Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil

Detalhes bibliográficos
Autor(a) principal: Noleto, Rodrigo Sevilla
Data de Publicação: 2021
Outros Autores: Pinto, Nathalia Silva, Godoy, Janine Silva Ribeiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/17787
Resumo: Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays.
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spelling Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in BrazilPelagra: Correlación entre diagnóstico y cuadro clínico más prevalente en BrasilPelagra: Correlação entre diagnóstico e o quadro clínico mais prevalente no BrasilPelagraNiacinaManifestaciones clínicas.PellagraNiacinClinical manifestations.PelagraNiacinaManifestações clínicas.Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays.Objetivo: Identificar si existe dificultad en el diagnóstico de la patología debido a las diversas manifestaciones clínicas y definir si existe una causa más prevalente. Método: El estudio consiste en una revisión integradora de la literatura, en la que se seleccionaron artículos de las bases de datos: SciELO y MEDLINE, utilizando como criterios de inclusión artículos en portugués, inglés y francés, publicados entre 1922-2012; que abordó el sesgo etiopatogénico de la pelagra; y con cualquier diseño metodológico. Se utilizaron los siguientes descriptores: “pelagra”, “niacina” y “manifestaciones clínicas”. La muestra final estuvo formada por 6 artículos. Resultados: Se observó que un alto porcentaje de pacientes presentan "Pelagra Sine Pelagra", o sea, sin la manifestación de las lesiones dermatológicas características de la pelagra, observándose así solo trastornos gastrointestinales y/o neurológicos, haciéndolo difícil el diagnóstico. Sobre la causa prevalente, el alcoholismo es el principal factor de riesgo para la aparición de la enfermedad. Conclusión: Se concluyó que el perfil más reportado fue el de individuos oligosintomáticos, especialmente pacientes con condiciones de “Pelagra Sine Pelagra”. La enfermedad comienza con trastornos de los órganos digestivos, seguidos de la aparición de lesiones cutáneas, y finalmente alteraciones nerviosas. Como resultado de esta condición de que no siempre es posible identificar la tríada clásica en los pacientes, existe un obstáculo para el diagnóstico. Además, se identificaron algunos factores de riesgo para la enfermedad, como el alcoholismo, los factores estacionales, la radiación solar y la desnutrición, siendo el alcoholismo la principal causa de la pelagra en la actualidad.Objetivo: Identificar se há dificuldade no diagnóstico da patologia em razão das variadas manifestações clínicas e definir se há uma causa mais prevalente. Método: O estudo consiste em uma Revisão Integrativa de literatura, em que foram selecionados artigos das bases de dados: SciELO e MEDLINE, utilizando como critérios de inclusão artigos em português, inglês e francês, publicados entre 1922-2012; que abordassem o viés etiopatogênico da pelagra; e com qualquer delineamento metodológico. Foram utilizados os descritores: “pelagra”, “niacina” e “manifestações clínicas''. A amostra final foi constituída de 6 artigos. Resultados: Observou-se nos artigos que compõem a amostra que uma porcentagem alta de pacientes apresentam a “Pelagra Sine Pelagra”, ou seja, sem a manifestação das lesões dermatológicas características da pelagra, observando-se desse modo somente os distúrbios gastrointestinais e/ou neurológicos, dificultando o diagnóstico da patologia. No tocante à causa prevalente, é possível definir o alcoolismo como o fator de risco principal para o surgimento da doença. Conclusão: Concluiu-se que o perfil mais relatado foi o de indivíduos oligossintomáticos, em especial pacientes que apresentam quadros de “Pelagra Sine Pelagra”. A doença inicia-se com desordens dos órgãos digestivos, seguido do surgimento de lesões cutâneas, e, por fim, alterações nervosas. Em decorrência desse quadro arrastado e de nem sempre ser possível identificar a tríade clássica nos pacientes, tem-se um empecilho no diagnóstico tanto precoce quanto a longo prazo. Ademais, identificou-se alguns fatores de risco para a patologia, como alcoolismo, fator sazonal, radiação solar e desnutrição, sendo o alcoolismo a maior causa de pelagra na atualidade.Research, Society and Development2021-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1778710.33448/rsd-v10i9.17787Research, Society and Development; Vol. 10 No. 9; e7210917787Research, Society and Development; Vol. 10 Núm. 9; e7210917787Research, Society and Development; v. 10 n. 9; e72109177872525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17787/15907Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoyhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNoleto, Rodrigo Sevilla Pinto, Nathalia Silva Godoy, Janine Silva Ribeiro 2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/17787Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:04.028326Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
Pelagra: Correlación entre diagnóstico y cuadro clínico más prevalente en Brasil
Pelagra: Correlação entre diagnóstico e o quadro clínico mais prevalente no Brasil
title Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
spellingShingle Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
Noleto, Rodrigo Sevilla
Pelagra
Niacina
Manifestaciones clínicas.
Pellagra
Niacin
Clinical manifestations.
Pelagra
Niacina
Manifestações clínicas.
title_short Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
title_full Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
title_fullStr Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
title_full_unstemmed Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
title_sort Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
author Noleto, Rodrigo Sevilla
author_facet Noleto, Rodrigo Sevilla
Pinto, Nathalia Silva
Godoy, Janine Silva Ribeiro
author_role author
author2 Pinto, Nathalia Silva
Godoy, Janine Silva Ribeiro
author2_role author
author
dc.contributor.author.fl_str_mv Noleto, Rodrigo Sevilla
Pinto, Nathalia Silva
Godoy, Janine Silva Ribeiro
dc.subject.por.fl_str_mv Pelagra
Niacina
Manifestaciones clínicas.
Pellagra
Niacin
Clinical manifestations.
Pelagra
Niacina
Manifestações clínicas.
topic Pelagra
Niacina
Manifestaciones clínicas.
Pellagra
Niacin
Clinical manifestations.
Pelagra
Niacina
Manifestações clínicas.
description Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/17787
10.33448/rsd-v10i9.17787
url https://rsdjournal.org/index.php/rsd/article/view/17787
identifier_str_mv 10.33448/rsd-v10i9.17787
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/17787/15907
dc.rights.driver.fl_str_mv Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoy
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoy
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 9; e7210917787
Research, Society and Development; Vol. 10 Núm. 9; e7210917787
Research, Society and Development; v. 10 n. 9; e7210917787
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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