The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2024 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/45015 |
Resumo: | The objective was to report the effectiveness of the use of cannabidiol (CBD) in the treatment of anxiety disorders, as neuroimaging investigations in humans indicate that its action occurs in limbic brain areas, associated with anxiety. The lack of control over the doses and amount of cannabidiol used was analyzed to understand its mechanism in patients with anxiety. It is an integrative review study, collecting articles from the following platforms: Latin American and Caribbean Literature in Health Sciences (LILACS) and U.S. National Library of Medicine (PUBMED). To maintain the theme and support the article, the descriptors “cannabidiol”, “cannabidiol”, “treatment”, “anxiety disorders”, “anxiety disorders” and “CBD” were used. As inclusion criteria: published articles in the last 5 years, free access and as exclusion criteria therapy studies combined with tetrahydrocannabinol (THC) and animal analysis. The therapeutic potential of cannabidiol in the treatment of anxiety was observed with a favorable safety profile; action in facilitating extinction of fear and reduction of present fearful behaviors; in addition to oral CBD administered in a corn oil formula without the bioconversion of tetrahydrocannabinol(THC), contrary to recent studies. It is concluded that cannabidiol acts as a modulator of inflammatory processes in addition to reducing oxidative stress, emerging as a less harmful alternative compared to conventional treatments for anxiety disorder, however its use in the treatment of anxiety disorder still requires more research with a more cautious approach. |
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The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature reviewLa eficacia del cannabidiol en el tratamiento de los trastornos de ansiedad: Una revisión integradora de la literaturaA eficácia do canabidiol no tratamento dos transtornos de ansiedade: Uma revisão integrativa de literaturaCanabidiolTranstornos de ansiedadeTerapêutica.CannabidiolAnxiety disordersTherapeutics.CannabidiolTrastornos de ansiedadTerapéutica.The objective was to report the effectiveness of the use of cannabidiol (CBD) in the treatment of anxiety disorders, as neuroimaging investigations in humans indicate that its action occurs in limbic brain areas, associated with anxiety. The lack of control over the doses and amount of cannabidiol used was analyzed to understand its mechanism in patients with anxiety. It is an integrative review study, collecting articles from the following platforms: Latin American and Caribbean Literature in Health Sciences (LILACS) and U.S. National Library of Medicine (PUBMED). To maintain the theme and support the article, the descriptors “cannabidiol”, “cannabidiol”, “treatment”, “anxiety disorders”, “anxiety disorders” and “CBD” were used. As inclusion criteria: published articles in the last 5 years, free access and as exclusion criteria therapy studies combined with tetrahydrocannabinol (THC) and animal analysis. The therapeutic potential of cannabidiol in the treatment of anxiety was observed with a favorable safety profile; action in facilitating extinction of fear and reduction of present fearful behaviors; in addition to oral CBD administered in a corn oil formula without the bioconversion of tetrahydrocannabinol(THC), contrary to recent studies. It is concluded that cannabidiol acts as a modulator of inflammatory processes in addition to reducing oxidative stress, emerging as a less harmful alternative compared to conventional treatments for anxiety disorder, however its use in the treatment of anxiety disorder still requires more research with a more cautious approach. El objetivo fue reportar la efectividad del uso del cannabidiol (CBD) en el tratamiento de los trastornos de ansiedad, ya que investigaciones de neuroimagen en humanos indican que su acción ocurre en áreas límbicas del cerebro, asociadas a la ansiedad. Se analizó el descontrol sobre las dosis y cantidad de cannabidiol utilizado para comprender su mecanismo en pacientes con ansiedad. Se trata de un estudio de revisión integradora, que recopila artículos de las siguientes plataformas: Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) y Biblioteca Nacional de Medicina de Estados Unidos (PUBMED). Para mantener la temática y sustentar el artículo se utilizaron los descriptores “cannabidiol”, “cannabidiol”, “tratamiento”, “trastornos de ansiedad”, “trastornos de ansiedad” y “CBD”. Como criterios de inclusión: artículos publicados en los últimos 5 años, estudios de terapia de libre acceso y como criterios de exclusión combinados con tetrahidrocannabinol (THC) y análisis en animales. Se observó el potencial terapéutico del cannabidiol en el tratamiento de la ansiedad con un perfil de seguridad favorable, acción para facilitar la extinción del miedo y reducción de las conductas temerosas presentes; además del CBD oral administrado en una fórmula de aceite de maíz sin la bioconversión de tetrahidrocannabinol (THC), contrario a estudios recientes, se concluye que el cannabidiol actúa como modulador de procesos inflamatorios además de reducir el estrés oxidativo, surgiendo como una alternativa menos dañina. Sin embargo, en comparación con los tratamientos convencionales para el trastorno de ansiedad, su uso en el tratamiento del trastorno de ansiedad aún requiere más investigación con un enfoque más cauteloso. O objetivo foi relatar a eficácia do uso do canabidiol (CBD) no tratamento dos transtornos de ansiedade, pois investigações de neuroimagem em humanos indicam que a ação dele ocorre em áreas cerebrais límbicas, associadas à ansiedade. Foi analisado o descontrole das doses e da quantidade de canabidiol utilizadas na compreensão do seu mecanismo em pacientes com ansiedade. Trata-se de um esstudo de revisão integrativa, com coleta de artigos nas seguintes plataformas: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e U.S. National Library of Medicine (PUBMED). Para manter a temática e fundamentar o artigo foram usados os descritores “canabidiol”, “cannabidiol”, “tratamento”, “transtornos de ansiedade", “anxiety disorders” e “CBD”. “treatment”. Como critério de inclusão: artigos publicados nos últimos 05 anos, de acesso livre e como critério de exclusão