New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis

Detalhes bibliográficos
Autor(a) principal: Rocha, Lara Lys Santos
Data de Publicação: 2020
Outros Autores: Freire, José Ednésio da Cruz
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/4491
Resumo: VMAT2 are glycoproteins capable of carrying monoamines from presynaptic vesicles to synaptic clefts during neuronal firing. Present in many species of animals including, mammals, reptiles and birds, this protein has been studied extensively, however, little is known about its physical-chemical characteristics and mode of interaction with native ligands or not. In order to better characterize human VMAT2, the present study was developed in order to explore various physical-chemical, biochemical and structural parameters related to this neurotransporter through in silico tools. In this work, new and relevant ideas about the structure and its mechanism of interaction with 5-HT are presented.
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spelling New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysisNuevos insights sobre las propiedades fisicoquímicas del transportador de monoamina VMAT2 humano y su modo de interacción con el neurotransmisor serotonina: Un análisis in silicoNovos insights sobre as propriedades físico-químicas do transportador de monoaminas VMAT2 humano e seu modo de interação com o neurotransmissor serotonina: Uma análise in silicoPhysicochemical predictionMolecular modelingMonoamine transportersSerotoninMolecular docking.Predição físico-químicaModelagem molecularTransportadores de monoaminasSerotoninaDocking molecularPredicción fisicoquímicaModelado molecularTransportadores de monoaminasSerotoninaAcoplamiento molecular.VMAT2 are glycoproteins capable of carrying monoamines from presynaptic vesicles to synaptic clefts during neuronal firing. Present in many species of animals including, mammals, reptiles and birds, this protein has been studied extensively, however, little is known about its physical-chemical characteristics and mode of interaction with native ligands or not. In order to better characterize human VMAT2, the present study was developed in order to explore various physical-chemical, biochemical and structural parameters related to this neurotransporter through in silico tools. In this work, new and relevant ideas about the structure and its mechanism of interaction with 5-HT are presented.VMAT2 son glicoproteínas capaces de transportar monoaminas desde vesículas presinápticas a hendiduras sinápticas durante la activación neuronal. Presente en muchas especies de animales, incluidos mamíferos, reptiles y aves, esta proteína se ha estudiado ampliamente, sin embargo, se sabe poco sobre sus características fisicoquímicas y el modo de interacción con ligandos nativos o no. Para caracterizar mejor el VMAT2 humano, el presente estudio se desarrolló para explorar diversos parámetros físico-químicos, bioquímicos y estructurales relacionados con este neurotransportador a través de herramientas in silico. En este trabajo, se presentan ideas nuevas y relevantes sobre la estructura y su mecanismo de interacción con 5-HT.As VMAT2 são glicoproteínas capazes de carrear monoaminas a partir de vesículas pré-sinápticas para as fendas sinápticas durante disparos neuronais. Presentes em muitas espécies de animais incluindo, mamíferos, répteis e aves, esta proteína tem sido estudada extensivamente, porém, pouco se sabe sobre suas características físico-químicas e modo de interação com ligantes nativos ou não. Com o intuito de melhor caracterizar a VMAT2 humana, o presente estudo foi desenvolvido a fim de explorar vários parâmetros físico-químicos, bioquímicos e estruturais relacionados a esse neurotransportador por meio de ferramentas in silico. Neste trabalho, são apresentadas ideias novas e relevantes sobre a estrutura e o seu mecanismo de interação com a 5-HT.Research, Society and Development2020-05-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/449110.33448/rsd-v9i7.4491Research, Society and Development; Vol. 9 No. 7; e530974491Research, Society and Development; Vol. 9 Núm. 7; e530974491Research, Society and Development; v. 9 n. 7; e5309744912525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/4491/3767Copyright (c) 2020 Lara Lys Santos Rocha, José Ednésio da Cruz Freireinfo:eu-repo/semantics/openAccessRocha, Lara Lys SantosFreire, José Ednésio da Cruz2020-08-20T18:05:03Zoai:ojs.pkp.sfu.ca:article/4491Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:28:19.581655Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
Nuevos insights sobre las propiedades fisicoquímicas del transportador de monoamina VMAT2 humano y su modo de interacción con el neurotransmisor serotonina: Un análisis in silico
Novos insights sobre as propriedades físico-químicas do transportador de monoaminas VMAT2 humano e seu modo de interação com o neurotransmissor serotonina: Uma análise in silico
title New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
spellingShingle New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
Rocha, Lara Lys Santos
Physicochemical prediction
Molecular modeling
Monoamine transporters
Serotonin
Molecular docking.
Predição físico-química
Modelagem molecular
Transportadores de monoaminas
Serotonina
Docking molecular
Predicción fisicoquímica
Modelado molecular
Transportadores de monoaminas
Serotonina
Acoplamiento molecular.
title_short New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
title_full New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
title_fullStr New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
title_full_unstemmed New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
title_sort New insights into the physicochemical properties of the human VMAT2 monoamine transporter and its mode of interaction with the neurotransmitter serotonin: An in silico analysis
author Rocha, Lara Lys Santos
author_facet Rocha, Lara Lys Santos
Freire, José Ednésio da Cruz
author_role author
author2 Freire, José Ednésio da Cruz
author2_role author
dc.contributor.author.fl_str_mv Rocha, Lara Lys Santos
Freire, José Ednésio da Cruz
dc.subject.por.fl_str_mv Physicochemical prediction
Molecular modeling
Monoamine transporters
Serotonin
Molecular docking.
Predição físico-química
Modelagem molecular
Transportadores de monoaminas
Serotonina
Docking molecular
Predicción fisicoquímica
Modelado molecular
Transportadores de monoaminas
Serotonina
Acoplamiento molecular.
topic Physicochemical prediction
Molecular modeling
Monoamine transporters
Serotonin
Molecular docking.
Predição físico-química
Modelagem molecular
Transportadores de monoaminas
Serotonina
Docking molecular
Predicción fisicoquímica
Modelado molecular
Transportadores de monoaminas
Serotonina
Acoplamiento molecular.
description VMAT2 are glycoproteins capable of carrying monoamines from presynaptic vesicles to synaptic clefts during neuronal firing. Present in many species of animals including, mammals, reptiles and birds, this protein has been studied extensively, however, little is known about its physical-chemical characteristics and mode of interaction with native ligands or not. In order to better characterize human VMAT2, the present study was developed in order to explore various physical-chemical, biochemical and structural parameters related to this neurotransporter through in silico tools. In this work, new and relevant ideas about the structure and its mechanism of interaction with 5-HT are presented.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4491
10.33448/rsd-v9i7.4491
url https://rsdjournal.org/index.php/rsd/article/view/4491
identifier_str_mv 10.33448/rsd-v9i7.4491
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4491/3767
dc.rights.driver.fl_str_mv Copyright (c) 2020 Lara Lys Santos Rocha, José Ednésio da Cruz Freire
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Lara Lys Santos Rocha, José Ednésio da Cruz Freire
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 7; e530974491
Research, Society and Development; Vol. 9 Núm. 7; e530974491
Research, Society and Development; v. 9 n. 7; e530974491
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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