Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria

Detalhes bibliográficos
Autor(a) principal: Marchiori, Gianna Fiori
Data de Publicação: 2022
Outros Autores: Tavares, Darlene Mara dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/37534
Resumo: Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival.
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spelling Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria Componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalarComponents of the frailty phenotype as predictors of mortality among older adults after four years of hospital discharge Idoso fragilizadoEstudos longitudinaisAlta do pacienteMortalidade.Anciano frágilEstudios LongitudinalesAlta del PacienteMortalidad.Frail elderlyLongitudinal studiesPatient DischargeMortality.Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival.Objetivo: verificar la asociación entre el deterioro de los componentes del fenotipo de fragilidad como predictores de mortalidad entre adultos mayores después de cuatro años del alta hospitalaria. Metodología: Investigación prospectiva y longitudinal, realizada con adultos mayores hospitalizados, al inicio y con seguimiento posterior al alta hospitalaria. De los 163 adultos mayores incluidos en el estudio, 43 fallecieron durante el seguimiento y 92 completaron el seguimiento de cuatro años. Se utilizaron los siguientes instrumentos: Mini Examen del Estado Mental, formulario para caracterizar datos sociodemográficos, económicos y de salud; y el fenotipo de fragilidad de Fried. El análisis de supervivencia se realizó mediante el método de Kaplan-Meier y la regresión de Cox para estimar la razón de riesgo (Hazard Ratio) de mortalidad entre los adultos mayores con deterioro en cada componente del fenotipo, considerando p<0,05. Resultados: El deterioro en los componentes del fenotipo fragilidad velocidad de marcha lenta (HR: 3,27; IC95%: 1,655-6,475; p<0,001); disminución de la fuerza muscular (HR:3,09; IC95%: 1,605-5,959; p=0,001); agotamiento y/o fatiga autoinformados (HR: 2,97; IC 95%: 1.508-5.853; p=0,002) y bajo nivel de actividad física (HR: 3,22; IC 95%: 1.693-6.138; p<0,001) como predictores de mortalidad, después del ajuste; y representó la menor probabilidad de supervivencia. Conclusión: El deterioro en los componentes de velocidad de la marcha, fuerza muscular, agotamiento y/o fatiga y actividad física al inicio del estudio representó un mayor riesgo de mortalidad entre los ancianos en el seguimiento. Así, existe la posibilidad de focalizar las intervenciones en grupos de riesgo para mejorar la condición de fragilidad y, consecuentemente, aumentar la supervivencia.Objetivo: verificar a associação entre comprometimento dos componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalar. Metodologia: Investigação prospectiva e longitudinal, realizada com idosos internados, no baseline, e acompanhados após a alta hospitalar. Dos 163 idosos incluídos no estudo, 43 foram a óbito ao longo do seguimento e 92 completaram o follow-up de quatro anos. Foram utilizados como instrumentos: Mini Exame do Estado Mental, formulário para caracterização dos dados sociodemográficos, econômicos e de saúde; e o fenótipo de fragilidade de Fried. Procedeu-se à análise de sobrevivência pelo método de Kaplan-Meier e regressão de Cox para estimar a razão de risco (Hazard Ratio) de mortalidade entre idosos com comprometimento em cada componente do fenótipo, considerando p<0,05. Resultados: O comprometimento nos componentes do fenótipo de fragilidade lentidão na velocidade de marcha (HR: 3,27; IC95%: 1,655-6,475; p<0,001); diminuição da força muscular (HR:3,09; IC95%: 1,605-5,959; p=0,001); autorrelato de exaustão e/ou fadiga (HR:2,97; IC95%: 1,508-5,853; p=0,002) e  baixo nível de atividade física (HR: 3,22; IC95%: 1,693-6,138; p<0,001) permaneceram como preditores de mortalidade, após o ajuste; e representaram menor probabilidade de sobrevida. Conclusão: O comprometimento nos componentes velocidade de marcha, força muscular, exaustão e/ou fadiga e atividade física no baseline representaram maior risco para mortalidade entre idosos no follow-up. Assim, há possibilidade de direcionamento de intervenções nos grupos de risco para melhora da condição de fragilidade e, consequentemente, aumento da sobrevida.Research, Society and Development2022-11-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3753410.33448/rsd-v11i15.37534Research, Society and Development; Vol. 11 No. 15; e510111537534Research, Society and Development; Vol. 11 Núm. 15; e510111537534Research, Society and Development; v. 11 n. 15; e5101115375342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/37534/31239Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavareshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMarchiori, Gianna FioriTavares, Darlene Mara dos Santos2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/37534Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:40.524502Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
Componentes do fenótipo de fragilidade como preditores de mortalidade entre idosos após quatro anos de alta hospitalar
Components of the frailty phenotype as predictors of mortality among older adults after four years of hospital discharge
title Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
spellingShingle Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
Marchiori, Gianna Fiori
Idoso fragilizado
Estudos longitudinais
Alta do paciente
Mortalidade.