estudos de terapia aliado ao tetraidrocanabinol (THC) e de análise em animal. Observou-se potencial terapêutico do canabidiol no tratamento da ansiedade com um perfil de segurança favorável; ação na facilitação da extinção do medo e na redução dos comportamentos temerosos presente; além do CBD oral admnistrado em fórmula de óleo de milho sem a bioconversão do tetraidrocanabinol(THC), contrariando estudos recentes. Conclui-se que o canabidiol age como modulador de processos inflamatórios além de reduzir o estresse oxidativo, emergindo como uma alternativa menos prejudicial em comparação com tratamentos convencionais para o transtorno de ansiedade, porém o uso no tratamento do transtorno de ansiedade ainda necessita de mais pesquisas com uma abordagem mais cautelosa.Research, Society and Development2024-02-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4501510.33448/rsd-v13i2.45015Research, Society and Development; Vol. 13 No. 2; e12213245015Research, Society and Development; Vol. 13 Núm. 2; e12213245015Research, Society and Development; v. 13 n. 2; e122132450152525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/45015/36011Copyright (c) 2024 Ketylla Lopes Tadaiesky Rodrigues; Leonardo Sales Correa do Nascimento; Lunna Martins Coelho; Maria Gabriela Perdigão Barros Monteiro; Vitória Carolina Pires de Castro; Isabela Guerreiro Diniz; Márcia Cristina Monteiro Guimarãeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRodrigues, Ketylla Lopes Tadaiesky Nascimento, Leonardo Sales Correa do Coelho, Lunna Martins Monteiro, Maria Gabriela Perdigão Barros Castro, Vitória Carolina Pires de Diniz, Isabela Guerreiro Guimarães, Márcia Cristina Monteiro 2024-03-04T09:47:20Zoai:ojs.pkp.sfu.ca:article/45015Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-03-04T09:47:20Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review La eficacia del cannabidiol en el tratamiento de los trastornos de ansiedad: Una revisión integradora de la literatura A eficácia do canabidiol no tratamento dos transtornos de ansiedade: Uma revisão integrativa de literatura |
| title |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| spellingShingle |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review Rodrigues, Ketylla Lopes Tadaiesky Canabidiol Transtornos de ansiedade Terapêutica. Cannabidiol Anxiety disorders Therapeutics. Cannabidiol Trastornos de ansiedad Terapéutica. |
| title_short |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| title_full |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| title_fullStr |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| title_full_unstemmed |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| title_sort |
The effectiveness of cannabidiol in the treatment of anxiety disorders: An integrative literature review |
| author |
Rodrigues, Ketylla Lopes Tadaiesky |
| author_facet |
Rodrigues, Ketylla Lopes Tadaiesky Nascimento, Leonardo Sales Correa do Coelho, Lunna Martins Monteiro, Maria Gabriela Perdigão Barros Castro, Vitória Carolina Pires de Diniz, Isabela Guerreiro Guimarães, Márcia Cristina Monteiro |
| author_role |
author |
| author2 |
Nascimento, Leonardo Sales Correa do Coelho, Lunna Martins Monteiro, Maria Gabriela Perdigão Barros Castro, Vitória Carolina Pires de Diniz, Isabela Guerreiro Guimarães, Márcia Cristina Monteiro |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Rodrigues, Ketylla Lopes Tadaiesky Nascimento, Leonardo Sales Correa do Coelho, Lunna Martins Monteiro, Maria Gabriela Perdigão Barros Castro, Vitória Carolina Pires de Diniz, Isabela Guerreiro Guimarães, Márcia Cristina Monteiro |
| dc.subject.por.fl_str_mv |
Canabidiol Transtornos de ansiedade Terapêutica. Cannabidiol Anxiety disorders Therapeutics. Cannabidiol Trastornos de ansiedad Terapéutica. |
| topic |
Canabidiol Transtornos de ansiedade Terapêutica. Cannabidiol Anxiety disorders Therapeutics. Cannabidiol Trastornos de ansiedad Terapéutica. |
| description |
The objective was to report the effectiveness of the use of cannabidiol (CBD) in the treatment of anxiety disorders, as neuroimaging investigations in humans indicate that its action occurs in limbic brain areas, associated with anxiety. The lack of control over the doses and amount of cannabidiol used was analyzed to understand its mechanism in patients with anxiety. It is an integrative review study, collecting articles from the following platforms: Latin American and Caribbean Literature in Health Sciences (LILACS) and U.S. National Library of Medicine (PUBMED). To maintain the theme and support the article, the descriptors “cannabidiol”, “cannabidiol”, “treatment”, “anxiety disorders”, “anxiety disorders” and “CBD” were used. As inclusion criteria: published articles in the last 5 years, free access and as exclusion criteria therapy studies combined with tetrahydrocannabinol (THC) and animal analysis. The therapeutic potential of cannabidiol in the treatment of anxiety was observed with a favorable safety profile; action in facilitating extinction of fear and reduction of present fearful behaviors; in addition to oral CBD administered in a corn oil formula without the bioconversion of tetrahydrocannabinol(THC), contrary to recent studies. It is concluded that cannabidiol acts as a modulator of inflammatory processes in addition to reducing oxidative stress, emerging as a less harmful alternative compared to conventional treatments for anxiety disorder, however its use in the treatment of anxiety disorder still requires more research with a more cautious approach. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-02-27 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/45015 10.33448/rsd-v13i2.45015 |
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https://rsdjournal.org/index.php/rsd/article/view/45015 |
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10.33448/rsd-v13i2.45015 |
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por |
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por |
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https://rsdjournal.org/index.php/rsd/article/view/45015/36011 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 13 No. 2; e12213245015 Research, Society and Development; Vol. 13 Núm. 2; e12213245015 Research, Society and Development; v. 13 n. 2; e12213245015 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052638125096960 |