Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster

Detalhes bibliográficos
Autor(a) principal: Carmo, Mayslla Keylla Brito do
Data de Publicação: 2021
Outros Autores: Figueiredo, Mayara Oliveira Vidotto, Souza, Joyce Marinho de, Souza, Anderson Oliveira, Lima, Carlos Antonio Couto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14179
Resumo: Acetylsalicylic acid or aspirin is the most widely used drug globally for its anti-inflammatory characteristics, although little is known about its actions on the central nervous system (CNS). We investigated aspirin's potential neuroprotective effects against paraquat-induced neurotoxicity (PQ) in the present study. Adult male wild-type flies were exposed to a diet containing PQ (3 mM) and/or aspirin (1 μM; 5 μM; 10 μM). Flies fed with PQ reduced locomotion and increased mortality. PQ-induced neurotoxicity has also been associated with a marked decrease in acetylcholinesterase (AChE) activity and lipid peroxidation. Co-exposure to aspirin (5 μM) increased survival, improved motor performance, increased AChE activity, and decreased lipid peroxidation. Our results suggest aspirin's neuroprotective effects, probably due to its lysosomal action and antioxidant characteristics. Thus, we demonstrate that the Drosophila melanogaster model can elucidate basic aspirin mechanisms to assist the evaluations carried out in higher animals to minimize the neurodegenerative effects caused by diseases such as Parkinson's and Alzheimer's.
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spelling Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogasterAcción neuroprotectora de la aspirina en la intoxicación por Paraquat en Drosophila melanogasterAção neuroprotetora da aspirina em Drosophila melanogaster intoxicadas por ParaquatDrosophila melanogasterAspirinaNeurodegeneração.Drosophila melanogasterAspirinaNeurodegeneración. Drosophila melanogasterAspirinNeurodegeneration.Acetylsalicylic acid or aspirin is the most widely used drug globally for its anti-inflammatory characteristics, although little is known about its actions on the central nervous system (CNS). We investigated aspirin's potential neuroprotective effects against paraquat-induced neurotoxicity (PQ) in the present study. Adult male wild-type flies were exposed to a diet containing PQ (3 mM) and/or aspirin (1 μM; 5 μM; 10 μM). Flies fed with PQ reduced locomotion and increased mortality. PQ-induced neurotoxicity has also been associated with a marked decrease in acetylcholinesterase (AChE) activity and lipid peroxidation. Co-exposure to aspirin (5 μM) increased survival, improved motor performance, increased AChE activity, and decreased lipid peroxidation. Our results suggest aspirin's neuroprotective effects, probably due to its lysosomal action and antioxidant characteristics. Thus, we demonstrate that the Drosophila melanogaster model can elucidate basic aspirin mechanisms to assist the evaluations carried out in higher animals to minimize the neurodegenerative effects caused by diseases such as Parkinson's and Alzheimer's.El ácido acetilsalicílico o aspirina es el fármaco más utilizado en el mundo por sus características antiinflamatorias, aunque se sabe poco sobre sus acciones sobre el sistema nervioso central (SNC). En el presente estudio, investigamos los posibles efectos neuroprotectores de la aspirina contra la neurotoxicidad inducida por paraquat (PQ). Las moscas machos adultos de tipo salvaje se expusieron a una dieta que contenía PQ (3 mM) y / o aspirina (1 μM; 5 μM; 10 μM). Las moscas alimentadas con PQ redujeron la locomoción y aumentaron la mortalidad. La neurotoxicidad inducida por PQ también se ha asociado con una marcada disminución de la actividad de la acetilcolinesterasa (AChE) y la peroxidación de lípidos. La coexposición a la aspirina (5 μM) aumentó la supervivencia, mejoró el rendimiento motor, aumentó la actividad de la AChE y disminuyó la peroxidación de lípidos. Nuestros resultados sugieren efectos neuroprotectores de la aspirina, probablemente debido a su acción lisosomal y características antioxidantes. Así, demostramos que el uso del modelo de Drosophila melanogaster puede dilucidar los mecanismos básicos de la aspirina para ayudar a las evaluaciones realizadas en animales superiores que tienen como objetivo minimizar los efectos neurodegenerativos provocados por enfermedades como el Parkinson y el Alzheimer.O ácido acetilsalicílico ou aspirina é o medicamento mais utilizado no mundo por suas características anti-inflamatórias, embora pouco se saiba sobre suas ações no sistema nervoso central (SNC). No presente estudo, investigamos os potenciais efeitos neuroprotetores da aspirina contra a neurotoxicidade induzida pelo paraquat (PQ). Moscas adultas machos do tipo selvagem foram expostas a dieta contendo PQ (3 mM) e/ ou aspirina (1 μM; 5 μM;10 μM). As moscas alimentadas com PQ reduziram a locomoção e aumentaram a mortalidade. A neurotoxicidade induzida pelo PQ também foi associada a uma