Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/11812 |
Resumo: | This study aimed to carry out a literature review on the influence of genetic susceptibility on the incidence and mortality of COVID-19. It is a descriptive review of the literature carried out in the PUBMED and Science direct databases using the following descriptors: genetic susceptibility “AND “COVID-19”. The inclusion criteria were scientific articles available for free, in English, Spanish and Portuguese, which were published in 2020. Duplicate articles between databases were excluded. At the end, 58 studies followed the established criteria. The ACE2 and TMPRSS2 genes have the potential for prophylactic and therapeutic intervention in the early stages of SARS-CoV-2 infection, playing a crucial role in the entry of the virus into host cells. In addition, the locus of Human Leukocyte Antigen (HLA) appears to be crucial to influence the susceptibility and severity of COVID-19. Male individuals have a higher mortality and severity rate for COVID-19, being related to a more significant expression of ACE2 and differences in the epigenetic regulation of ACE2. Genetic susceptibility can contribute to the interindividual clinical variability associated with COVID-19, allowing for an evidence-based risk assessment leading to personalized preventive measures and therapeutic options. |
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Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2)Influencia de la suscetibilidad genética sobre la incidencia y mortalidad del COVID-19 (SARS-COV-2)Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2)Suscetibilidade genéticaCOVID-19Síndrome respiratória aguda grave coronavírus 2 (Sars-cov-2).Predisposicion genéticaCOVID-19Síndrome respiratorio agudo severo coronavirus 2 (Sars-cov-2).Genetic susceptibilityCOVID-19Severe acute respiratory syndrome coronavirus 2 (Sars-cov-2).This study aimed to carry out a literature review on the influence of genetic susceptibility on the incidence and mortality of COVID-19. It is a descriptive review of the literature carried out in the PUBMED and Science direct databases using the following descriptors: genetic susceptibility “AND “COVID-19”. The inclusion criteria were scientific articles available for free, in English, Spanish and Portuguese, which were published in 2020. Duplicate articles between databases were excluded. At the end, 58 studies followed the established criteria. The ACE2 and TMPRSS2 genes have the potential for prophylactic and therapeutic intervention in the early stages of SARS-CoV-2 infection, playing a crucial role in the entry of the virus into host cells. In addition, the locus of Human Leukocyte Antigen (HLA) appears to be crucial to influence the susceptibility and severity of COVID-19. Male individuals have a higher mortality and severity rate for COVID-19, being related to a more significant expression of ACE2 and differences in the epigenetic regulation of ACE2. Genetic susceptibility can contribute to the interindividual clinical variability associated with COVID-19, allowing for an evidence-based risk assessment leading to personalized preventive measures and therapeutic options.Este estudio tuvo como objetivo realizar una revisión de la literatura sobre la influencia de la susceptibilidad genética en la incidencia y mortalidad de COVID-19. Se trata de una revisión descriptiva de la literatura realizada en las bases de datos PUBMED y Science direct utilizando los siguientes descriptores: susceptibilidad genética ”Y“ COVID-19 ”. Los criterios de inclusión fueron artículos científicos disponibles de forma gratuita, en inglés, español y portugués, que fueron publicados en 2020. Se excluyeron artículos duplicados entre bases de datos. Al final, 58 estudios siguieron los criterios establecidos. Los genes ACE2 y TMPRSS2 tienen el potencial de una intervención profiláctica y terapéutica en las primeras etapas de la infección por SARS-CoV-2, desempeñando un papel crucial en la entrada del virus en las células huésped. Además, el locus del antígeno leucocitario humano (HLA) parece ser crucial para influir en la susceptibilidad y la gravedad de COVID-19. Los varones tienen una mayor tasa de mortalidad y gravedad para COVID-19, lo que se relaciona con una expresión más significativa de ACE2 y diferencias en la regulación epigenética de ACE2. La susceptibilidad genética puede contribuir a la variabilidad clínica interindividual asociada con COVID-19, lo que permite una evaluación del riesgo basada en la evidencia que conduce a medidas preventivas personalizadas y opciones terapêuticas.Este estudo teve como objetivo realizar uma revisão bibliográfica sobre a influência da suscetibilidade genética na incidência e mortalidade de COVID-19. Trata-se de uma revisão descritiva da literatura realizada nas bases de dados PUBMED e Science direct utilizando os seguintes descritores: genetic susceptibility” AND “COVID-19”. Os critérios de inclusão foram artigos científicos disponíveis gratuitamente, nos idiomas inglês, espanhol e português e que foram publicados em 2020. Foram excluídos os artigos duplicados entre as bases. Ao final 58 estudos seguiam os critérios estabelecidos. Os genes ACE2 e TMPRSS2, têm potencial para intervenção profilática e terapêutica nos estágios iniciais de infecção por SARS-CoV-2, desempenhando um papel crucial para a entrada do vírus nas células hospedeiras. Além disso, o lócus do Antígeno Leucocitário Humano (HLA), parece ser crucial para influenciar a suscetibilidade e a gravidade do COVID-19. Indivíduos do sexo masculino apresentam uma maior taxa de mortalidade e de gravidade para a COVID-19, sendo relacionado a uma expressão mais significativa de ACE2 e diferenças na regulação epigenética de ACE2. A suscetibilidade genética pode contribuir para a variabilidade clínica interindividual associada ao COVID-19, permitindo uma avaliação de risco baseada em evidências levando a