Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review

Detalhes bibliográficos
Autor(a) principal: Cruvinel, Mônica Ferreira Silva
Data de Publicação: 2021
Outros Autores: Silva, Davi de Lima, Silva, Thaís Ferreira da, Hillades, Maria Vitória Pereira, Bernardes, Tiago Soares, Abdalla, Michel Reis, Abdalla, Douglas Reis
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/23482
Resumo: A promising tool to act as circulating biomarkers are cellular ratios, which reflect systemic inflammation and are potential predictors for mortality prognosis in various populations. Therefore, the aim of this review is to discuss the compliance of cellular relationships and their significance in COVID-19 infection. In the present study, an integrative review was conducted. After defining the guiding question, locating and selecting articles, 491 potentially eligible publications were identified. After applying the inclusion and exclusion criteria, the sample consisted of 35 articles. It was found that elevated peripheral blood cell ratios indicate unsatisfactory clinical outcome of COVID-19. Patients with these elevated cell ratios had higher incidence of acute respiratory distress syndrome, higher rate of need for mechanical ventilation, and higher mortality rates. In conclusion, it was found that there was an association between the quantitative value of the cell ratios with the evolution of the patient with COVID-19. It was observed that the higher the neutrophil/lymphocyte, platelet/lymphocyte, and lymphocyte/monocyte ratios, the worse the prognosis of the patient infected with SARS-CoV 2. Further research is needed to confirm these findings and to compare the predictive ability of the ratios in the evolution of COVID-19 infection.
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spelling Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature ReviewImplicaciones clínicas de las relaciones celulares en la infección por SARS-CoV-2 y resultados de COVID-19: Una Revisión Bibliográfica IntegradoraImplicações clínicas das relações celulares na infecção pelo SARS-CoV-2 e desfechos da COVID-19: Revisão Integrativa da LiteraturaCOVID-19SARS-CoV-2InflamaciónPronóstico.COVID-19SARS-CoV-2InflammationPrognosis.COVID-19SARS-CoV-2InflamaçãoPrognóstico.A promising tool to act as circulating biomarkers are cellular ratios, which reflect systemic inflammation and are potential predictors for mortality prognosis in various populations. Therefore, the aim of this review is to discuss the compliance of cellular relationships and their significance in COVID-19 infection. In the present study, an integrative review was conducted. After defining the guiding question, locating and selecting articles, 491 potentially eligible publications were identified. After applying the inclusion and exclusion criteria, the sample consisted of 35 articles. It was found that elevated peripheral blood cell ratios indicate unsatisfactory clinical outcome of COVID-19. Patients with these elevated cell ratios had higher incidence of acute respiratory distress syndrome, higher rate of need for mechanical ventilation, and higher mortality rates. In conclusion, it was found that there was an association between the quantitative value of the cell ratios with the evolution of the patient with COVID-19. It was observed that the higher the neutrophil/lymphocyte, platelet/lymphocyte, and lymphocyte/monocyte ratios, the worse the prognosis of the patient infected with SARS-CoV 2. Further research is needed to confirm these findings and to compare the predictive ability of the ratios in the evolution of COVID-19 infection.Una herramienta prometedora para actuar como biomarcadores circulantes son los ratios celulares, que reflejan la inflamación sistémica, siendo potenciales predictores del pronóstico de mortalidad en diversas poblaciones. Por lo tanto, el objetivo de esta revisión es discutir el cumplimiento de las relaciones celulares y su importancia en la infección por COVID-19. En el presente estudio se realizó una revisión integradora. Tras definir la pregunta guía, localizar y seleccionar los artículos, se identificaron 491 publicaciones potencialmente elegibles. Tras aplicar los criterios de inclusión y exclusión, la muestra quedó compuesta por 35 artículos. Se descubrió que los índices elevados de células sanguíneas periféricas indican un resultado clínico insatisfactorio de COVID-19. Los pacientes con estos índices celulares elevados tenían una mayor incidencia de síndrome de dificultad respiratoria aguda, mayor necesidad de ventilación mecánica y mayores tasas de mortalidad. En conclusión, se encontró que había una asociación entre el valor cuantitativo de los ratios celulares con la evolución del paciente con COVID-19. Se observó que cuanto más altos eran los ratios neutrófilos/linfocitos, plaquetas/linfocitos y linfocitos/monocitos, peor era el pronóstico del paciente infectado por el SARS-CoV 2. Se necesitan más investigaciones para confirmar estos hallazgos y comparar la capacidad predictiva de los ratios en la evolución de la infección por COVID-19.Uma ferramenta promissora para atuar como biomarcadores circulantes são as relações celulares, que refletem a inflamação sistêmica, sendo potenciais preditores para o prognóstico de mortalidade em várias populações. Portanto, o objetivo desta revisão consiste em discutir a conformidade entre as relações celulares e seus significados na infecção COVID-19. No presente estudo foi conduzida uma revisão integrativa. Após a definição da questão norteadora, localização e seleção dos artigos, foram identificadas 491 publicações potencialmente elegíveis. Após a aplicação