Chemical profile and antimicrobial activity of abarema cochliacarpos

• Autor(a) principal: Santos, Pietra Alexia Lima dos
• Data de Publicação: 2022
• Outros Autores: Santos, Ludmila Cruz dos, Costa, Rôas de Araujo, Estevam, Adriana dos Santos, Silva, Mário Rodrigues Pereira da, Reis, Igor Adriano de Oliveira, Oliveira, Jeison Saturnino de, Araujo, Brancilene Santos de, Lucca Junior, Waldecy de, Santos, Samuel Bruno dos, Estevam, Charles dos Santos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• DOI: 10.33448/rsd-v11i4.27226
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/27226
• topic: Abarema cochliacarpos; Folhas, atividade biológica; Análise citotóxica; Compostos fenólicos.; Abarema cochliacarpos; Leaves, biological activity; Cytotoxic analysis; Phenolic compounds.; Abarema cochliacarpos; Hojas, actividad biológica; Análisis citotóxico; Compuestos fenólicos.

Abarema cochliacarpos is an endemic species from Brazil, it belongs to the Fabaceae family and is popularly known as barbatimão, being present in the Brazilian caatinga and cerrado. In Sergipe, its use is in the form of teas for anti-inflammatory and healing activities. As objects of this study, the leaves of the plant were used in order to qualitatively know the chemical constituents of the fractions obtained from the crude extract: chloroform fraction (FCL), hexane fraction (FHX), ethyl acetate fraction (FAE) and hydromethanolic fraction ( FHM) through phytochemical prospection by colorimetric assays, being detected the presence of secondary metabolites such as phenols, tannins, flavonols, catechins, steroids, triterpenoids and saponins. In the antimicrobial analysis, only two fractions showed inhibition halos. The FAE for Staphylococcus aureus (19.3 mm), Enterococcus durans hirae (10 mm), derived Escherichia coli (9.6 mm) and derived Pseudomonas aeruginosa (15 mm) strains, and the FCL for the E. durans strain hirae (9 mm). In the minimal inhibitory concentration (MIC) the FAE excelled with 12.5 µg.mL-1 for S. aureus and E. durans, while the FCL obtained 25 µg.mL-1 for E. durans. As for the cytotoxic analysis, FAE at the concentrations tested did not favor cell viability in 75%, showing antiproliferative capacity, except for FLC at 20 µg.mL-1. FAE and FCL showed antioxidant properties and obtained an antimicrobial effect, in addition to having metabolites that corroborate these functions.