Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes

Detalhes bibliográficos
Autor(a) principal: Andrighetti, Talita Tonin
Data de Publicação: 2022
Outros Autores: Jacques, Mariah Cristofoli, Schmitt, Carolina, Antunes , Andréa Steinhorst, Barros, Carolina Fernanda de, Freitas , Claudia Mara Dessanti de, Bunhak , Élcio José, Lima, Isabela Angeli de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/37082
Resumo: Healing films provide excellent results in the adjuvant treatment of injuries. Its association with plant extracts allows the achievement of therapeutic activities, favoring skin regeneration. This study aimed to develop pullulan films incorporated with an extract from the aerial parts of Cyclospermum leptophyllum to be used as healing dressings and to evaluate their morphological and physicochemical characteristics and their potential antioxidant activity. Polymeric films in the proportion of 4% PU (m/v) and 15% plant extract and control films composed only of the polymer matrix were produced using the casting method. The films were evaluated for thickness, visual aspects, solubility, water vapor permeability, swelling, degradation, and antioxidant activity. They showed good appearance and flexibility but heterogeneity due to the precipitation of components. A high degree of solubility and swelling was observed, and despite its rapid dissolution in contact with water, the formation of a hydrogel can enable greater adherence to wounds. The films have controlled water vapor transmission, that allows gas exchange. A DPPH radical inhibition rate of 17.23% was obtained, proving its antioxidant activity. Therefore, the biofilms produced have healing potential, which can be better studied in the future through tests demonstrating antimicrobial, and anti-inflammatory activities.
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spelling Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes Filmes poliméricos de pululana incorporados com extrato de Cyclospermum leptophyllum (pers.) Sprague para fins cicatrizantes Películas poliméricas de pululano incorporadas con extracto de Cyclospermum leptophyllum (pers.) Sprague con fines cicatrizantes Apium leptophyllum BiopelículasApio silvestreAntioxidanteApósito adhesive.Apium leptophyllumBiofilmesAipo silvestreAntioxidanteCurativo.Apium leptophyllumBiofilmsWild celeryAntioxidantDressing.Healing films provide excellent results in the adjuvant treatment of injuries. Its association with plant extracts allows the achievement of therapeutic activities, favoring skin regeneration. This study aimed to develop pullulan films incorporated with an extract from the aerial parts of Cyclospermum leptophyllum to be used as healing dressings and to evaluate their morphological and physicochemical characteristics and their potential antioxidant activity. Polymeric films in the proportion of 4% PU (m/v) and 15% plant extract and control films composed only of the polymer matrix were produced using the casting method. The films were evaluated for thickness, visual aspects, solubility, water vapor permeability, swelling, degradation, and antioxidant activity. They showed good appearance and flexibility but heterogeneity due to the precipitation of components. A high degree of solubility and swelling was observed, and despite its rapid dissolution in contact with water, the formation of a hydrogel can enable greater adherence to wounds. The films have controlled water vapor transmission, that allows gas exchange. A DPPH radical inhibition rate of 17.23% was obtained, proving its antioxidant activity. Therefore, the biofilms produced have healing potential, which can be better studied in the future through tests demonstrating antimicrobial, and anti-inflammatory activities.Filmes curativos propiciam excelentes resultados no tratamento adjuvante de lesões. Sua associação à extratos vegetais permite a obtenção de atividades terapêuticas, favorecendo a regeneração cutânea. O objetivo do trabalho foi desenvolver filmes de pululana incorporados com extrato das partes aéreas de Cyclospermum leptophyllum para serem utilizados como curativos cicatrizantes, bem como avaliar suas características morfológicas e físico-químicas e sua potencial atividade antioxidante. Foram produzidos pelo método de casting filmes poliméricos na proporção de 4% PU (m/v) e 15% extrato vegetal e filmes controle compostos apenas pela matriz polimérica. Os filmes foram avaliados quanto a espessura, aspectos visuais, solubilidade, permeabilidade ao vapor d'água, intumescimento, degradação e atividade antioxidante. Eles apresentaram boa aparência e flexibilidade, mas heterogeneidade pela precipitação de componentes. Observou-se alto grau de solubilidade e intumescimento, e apesar de sua rápida dissolução em contato com a água, a formação de um hidrogel pode possibilitar melhor aderência à feridas. Apresentaram também controlada transmissão de vapor d'água, a qual permite a troca gasosa. Uma taxa de inibição do radical DPPH de 17,23% foi obtida, comprovando sua atividade antioxidante.  Portanto, os biofilmes produzidos apresentam potencial atividade curativa, a qual pode ser melhor estudada em futuros estudos por meio da realização de testes que demonstrem suas exatas atividades antioxidante, antimicrobiana e antiinflamatória.Las películas cicatrizantes proporcionan excelentes resultados en el tratamiento adyuvante de lesiones. Su asociación con extractos de plantas permite la consecución de actividades terapéuticas, favoreciendo la regeneración de la piel. El objetivo de este trabajo fue desarrollar películas de pululano incorporadas con extracto de partes aéreas de Cyclospermum leptophyllum para ser utilizadas como apósitos cicatrizantes, así como evaluar sus características morfológicas, fisicoquímicas y su potencial actividad antioxidante. Se produjeron películas poliméricas en la proporción de 4% PU (m/v) y 15% de extracto vegetal y películas de control compuestas únicamente por la matriz polimérica por el método de fundición. Se evaluó el