dal Forno, Gonzalo Ogliari
author_facet Dal Forno, Gonzalo Ogliari
Romano, Marco Aurélio
Romano, Renata Marino
author_role author
author2 Romano, Marco Aurélio
Romano, Renata Marino
author2_role author
author
dc.contributor.author.fl_str_mv Dal Forno, Gonzalo Ogliari
Romano, Marco Aurélio
Romano, Renata Marino
dc.subject.por.fl_str_mv Isoflavones
Endocrine disruptors
Thyroid gland
Thyroid hormones.
Isoflavonas
Disruptores endócrinos
Hormônios tireóideos
Glândula tireoide.
Isoflavonas
Disruptores endócrinos
Glándula tiroides
Hormonas tiroideas.
topic Isoflavones
Endocrine disruptors
Thyroid gland
Thyroid hormones.
Isoflavonas
Disruptores endócrinos
Hormônios tireóideos
Glândula tireoide.
Isoflavonas
Disruptores endócrinos
Glándula tiroides
Hormonas tiroideas.
description The increased consumption of soy-based products may be related to health problems, since the content of isoflavones consumed daily starts to represent levels capable of interfering with body homeostasis, acting as a chemical endocrine disruptor. Interference caused by isoflavones in the hypothalamic-pituitary-thyroid (HHT) axis can affect the production of thyroid hormones by interacting with estrogen receptors located in the thyroid, in addition to influencing the action of deiodases for hormone conversion in peripheral tissues. Thus, the objective of this review was to highlight the possible changes caused by the consumption of isoflavones and their impact on the production of thyroid hormones. For this, search platforms such as PubMed, Science Direct and Google Scholar were used. Search filters limiting the year of publication of the articles used as reference were not applied in this research due to the relevance of initial studies that address the relationship between isoflavones/soy and endocrine disruption. Effects of exposure to soy isoflavones (ISOF) on thyroid functions related to subclinical hypothyroidism were evidenced.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/32089
10.33448/rsd-v11i9.32089
url https://rsdjournal.org/index.php/rsd/article/view/32089
identifier_str_mv 10.33448/rsd-v11i9.32089
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/32089/27330
dc.rights.driver.fl_str_mv Copyright (c) 2022 Gonzalo Ogliari Dal Forno; Marco Aurélio Romano; Renata Marino Romano
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Gonzalo Ogliari Dal Forno; Marco Aurélio Romano; Renata Marino Romano
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 9; e47011932089
Research, Society and Development; Vol. 11 Núm. 9; e47011932089
Research, Society and Development; v. 11 n. 9; e47011932089
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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