Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster

Detalhes bibliográficos
Autor(a) principal: Oliveira, Rafaela da Mata
Data de Publicação: 2022
Outros Autores: Orsolin, Priscila Capelari
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/33972
Resumo: Introduction: The estimate of new cases of cancer by the National Cancer Institute (INCA), in 2020, was more than 620 thousand cases and the important association between neoplasms and lifestyle should be considered. Kefir has been gaining ground due to its properties, including its anti-cancer action. Objective: To evaluate the anticarcinogenic effect of kefir on Drosophila melanogaster cells. Methodology: Kefir was tested by means of the Epithelial Tumor Test (ETT) in D. melanogaster. Females of the wts lineage and males of the mwh lineage were crossed. The offspring larvae were treated with three concentrations of kefir: 1.25mg/mL; 2.5mg/mL and 5.0mg/mL alone and in association with the chemotherapy drug doxorubicin (DXR). Results and discussion: Kefir was not carcinogenic at any of the concentrations tested and had an anticarcinogenic effect at the three concentrations tested. Final considerations: The study suggests a beneficial effect of kefir in cancer prevention and treatment.
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spelling Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogasterEvaluación del efecto anticarcinogénico del Kefir sobre Drosophila melanogasterAvaliação do efeito anticarcinogênico do Kefir em Drosophila melanogasterCáncerDrosophila melanogasterKéfir.CancerDrosophila melanogasterKefir.Drosophila melanogasterCâncerKefir.Introduction: The estimate of new cases of cancer by the National Cancer Institute (INCA), in 2020, was more than 620 thousand cases and the important association between neoplasms and lifestyle should be considered. Kefir has been gaining ground due to its properties, including its anti-cancer action. Objective: To evaluate the anticarcinogenic effect of kefir on Drosophila melanogaster cells. Methodology: Kefir was tested by means of the Epithelial Tumor Test (ETT) in D. melanogaster. Females of the wts lineage and males of the mwh lineage were crossed. The offspring larvae were treated with three concentrations of kefir: 1.25mg/mL; 2.5mg/mL and 5.0mg/mL alone and in association with the chemotherapy drug doxorubicin (DXR). Results and discussion: Kefir was not carcinogenic at any of the concentrations tested and had an anticarcinogenic effect at the three concentrations tested. Final considerations: The study suggests a beneficial effect of kefir in cancer prevention and treatment.Introducción: La estimación de nuevos casos de cáncer por parte del Instituto Nacional del Cáncer (INCA), en 2020, fue de más de 620 mil casos y se debe considerar la importante asociación entre las neoplasias y el estilo de vida. El kéfir ha ido ganando terreno debido a sus propiedades, entre ellas su acción anticancerígena. Metas: Evaluar el efecto anticancerígeno del kéfir sobre las células de Drosophila melanogaster. Metodología: El kéfir se probó mediante el Epithelial Tumor Test (ETT) en D. melanogaster. Se cruzaron hembras del linaje wts y machos del linaje mwh. Las larvas descendientes se trataron con tres concentraciones de kéfir: 1,25 mg/mL; 2,5 mg/mL y 5,0 mg/mL solos y en asociación con el fármaco de quimioterapia doxorrubicina (DXR). Resultados y Discusión: El kéfir no fue cancerígeno en ninguna de las concentraciones probadas y tuvo un efecto anticancerígeno en las tres concentraciones probadas. Consideraciones finales: El estudio sugiere un efecto beneficioso del kéfir en la prevención y el tratamiento del cáncer.Introdução: A estimativa de novos casos de câncer pelo Instituto Nacional de Câncer (INCA), no ano de 2020, foi de mais de 620 mil casos e deve-se considerar a importante associação entre as neoplasias e o estilo de vida. O kefir vem ganhando espaço por suas propriedades, entre elas, sua ação anticâncer. Objetivos: Avaliar o efeito anticarcinogênico do kefir em células de Drosophila melanogaster. Metodologia: O kefir foi testado por meio do Teste de tumores epiteliais (ETT) em D. melanogaster. Foram cruzadas fêmeas da linhagem wts e machos da