ANTI-Candida activity of ethanolic extract of Libidibia ferrea

Detalhes bibliográficos
Autor(a) principal: Fernandes, Anna Luisa Barbosa
Data de Publicação: 2021
Outros Autores: Trivelli, Gil Guimaraes Barbosa, Monteiro, Julia de Abreu, Ribeiro, Marina Ramos, Esper, Pedro Tomaz, Fontoura, Humberto de Sousa, Afonso, João Pedro Ribeiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/23645
Resumo: Candidiasis among the fungal infections that affect humans presents, with Candida albicans as the most common etiologic agent, however Candida parapsilosis and Candida tropicalis have emerged as causes of candidiasis episodes. Native to the Brazilian Atlantic Forest, a Libidibia ferrea, is a plant that has been studied for its microbiological control capacity. The present work aims to evaluate an antifungal activity of L. ferrea on C. parapsilosis, C. albicans and C. tropicalis. The evaluation of the antifungal capacity of the ethanolic extracts of L. ferrea was done using the method of serial macrodilution, and inhibition was identified in the maximum concentration tested, from 1.3% of the extract yield, according to the sensitivity test in plates. The antifungal capacity will be assessed using the broth dilution test and the diffusion disc method. In addition, an analysis of the synergism between the extract and antifungals traditionally used will be carried out. Thus, it is expected that the ethanolic extract of L. ferrea will inhibit the growth of Candida ssp cells, thus generating a candidate for antifungal in association with conventional treatment or in monotherapy.
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spelling ANTI-Candida activity of ethanolic extract of Libidibia ferreaActividad anti-Candida del extracto etanólico de Libidibia ferreaAtividade anti-Candida do extrato etanólico de Libidibia ferreaCandida sspCandidíaseLibidibia ferreaPlantas medicinais.Candida sspCandidiasis Libidibia ferreaMedicinal plants.Candida sspCandidiasisLibidibia ferreaPlantas medicinales.Candidiasis among the fungal infections that affect humans presents, with Candida albicans as the most common etiologic agent, however Candida parapsilosis and Candida tropicalis have emerged as causes of candidiasis episodes. Native to the Brazilian Atlantic Forest, a Libidibia ferrea, is a plant that has been studied for its microbiological control capacity. The present work aims to evaluate an antifungal activity of L. ferrea on C. parapsilosis, C. albicans and C. tropicalis. The evaluation of the antifungal capacity of the ethanolic extracts of L. ferrea was done using the method of serial macrodilution, and inhibition was identified in the maximum concentration tested, from 1.3% of the extract yield, according to the sensitivity test in plates. The antifungal capacity will be assessed using the broth dilution test and the diffusion disc method. In addition, an analysis of the synergism between the extract and antifungals traditionally used will be carried out. Thus, it is expected that the ethanolic extract of L. ferrea will inhibit the growth of Candida ssp cells, thus generating a candidate for antifungal in association with conventional treatment or in monotherapy.Entre las infecciones fúngicas que afectan al ser humano, la candidiasis es muy relevante, siendo Candida albicans el agente etiológico más común. Sin embargo, Candida parapsilosis y Candida tropicalis también han surgido como causas de candidiasis. Originaria de la Mata Atlántica brasileña, Libidibia ferrea es una planta que ha sido estudiada por su capacidad de control microbiológico. Por tanto, el presente trabajo tiene como objetivo evaluar la actividad antifúngica de L. ferrea sobre C. parapsilosis, C. albicans y C. tropicalis. La capacidad antifúngica de los extractos etanólicos de L. ferrea se analizó mediante el método de macrodilución seriada, en el que se identificó la inhibición a la concentración máxima ensayada, a partir del 1,3% del rendimiento del extracto. La prueba de sensibilidad en placas mostró inhibición del crecimiento de C. albicans y C. tropicalis a la concentración más alta probada, mientras que la inhibición de C. parapsilosis se observó de manera dosis-dependiente a partir de 0.5 mg / mL del extracto etanólico de L. planchar. La capacidad antifúngica también se evaluó mediante discos de difusión, los cuales no se observó que inhibieran el crecimiento de C. albicans, C. tropicalis y C. parapsilosis en ninguna de las concentraciones realizadas. Además, se realizó una prueba de sinergia entre el extracto y los agentes antifúngicos utilizados, observándose la acción sinérgica del extracto con fluconazol en las placas que contienen C. parapsilosis, pero sin cambios sinérgicos o antagonistas bajo las otras especies.Dentre as infecções fúngicas que acometem seres humanos, a candidíase apresenta muita relevância, tendo a Candida albicans como o agente etiológico mais comum. Porém, Candida parapsilosis e Candida tropicalis também têm emergido como causadoras de candidíase. Nativa da mata atlântica brasileira, a Libidibia ferrea é uma planta que tem sido estudada por sua capacidade de controle microbiológico. Portanto, o presente trabalho tem como objetivo avaliar a atividade antifúngica de L. ferrea sobre C. parapsilosis, C. albicans e C. tropicalis. A capacidade antifúngica dos extratos etanólicos de L. férrea foi analisada por meio do método de macrodiluição seriada, no qual identificou-se inibição na concentração máxima testada, a