Antidepressant use during pregnancy and gestational diabetes: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/26278 |
Resumo: | A high number of women are exposed to antidepressants during pregnancy. Considering that an association between exposure to antidepressants and type 2 diabetes was found in the general population and pregnant women are inherently susceptible to insulin resistance, this study aimed to investigate data in the scientific literature on the association between antidepressant use during pregnancy and the risk of developing gestational diabetes mellitus (GDM). This systematic review was conducted according to the PRISMA guidelines. PubMed, Virtual Health Library (VHS), and Web of Science databases were searched to identify observational studies reporting the association between antidepressant use during pregnancy and GDM. Review articles, case reports, case series, clinical trials, and animal studies were excluded. In total, 67 studies were retrieved, of which 3 were included in the systematic review: one case-control and two cohort studies. According to the Newcastle-Ottawa Scale, the three studies were considered high-quality. Through this systematic review, selective serotonin reuptake inhibitors (SSRI) use during pregnancy is not significantly associated with a higher risk of developing GDM. There are still controversies about the association between serotonin and norepinephrine reuptake inhibitors (SNRI) and GDM. The use of tricyclic, tetracyclic, and atypical antidepressants by pregnant women appears to be associated with GDM. Therefore, the available information about the topic is scarce and the condition of further studies is needed. |
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Antidepressant use during pregnancy and gestational diabetes: a systematic reviewUso de antidepresivos durante el embarazo y diabetes gestacional: una revisión sistemáticaUso de antidepressivos durante a gestação e diabetes gestacional: uma revisão sistemáticaAntidepressive AgentsDiabetes, GestationalPregnancySystematic Review.AntidepresivoDiabetes GestationalEmbarazoRevisión Sistemática.AntidepressivosDiabetes GestationalGravidezRevisão Sistemática.A high number of women are exposed to antidepressants during pregnancy. Considering that an association between exposure to antidepressants and type 2 diabetes was found in the general population and pregnant women are inherently susceptible to insulin resistance, this study aimed to investigate data in the scientific literature on the association between antidepressant use during pregnancy and the risk of developing gestational diabetes mellitus (GDM). This systematic review was conducted according to the PRISMA guidelines. PubMed, Virtual Health Library (VHS), and Web of Science databases were searched to identify observational studies reporting the association between antidepressant use during pregnancy and GDM. Review articles, case reports, case series, clinical trials, and animal studies were excluded. In total, 67 studies were retrieved, of which 3 were included in the systematic review: one case-control and two cohort studies. According to the Newcastle-Ottawa Scale, the three studies were considered high-quality. Through this systematic review, selective serotonin reuptake inhibitors (SSRI) use during pregnancy is not significantly associated with a higher risk of developing GDM. There are still controversies about the association between serotonin and norepinephrine reuptake inhibitors (SNRI) and GDM. The use of tricyclic, tetracyclic, and atypical antidepressants by pregnant women appears to be associated with GDM. Therefore, the available information about the topic is scarce and the condition of further studies is needed.Un alto número de mujeres están expuestas a los antidepresivos durante el embarazo. Teniendo en cuenta que hay una asociación entre la exposición a los antidepresivos y la diabetes tipo 2 en la población general y que las mujeres embarazadas son inherentemente susceptibles a la resistencia a la insulina, este estudio tuvo como objetivo investigar datos en la literatura científica sobre la asociación entre el uso de antidepresivos durante el embarazo y el riesgo de desarrollar diabetes mellitus gestacional (DMG). Esta revisión sistemática fue realizada de acuerdo con las pautas del PRISMA. Se realizaron búsquedas en las bases de datos PubMed, Biblioteca Virtual em Salud (BVS) y Web of Science para identificar estudios observacionales que informaran sobre la asociación entre el uso de antidepresivos durante el embarazo y la DMG. Se excluyeron artículos de revisión, informes de casos, series de casos, ensayos clínicos y estudios en animales. En total, se recuperaron 67 estudios, de los cuales 3 se incluyeron en la revisión sistemática: un estudio de casos y controles y dos estudios de cohortes. Según la Newcastle-Ottawa Scale, los tres estudios se consideraron de alta calidad metodológica. A través de esta revisión sistemática, el uso de inhibidores selectivos de la recaptación de serotonina (ISRS) durante el embarazo no se asocia significativamente con un mayor riesgo de desarrollar DMG. Todavía hay controversias sobre la asociación entre inhibidores de la recaptación de serotonina y norepinefrina (IRSN) y DMG. El uso de antidepresivos tricíclicos, tetracíclicos y atípicos durante el embarazo parece estar asociado con DMG. Por lo tanto, la información disponible sobre el tema es escasa y se necesitan más estudios. Um grande número de mulheres são expostas a antidepressivos durante a gravidez. Considerando que a associação entre a exposição a antidepressivos e diabetes tipo 2 foi encontrada na população geral e as gestantes são inerentemente suscetíveis à resistência à insulina, este estudo teve como objetivo investigar dados na literatura científica sobre a associação entre o uso de antidepressivos durante a gravidez e o risco de desenvolver diabetes mellitus gestacional (DMG). Esta revisão sistemática foi realizada de acordo com as diretrizes do PRISMA. As bases de dados PubMed, Biblioteca Virtual em Saúde (BVS) e Web of Science foram pesquisadas para identificar estudos observacionais relatando a associação entre o uso de antidepressivos durante a gravidez e DMG. Foram excluídos artigos de