Cytokine storm and development of autoimmune diseases as a sequel of Covid-19

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Bárbara Queiroz de
Data de Publicação: 2021
Outros Autores: Araújo, Ana Paula Ferreira, Silva, Carlos Daniel, Cabral, Diego Arthur Castro, Amorim, Gardênia Silva, Medeiros, Gustavo Alves, Presot, Isadora Queiroz, Queiroz, Júlia de Mendonça, Miranda, Luana Damaceno, Lessa, Maria Paula Pereira, Delboni, Vinícius Slonski
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/19385
Resumo: Introduction: Researchers at Rockefeller University, New York, found in some seriously ill patients with Covid-19 a type of autoantibody that attacks other cells of the immune system. For scientists, this would be an indication that these patients had preexisting autoantibodies to the disease and that this would be the reason why they developed the severe form of Covid-19. Objective: Answer what is the evidence on the infection by Sars-CoV-2 and triggering of autoimmunity. Methodology: This is a descriptive research of the integrative literature review type, which sought to answer what is the evidence on Sars-CoV-2 infection and triggering of autoimmunity. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, July 2021. Results: It is believed that Covid-19 has clinical characteristics similar to autoimmune diseases, as both share major immune responses of pathogenesis. Case reports of patients who developed Guillain-Barré syndrome, autoimmune hemolytic anemia and systemic lupus erythematosus were presented. Conclusion: Sars-CoV-2 can alter self-tolerance and generate autoimmune responses through cross-reactivity with host cells. However, it will be up to the scientific community to investigate this possibility further to validate or disprove this hypothesis, given the ease of detecting autoantibodies, thus corroborating the finding that they, triggered or not by Covid-19, are really a threat of alteration in the immune system.
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spelling Cytokine storm and development of autoimmune diseases as a sequel of Covid-19Tormenta de citocinas y desarrollo de enfermidades autoimunes como secuela de Covid-19 Tempestade de citocinas e desenvolvimento de doenças autoimunes como sequela da Covid-19Covid-19AutoinmunidadCitocinasSistema inmunológico.Covid-19AutoimmunityCytokinesImmune system.Covid-19AutoimunidadeCitocinasSistema imunológico.Introduction: Researchers at Rockefeller University, New York, found in some seriously ill patients with Covid-19 a type of autoantibody that attacks other cells of the immune system. For scientists, this would be an indication that these patients had preexisting autoantibodies to the disease and that this would be the reason why they developed the severe form of Covid-19. Objective: Answer what is the evidence on the infection by Sars-CoV-2 and triggering of autoimmunity. Methodology: This is a descriptive research of the integrative literature review type, which sought to answer what is the evidence on Sars-CoV-2 infection and triggering of autoimmunity. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, July 2021. Results: It is believed that Covid-19 has clinical characteristics similar to autoimmune diseases, as both share major immune responses of pathogenesis. Case reports of patients who developed Guillain-Barré syndrome, autoimmune hemolytic anemia and systemic lupus erythematosus were presented. Conclusion: Sars-CoV-2 can alter self-tolerance and generate autoimmune responses through cross-reactivity with host cells. However, it will be up to the scientific community to investigate this possibility further to validate or disprove this hypothesis, given the ease of detecting autoantibodies, thus corroborating the finding that they, triggered or not by Covid-19, are really a threat of alteration in the immune system.Introducción: Investigadores de la Universidad Rockefeller, Nueva York, han encontrado en algunos pacientes gravemente enfermos con Covid-19 un tipo de autoanticuerpo que ataca a otras células del sistema inmunológico. Para los científicos, esto sería una indicación de que estos pacientes tenían autoanticuerpos preexistentes contra la enfermedad y que esta sería la razón por la que desarrollaron la forma severa de Covid-19. Objetivo: Responder cuál es la evidencia sobre la infección por Sars-CoV-2 y desencadenamiento