espesor de las películas, aspectos visuales, solubilidad, permeabilidad al vapor de agua, hinchamiento, degradación y actividad antioxidante. Presentaron buena apariencia y flexibilidad, pero heterogeneidad debido a la precipitación de componentes. Se observó un alto grado de solubilidad e hinchamiento y, a pesar de su rápida disolución en contacto con el agua, la formación de un hidrogel puede permitir una mejor adherencia a las heridas. También mostraron transmisión controlada de vapor de agua, lo que permite el intercambio de gases. Se obtuvo una tasa de inhibición del radical DPPH del 17,23%, demostrando su actividad antioxidante. Por lo tanto, las biopelículas producidas tienen una actividad curativa potencial, que puede estudiarse mejor en futuros estudios a través de pruebas que demuestren sus actividades antioxidantes, antimicrobianas y antiinflamatorias exactas.Research, Society and Development2022-11-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3708210.33448/rsd-v11i15.37082Research, Society and Development; Vol. 11 No. 15; e209111537082Research, Society and Development; Vol. 11 Núm. 15; e209111537082Research, Society and Development; v. 11 n. 15; e2091115370822525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/37082/30925Copyright (c) 2022 Talita Tonin Andrighetti; Mariah Cristofoli Jacques; Carolina Schmitt; Andréa Steinhorst Antunes ; Carolina Fernanda de Barros; Claudia Mara Dessanti de Freitas ; Élcio José Bunhak ; Isabela Angeli de Limahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAndrighetti, Talita Tonin Jacques, Mariah Cristofoli Schmitt, CarolinaAntunes , Andréa Steinhorst Barros, Carolina Fernanda de Freitas , Claudia Mara Dessanti de Bunhak , Élcio José Lima, Isabela Angeli de 2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/37082Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:23.338372Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
Filmes poliméricos de pululana incorporados com extrato de Cyclospermum leptophyllum (pers.) Sprague para fins cicatrizantes
Películas poliméricas de pululano incorporadas con extracto de Cyclospermum leptophyllum (pers.) Sprague con fines cicatrizantes
title Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
spellingShingle Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
Andrighetti, Talita Tonin
Apium leptophyllum
Biopelículas
Apio silvestre
Antioxidante
Apósito adhesive.
Apium leptophyllum
Biofilmes
Aipo silvestre
Antioxidante
Curativo.
Apium leptophyllum
Biofilms
Wild celery
Antioxidant
Dressing.
title_short Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
title_full Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
title_fullStr Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
title_full_unstemmed Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
title_sort Polymeric pullulan films incorporated with extract of Cyclospermum leptophyllum (pers.) Sprague for healing purposes
author Andrighetti, Talita Tonin
author_facet Andrighetti, Talita Tonin
Jacques, Mariah Cristofoli
Schmitt, Carolina
Antunes , Andréa Steinhorst
Barros, Carolina Fernanda de
Freitas , Claudia Mara Dessanti de
Bunhak , Élcio José
Lima, Isabela Angeli de
author_role author
author2 Jacques, Mariah Cristofoli
Schmitt, Carolina
Antunes , Andréa Steinhorst
Barros, Carolina Fernanda de
Freitas , Claudia Mara Dessanti de
Bunhak , Élcio José
Lima, Isabela Angeli de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrighetti, Talita Tonin
Jacques, Mariah Cristofoli
Schmitt, Carolina
Antunes , Andréa Steinhorst
Barros, Carolina Fernanda de
Freitas , Claudia Mara Dessanti de
Bunhak , Élcio José
Lima, Isabela Angeli de
dc.subject.por.fl_str_mv Apium leptophyllum
Biopelículas
Apio silvestre
Antioxidante
Apósito adhesive.
Apium leptophyllum
Biofilmes
Aipo silvestre
Antioxidante
Curativo.
Apium leptophyllum
Biofilms
Wild celery
Antioxidant
Dressing.
topic Apium leptophyllum
Biopelículas
Apio silvestre
Antioxidante
Apósito adhesive.
Apium leptophyllum
Biofilmes
Aipo silvestre
Antioxidante
Curativo.
Apium leptophyllum
Biofilms
Wild celery
Antioxidant
Dressing.
description Healing films provide excellent results in the adjuvant treatment of injuries. Its association with plant extracts allows the achievement of therapeutic activities, favoring skin regeneration. This study aimed to develop pullulan films incorporated with an extract from the aerial parts of Cyclospermum leptophyllum to be used as healing dressings and to evaluate their morphological and physicochemical characteristics and their potential antioxidant activity. Polymeric films in the proportion of 4% PU (m/v) and 15% plant extract and control films composed only of the polymer matrix were produced using the casting method. The films were evaluated for thickness, visual aspects, solubility, water vapor permeability, swelling, degradation, and antioxidant activity. They showed good appearance and flexibility but heterogeneity due to the precipitation of components. A high degree of solubility and swelling was observed, and despite its rapid dissolution in contact with water, the formation of a hydrogel can enable greater adherence to wounds. The films have controlled water vapor transmission, that allows gas exchange. A DPPH radical inhibition rate of 17.23% was obtained, proving its antioxidant activity. Therefore, the biofilms produced have healing potential, which can be better studied in the future through tests demonstrating antimicrobial, and anti-inflammatory activities.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37082
10.33448/rsd-v11i15.37082
url https://rsdjournal.org/index.php/rsd/article/view/37082
identifier_str_mv 10.33448/rsd-v11i15.37082
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37082/30925
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e209111537082
Research, Society and Development; Vol. 11 Núm. 15; e209111537082
Research, Society and Development; v. 11 n. 15; e209111537082
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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