The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/17461 |
Resumo: | Himatanthus obovatus, known as janaguba, is found in Northeastern Brazil. Its leaves are used for hypertension, skin blemishes and as an anti-tumor, however studies regarding its healing action are still incipient. The study aimed to analyze the phytochemical profile and the healing effect of the ethanol extract of H. obovatus leaves in mice. The phytochemical prospection of the extract was carried out by the colorimetric test. The gels (carbopol plus the extract) were made with doses of 50, 75 and 100 mg/kg. Carbopol, distilled water, Nebacetin® ointment and extract (gel) were applied topically to the area of the mice lesion as negative control (NC), solvent (SC), positive (PC) and treatment group, respectively, for 21 days. Wounds were recorded on days 0, 7, 14 and 21 days for macroscopic and histological analysis after 21 days. Data were analyzed using the Kruskal-Wallis or Tukey test (p < 0.05). The results showed the presence of tannins, reducing sugars, phenols, flavonoids and alkaloids. In the intergroup, the extract did not show significant difference in the area of the lesion when compared to the PC after the 14th (50 and 75 mg/kg) and 21st days for all doses. In the intragroup, all doses of extract showed a reduction after the 14th and 21st to 100 mg/kg. The extract showed a significant increase in fibroblasts and collagen area at 50 and 100 mg/kg. Thus, the extract has the potential to be explored as an herbal medicine that can be used as a healing gel. |
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The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) WoodsonEl efecto curativo del extracto de etanol de las hojas de Himatanthus obovatus (Müll Arg.) WoodsonO efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) WoodsonFeridasJanagubaPlanta medicinal.HeridasJanagubaPlanta medicinal.Medicinal plantJanagubaWound.Himatanthus obovatus, known as janaguba, is found in Northeastern Brazil. Its leaves are used for hypertension, skin blemishes and as an anti-tumor, however studies regarding its healing action are still incipient. The study aimed to analyze the phytochemical profile and the healing effect of the ethanol extract of H. obovatus leaves in mice. The phytochemical prospection of the extract was carried out by the colorimetric test. The gels (carbopol plus the extract) were made with doses of 50, 75 and 100 mg/kg. Carbopol, distilled water, Nebacetin® ointment and extract (gel) were applied topically to the area of the mice lesion as negative control (NC), solvent (SC), positive (PC) and treatment group, respectively, for 21 days. Wounds were recorded on days 0, 7, 14 and 21 days for macroscopic and histological analysis after 21 days. Data were analyzed using the Kruskal-Wallis or Tukey test (p < 0.05). The results showed the presence of tannins, reducing sugars, phenols, flavonoids and alkaloids. In the intergroup, the extract did not show significant difference in the area of the lesion when compared to the PC after the 14th (50 and 75 mg/kg) and 21st days for all doses. In the intragroup, all doses of extract showed a reduction after the 14th and 21st to 100 mg/kg. The extract showed a significant increase in fibroblasts and collagen area at 50 and 100 mg/kg. Thus, the extract has the potential to be explored as an herbal medicine that can be used as a healing gel.Himatanthus obovatus, conocido como janaguba, se encuentra en el noreste de Brasil. Sus hojas se utilizan para la hipertensión, imperfecciones cutáneas y como antitumoral, sin embargo los estudios sobre su acción cicatrizante aún son incipientes. El estudio tuvo como objetivo analizar el perfil fitoquímico y el efecto curativo del extracto etanólico de hojas de H. obovatus en ratones. La prospección fitoquímica del extracto se realizó mediante la prueba colorimétrica. Los geles (carbopol más el extracto) se elaboraron con dosis de 50, 75 y 100 mg/kg. Se aplicaron tópicamente Carbopol, agua destilada, pomada de Nebacetin® y el extracto (gel) al área de la lesión del ratón como control negativo (CN), solvente (CS), positivo (CP) y grupo de tratamiento, respectivamente, durante 21 días. Las heridas se registraron los días 0, 7, 14 y 21 días para análisis macroscópico e histológico después de 21 días. Los datos se analizaron mediante la prueba de Kruskal-Wallis o Tukey (p <0,05). Los resultados mostraron la presencia de taninos, azúcares reductores, fenoles, flavonoides y alcaloides. En el intergrupo, el extracto no mostró diferencia significativa en el área de la lesión en comparación con el CP después de los días 14 (50 y 75 mg/kg) y 21 para todas las dosis. En el intragrupo, todas las dosis del extracto mostraron una reducción después del 14 y 21 a 100 mg/kg. El extracto mostró un aumento significativo de fibroblastos y área de colágeno a 50 y 100 mg/kg. Por lo tanto, el extracto tiene el potencial de ser explorado como una medicina herbal que puede usarse como gel curativo.Himatanthus obovatus, conhecida como janaguba, é encontrada no Nordeste