dos critérios de inclusão e exclusão a amostra foi composta por 35 artigos. Constatou-se que a elevação das relações celulares do sangue periférico indicam desfecho clínico insatisfatório de COVID-19. Os pacientes com essas relações celulares elevadas apresentaram maior incidência de síndrome do desconforto respiratório agudo, maior taxa de necessidade de ventilação mecânica e maiores taxas de mortalidade. Em conclusão, constatou-se que houve associação entre o valor quantitativo das relações celulares com a evolução do paciente com COVID-19. Observou-se que quanto maior forem as relações neutrófilo/linfócito, plaqueta/linfócito e linfócito/monócito, pior será o prognóstico do paciente infectado pelo SARS-CoV 2. Mais pesquisas são necessárias para confirmar esses achados e para comparar a capacidade preditiva das relações na evolução da infecção da COVID-19.Research, Society and Development2021-12-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2348210.33448/rsd-v10i16.23482Research, Society and Development; Vol. 10 No. 16; e164101623482Research, Society and Development; Vol. 10 Núm. 16; e164101623482Research, Society and Development; v. 10 n. 16; e1641016234822525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23482/20831Copyright (c) 2021 Mônica Ferreira Silva Cruvinel; Davi de Lima Silva; Thaís Ferreira da Silva; Maria Vitória Pereira Hillades; Tiago Soares Bernardes; Michel Reis Abdalla; Douglas Reis Abdallahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCruvinel, Mônica Ferreira Silva Silva, Davi de Lima Silva, Thaís Ferreira da Hillades, Maria Vitória Pereira Bernardes, Tiago Soares Abdalla, Michel Reis Abdalla, Douglas Reis2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/23482Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:20.317594Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
Implicaciones clínicas de las relaciones celulares en la infección por SARS-CoV-2 y resultados de COVID-19: Una Revisión Bibliográfica Integradora
Implicações clínicas das relações celulares na infecção pelo SARS-CoV-2 e desfechos da COVID-19: Revisão Integrativa da Literatura
title Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
spellingShingle Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
Cruvinel, Mônica Ferreira Silva
COVID-19
SARS-CoV-2
Inflamación
Pronóstico.
COVID-19
SARS-CoV-2
Inflammation
Prognosis.
COVID-19
SARS-CoV-2
Inflamação
Prognóstico.
title_short Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
title_full Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
title_fullStr Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
title_full_unstemmed Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
title_sort Clinical Implications of Cellular Ratios in SARS-CoV-2 Infection and Outcomes of COVID-19: An Integrative Literature Review
author Cruvinel, Mônica Ferreira Silva
author_facet Cruvinel, Mônica Ferreira Silva
Silva, Davi de Lima
Silva, Thaís Ferreira da
Hillades, Maria Vitória Pereira
Bernardes, Tiago Soares
Abdalla, Michel Reis
Abdalla, Douglas Reis
author_role author
author2 Silva, Davi de Lima
Silva, Thaís Ferreira da
Hillades, Maria Vitória Pereira
Bernardes, Tiago Soares
Abdalla, Michel Reis
Abdalla, Douglas Reis
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruvinel, Mônica Ferreira Silva
Silva, Davi de Lima
Silva, Thaís Ferreira da
Hillades, Maria Vitória Pereira
Bernardes, Tiago Soares
Abdalla, Michel Reis
Abdalla, Douglas Reis
dc.subject.por.fl_str_mv COVID-19
SARS-CoV-2
Inflamación
Pronóstico.
COVID-19
SARS-CoV-2
Inflammation
Prognosis.
COVID-19
SARS-CoV-2
Inflamação
Prognóstico.
topic COVID-19
SARS-CoV-2
Inflamación
Pronóstico.
COVID-19
SARS-CoV-2
Inflammation
Prognosis.
COVID-19
SARS-CoV-2
Inflamação
Prognóstico.
description A promising tool to act as circulating biomarkers are cellular ratios, which reflect systemic inflammation and are potential predictors for mortality prognosis in various populations. Therefore, the aim of this review is to discuss the compliance of cellular relationships and their significance in COVID-19 infection. In the present study, an integrative review was conducted. After defining the guiding question, locating and selecting articles, 491 potentially eligible publications were identified. After applying the inclusion and exclusion criteria, the sample consisted of 35 articles. It was found that elevated peripheral blood cell ratios indicate unsatisfactory clinical outcome of COVID-19. Patients with these elevated cell ratios had higher incidence of acute respiratory distress syndrome, higher rate of need for mechanical ventilation, and higher mortality rates. In conclusion, it was found that there was an association between the quantitative value of the cell ratios with the evolution of the patient with COVID-19. It was observed that the higher the neutrophil/lymphocyte, platelet/lymphocyte, and lymphocyte/monocyte ratios, the worse the prognosis of the patient infected with SARS-CoV 2. Further research is needed to confirm these findings and to compare the predictive ability of the ratios in the evolution of COVID-19 infection.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23482
10.33448/rsd-v10i16.23482
url https://rsdjournal.org/index.php/rsd/article/view/23482
identifier_str_mv 10.33448/rsd-v10i16.23482
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23482/20831
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 16; e164101623482
Research, Society and Development; Vol. 10 Núm. 16; e164101623482
Research, Society and Development; v. 10 n. 16; e164101623482
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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