Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17227 |
Resumo: | Cystic fibrosis (CF) is a genetic disease of autosomal recessive profile and is characterized by dysfunction of the CFTR gene, which will affect some organs such as the lungs, pancreas, liver, intestines, and testes, with the lungs being the most characteristic. Such changes are capable of causing consistent obstructions due to the viscous mucus produced. Infections are a recurrent factor in carriers of this disease due to the presence of secretion, becoming an ideal environment for the propagation of microorganisms, such as fungi and bacteria, which can colonize the airways of patients and bring about an aggravation, worsening the patient's clinical picture. This is the case of the fungus Aspergillus fumigattus, the cause of allergic bronchopulmonary aspergillosis (ABPA), which can lead to relevant complications, especially in lung function. Analyzing the factors that make CF patients more likely to contract ABPA and how this can worsen their clinical condition, searching for materials from the PUBMED and SCIELO platforms, using the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), the results obtained in this study show that the presence of ABPA in cystic fibrosis patients brings increased microbial colonization, lung deterioration, poorer nutritional status, and greater respiratory obstruction by mucus that causes a greater increase in hospitalization. |
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Allergic bronchopulmonary aspergillosis in patients with Cystic FibrosisAspergilosis broncopulmonar alérgica em pacientes com Fibrosis Quística Aspergilose broncopulmonar alérgica em pacientes com Fibrose CísticaFibrosis quísticaAspergillus fumigatusAspergilosis broncopulmonar alérgica.Cystic fibrosisAspergillus fumigatusAllergic bronchopulmonary aspergillosis.Fibrose císticaAspergillus fumigatusAspergilose broncopulmonar alérgica.Cystic fibrosis (CF) is a genetic disease of autosomal recessive profile and is characterized by dysfunction of the CFTR gene, which will affect some organs such as the lungs, pancreas, liver, intestines, and testes, with the lungs being the most characteristic. Such changes are capable of causing consistent obstructions due to the viscous mucus produced. Infections are a recurrent factor in carriers of this disease due to the presence of secretion, becoming an ideal environment for the propagation of microorganisms, such as fungi and bacteria, which can colonize the airways of patients and bring about an aggravation, worsening the patient's clinical picture. This is the case of the fungus Aspergillus fumigattus, the cause of allergic bronchopulmonary aspergillosis (ABPA), which can lead to relevant complications, especially in lung function. Analyzing the factors that make CF patients more likely to contract ABPA and how this can worsen their clinical condition, searching for materials from the PUBMED and SCIELO platforms, using the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), the results obtained in this study show that the presence of ABPA in cystic fibrosis patients brings increased microbial colonization, lung deterioration, poorer nutritional status, and greater respiratory obstruction by mucus that causes a greater increase in hospitalization.La fibrosis quística (FQ) es una enfermedad genética de perfil autosómico recesivo y se caracteriza por la disfunción del gen CFTR, que afectará a algunos órganos como los pulmones, el páncreas, el hígado, el intestino y los testículos, siendo los pulmones los más característicos. Estas alteraciones son capaces de provocar obstrucciones consistentes debido al moco viscoso producido. Las infecciones son un factor recurrente en los portadores de esta enfermedad debido a la presencia de secreciones, convirtiéndose en un ambiente ideal para la propagación de microorganismos como hongos y bacterias, que pueden colonizar las vías respiratorias de los pacientes y traer un agravamiento, empeorando el cuadro clínico del paciente. Es el caso del hongo Aspergillus fumigattus, causante de la aspergilosis broncopulmonar alérgica (ABPA), que puede dar lugar a complicaciones relevantes, especialmente en la función pulmonar. Analizando los factores que hacen que los pacientes con FQ sean más propensos a contraer ABPA y cómo esto puede empeorar su condición clínica, con una búsqueda de materiales de las plataformas PUBMED y SCIELO, utilizando las recomendaciones de los Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), los resultados obtenidos en este estudio muestran que la presencia de ABPA en los pacientes con fibrosis quística conlleva un aumento de la colonización microbiana, deterioro pulmonar, peor estado nutricional y mayor obstrucción respiratoria por mucosidad, lo que provoca un mayor aumento de la hospitalización.A fibrose cística (FC) é uma doença genética de perfil autossômico recessivo e é caracterizada pela disfunção do gene CFTR, o que irá afetar alguns órgãos como pulmão, pâncreas, fígado, intestino e testículos, sendo os pulmões o mais acometido. Tais alterações são capazes de provocar obstruções consistentes devido ao muco viscoso produzido. As infecções são um fator recorrente nos portadores dessa doença devido a presença da secreção, tornando-se um ambiente ideal para propagação de micro-organismos, como