linhagem mwh. As larvas descendentes foram tratadas com três concentrações de kefir: 1,25mg/mL; 2,5mg/mL e 5,0mg/mL isoladamente e em associação ao quimioterápico doxorrubicina (DXR). Resultados e Discussão: O kefir não foi carcinogênico em nenhuma das concentrações testadas e apresentou efeito anticarcinogênico nas três concentrações em teste. Considerações Finais: O estudo sugere um efeito benéfico do kefir na prevenção e tratamento do câncer.Research, Society and Development2022-11-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3397210.33448/rsd-v11i15.33972Research, Society and Development; Vol. 11 No. 15; e172111533972Research, Society and Development; Vol. 11 Núm. 15; e172111533972Research, Society and Development; v. 11 n. 15; e1721115339722525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/33972/30886Copyright (c) 2022 Rafaela da Mata Oliveira; Priscila Capelari Orsolinhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Rafaela da Mata Orsolin, Priscila Capelari 2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/33972Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:49:27.347984Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
Evaluación del efecto anticarcinogénico del Kefir sobre Drosophila melanogaster
Avaliação do efeito anticarcinogênico do Kefir em Drosophila melanogaster
title Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
spellingShingle Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
Oliveira, Rafaela da Mata
Cáncer
Drosophila melanogaster
Kéfir.
Cancer
Drosophila melanogaster
Kefir.
Drosophila melanogaster
Câncer
Kefir.
title_short Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
title_full Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
title_fullStr Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
title_full_unstemmed Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
title_sort Evaluation of the anticarcinogenic effect of Kefir in Drosophila melanogaster
author Oliveira, Rafaela da Mata
author_facet Oliveira, Rafaela da Mata
Orsolin, Priscila Capelari
author_role author
author2 Orsolin, Priscila Capelari
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Rafaela da Mata
Orsolin, Priscila Capelari
dc.subject.por.fl_str_mv Cáncer
Drosophila melanogaster
Kéfir.
Cancer
Drosophila melanogaster
Kefir.
Drosophila melanogaster
Câncer
Kefir.
topic Cáncer
Drosophila melanogaster
Kéfir.
Cancer
Drosophila melanogaster
Kefir.
Drosophila melanogaster
Câncer
Kefir.
description Introduction: The estimate of new cases of cancer by the National Cancer Institute (INCA), in 2020, was more than 620 thousand cases and the important association between neoplasms and lifestyle should be considered. Kefir has been gaining ground due to its properties, including its anti-cancer action. Objective: To evaluate the anticarcinogenic effect of kefir on Drosophila melanogaster cells. Methodology: Kefir was tested by means of the Epithelial Tumor Test (ETT) in D. melanogaster. Females of the wts lineage and males of the mwh lineage were crossed. The offspring larvae were treated with three concentrations of kefir: 1.25mg/mL; 2.5mg/mL and 5.0mg/mL alone and in association with the chemotherapy drug doxorubicin (DXR). Results and discussion: Kefir was not carcinogenic at any of the concentrations tested and had an anticarcinogenic effect at the three concentrations tested. Final considerations: The study suggests a beneficial effect of kefir in cancer prevention and treatment.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/33972
10.33448/rsd-v11i15.33972
url https://rsdjournal.org/index.php/rsd/article/view/33972
identifier_str_mv 10.33448/rsd-v11i15.33972
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/33972/30886
dc.rights.driver.fl_str_mv Copyright (c) 2022 Rafaela da Mata Oliveira; Priscila Capelari Orsolin
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Rafaela da Mata Oliveira; Priscila Capelari Orsolin
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e172111533972
Research, Society and Development; Vol. 11 Núm. 15; e172111533972
Research, Society and Development; v. 11 n. 15; e172111533972
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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