diminuição acentuada na atividade da acetilcolinesterase (AChE) e peroxidação lipídica. A co-exposição à aspirina (5 μM) aumentou a sobrevida, melhorou o desempenho motor, aumentou a atividade da atividade da AChE e diminuiu a peroxidação lipídica. Nossos resultados sugerem efeitos neuroprotetores da aspirina, provavelmente devido à sua ação lisossomal e características antioxidantes. Assim, demostramos que a utilização do modelo Drosophila melanogaster possa elucidar mecanismos básicos da aspirina de maneira à auxiliar as avaliações realizadas em animais superiores que visam minimizar os efeitos neurodegenerativos causadas por doenças como Parkinson e Alzheimer. Research, Society and Development2021-04-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1417910.33448/rsd-v10i4.14179Research, Society and Development; Vol. 10 No. 4; e30710414179Research, Society and Development; Vol. 10 Núm. 4; e30710414179Research, Society and Development; v. 10 n. 4; e307104141792525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/14179/12717Copyright (c) 2021 Mayslla Keylla Brito do Carmo; Mayara Oliveira Vidotto Figueiredo; Joyce Marinho de Souza; Anderson Oliveira Souza; Carlos Antonio Couto Limahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarmo, Mayslla Keylla Brito do Figueiredo, Mayara Oliveira Vidotto Souza, Joyce Marinho de Souza, Anderson Oliveira Lima, Carlos Antonio Couto 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14179Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:21.681271Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
Acción neuroprotectora de la aspirina en la intoxicación por Paraquat en Drosophila melanogaster
Ação neuroprotetora da aspirina em Drosophila melanogaster intoxicadas por Paraquat
title Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
spellingShingle Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
Carmo, Mayslla Keylla Brito do
Drosophila melanogaster
Aspirina
Neurodegeneração.
Drosophila melanogaster
Aspirina
Neurodegeneración.
Drosophila melanogaster
Aspirin
Neurodegeneration.
title_short Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
title_full Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
title_fullStr Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
title_full_unstemmed Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
title_sort Neuroprotective action of aspirin on Paraquat intoxication in on Drosophila melanogaster
author Carmo, Mayslla Keylla Brito do
author_facet Carmo, Mayslla Keylla Brito do
Figueiredo, Mayara Oliveira Vidotto
Souza, Joyce Marinho de
Souza, Anderson Oliveira
Lima, Carlos Antonio Couto
author_role author
author2 Figueiredo, Mayara Oliveira Vidotto
Souza, Joyce Marinho de
Souza, Anderson Oliveira
Lima, Carlos Antonio Couto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carmo, Mayslla Keylla Brito do
Figueiredo, Mayara Oliveira Vidotto
Souza, Joyce Marinho de
Souza, Anderson Oliveira
Lima, Carlos Antonio Couto
dc.subject.por.fl_str_mv Drosophila melanogaster
Aspirina
Neurodegeneração.
Drosophila melanogaster
Aspirina
Neurodegeneración.
Drosophila melanogaster
Aspirin
Neurodegeneration.
topic Drosophila melanogaster
Aspirina
Neurodegeneração.
Drosophila melanogaster
Aspirina
Neurodegeneración.
Drosophila melanogaster
Aspirin
Neurodegeneration.
description Acetylsalicylic acid or aspirin is the most widely used drug globally for its anti-inflammatory characteristics, although little is known about its actions on the central nervous system (CNS). We investigated aspirin's potential neuroprotective effects against paraquat-induced neurotoxicity (PQ) in the present study. Adult male wild-type flies were exposed to a diet containing PQ (3 mM) and/or aspirin (1 μM; 5 μM; 10 μM). Flies fed with PQ reduced locomotion and increased mortality. PQ-induced neurotoxicity has also been associated with a marked decrease in acetylcholinesterase (AChE) activity and lipid peroxidation. Co-exposure to aspirin (5 μM) increased survival, improved motor performance, increased AChE activity, and decreased lipid peroxidation. Our results suggest aspirin's neuroprotective effects, probably due to its lysosomal action and antioxidant characteristics. Thus, we demonstrate that the Drosophila melanogaster model can elucidate basic aspirin mechanisms to assist the evaluations carried out in higher animals to minimize the neurodegenerative effects caused by diseases such as Parkinson's and Alzheimer's.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14179
10.33448/rsd-v10i4.14179
url https://rsdjournal.org/index.php/rsd/article/view/14179
identifier_str_mv 10.33448/rsd-v10i4.14179
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14179/12717
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e30710414179
Research, Society and Development; Vol. 10 Núm. 4; e30710414179
Research, Society and Development; v. 10 n. 4; e30710414179
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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