Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease

Detalhes bibliográficos
Autor(a) principal: Souza, Lívia Bruni de
Data de Publicação: 2022
Outros Autores: Guzzoni, Vinicius, Cunha, Tatiana Sousa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/30040
Resumo: Objective: The purpose of the present study was to show information about the effects of probiotics on inflammatory and Renin Angiotensin System (RAS) balance, and their potential therapeutic role in the management of COVID-19. Methodology: This is a narrative literature review and the databases used were Google Scholar and Medline/Pubmed. Results: Some components of the intestinal microbiota, including Coprobacillus, Clostridium ramosum, Morganella morganii, and Streptococcus infantile were identified as positively correlated with the severity of the disease, while Faecalibacterium prausnitzii showed a negative correlation with SARS-CoV-2 infection. Probiotics emerge as a therapeutic alternative for the treatment of inflammatory conditions due to their effects on the maintenance of gastrointestinal integrity and repair properties. More specifically, probiotics from Bifidobacterium e Lactobacillus genus show benefits in the management of respiratory diseases and might enhance vaccine immunogenicity. Conclusion: The present study demonstrates the complementary therapeutic potential of probiotics in the treatment of respiratory infections, such as COVID-19. Beyond that, considering the diversity of probiotic strains, the evaluations already carried out and the data available in the literature, the present study points to the need for complementary studies to understand the mechanisms related to the effects of probiotics on COVID-19.
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spelling Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the diseasePapel de la microbiota intestinal en la infección por SARS-CoV-2 y los beneficios de los probióticos en el manejo de la enfermedadPapel da microbiota intestinal na infecção por SARS-CoV-2 e os benefícios dos probióticos no manejo da doençaCOVID-19Renin-angiotensin systemInflammationVaccines. COVID-19Sistema renina-angiotensinaInflamaciónVacunas.COVID-19Sistema renina-angiotensinaInflamaçãoVacinas.Objective: The purpose of the present study was to show information about the effects of probiotics on inflammatory and Renin Angiotensin System (RAS) balance, and their potential therapeutic role in the management of COVID-19. Methodology: This is a narrative literature review and the databases used were Google Scholar and Medline/Pubmed. Results: Some components of the intestinal microbiota, including Coprobacillus, Clostridium ramosum, Morganella morganii, and Streptococcus infantile were identified as positively correlated with the severity of the disease, while Faecalibacterium prausnitzii showed a negative correlation with SARS-CoV-2 infection. Probiotics emerge as a therapeutic alternative for the treatment of inflammatory conditions due to their effects on the maintenance of gastrointestinal integrity and repair properties. More specifically, probiotics from Bifidobacterium e Lactobacillus genus show benefits in the management of respiratory diseases and might enhance vaccine immunogenicity. Conclusion: The present study demonstrates the complementary therapeutic potential of probiotics in the treatment of respiratory infections, such as COVID-19. Beyond that, considering the diversity of probiotic strains, the evaluations already carried out and the data available in the literature, the present study points to the need for complementary studies to understand the mechanisms related to the effects of probiotics on COVID-19.Meta: El objetivo de este estudio fue presentar información sobre los efectos de los probióticos en el estado inflamatorio y el equilíbrio Sistema Renina-Angiotensina (RAS), el potencial terapéutico en el manejo de COVID-19. Metodología: Se trata de una revisión narrativa y las bases de datos utilizadas fueron Google Scholar y Medline/Pubmed. Resultados: Coprobacillus, Clostridium ramosum, Morganella morganii y Streptococcus infantil de la microbiota intestinal mostraron una correlación positiva con la gravedad de la enfermedad, mientras que una correlación negativa se asoció con Faecalibacterium prausnitzii en la infección por SARS-CoV-2. Debido a la capacidad de mantener la integridad y reparar el daño intestinal, los probióticos emergen como una alternativa terapéutica para el tratamiento de enfermedades relacionadas con el metabolismo y condiciones inflamatorias inducidas por infecciones intestinales. Los probióticos de los géneros Bifidobacterium y Lactobacillus muestran beneficios en enfermedades respiratorias además de aumentar la inmunogenicidad de las vacunas. Conclusión: El presente estudio demuestra el potencial terapéutico complementario de los probióticos en el tratamiento de infecciones respiratorias, incluida la COVID-19. Además, considerando la diversidad de cepas probióticas, las evaluaciones ya realizadas y los datos disponibles en la literatura, el presente estudio también apunta a la necesidad de estudios complementarios que busquen comprender los mecanismos relacionados con los efectos de los probióticos en la COVID-19.Objetivo: O objetivo do presente estudo foi apresentar informações acerca dos efeitos de probióticos sobre o estado inflamatório e balanço do Sistema Renina Angiotensina (SRA) e potencial terapêutico no manejo da COVID-19. Metodologia: Trata-se de uma revisão narrativa e as bases de dados utilizadas foram Google Scholar e Medline/Pubmed. Resultados: Foram identificados componentes da microbiota intestinal, incluindo Coprobacillus, Clostridium ramosum, Morganella