de autoinmunidad. Metodología: Se trata de una investigación descriptiva del tipo revisión integradora de la literatura, que buscó dar respuesta a cuál es la evidencia sobre la infección por Sars-CoV-2 y el desencadenamiento de autoinmunidad. La búsqueda se realizó a través del acceso online en la Biblioteca Nacional de Medicina (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) y bases de datos EBSCO Information Services, Julio de 2021. Resultados: Se cree que Covid-19 tiene características clínicas similares a las enfermedades autoinmunes, ya que ambas comparten las principales respuestas inmunitarias de patogénesis. Se presentaron informes de casos de pacientes que desarrollaron síndrome de Guillain-Barré, anemia hemolítica autoinmune y lupus eritematoso sistémico. Conclusión: Sars-CoV-2 puede alterar la auto-tolerancia y generar respuestas autoinmunes a través de reactividad cruzada con células huésped. Sin embargo, corresponderá a la comunidad científica investigar más a fondo esta posibilidad para validar o refutar esta hipótesis, dada la facilidad para detectar autoanticuerpos, corroborando así el hallazgo de que, desencadenados o no por Covid-19, son realmente una amenaza de alteración. en el sistema inmunológico.Introdução: Pesquisadores da Universidade de Rockefeller, em Nova York, encontraram em alguns doentes graves por Covid-19 um tipo de autoanticorpo que ataca outras células do sistema imunológico. Para os cientistas, isso seria um indício de que esses pacientes tinham autoanticorpos preexistentes à doença e que esse seria o motivo pelo qual desenvolveram a forma grave da Covid-19. Objetivo: Responder quais as evidências sobre a infecção por Sars-CoV-2 e desencadeamento de autoimunidade. Metodologia: Trata-se de uma pesquisa descritiva do tipo revisão integrativa da literatura, que buscou responder quais as evidências sobre a infecção por Sars-CoV-2 e desencadeamento de autoimunidade. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services, no mês de julho de 2021. Resultados: Acredita-se que o Covid-19 possua características clínicas semelhantes às doenças autoimunes, pois ambas compartilham grandes reações imunes da patogênese. Relatos de caso de pacientes que desenvolveram síndrome de Guillain-Barré, anemia hemolítica autoimune e lúpus eritematoso sistêmico foram expostos. Conclusão: O Sars-CoV-2 pode alterar a autotolerância e gerar respostas autoimunes através da reatividade cruzada com células hospedeiras. No entanto, ficará a cargo da comunidade científica investigar essa possibilidade mais a fundo para validar ou reprovar essa hipótese, haja vista a facilidade em detectar autoanticorpos, corroborando, dessa forma, a constatação de que eles, desencadeados ou não pela Covid-19, são realmente uma ameaça de alteração no sistema imunológico.Research, Society and Development2021-08-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1938510.33448/rsd-v10i11.19385Research, Society and Development; Vol. 10 No. 11; e38101119385Research, Society and Development; Vol. 10 Núm. 11; e38101119385Research, Society and Development; v. 10 n. 11; e381011193852525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19385/17252Copyright (c) 2021 Bárbara Queiroz de Figueiredo; Ana Paula Ferreira Araújo; Carlos Daniel Silva; Diego Arthur Castro Cabral; Gardênia Silva Amorim; Gustavo Alves Medeiros; Isadora Queiroz Presot; Júlia de Mendonça Queiroz; Luana Damaceno Miranda; Maria Paula Pereira Lessa; Vinícius Slonski Delbonihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFigueiredo, Bárbara Queiroz deAraújo, Ana Paula FerreiraSilva, Carlos DanielCabral, Diego Arthur CastroAmorim, Gardênia SilvaMedeiros, Gustavo AlvesPresot, Isadora QueirozQueiroz, Júlia de MendonçaMiranda, Luana DamacenoLessa, Maria Paula PereiraDelboni, Vinícius Slonski2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19385Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:17.427039Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
Tormenta de citocinas y desarrollo de enfermidades autoimunes como secuela de Covid-19
Tempestade de citocinas e desenvolvimento de doenças autoimunes como sequela da Covid-19
title Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
spellingShingle Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
Figueiredo, Bárbara Queiroz de
Covid-19
Autoinmunidad
Citocinas
Sistema inmunológico.