Anciano frágil
Estudios Longitudinales
Alta del Paciente
Mortalidad.
Frail elderly
Longitudinal studies
Patient Discharge
Mortality.
title_short Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
title_full Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
title_fullStr Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
title_full_unstemmed Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
title_sort Componentes del fenotipo fragilidad como predictores de mortalidad en adultos mayores después de cuatro años del alta hospitalaria
author Marchiori, Gianna Fiori
author_facet Marchiori, Gianna Fiori
Tavares, Darlene Mara dos Santos
author_role author
author2 Tavares, Darlene Mara dos Santos
author2_role author
dc.contributor.author.fl_str_mv Marchiori, Gianna Fiori
Tavares, Darlene Mara dos Santos
dc.subject.por.fl_str_mv Idoso fragilizado
Estudos longitudinais
Alta do paciente
Mortalidade.
Anciano frágil
Estudios Longitudinales
Alta del Paciente
Mortalidad.
Frail elderly
Longitudinal studies
Patient Discharge
Mortality.
topic Idoso fragilizado
Estudos longitudinais
Alta do paciente
Mortalidade.
Anciano frágil
Estudios Longitudinales
Alta del Paciente
Mortalidad.
Frail elderly
Longitudinal studies
Patient Discharge
Mortality.
description Objective: to verify the association between impairment of frailty phenotype components as predictors of mortality among older adults after four years of hospital discharge. Methodology: Prospective and longitudinal investigation, carried out with hospitalized older adults, at baseline, and followed up after hospital discharge. Of the 163 older adults included in the study, 43 died during follow-up and 92 completed the four-year follow-up. The following instruments were used: Mini Mental State Examination, a form for characterizing sociodemographic, economic and health data; and Fried's frailty phenotype. Survival analysis was performed using the Kaplan-Meier method and Cox regression to estimate the risk ratio (Hazard Ratio) of mortality among older adults with impairment in each component of the phenotype, considering p<0.05. Results: The impairment in the components of the frailty phenotype slow gait speed (HR: 3.27; 95%CI: 1.655-6.475; p<0.001); decreased muscle strength (HR:3.09; 95%CI: 1.605-5.959; p=0.001); self-reported exhaustion and/or fatigue (HR: 2.97; 95%CI: 1.508-5.853; p=0.002) and low level of physical activity (HR: 3.22; 95%CI: 1.693-6.138; p<0.001) remained as predictors of mortality, after adjustment; and represented a lower probability of survival. Conclusion: Impairment in the components of gait speed, muscle strength, exhaustion and/or fatigue and physical activity at baseline represented a higher risk for mortality among the elderly at follow-up. Thus, there is the possibility of targeting interventions in risk groups to improve the condition of frailty and, consequently, increase survival.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37534
10.33448/rsd-v11i15.37534
url https://rsdjournal.org/index.php/rsd/article/view/37534
identifier_str_mv 10.33448/rsd-v11i15.37534
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37534/31239
dc.rights.driver.fl_str_mv Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavares
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Gianna Fiori Marchiori; Darlene Mara dos Santos Tavares
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e510111537534
Research, Society and Development; Vol. 11 Núm. 15; e510111537534
Research, Society and Development; v. 11 n. 15; e510111537534
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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