Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/37534 |
Resumo: | Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival. |
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Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria Componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalarComponents of the frailty phenotype as predictors of mortality among older adults after four years of hospital discharge Idoso fragilizadoEstudos longitudinaisAlta do pacienteMortalidade.Anciano frágilEstudios LongitudinalesAlta del PacienteMortalidad.Frail elderlyLongitudinal studiesPatient DischargeMortality.Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival.Objetivo: verificar la asociación entre el deterioro de los componentes del fenotipo de fragilidad como predictores de mortalidad entre adultos mayores después de cuatro años del alta hospitalaria. Metodología: Investigación prospectiva y longitudinal, realizada con adultos mayores hospitalizados, al inicio y con seguimiento posterior al alta hospitalaria. De los 163 adultos mayores incluidos en el estudio, 43 fallecieron durante el seguimiento y 92 completaron el seguimiento de cuatro años. Se utilizaron los siguientes instrumentos: Mini Examen del Estado Mental, formulario para caracterizar datos sociodemográficos, económicos y de salud; y el fenotipo de fragilidad de Fried. El análisis de supervivencia se realizó mediante el método de Kaplan-Meier y la regresión de Cox para estimar la razón de riesgo (Hazard Ratio) de mortalidad entre los adultos mayores con deterioro en cada componente del fenotipo, considerando p<0,05. Resultados: El deterioro en los componentes del fenotipo fragilidad velocidad de marcha lenta (HR: 3,27; IC95%: 1,655-6,475; p<0,001); disminución de la fuerza muscular (HR:3,09; IC95%: 1,605-5,959; p=0,001); agotamiento y/o fatiga autoinformados (HR: 2,97; IC 95%: 1.508-5.853; p=0,002) y bajo nivel de actividad física (HR: 3,22; IC 95%: 1.693-6.138; p<0,001) como predictores de mortalidad, después del ajuste; y representó la menor probabilidad de supervivencia. Conclusión: El deterioro en los componentes de velocidad de la marcha, fuerza muscular, agotamiento y/o fatiga y actividad física al inicio del estudio representó un mayor riesgo de mortalidad entre los ancianos en el seguimiento. Así, existe la posibilidad de focalizar las intervenciones en grupos de riesgo para mejorar la condición de fragilidad y, consecuentemente, aumentar la supervivencia.Objetivo: verificar a associação entre comprometimento dos componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalar. Metodologia: Investigação prospectiva e longitudinal, realizada com idosos internados, no baseline, e acompanhados após a alta hospitalar. Dos 163 idosos incluídos no estudo, 43 foram a óbito ao longo do seguimento e 92 completaram o follow-up de quatro anos. Foram utilizados como instrumentos: Mini Exame do Estado Mental, formulário para caracterização dos dados sociodemográficos, econômicos e de saúde; e o fenótipo de fragilidade de Fried. Procedeu-se à análise de sobrevivência pelo método de Kaplan-Meier e regressão de Cox para estimar a razão de risco (Hazard Ratio) de mortalidade entre idosos com comprometimento em cada componente do fenótipo, considerando p<0,05. Resultados: O comprometimento nos componentes do fenótipo de fragilidade lentidão na velocidade de marcha (HR: 3,27; IC95%: 1,655-6,475; p<0,001); diminuição da força muscular (HR:3,09; IC95%: 1,605-5,959; p=0,001); autorrelato de exaustão e/ou fadiga (HR:2,97; IC95%: 1,508-5,853; p=0,002) e baixo nível de atividade física (HR: 3,22; IC95%: 1,693-6,138; p<0,001) permaneceram como preditores de mortalidade, após o ajuste; e representaram menor probabilidade de sobrevida. Conclusão: O comprometimento nos componentes velocidade de marcha, força muscular, exaustão e/ou fadiga e atividade física no baseline representaram maior risco para mortalidade entre idosos no follow-up. Assim, há possibilidade de direcionamento de intervenções nos grupos de risco para melhora da condição de fragilidade e, consequentemente, aumento da sobrevida.Research, Society and Development2022-11-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3753410.33448/rsd-v11i15.37534Research, Society and Development; Vol. 11 No. 15; e510111537534Research, Society and Development; Vol. 11 Núm. 15; e510111537534Research, Society and Development; v. 11 n. 15; e5101115375342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/37534/31239Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavareshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMarchiori, Gianna FioriTavares, Darlene Mara dos Santos2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/37534Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:40.524502Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria Componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalar Components of the frailty phenotype as predictors of mortality among older adults after four years of hospital discharge |
title |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
spellingShingle |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria Marchiori, Gianna Fiori Idoso fragilizado Estudos longitudinais Alta do paciente Mortalidade. Anciano frágil Estudios Longitudinales Alta del Paciente Mortalidad. Frail elderly Longitudinal studies Patient Discharge Mortality. |
title_short |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
title_full |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
title_fullStr |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
title_full_unstemmed |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
title_sort |
Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria |
author |
Marchiori, Gianna Fiori |
author_facet |
Marchiori, Gianna Fiori Tavares, Darlene Mara dos Santos |
author_role |
author |
author2 |
Tavares, Darlene Mara dos Santos |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Marchiori, Gianna Fiori Tavares, Darlene Mara dos Santos |
dc.subject.por.fl_str_mv |
Idoso fragilizado Estudos longitudinais Alta do paciente Mortalidade. Anciano frágil Estudios Longitudinales Alta del Paciente Mortalidad. Frail elderly Longitudinal studies Patient Discharge Mortality. |
topic |
Idoso fragilizado Estudos longitudinais Alta do paciente Mortalidade. Anciano frágil Estudios Longitudinales Alta del Paciente Mortalidad. Frail elderly Longitudinal studies Patient Discharge Mortality. |
description |
Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/37534 10.33448/rsd-v11i15.37534 |
url |
https://rsdjournal.org/index.php/rsd/article/view/37534 |
identifier_str_mv |
10.33448/rsd-v11i15.37534 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/37534/31239 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavares https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavares https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 15; e510111537534 Research, Society and Development; Vol. 11 Núm. 15; e510111537534 Research, Society and Development; v. 11 n. 15; e510111537534 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052774715752448 |