Systematic analysis on the obtaining of fibrinolytic fungi enzymes
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25449 |
Resumo: | Fibrinolytic proteases operate directly on fibrin clot and are able to maintain blood flow. Fungi show up as viable sources for obtaining this enzyme. The purpose of this systematic review is to is to unveil all the information concerning production, purification and characterization of fibrinolytic proteases by fungi. The search was conducted in ScienceDirect, PubMed and Scopus databases, using as keywords “(Fibrinolytic enzyme) OR (Fibrinolytic protease) AND (Fungal or Fungus or Fungi)”. Delimiting period of 10 years (2011-2021). The results obtained were filtered by selection criteria, and review articles or articles outside the scope of this work were excluded. The articles were evaluated and scored (0-10) according to pre-established criteria. None of the studies obtained the score 10, however the study with the highest score (9) presented relevant data in all criteria analyzed, obtaining fibrinolytic enzyme from Xylaria curta. Among the 21 selected articles, 12 different genera appear and Submerged Fermentation and purification of Serino-proteases were more described. This work also observed a greater representation of purification and characterization steps, indicating the need for attention to cultivation process and enzymatic application. It is clear that the production of these enzymes by fungi is pertinent towards the high recovery observed even after purification and its tendency for pharmaceutical application. |
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Systematic analysis on the obtaining of fibrinolytic fungi enzymesAnálisis sistemático sobre la obtención de enzimas fibrinolíticas a partir de hongosAnálise sistemática sobre a obtenção de enzimas fibrinolíticas a partir de fungos ProteaseTrombolíticoCogumeloFungos filamentososFermentaçãoPurificação.ProteasaTrombolíticoChampiñónHongos filamentososFermentaciónPurificación.ProteaseThrombolyticMushroomFilamentous fungiFermentationPurification. Fibrinolytic proteases operate directly on fibrin clot and are able to maintain blood flow. Fungi show up as viable sources for obtaining this enzyme. The purpose of this systematic review is to is to unveil all the information concerning production, purification and characterization of fibrinolytic proteases by fungi. The search was conducted in ScienceDirect, PubMed and Scopus databases, using as keywords “(Fibrinolytic enzyme) OR (Fibrinolytic protease) AND (Fungal or Fungus or Fungi)”. Delimiting period of 10 years (2011-2021). The results obtained were filtered by selection criteria, and review articles or articles outside the scope of this work were excluded. The articles were evaluated and scored (0-10) according to pre-established criteria. None of the studies obtained the score 10, however the study with the highest score (9) presented relevant data in all criteria analyzed, obtaining fibrinolytic enzyme from Xylaria curta. Among the 21 selected articles, 12 different genera appear and Submerged Fermentation and purification of Serino-proteases were more described. This work also observed a greater representation of purification and characterization steps, indicating the need for attention to cultivation process and enzymatic application. It is clear that the production of these enzymes by fungi is pertinent towards the high recovery observed even after purification and its tendency for pharmaceutical application.Las proteasas fibrinolíticas destacan por actuar directamente sobre el coágulo de fibrina y mantener el flujo sanguíneo. Los hongos aparecen en la literatura como fuentes viables para la obtención de esta enzima. Así, el propósito de esta revisión sistemática es analizar la información disponible sobre la producción, purificación y caracterización de proteasas fibrinolíticas por hongos. La búsqueda se realizó en las bases de datos ScienceDirect, PubMed y Scopus, utilizando como palabras clave “ (Enzima fibrinolítica) OR (Proteasa fibrinolítica) AND (Fungal or Fungus or Fungi) ”. Plazo delimitador de 10 años (2011-2021). Los resultados obtenidos fueron filtrados por criterios de selección, excluyendo artículos de revisión y artículos fuera del campo de aplicación de este trabajo. Los artículos fueron evaluados y puntuados (0-10) según criterios preestablecidos. Ninguno de los estudios obtuvo la mayor puntuación, sin embargo el estudio con mayor puntuación (9) presentó datos relevantes en todos los criterios analizados, obteniendo la enzima fibrinolítica de Xylaria curta. Entre los 21 artículos seleccionados, se describieron 12 géneros diferentes y se describió más el uso de Fermentación Sumergida y la purificación de Serino proteasas. Este trabajo también observó una mayor representación de los pasos de purificación y caracterización, lo que indica la necesidad de atención al cultivo y la aplicación enzimática. Es evidente que la producción de estas enzimas por hongos es pertinente en vista de la alta recuperación observada incluso después de la purificación y su tendencia a la aplicación farmacéutica.Proteases fibrinolíticas destacam-se por atuarem diretamente no coágulo de fibrina e conseguir manter o fluxo sanguíneo. Fungos despontam na literatura como fontes viáveis na obtenção dessa enzima. Desta forma, o propósito desta revisão sistemática é analisar as informações disponiveis a respeito da produção, purificação e caracterização de proteases fibrinolíticas por fungos. A pesquisa foi conduzida nas bases ScienceDirect, PubMed e Scopus, utilizando como palavras-chave “ (Fibrinolytic enzyme) OR (Fibrinolytic protease) AND (Fungal or Fungus or Fungi) ”. Delimitando período de 10 anos (2011-2021). Os resultados obtidos foram filtrados por critérios de seleção, sendo excluídos artigos de revisão e artigos fora do escopo deste trabalho. Os artigos foram avaliados e pontuados (0-10) segundo critérios pré-estabelecidos. Nenhum dos trabalhos obteve pontuação