Covid-19
Autoimmunity
Cytokines
Immune system.
Covid-19
Autoimunidade
Citocinas
Sistema imunológico.
title_short Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
title_full Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
title_fullStr Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
title_full_unstemmed Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
title_sort Cytokine storm and development of autoimmune diseases as a sequel of Covid-19
author Figueiredo, Bárbara Queiroz de
author_facet Figueiredo, Bárbara Queiroz de
Araújo, Ana Paula Ferreira
Silva, Carlos Daniel
Cabral, Diego Arthur Castro
Amorim, Gardênia Silva
Medeiros, Gustavo Alves
Presot, Isadora Queiroz
Queiroz, Júlia de Mendonça
Miranda, Luana Damaceno
Lessa, Maria Paula Pereira
Delboni, Vinícius Slonski
author_role author
author2 Araújo, Ana Paula Ferreira
Silva, Carlos Daniel
Cabral, Diego Arthur Castro
Amorim, Gardênia Silva
Medeiros, Gustavo Alves
Presot, Isadora Queiroz
Queiroz, Júlia de Mendonça
Miranda, Luana Damaceno
Lessa, Maria Paula Pereira
Delboni, Vinícius Slonski
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Bárbara Queiroz de
Araújo, Ana Paula Ferreira
Silva, Carlos Daniel
Cabral, Diego Arthur Castro
Amorim, Gardênia Silva
Medeiros, Gustavo Alves
Presot, Isadora Queiroz
Queiroz, Júlia de Mendonça
Miranda, Luana Damaceno
Lessa, Maria Paula Pereira
Delboni, Vinícius Slonski
dc.subject.por.fl_str_mv Covid-19
Autoinmunidad
Citocinas
Sistema inmunológico.
Covid-19
Autoimmunity
Cytokines
Immune system.
Covid-19
Autoimunidade
Citocinas
Sistema imunológico.
topic Covid-19
Autoinmunidad
Citocinas
Sistema inmunológico.
Covid-19
Autoimmunity
Cytokines
Immune system.
Covid-19
Autoimunidade
Citocinas
Sistema imunológico.
description Introduction: Researchers at Rockefeller University, New York, found in some seriously ill patients with Covid-19 a type of autoantibody that attacks other cells of the immune system. For scientists, this would be an indication that these patients had preexisting autoantibodies to the disease and that this would be the reason why they developed the severe form of Covid-19. Objective: Answer what is the evidence on the infection by Sars-CoV-2 and triggering of autoimmunity. Methodology: This is a descriptive research of the integrative literature review type, which sought to answer what is the evidence on Sars-CoV-2 infection and triggering of autoimmunity. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, July 2021. Results: It is believed that Covid-19 has clinical characteristics similar to autoimmune diseases, as both share major immune responses of pathogenesis. Case reports of patients who developed Guillain-Barré syndrome, autoimmune hemolytic anemia and systemic lupus erythematosus were presented. Conclusion: Sars-CoV-2 can alter self-tolerance and generate autoimmune responses through cross-reactivity with host cells. However, it will be up to the scientific community to investigate this possibility further to validate or disprove this hypothesis, given the ease of detecting autoantibodies, thus corroborating the finding that they, triggered or not by Covid-19, are really a threat of alteration in the immune system.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/19385
10.33448/rsd-v10i11.19385
url https://rsdjournal.org/index.php/rsd/article/view/19385
identifier_str_mv 10.33448/rsd-v10i11.19385
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/19385/17252
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 11; e38101119385
Research, Society and Development; Vol. 10 Núm. 11; e38101119385
Research, Society and Development; v. 10 n. 11; e38101119385
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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