The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease

Detalhes bibliográficos
Autor(a) principal: Cavalcante, Daniel Alexandre Lima
Data de Publicação: 2021
Outros Autores: Fernandes, Laura Trindade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15418
Resumo: Objectives: To analyze and evaluate the current conjuncture inherent to the therapeutic use of natural cannabinoids in delay and protection against the pathophysiological actions caused by Alzheimer's disease. Methods: Overview of systematic reviews. The search and selection of the studies were predominantly in the databases of the Medical Literature Analysis and Retrieval System Online (Medline), National Library of Medicine (Pubmed) and Scientific Electronic Library Online (SciELO) in  the period between March and August  2020.  Key findings: Current results showed promising therapeutic effects of natural cannabinoids in the treatment of Alzheimer's disease, such as reduction of motor and cognitive symptoms, and protective neuroprotective action. These results can be explained, in part, by the anti-inflammatory, antioxidant, antagonist action of CB1 receptors, as well as by the activation of PPAR-gamma receptors produced by these substances. Conclusions: The systematic research presented in this overview converges in the sense that the therapeutic applications provided by natural cannabinoids and their analogues may play a unique role in the modulation of molecular targets involved in central nervous system dysfunctions caused by Alzheimer's disease, thus enabling the development of innovative drugs, safer and more effective in the treatment of patients not responsive to conventional clinical practice, with significant improvement in quality of life.   
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spelling The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's diseaseLos beneficios terapéuticos de los cannabinoides naturales para retrasar la fisiopatología de la enfermedad de AlzheimerOs benefícios terapêuticos dos canabinoides naturais no retardo da fisiopatologia da Doença de AlzhemerAlzheimer's diseasePathophysiologyNeurologyNatural cannabidiodes.Enfermedad de AlzheimerFisiopatologíaNeurologíaCannabidiodes naturales.Doença de AlzheimerFisiopatologiaNeurologiaCanabidioides naturais.Objectives: To analyze and evaluate the current conjuncture inherent to the therapeutic use of natural cannabinoids in delay and protection against the pathophysiological actions caused by Alzheimer's disease. Methods: Overview of systematic reviews. The search and selection of the studies were predominantly in the databases of the Medical Literature Analysis and Retrieval System Online (Medline), National Library of Medicine (Pubmed) and Scientific Electronic Library Online (SciELO) in  the period between March and August  2020.  Key findings: Current results showed promising therapeutic effects of natural cannabinoids in the treatment of Alzheimer's disease, such as reduction of motor and cognitive symptoms, and protective neuroprotective action. These results can be explained, in part, by the anti-inflammatory, antioxidant, antagonist action of CB1 receptors, as well as by the activation of PPAR-gamma receptors produced by these substances. Conclusions: The systematic research presented in this overview converges in the sense that the therapeutic applications provided by natural cannabinoids and their analogues may play a unique role in the modulation of molecular targets involved in central nervous system dysfunctions caused by Alzheimer's disease, thus enabling the development of innovative drugs, safer and more effective in the treatment of patients not responsive to conventional clinical practice, with significant improvement in quality of life.   Objetivo: Analizar y evaluar la situación actual inherente al uso terapéutico de dos cannabinoides naturales que no retrasan y protegen frente a las acciones fisiopatológicas provocadas por la enseñanza de Alzhemer, destacando algunos de los dos principales mecanismos bioquímicos y moleculares subyacentes a esta protección, así como, Cuáles son las perspectivas de uso Estos agentes son de corto y mediano plazo, buscando un tratamiento más efectivo frente a dicha patología. Métodos: Resumen de revisiones sistemáticas. La búsqueda de una selección de dos estudios atravesará predominantemente las bases de datos Medical Literature Analysis and Retrieval System Online (Medline), National Library of Medicine (Pubmed) y Scientific Electronic Library Online (SciELO), sin período entre marzo y agosto de 2020. The Alzhemer's Se combinaron termo de enfermedades, fisiopatología, farmacología y cannabidiodes naturales. Como factor de prioridad para dos criterios de inclusión, seleccionamos revisiones sistemáticas en forma de semi-metaanálisis, publicadas en los últimos 5 años, que difieren en los detalles sobre el tema. Además de la aplicación de dos criterios de inclusión y exclusión, se realizó un análisis de las investigaciones en cuanto a alineación con el objetivo de la cola. Resultados: Los resultados actuales mostrarán efectos terapéuticos prometedores de los cannabinoides naturales no con el tratamiento de la enfermedad de Alzheimer, como la reducción de los síntomas motores y cognitivos y la acción neuroprotectora. Estos resultados pueden explicarse, en parte, por el antiinflamatorio, antioxidante, antagonista de los receptores CB1, así como por la activación de dos receptores PPAR-gamma producidos por estas sustancias. Conclusiones: Las investigaciones sistemáticas presentadas en un resumen convergen sin la noción de que las aplicaciones terapéuticas proporcionadas por las hebras de cannabidos naturales y sus análogos pueden jugar un papel único en la modulación de dianas moleculares involucradas en disfunciones del sistema nervioso central, causadas por la posibilidad de desarrollo. , asumiendo fármacos innovadores, más seguros y más efectivos, sin tratar a pacientes que no responden a la práctica convencional, con un tiempo significativo en la calidad de vida.Objetivo: Analisar e avaliar a atual conjuntura inerente à utilização terapêutica dos canabinoides naturais no retardo e proteção contra as ações fisiopatológicas ocasionadas pela doença de Alzhemer, destacando alguns dos principais mecanismos bioquímicos e moleculares subjacentes à referida proteção, bem como, quais as perspectivas de utilização de tais agentes a curto e médio prazo, na busca por um tratamento mais eficiente