Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17787 |
Resumo: | Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays. |
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Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in BrazilPelagra: Correlación entre diagnóstico y cuadro clínico más prevalente en BrasilPelagra: Correlação entre diagnóstico e o quadro clínico mais prevalente no BrasilPelagraNiacinaManifestaciones clínicas.PellagraNiacinClinical manifestations.PelagraNiacinaManifestações clínicas.Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays.Objetivo: Identificar si existe dificultad en el diagnóstico de la patología debido a las diversas manifestaciones clínicas y definir si existe una causa más prevalente. Método: El estudio consiste en una revisión integradora de la literatura, en la que se seleccionaron artículos de las bases de datos: SciELO y MEDLINE, utilizando como criterios de inclusión artículos en portugués, inglés y francés, publicados entre 1922-2012; que abordó el sesgo etiopatogénico de la pelagra; y con cualquier diseño metodológico. Se utilizaron los siguientes descriptores: “pelagra”, “niacina” y “manifestaciones clínicas”. La muestra final estuvo formada por 6 artículos. Resultados: Se observó que un alto porcentaje de pacientes presentan "Pelagra Sine Pelagra", o sea, sin la manifestación de las lesiones dermatológicas características de la pelagra, observándose así solo trastornos gastrointestinales y/o neurológicos, haciéndolo difícil el diagnóstico. Sobre la causa prevalente, el alcoholismo es el principal factor de riesgo para la aparición de la enfermedad. Conclusión: Se concluyó que el perfil más reportado fue el de individuos oligosintomáticos, especialmente pacientes con condiciones de “Pelagra Sine Pelagra”. La enfermedad comienza con trastornos de los órganos digestivos, seguidos de la aparición de lesiones cutáneas, y finalmente alteraciones nerviosas. Como resultado de esta condición de que no siempre es posible identificar la tríada clásica en los pacientes, existe un obstáculo para el diagnóstico. Además, se identificaron algunos factores de riesgo para la enfermedad, como el alcoholismo, los factores estacionales, la radiación solar y la desnutrición, siendo el alcoholismo la principal causa de la pelagra en la actualidad.Objetivo: Identificar se há dificuldade no diagnóstico da patologia em razão das variadas manifestações clínicas e definir se há uma causa mais prevalente. Método: O estudo consiste em uma Revisão Integrativa de literatura, em que foram selecionados artigos das bases de dados: SciELO e MEDLINE, utilizando como critérios de inclusão artigos em português, inglês e francês, publicados entre 1922-2012; que abordassem o viés etiopatogênico da pelagra; e com qualquer delineamento metodológico. Foram utilizados os descritores: “pelagra”, “niacina” e “manifestações clínicas''. A amostra final foi constituída de 6 artigos. Resultados: Observou-se nos artigos que compõem a amostra que uma porcentagem alta de pacientes apresentam a “Pelagra Sine Pelagra”, ou seja, sem a manifestação das lesões dermatológicas características da pelagra, observando-se desse modo somente os distúrbios gastrointestinais e/ou neurológicos, dificultando o diagnóstico da patologia. No tocante à causa prevalente, é possível definir o alcoolismo como o fator de risco principal para o surgimento da doença. Conclusão: Concluiu-se que o perfil mais relatado foi o de indivíduos oligossintomáticos, em especial pacientes que apresentam quadros de “Pelagra Sine Pelagra”. A doença inicia-se com desordens dos órgãos digestivos, seguido do surgimento de lesões cutâneas, e, por fim, alterações nervosas. Em decorrência desse quadro arrastado e de nem sempre ser possível identificar a tríade clássica nos pacientes, tem-se um empecilho no diagnóstico tanto precoce quanto a longo prazo. Ademais, identificou-se alguns fatores de risco para a patologia, como alcoolismo, fator sazonal, radiação solar e desnutrição, sendo o alcoolismo a maior causa de pelagra na atualidade.Research, Society and Development2021-07-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1778710.33448/rsd-v10i9.17787Research, Society and Development; Vol. 10 No. 9; e7210917787Research, Society and Development; Vol. 10 Núm. 9; e7210917787Research, Society and Development; v. 10 n. 9; e72109177872525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17787/15907Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoyhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNoleto, Rodrigo Sevilla Pinto, Nathalia Silva Godoy, Janine Silva Ribeiro 2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/17787Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:04.028326Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil Pelagra: Correlación entre diagnóstico y cuadro clínico más prevalente en Brasil Pelagra: Correlação entre diagnóstico e o quadro clínico mais prevalente no Brasil |
title |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
spellingShingle |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil Noleto, Rodrigo Sevilla Pelagra Niacina Manifestaciones clínicas. Pellagra Niacin Clinical manifestations. Pelagra Niacina Manifestações clínicas. |
title_short |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
title_full |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
title_fullStr |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
title_full_unstemmed |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
title_sort |
Pellagra: Correlation between diagnosis and the most prevalent clinical presentation in Brazil |
author |
Noleto, Rodrigo Sevilla |
author_facet |
Noleto, Rodrigo Sevilla Pinto, Nathalia Silva Godoy, Janine Silva Ribeiro |
author_role |
author |
author2 |
Pinto, Nathalia Silva Godoy, Janine Silva Ribeiro |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Noleto, Rodrigo Sevilla Pinto, Nathalia Silva Godoy, Janine Silva Ribeiro |
dc.subject.por.fl_str_mv |
Pelagra Niacina Manifestaciones clínicas. Pellagra Niacin Clinical manifestations. Pelagra Niacina Manifestações clínicas. |
topic |
Pelagra Niacina Manifestaciones clínicas. Pellagra Niacin Clinical manifestations. Pelagra Niacina Manifestações clínicas. |
description |
Objective: To identify if there is difficulty in diagnosing the pathology due to the varied clinical manifestations and to define if there is a more prevalent cause. Method: The study is an Integrative Literature Review, in which articles were selected from the databases: SciELO and MEDLINE, using as inclusion criteria articles in Portuguese, English and French, published between 1922-2012; addressing the etiopathogenic bias of pellagra; and with methodological delimitation. The descriptors used were: “pellagra”, “niacin” and “clinical manifestations”. The final sample consisted of 6 articles. Results: It was observed that a high percentage of patients present the “Pelagra Sine Pelagra”, that is, without the manifestation of the dermatological lesions characteristic of the pellagra, thus observing only the gastrointestinal and/or neurological disorders, making diagnosis of the pathology difficult. About the prevalent cause, alcoholism is the main risk factor for the onset of the disease. Conclusion: It is understood that the most reported profile was that of oligosymptomatic individuals, especially patients who present “Pelagra Sine Pelagra”. The disease begins with disorders of digestive organs, followed by the appearance of skin lesions, and, finally, nerve alterations. As a result of this sluggish presentation and the fact that it is not always possible to identify the classic triad in patients, there is an obstacle in the diagnosis, both early and in the long term. In addition, some risk factors for pathology have been identified, such as alcoholism, seasonal factors, solar radiation and malnutrition, with alcoholism being the main cause of pellagra nowadays. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17787 10.33448/rsd-v10i9.17787 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17787 |
identifier_str_mv |
10.33448/rsd-v10i9.17787 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17787/15907 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoy https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Rodrigo Sevilla Noleto; Nathalia Silva Pinto; Janine Silva Ribeiro Godoy https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 9; e7210917787 Research, Society and Development; Vol. 10 Núm. 9; e7210917787 Research, Society and Development; v. 10 n. 9; e7210917787 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052833203224576 |