fungos e bactérias, que podem colonizar as vias aéreas dos pacientes e provocar agravos, piorando o quadro clínico do paciente. Como é o caso do fungo Aspergillus fumigattus, causador da aspergilose broncopulmonar alérgica (ABPA), que pode acarretar relevantes complicações principalmente nas funções pulmonares. Analisando os fatores que faz com que os pacientes com FC tenha maior facilidade em contrair a ABPA e como isso pode agravar seu quadro clínico, com busca de materiais a partir das plataformas PUBMED e SCIELO, utilizando as recomendações do Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), os resultados obtidos nesse estudo mostram que a presença de ABPA nos fibrocísticos favorecem um aumento nas colonizações microbianas, deterioração pulmonar, pior estado nutricional além de maior obstrução respiratória por muco, contribuindo pelo aumento nos índices de hospitalização.Research, Society and Development2021-06-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1722710.33448/rsd-v10i7.17227Research, Society and Development; Vol. 10 No. 7; e47610717227Research, Society and Development; Vol. 10 Núm. 7; e47610717227Research, Society and Development; v. 10 n. 7; e476107172272525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17227/14695Copyright (c) 2021 Reinaldo José dos Santos Júnior; Natália Millena Silva; Pâmella Grasielle Vital Dias de Souzahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos Júnior, Reinaldo José dosSilva, Natália MillenaSouza, Pâmella Grasielle Vital Dias de 2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/17227Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:36.743054Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis Aspergilosis broncopulmonar alérgica em pacientes com Fibrosis Quística Aspergilose broncopulmonar alérgica em pacientes com Fibrose Cística |
title |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
spellingShingle |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis Santos Júnior, Reinaldo José dos Fibrosis quística Aspergillus fumigatus Aspergilosis broncopulmonar alérgica. Cystic fibrosis Aspergillus fumigatus Allergic bronchopulmonary aspergillosis. Fibrose cística Aspergillus fumigatus Aspergilose broncopulmonar alérgica. |
title_short |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
title_full |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
title_fullStr |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
title_full_unstemmed |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
title_sort |
Allergic bronchopulmonary aspergillosis in patients with Cystic Fibrosis |
author |
Santos Júnior, Reinaldo José dos |
author_facet |
Santos Júnior, Reinaldo José dos Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
author_role |
author |
author2 |
Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Santos Júnior, Reinaldo José dos Silva, Natália Millena Souza, Pâmella Grasielle Vital Dias de |
dc.subject.por.fl_str_mv |
Fibrosis quística Aspergillus fumigatus Aspergilosis broncopulmonar alérgica. Cystic fibrosis Aspergillus fumigatus Allergic bronchopulmonary aspergillosis. Fibrose cística Aspergillus fumigatus Aspergilose broncopulmonar alérgica. |
topic |
Fibrosis quística Aspergillus fumigatus Aspergilosis broncopulmonar alérgica. Cystic fibrosis Aspergillus fumigatus Allergic bronchopulmonary aspergillosis. Fibrose cística Aspergillus fumigatus Aspergilose broncopulmonar alérgica. |
description |
Cystic fibrosis (CF) is a genetic disease of autosomal recessive profile and is characterized by dysfunction of the CFTR gene, which will affect some organs such as the lungs, pancreas, liver, intestines, and testes, with the lungs being the most characteristic. Such changes are capable of causing consistent obstructions due to the viscous mucus produced. Infections are a recurrent factor in carriers of this disease due to the presence of secretion, becoming an ideal environment for the propagation of microorganisms, such as fungi and bacteria, which can colonize the airways of patients and bring about an aggravation, worsening the patient's clinical picture. This is the case of the fungus Aspergillus fumigattus, the cause of allergic bronchopulmonary aspergillosis (ABPA), which can lead to relevant complications, especially in lung function. Analyzing the factors that make CF patients more likely to contract ABPA and how this can worsen their clinical condition, searching for materials from the PUBMED and SCIELO platforms, using the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), the results obtained in this study show that the presence of ABPA in cystic fibrosis patients brings increased microbial colonization, lung deterioration, poorer nutritional status, and greater respiratory obstruction by mucus that causes a greater increase in hospitalization. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17227 10.33448/rsd-v10i7.17227 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17227 |
identifier_str_mv |
10.33448/rsd-v10i7.17227 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17227/14695 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 7; e47610717227 Research, Society and Development; Vol. 10 Núm. 7; e47610717227 Research, Society and Development; v. 10 n. 7; e47610717227 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052681784655872 |