revisão, relatos de casos, séries de casos, ensaios clínicos e estudos em animais. No total, 67 estudos foram recuperados, dos quais 3 foram incluídos na revisão sistemática: um caso-controle e dois estudos de coorte. De acordo com a Newcastle-Ottawa Scale, os três estudos foram considerados de alta qualidade metodológica. Por meio desta revisão sistemática, o uso de inibidores seletivos da recaptação da serotonina (ISRS) durante a gravidez não está significativamente associado a um maior risco de desenvolver DMG. Ainda há controvérsias sobre a associação entre inibidores da recaptação de serotonina e norepinefrina (IRSN) e DMG. O uso de antidepressivos tricíclicos, tetracíclicos e atípicos durante a gravidez parece estar associado ao DMG. Sendo assim, as informações disponíveis sobre o tema são escassas, sendo necessária a condução de novos estudos.Research, Society and Development2022-02-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2627810.33448/rsd-v11i2.26278Research, Society and Development; Vol. 11 No. 2; e53911226278Research, Society and Development; Vol. 11 Núm. 2; e53911226278Research, Society and Development; v. 11 n. 2; e539112262782525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/26278/22848Copyright (c) 2022 Beatriz Tianeze de Castro; Andressa Oliveira Azevedo; Anna Luzia Pinho Quaresma; Ana Flávia Souto Figueiredo Nepomuceno; Mariana Souto Figueiredo; Lucas Santana Coelho da Silva; Romana Santos Gama; Caroline Tianeze de Castrohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCastro, Beatriz Tianeze deAzevedo, Andressa OliveiraQuaresma, Anna Luzia PinhoNepomuceno, Ana Flávia Souto FigueiredoFigueiredo, Mariana SoutoSilva, Lucas Santana Coelho daGama, Romana SantosCastro, Caroline Tianeze de2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/26278Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:21.562250Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Antidepressant use during pregnancy and gestational diabetes: a systematic review Uso de antidepresivos durante el embarazo y diabetes gestacional: una revisión sistemática Uso de antidepressivos durante a gestação e diabetes gestacional: uma revisão sistemática |
title |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
spellingShingle |
Antidepressant use during pregnancy and gestational diabetes: a systematic review Castro, Beatriz Tianeze de Antidepressive Agents Diabetes, Gestational Pregnancy Systematic Review. Antidepresivo Diabetes Gestational Embarazo Revisión Sistemática. Antidepressivos Diabetes Gestational Gravidez Revisão Sistemática. |
title_short |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
title_full |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
title_fullStr |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
title_full_unstemmed |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
title_sort |
Antidepressant use during pregnancy and gestational diabetes: a systematic review |
author |
Castro, Beatriz Tianeze de |
author_facet |
Castro, Beatriz Tianeze de Azevedo, Andressa Oliveira Quaresma, Anna Luzia Pinho Nepomuceno, Ana Flávia Souto Figueiredo Figueiredo, Mariana Souto Silva, Lucas Santana Coelho da Gama, Romana Santos Castro, Caroline Tianeze de |
author_role |
author |
author2 |
Azevedo, Andressa Oliveira Quaresma, Anna Luzia Pinho Nepomuceno, Ana Flávia Souto Figueiredo Figueiredo, Mariana Souto Silva, Lucas Santana Coelho da Gama, Romana Santos Castro, Caroline Tianeze de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Castro, Beatriz Tianeze de Azevedo, Andressa Oliveira Quaresma, Anna Luzia Pinho Nepomuceno, Ana Flávia Souto Figueiredo Figueiredo, Mariana Souto Silva, Lucas Santana Coelho da Gama, Romana Santos Castro, Caroline Tianeze de |
dc.subject.por.fl_str_mv |
Antidepressive Agents Diabetes, Gestational Pregnancy Systematic Review. Antidepresivo Diabetes Gestational Embarazo Revisión Sistemática. Antidepressivos Diabetes Gestational Gravidez Revisão Sistemática. |
topic |
Antidepressive Agents Diabetes, Gestational Pregnancy Systematic Review. Antidepresivo Diabetes Gestational Embarazo Revisión Sistemática. Antidepressivos Diabetes Gestational Gravidez Revisão Sistemática. |
description |
A high number of women are exposed to antidepressants during pregnancy. Considering that an association between exposure to antidepressants and type 2 diabetes was found in the general population and pregnant women are inherently susceptible to insulin resistance, this study aimed to investigate data in the scientific literature on the association between antidepressant use during pregnancy and the risk of developing gestational diabetes mellitus (GDM). This systematic review was conducted according to the PRISMA guidelines. PubMed, Virtual Health Library (VHS), and Web of Science databases were searched to identify observational studies reporting the association between antidepressant use during pregnancy and GDM. Review articles, case reports, case series, clinical trials, and animal studies were excluded. In total, 67 studies were retrieved, of which 3 were included in the systematic review: one case-control and two cohort studies. According to the Newcastle-Ottawa Scale, the three studies were considered high-quality. Through this systematic review, selective serotonin reuptake inhibitors (SSRI) use during pregnancy is not significantly associated with a higher risk of developing GDM. There are still controversies about the association between serotonin and norepinephrine reuptake inhibitors (SNRI) and GDM. The use of tricyclic, tetracyclic, and atypical antidepressants by pregnant women appears to be associated with GDM. Therefore, the available information about the topic is scarce and the condition of further studies is needed. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26278 10.33448/rsd-v11i2.26278 |
url |
https://rsdjournal.org/index.php/rsd/article/view/26278 |
identifier_str_mv |
10.33448/rsd-v11i2.26278 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26278/22848 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e53911226278 Research, Society and Development; Vol. 11 Núm. 2; e53911226278 Research, Society and Development; v. 11 n. 2; e53911226278 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052762751500288 |