máxima, entretanto o trabalho com maior pontuação (9) apresentou dados relevantes em todos os critérios analisados, obtendo enzima fibrinolítica de Xylaria curta. Dentre os 21 artigos selecionados foram descritos 12 gêneros diferentes e o uso de Fermentação Submersa e a purificação de Serino proteases foram mais descritos. Este trabalho também observou maior representação de etapas de purificação e caracterização, indicando a necessidade de atenção ao cultivo e aplicação enzimática. Está claro que a produção destas enzimas por fungos é pertinente tendo em vista a alta recuperação observada mesmo após purificação e sua tendência a aplicação farmacêutica.Research, Society and Development2022-01-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2544910.33448/rsd-v11i2.25449Research, Society and Development; Vol. 11 No. 2; e13611225449Research, Society and Development; Vol. 11 Núm. 2; e13611225449Research, Society and Development; v. 11 n. 2; e136112254492525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/25449/22388Copyright (c) 2022 Kethylen Barbara Barbosa Cardoso; Maria Clara Nascimento; Anna Carolina Batista; Vagne de Melo Oliveira; Thiago Pajeú Nascimento; Juanize Matias da Silva Batista; Romero Marcos Pedrosa Brandão Costa; Lorenzo Pastrana; Ana Lúcia Figueiredo Portohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardoso, Kethylen Barbara Barbosa Nascimento, Maria Clara Batista, Anna Carolina Oliveira, Vagne de Melo Nascimento, Thiago PajeúBatista, Juanize Matias da Silva Costa, Romero Marcos Pedrosa Brandão Pastrana, LorenzoPorto, Ana Lúcia Figueiredo2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25449Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:43.526019Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes Análisis sistemático sobre la obtención de enzimas fibrinolíticas a partir de hongos Análise sistemática sobre a obtenção de enzimas fibrinolíticas a partir de fungos |
title |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
spellingShingle |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes Cardoso, Kethylen Barbara Barbosa Protease Trombolítico Cogumelo Fungos filamentosos Fermentação Purificação. Proteasa Trombolítico Champiñón Hongos filamentosos Fermentación Purificación. Protease Thrombolytic Mushroom Filamentous fungi Fermentation Purification. |
title_short |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
title_full |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
title_fullStr |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
title_full_unstemmed |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
title_sort |
Systematic analysis on the obtaining of fibrinolytic fungi enzymes |
author |
Cardoso, Kethylen Barbara Barbosa |
author_facet |
Cardoso, Kethylen Barbara Barbosa Nascimento, Maria Clara Batista, Anna Carolina Oliveira, Vagne de Melo Nascimento, Thiago Pajeú Batista, Juanize Matias da Silva Costa, Romero Marcos Pedrosa Brandão Pastrana, Lorenzo Porto, Ana Lúcia Figueiredo |
author_role |
author |
author2 |
Nascimento, Maria Clara Batista, Anna Carolina Oliveira, Vagne de Melo Nascimento, Thiago Pajeú Batista, Juanize Matias da Silva Costa, Romero Marcos Pedrosa Brandão Pastrana, Lorenzo Porto, Ana Lúcia Figueiredo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso, Kethylen Barbara Barbosa Nascimento, Maria Clara Batista, Anna Carolina Oliveira, Vagne de Melo Nascimento, Thiago Pajeú Batista, Juanize Matias da Silva Costa, Romero Marcos Pedrosa Brandão Pastrana, Lorenzo Porto, Ana Lúcia Figueiredo |
dc.subject.por.fl_str_mv |
Protease Trombolítico Cogumelo Fungos filamentosos Fermentação Purificação. Proteasa Trombolítico Champiñón Hongos filamentosos Fermentación Purificación. Protease Thrombolytic Mushroom Filamentous fungi Fermentation Purification. |
topic |
Protease Trombolítico Cogumelo Fungos filamentosos Fermentação Purificação. Proteasa Trombolítico Champiñón Hongos filamentosos Fermentación Purificación. Protease Thrombolytic Mushroom Filamentous fungi Fermentation Purification. |
description |
Fibrinolytic proteases operate directly on fibrin clot and are able to maintain blood flow. Fungi show up as viable sources for obtaining this enzyme. The purpose of this systematic review is to is to unveil all the information concerning production, purification and characterization of fibrinolytic proteases by fungi. The search was conducted in ScienceDirect, PubMed and Scopus databases, using as keywords “(Fibrinolytic enzyme) OR (Fibrinolytic protease) AND (Fungal or Fungus or Fungi)”. Delimiting period of 10 years (2011-2021). The results obtained were filtered by selection criteria, and review articles or articles outside the scope of this work were excluded. The articles were evaluated and scored (0-10) according to pre-established criteria. None of the studies obtained the score 10, however the study with the highest score (9) presented relevant data in all criteria analyzed, obtaining fibrinolytic enzyme from Xylaria curta. Among the 21 selected articles, 12 different genera appear and Submerged Fermentation and purification of Serino-proteases were more described. This work also observed a greater representation of purification and characterization steps, indicating the need for attention to cultivation process and enzymatic application. It is clear that the production of these enzymes by fungi is pertinent towards the high recovery observed even after purification and its tendency for pharmaceutical application. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25449 10.33448/rsd-v11i2.25449 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25449 |
identifier_str_mv |
10.33448/rsd-v11i2.25449 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25449/22388 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e13611225449 Research, Society and Development; Vol. 11 Núm. 2; e13611225449 Research, Society and Development; v. 11 n. 2; e13611225449 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052702522343424 |