Diabetic Mastopathy as a differential diagnosis for breast cancer: integrative literature review

• Autor(a) principal: Troncoso, Gabriela
• Data de Publicação: 2021
• Outros Autores: Sá Júnior, Álvaro Alves de, Escoura, Letícia Dias, Sisconetto, Rafaela Melo, Abdalla, Douglas Reis
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• DOI: 10.33448/rsd-v10i14.21961
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/21961
• topic: Diabetes mellitus; Carcinoma de mama; Complicaciones de la diabetes.; Diabetes Mellitus; Carcinoma Mamário; Complicações do diabetes.; Diabetes mellitus; Breast carcinoma; Diabetes complications.

Introduction: Diabetic Mastopathy is a rare and benign disease that affects the breasts, being one of the main differential diagnoses related to breast carcinomas. However, despite presenting imaging and clinical features similar to malignant breast processes, it was evidenced that this pathology is not related to premalignant or malignant evolutions. This pathology seems to be related to an autoimmune response secondary to a prolonged hyperglycemic state, present in diabetic patients. Objective: To search the literature for evidence of diabetic mastopathy as a differential manifestation of neoplastic breast lesions. Methodology: Integrative literature review on the PubMed database of productions from 2008 to 2021. The descriptors used were: "diabetic mastopathy"; "mastopathy"; "diabetes mellitus"; "breast"; "breast pathologies", which were conjugated to delimit the search. Results: The search found 45 studies, from which 13 were selected that contemplated the guiding question. The review revealed that the pathology portrayed presents characteristics that require a careful analysis of the clinical history with physical examination and complementation with imaging exams. Biopsy, especially by thick needle, is the most efficient diagnostic method for histopathological elucidation. Furthermore, due to the increasing presence of risk factors for the development of this disease in the current population, diabetic mastopathy is expected to become more common. Final considerations: Diabetic mastopathy is, therefore, an important differential diagnosis for breast neoplasms whose diagnosis is quite complex and requires, besides clinical aspects, the analysis of radiological and laboratory components.