contra tal patologia. Métodos: Overview de revisões sistemáticas. A busca e a seleção dos estudos transcorreram predominantemente nas bases de dados da Medical Literature Analysis and Retrieval System Online (Medline), National Library of Medicine (Pubmed) e Scientific Electronic Library Online (SciELO), no período compreendido entre março e agosto de 2020. Foram combinando os termos Doença de Alzhemer, fisiopatologia, farmacologia e canabidiodes naturais. Como fator prioritário dos critérios de inclusão, foram selecionados revisões sistemáticas com ou sem metanálise, publicadas nos últimos 5 anos, que discorressem detalhadamente sobre o tema. Após a aplicação dos critérios de inclusão e exclusão, foi realizada a análise das pesquisas as quais se alinhavam ao objetivo da coleta. Resultados: Os resultados atuais mostraram efeitos terapêuticos promissores do canabinoides naturais no tratamento da doença de Alzhmer, tais como redução de sintomas motores e cognitivos, e ação neuroprotetora. Tais resultados podem ser explicados, em parte, pela ação antiinflamatória, an­tioxidante, antagonista de receptores CB1, bem como, pela ativação dos receptores PPAR-gama produzido por estas substâncias. Conclusões: As pesquisas sistemáticas apresentadas nesse overview convergem no sentido de que a aplicações terapêuticas proporcionadas pelos canabidiodes naturais e seus análogos podem desempenhar papel singular na modulação de alvos moleculares envolvidos em disfunções do sistema nervoso central, ocasionadas pela doença de Alzhemer, possibilitando assim o desenvolvimento de fármacos inovadores, mais seguros e eficazes no tratamento de pacientes não responsivos à clínica convencional, com melhora significativa na qualidade de vida.Research, Society and Development2021-05-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1541810.33448/rsd-v10i6.15418Research, Society and Development; Vol. 10 No. 6; e0310615418Research, Society and Development; Vol. 10 Núm. 6; e0310615418Research, Society and Development; v. 10 n. 6; e03106154182525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/15418/13767Copyright (c) 2021 Daniel Alexandre Lima Cavalcante; Laura Trindade Fernandeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCavalcante, Daniel Alexandre Lima Fernandes, Laura Trindade 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/15418Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:14.723178Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
Los beneficios terapéuticos de los cannabinoides naturales para retrasar la fisiopatología de la enfermedad de Alzheimer
Os benefícios terapêuticos dos canabinoides naturais no retardo da fisiopatologia da Doença de Alzhemer
title The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
spellingShingle The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
Cavalcante, Daniel Alexandre Lima
Alzheimer's disease
Pathophysiology
Neurology
Natural cannabidiodes.
Enfermedad de Alzheimer
Fisiopatología
Neurología
Cannabidiodes naturales.
Doença de Alzheimer
Fisiopatologia
Neurologia
Canabidioides naturais.
title_short The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
title_full The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
title_fullStr The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
title_full_unstemmed The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
title_sort The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease
author Cavalcante, Daniel Alexandre Lima
author_facet Cavalcante, Daniel Alexandre Lima
Fernandes, Laura Trindade
author_role author
author2 Fernandes, Laura Trindade
author2_role author
dc.contributor.author.fl_str_mv Cavalcante, Daniel Alexandre Lima
Fernandes, Laura Trindade
dc.subject.por.fl_str_mv Alzheimer's disease
Pathophysiology
Neurology
Natural cannabidiodes.
Enfermedad de Alzheimer
Fisiopatología
Neurología
Cannabidiodes naturales.
Doença de Alzheimer
Fisiopatologia
Neurologia
Canabidioides naturais.
topic Alzheimer's disease
Pathophysiology
Neurology
Natural cannabidiodes.
Enfermedad de Alzheimer
Fisiopatología
Neurología
Cannabidiodes naturales.
Doença de Alzheimer
Fisiopatologia
Neurologia
Canabidioides naturais.
description Objectives: To analyze and evaluate the current conjuncture inherent to the therapeutic use of natural cannabinoids in delay and protection against the pathophysiological actions caused by Alzheimer's disease. Methods: Overview of systematic reviews. The search and selection of the studies were predominantly in the databases of the Medical Literature Analysis and Retrieval System Online (Medline), National Library of Medicine (Pubmed) and Scientific Electronic Library Online (SciELO) in  the period between March and August  2020.  Key findings: Current results showed promising therapeutic effects of natural cannabinoids in the treatment of Alzheimer's disease, such as reduction of motor and cognitive symptoms, and protective neuroprotective action. These results can be explained, in part, by the anti-inflammatory, antioxidant, antagonist action of CB1 receptors, as well as by the activation of PPAR-gamma receptors produced by these substances. Conclusions: The systematic research presented in this overview converges in the sense that the therapeutic applications provided by natural cannabinoids and their analogues may play a unique role in the modulation of molecular targets involved in central nervous system dysfunctions caused by Alzheimer's disease, thus enabling the development of innovative drugs, safer and more effective in the treatment of patients not responsive to conventional clinical practice, with significant improvement in quality of life.   
publishDate 2021
dc.date.none.fl_str_mv 2021-05-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15418
10.33448/rsd-v10i6.15418
url https://rsdjournal.org/index.php/rsd/article/view/15418
identifier_str_mv 10.33448/rsd-v10i6.15418
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15418/13767
dc.rights.driver.fl_str_mv Copyright (c) 2021 Daniel Alexandre Lima Cavalcante; Laura Trindade Fernandes
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Daniel Alexandre Lima Cavalcante; Laura Trindade Fernandes
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e0310615418
Research, Society and Development; Vol. 10 Núm. 6; e0310615418
Research, Society and Development; v. 10 n. 6; e0310615418
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052785549639680

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