partir de 1,3% de rendimento do extrato. O teste de sensibilidade em placas mostrou inibição do crescimento de C. albicans e C. tropicalis na maior concentração testada, enquanto a inibição de C. parapsilosis foi observada de maneira dose-dependente a partir de 0,5mg/mL do extrato etanólico de L. ferrea. A capacidade antifúngica também foi avaliada por meio dos discos de difusão, dos quais não se observou inibição do crescimento de C. albicans, C. tropicalis e C. parapsilosis em nenhuma das concentrações realizadas. Além disso, foi realizado o teste de sinergismo entre o extrato e antifúngicos utilizados, observando ação sinérgica do extrato com fluconazol sobre as placas contendo C. parapsilosis, mas sem alterações sinérgicas ou antagônicas sob as demais espécies.Research, Society and Development2021-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2364510.33448/rsd-v10i16.23645Research, Society and Development; Vol. 10 No. 16; e285101623645Research, Society and Development; Vol. 10 Núm. 16; e285101623645Research, Society and Development; v. 10 n. 16; e2851016236452525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/23645/20936Copyright (c) 2021 Anna Luisa Barbosa Fernandes; Gil Guimaraes Barbosa Trivelli; Julia de Abreu Monteiro; Marina Ramos Ribeiro; Pedro Tomaz Esper; Humberto de Sousa Fontoura; João Pedro Ribeiro Afonsohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes, Anna Luisa Barbosa Trivelli, Gil Guimaraes Barbosa Monteiro, Julia de AbreuRibeiro, Marina Ramos Esper, Pedro Tomaz Fontoura, Humberto de Sousa Afonso, João Pedro Ribeiro 2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/23645Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:27.159504Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv ANTI-Candida activity of ethanolic extract of Libidibia ferrea
Actividad anti-Candida del extracto etanólico de Libidibia ferrea
Atividade anti-Candida do extrato etanólico de Libidibia ferrea
title ANTI-Candida activity of ethanolic extract of Libidibia ferrea
spellingShingle ANTI-Candida activity of ethanolic extract of Libidibia ferrea
Fernandes, Anna Luisa Barbosa
Candida ssp
Candidíase
Libidibia ferrea
Plantas medicinais.
Candida ssp
Candidiasis
Libidibia ferrea
Medicinal plants.
Candida ssp
Candidiasis
Libidibia ferrea
Plantas medicinales.
title_short ANTI-Candida activity of ethanolic extract of Libidibia ferrea
title_full ANTI-Candida activity of ethanolic extract of Libidibia ferrea
title_fullStr ANTI-Candida activity of ethanolic extract of Libidibia ferrea
title_full_unstemmed ANTI-Candida activity of ethanolic extract of Libidibia ferrea
title_sort ANTI-Candida activity of ethanolic extract of Libidibia ferrea
author Fernandes, Anna Luisa Barbosa
author_facet Fernandes, Anna Luisa Barbosa
Trivelli, Gil Guimaraes Barbosa
Monteiro, Julia de Abreu
Ribeiro, Marina Ramos
Esper, Pedro Tomaz
Fontoura, Humberto de Sousa
Afonso, João Pedro Ribeiro
author_role author
author2 Trivelli, Gil Guimaraes Barbosa
Monteiro, Julia de Abreu
Ribeiro, Marina Ramos
Esper, Pedro Tomaz
Fontoura, Humberto de Sousa
Afonso, João Pedro Ribeiro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Anna Luisa Barbosa
Trivelli, Gil Guimaraes Barbosa
Monteiro, Julia de Abreu
Ribeiro, Marina Ramos
Esper, Pedro Tomaz
Fontoura, Humberto de Sousa
Afonso, João Pedro Ribeiro
dc.subject.por.fl_str_mv Candida ssp
Candidíase
Libidibia ferrea
Plantas medicinais.
Candida ssp
Candidiasis
Libidibia ferrea
Medicinal plants.
Candida ssp
Candidiasis
Libidibia ferrea
Plantas medicinales.
topic Candida ssp
Candidíase
Libidibia ferrea
Plantas medicinais.
Candida ssp
Candidiasis
Libidibia ferrea
Medicinal plants.
Candida ssp
Candidiasis
Libidibia ferrea
Plantas medicinales.
description Candidiasis among the fungal infections that affect humans presents, with Candida albicans as the most common etiologic agent, however Candida parapsilosis and Candida tropicalis have emerged as causes of candidiasis episodes. Native to the Brazilian Atlantic Forest, a Libidibia ferrea, is a plant that has been studied for its microbiological control capacity. The present work aims to evaluate an antifungal activity of L. ferrea on C. parapsilosis, C. albicans and C. tropicalis. The evaluation of the antifungal capacity of the ethanolic extracts of L. ferrea was done using the method of serial macrodilution, and inhibition was identified in the maximum concentration tested, from 1.3% of the extract yield, according to the sensitivity test in plates. The antifungal capacity will be assessed using the broth dilution test and the diffusion disc method. In addition, an analysis of the synergism between the extract and antifungals traditionally used will be carried out. Thus, it is expected that the ethanolic extract of L. ferrea will inhibit the growth of Candida ssp cells, thus generating a candidate for antifungal in association with conventional treatment or in monotherapy.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23645
10.33448/rsd-v10i16.23645
url https://rsdjournal.org/index.php/rsd/article/view/23645
identifier_str_mv 10.33448/rsd-v10i16.23645
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/23645/20936
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 16; e285101623645
Research, Society and Development; Vol. 10 Núm. 16; e285101623645
Research, Society and Development; v. 10 n. 16; e285101623645
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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