Orofacial findings of congenital generalized lipodystrophy: a systematic review

• Autor(a) principal: Sousa, Lucas Cavalcante de
• Data de Publicação: 2020
• Outros Autores: Amancio, Amanda de Medeiros, Silva, Érika Giovana Carvalho da, Oliveira, Francisca Jennifer Duarte de, Gonçalves, Gabriel Coutinho, Almeida, Dennys Ramon de Melo Fernandes, Silva, Gabriel Gomes da, Pinheiro, Juliana Campos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/6659
• topic: Lipodistrofia generalizada congênita; Alterações orofaciais; Manifestações orofaciais.; Lipodistrofia congénita generalizada; Cambios orofaciales; Manifestaciones orofaciales.; Congenital generalized lipodystrophy; Orofacial changes; Orofacial manifestations.

This study aims to verify the orofacial findings of congenital generalized lipodystrophy (LGC) in patients diagnosed with this condition. This is a systematic review of the literature, carried out in accordance with the PubMed, Web of Science and Scopus databases. 14 studies published in the last 15 years that addressed the orofacial clinical findings of LGC were included. LGC is a rare autosomal recessive condition, presenting a wide variety of manifestations that affect the oral and facial regions. The main orofacial findings identified were prognathism, absence of facial subcutaneous fat, prominent frontal and supraorbital protrusions, low frontal hairline, triangular face, facial hirsutism, macroglossia, labial hypertrophy, abnormal dental morphology, dental caries, tooth absences, diastemas and crowding dental. The results indicate that LGC can cause significant orofacial changes in individuals, and it is important that these patients are monitored by a multidisciplinary health team, and that these professionals have knowledge based on scientific evidence regarding these clinical findings, to offer a better prognosis for these patients.