medidas preventivas personalizadas e opções terapêuticas.Research, Society and Development2021-01-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1181210.33448/rsd-v10i1.11812Research, Society and Development; Vol. 10 No. 1; e31810111812Research, Society and Development; Vol. 10 Núm. 1; e31810111812Research, Society and Development; v. 10 n. 1; e318101118122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/11812/10564Copyright (c) 2021 Steffany Larissa Galdino Galisa; Raysla Maria de Sousa Almeida; Adriana Raquel Araújo Pereira Soares; Radmila Raianni Alves Ribeiro; Fábio Rodrigo Araújo Pereira; Kedma Anne Lima Gomes; Milena Edite Casé de Oliveira; Waleska Fernanda Souto Nóbrega; Lorena Sofia dos Santos Andrade; Tácila Thamires de Melo Santos; Beatriz Leodelgario Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGalisa, Steffany Larissa Galdino Almeida, Raysla Maria de Sousa Soares, Adriana Raquel Araújo Pereira Ribeiro, Radmila Raianni Alves Pereira, Fábio Rodrigo Araújo Gomes, Kedma Anne Lima Oliveira, Milena Edite Casé de Nóbrega, Waleska Fernanda Souto Andrade, Lorena Sofia dos Santos Santos, Tácila Thamires de Melo Silva, Beatriz Leodelgario 2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11812Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:32.676010Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) Influencia de la suscetibilidad genética sobre la incidencia y mortalidad del COVID-19 (SARS-COV-2) Influência da suscetibilidade genética na incidência e mortalidade de COVID-19 (SARS-CoV-2) |
title |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
spellingShingle |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) Galisa, Steffany Larissa Galdino Suscetibilidade genética COVID-19 Síndrome respiratória aguda grave coronavírus 2 (Sars-cov-2). Predisposicion genética COVID-19 Síndrome respiratorio agudo severo coronavirus 2 (Sars-cov-2). Genetic susceptibility COVID-19 Severe acute respiratory syndrome coronavirus 2 (Sars-cov-2). |
title_short |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
title_full |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
title_fullStr |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
title_full_unstemmed |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
title_sort |
Influence of genetic suscetibility on the incidence and mortality of COVID-19 (SARS-COV-2) |
author |
Galisa, Steffany Larissa Galdino |
author_facet |
Galisa, Steffany Larissa Galdino Almeida, Raysla Maria de Sousa Soares, Adriana Raquel Araújo Pereira Ribeiro, Radmila Raianni Alves Pereira, Fábio Rodrigo Araújo Gomes, Kedma Anne Lima Oliveira, Milena Edite Casé de Nóbrega, Waleska Fernanda Souto Andrade, Lorena Sofia dos Santos Santos, Tácila Thamires de Melo Silva, Beatriz Leodelgario |
author_role |
author |
author2 |
Almeida, Raysla Maria de Sousa Soares, Adriana Raquel Araújo Pereira Ribeiro, Radmila Raianni Alves Pereira, Fábio Rodrigo Araújo Gomes, Kedma Anne Lima Oliveira, Milena Edite Casé de Nóbrega, Waleska Fernanda Souto Andrade, Lorena Sofia dos Santos Santos, Tácila Thamires de Melo Silva, Beatriz Leodelgario |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Galisa, Steffany Larissa Galdino Almeida, Raysla Maria de Sousa Soares, Adriana Raquel Araújo Pereira Ribeiro, Radmila Raianni Alves Pereira, Fábio Rodrigo Araújo Gomes, Kedma Anne Lima Oliveira, Milena Edite Casé de Nóbrega, Waleska Fernanda Souto Andrade, Lorena Sofia dos Santos Santos, Tácila Thamires de Melo Silva, Beatriz Leodelgario |
dc.subject.por.fl_str_mv |
Suscetibilidade genética COVID-19 Síndrome respiratória aguda grave coronavírus 2 (Sars-cov-2). Predisposicion genética COVID-19 Síndrome respiratorio agudo severo coronavirus 2 (Sars-cov-2). Genetic susceptibility COVID-19 Severe acute respiratory syndrome coronavirus 2 (Sars-cov-2). |
topic |
Suscetibilidade genética COVID-19 Síndrome respiratória aguda grave coronavírus 2 (Sars-cov-2). Predisposicion genética COVID-19 Síndrome respiratorio agudo severo coronavirus 2 (Sars-cov-2). Genetic susceptibility COVID-19 Severe acute respiratory syndrome coronavirus 2 (Sars-cov-2). |
description |
This study aimed to carry out a literature review on the influence of genetic susceptibility on the incidence and mortality of COVID-19. It is a descriptive review of the literature carried out in the PUBMED and Science direct databases using the following descriptors: genetic susceptibility “AND “COVID-19”. The inclusion criteria were scientific articles available for free, in English, Spanish and Portuguese, which were published in 2020. Duplicate articles between databases were excluded. At the end, 58 studies followed the established criteria. The ACE2 and TMPRSS2 genes have the potential for prophylactic and therapeutic intervention in the early stages of SARS-CoV-2 infection, playing a crucial role in the entry of the virus into host cells. In addition, the locus of Human Leukocyte Antigen (HLA) appears to be crucial to influence the susceptibility and severity of COVID-19. Male individuals have a higher mortality and severity rate for COVID-19, being related to a more significant expression of ACE2 and differences in the epigenetic regulation of ACE2. Genetic susceptibility can contribute to the interindividual clinical variability associated with COVID-19, allowing for an evidence-based risk assessment leading to personalized preventive measures and therapeutic options. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11812 10.33448/rsd-v10i1.11812 |
url |
https://rsdjournal.org/index.php/rsd/article/view/11812 |
identifier_str_mv |
10.33448/rsd-v10i1.11812 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11812/10564 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 1; e31810111812 Research, Society and Development; Vol. 10 Núm. 1; e31810111812 Research, Society and Development; v. 10 n. 1; e31810111812 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052668114370560 |