morganii e Streptococcus infantile, que estão positivamente correlacionados com a severidade da doença, enquanto Faecalibacterium prausnitzii apresentou correlação negativa na infecção por SARS-CoV-2. De acordo com os resultados encontrados, observa-se que os probióticos constituem uma alternativa terapêutica para o tratamento de condições inflamatórias devido aos seus efeitos sobre a manutenção da integridade gastrointestinal e propriedade de reparo. Mais especificamente, os probióticos dos gêneros Bifidobacterium e Lactobacillus mostram benefícios no manejo de doenças respiratórias, além de proporcionarem aumento da imunogenicidade às vacinas. Conclusão: O presente estudo demonstra o potencial terapêutico complementar dos probióticos no tratamento das infecções respiratórias, incluindo a COVID-19. Além disto, considerando a diversidade de cepas de probióticos, as avaliações já realizadas e os dados disponíveis na literatura, o presente estudo também aponta para a necessidade de estudos complementares buscando compreender os mecanismos relacionados aos efeitos dos probióticos na COVID-19.Research, Society and Development2022-06-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3004010.33448/rsd-v11i7.30040Research, Society and Development; Vol. 11 No. 7; e48811730040Research, Society and Development; Vol. 11 Núm. 7; e48811730040Research, Society and Development; v. 11 n. 7; e488117300402525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/30040/26083Copyright (c) 2022 Lívia Bruni de Souza; Vinicius Guzzoni; Tatiana Sousa Cunhahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSouza, Lívia Bruni deGuzzoni, ViniciusCunha, Tatiana Sousa 2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/30040Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:56.048109Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
Papel de la microbiota intestinal en la infección por SARS-CoV-2 y los beneficios de los probióticos en el manejo de la enfermedad
Papel da microbiota intestinal na infecção por SARS-CoV-2 e os benefícios dos probióticos no manejo da doença
title Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
spellingShingle Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
Souza, Lívia Bruni de
COVID-19
Renin-angiotensin system
Inflammation
Vaccines.
COVID-19
Sistema renina-angiotensina
Inflamación
Vacunas.
COVID-19
Sistema renina-angiotensina
Inflamação
Vacinas.
title_short Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
title_full Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
title_fullStr Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
title_full_unstemmed Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
title_sort Role of gut microbiota in SARS-CoV-2 infection and the beneficial effects of probiotics on the management of the disease
author Souza, Lívia Bruni de
author_facet Souza, Lívia Bruni de
Guzzoni, Vinicius
Cunha, Tatiana Sousa
author_role author
author2 Guzzoni, Vinicius
Cunha, Tatiana Sousa
author2_role author
author
dc.contributor.author.fl_str_mv Souza, Lívia Bruni de
Guzzoni, Vinicius
Cunha, Tatiana Sousa
dc.subject.por.fl_str_mv COVID-19
Renin-angiotensin system
Inflammation
Vaccines.
COVID-19
Sistema renina-angiotensina
Inflamación
Vacunas.
COVID-19
Sistema renina-angiotensina
Inflamação
Vacinas.
topic COVID-19
Renin-angiotensin system
Inflammation
Vaccines.
COVID-19
Sistema renina-angiotensina
Inflamación
Vacunas.
COVID-19
Sistema renina-angiotensina
Inflamação
Vacinas.
description Objective: The purpose of the present study was to show information about the effects of probiotics on inflammatory and Renin Angiotensin System (RAS) balance, and their potential therapeutic role in the management of COVID-19. Methodology: This is a narrative literature review and the databases used were Google Scholar and Medline/Pubmed. Results: Some components of the intestinal microbiota, including Coprobacillus, Clostridium ramosum, Morganella morganii, and Streptococcus infantile were identified as positively correlated with the severity of the disease, while Faecalibacterium prausnitzii showed a negative correlation with SARS-CoV-2 infection. Probiotics emerge as a therapeutic alternative for the treatment of inflammatory conditions due to their effects on the maintenance of gastrointestinal integrity and repair properties. More specifically, probiotics from Bifidobacterium e Lactobacillus genus show benefits in the management of respiratory diseases and might enhance vaccine immunogenicity. Conclusion: The present study demonstrates the complementary therapeutic potential of probiotics in the treatment of respiratory infections, such as COVID-19. Beyond that, considering the diversity of probiotic strains, the evaluations already carried out and the data available in the literature, the present study points to the need for complementary studies to understand the mechanisms related to the effects of probiotics on COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30040
10.33448/rsd-v11i7.30040
url https://rsdjournal.org/index.php/rsd/article/view/30040
identifier_str_mv 10.33448/rsd-v11i7.30040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30040/26083
dc.rights.driver.fl_str_mv Copyright (c) 2022 Lívia Bruni de Souza; Vinicius Guzzoni; Tatiana Sousa Cunha
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Lívia Bruni de Souza; Vinicius Guzzoni; Tatiana Sousa Cunha
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 7; e48811730040
Research, Society and Development; Vol. 11 Núm. 7; e48811730040
Research, Society and Development; v. 11 n. 7; e48811730040
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052812386893824

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