brasileiro. As suas folhas são usadas para hipertensão, manchas na pele e como antitumoral, no entanto ainda são incipientes os estudos quanto à ação cicatrizante. O estudo teve como objetivo analisar o perfil fitoquímico e o efeito cicatrizante do extrato etanólico das folhas de H. obovatus em camundongos. A prospecção fitoquímica do extrato foi realizada pelo teste colorimétrico. Os geis (carbopol mais o extrato) foram confeccionados obtendo as doses de 50, 75 e 100 mg/Kg. O carbopol, água destilada, pomada Nebacetin® e o extrato (gel) foram aplicados de forma tópica na área da lesão dos camundongos como controle negativo (CN), solvente (CS), positivo (CP) e grupo tratamento, respectivamente, durante 21 dias. As feridas foram registradas nos dias 0, 7, 14 e 21 dias para análise macroscópica e histológica após 21 dias. Os dados foram analisados pelo teste de Kruskal-Wallis ou Tukey (p < 0,05). Os resultados mostraram a presença de taninos, açúcares redutores, fenóis, flavonoides e alcaloides. No intergrupo, o extrato não apresentou diferença significativa da área da lesão quando comparado com o CP após o 14° (50 e 75 mg/kg) e 21º dias para todas as doses. No intragrupo, todas as doses do extrato apresentaram redução após o 14° e no 21° para 100 mg/Kg. O extrato mostrou aumento significativo de fibroblastos e área de colágeno em 50 e 100 mg/Kg. Sendo assim, o extrato apresenta potencial para ser explorado como um fitoterápico que possa ser utilizado como gel cicatrizante.Research, Society and Development2021-07-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1746110.33448/rsd-v10i8.17461Research, Society and Development; Vol. 10 No. 8; e29010817461Research, Society and Development; Vol. 10 Núm. 8; e29010817461Research, Society and Development; v. 10 n. 8; e290108174612525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17461/15505Copyright (c) 2021 Wesley Wagner dos Santos; Pedro Marcos de Almeida; Wellington Santos Alves; Letícia Lima Bacelar; Antônio Luiz Martins Maia Filho; Maria das Dores Alves de Oliveira; Danniel Cabral Leão Ferreira; Francisco Soares Santos Filho; Francielle Alline Martinshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Wesley Wagner dos Almeida, Pedro Marcos de Alves, Wellington Santos Bacelar, Letícia Lima Maia Filho, Antônio Luiz Martins Oliveira, Maria das Dores Alves de Ferreira, Danniel Cabral Leão Santos Filho, Francisco Soares Martins, Francielle Alline 2021-08-21T18:46:59Zoai:ojs.pkp.sfu.ca:article/17461Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:47.469825Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson El efecto curativo del extracto de etanol de las hojas de Himatanthus obovatus (Müll Arg.) Woodson O efeito cicatrizante do extrato etanólico das folhas de Himatanthus obovatus (Müll Arg.) Woodson |
title |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
spellingShingle |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson Santos, Wesley Wagner dos Feridas Janaguba Planta medicinal. Heridas Janaguba Planta medicinal. Medicinal plant Janaguba Wound. |
title_short |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
title_full |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
title_fullStr |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
title_full_unstemmed |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
title_sort |
The healing effect of the ethanol extract of the leaves of Himatanthus obovatus (Müll Arg.) Woodson |
author |
Santos, Wesley Wagner dos |
author_facet |
Santos, Wesley Wagner dos Almeida, Pedro Marcos de Alves, Wellington Santos Bacelar, Letícia Lima Maia Filho, Antônio Luiz Martins Oliveira, Maria das Dores Alves de Ferreira, Danniel Cabral Leão Santos Filho, Francisco Soares Martins, Francielle Alline |
author_role |
author |
author2 |
Almeida, Pedro Marcos de Alves, Wellington Santos Bacelar, Letícia Lima Maia Filho, Antônio Luiz Martins Oliveira, Maria das Dores Alves de Ferreira, Danniel Cabral Leão Santos Filho, Francisco Soares Martins, Francielle Alline |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Wesley Wagner dos Almeida, Pedro Marcos de Alves, Wellington Santos Bacelar, Letícia Lima Maia Filho, Antônio Luiz Martins Oliveira, Maria das Dores Alves de Ferreira, Danniel Cabral Leão Santos Filho, Francisco Soares Martins, Francielle Alline |
dc.subject.por.fl_str_mv |
Feridas Janaguba Planta medicinal. Heridas Janaguba Planta medicinal. Medicinal plant Janaguba Wound. |
topic |
Feridas Janaguba Planta medicinal. Heridas Janaguba Planta medicinal. Medicinal plant Janaguba Wound. |
description |
Himatanthus obovatus, known as janaguba, is found in Northeastern Brazil. Its leaves are used for hypertension, skin blemishes and as an anti-tumor, however studies regarding its healing action are still incipient. The study aimed to analyze the phytochemical profile and the healing effect of the ethanol extract of H. obovatus leaves in mice. The phytochemical prospection of the extract was carried out by the colorimetric test. The gels (carbopol plus the extract) were made with doses of 50, 75 and 100 mg/kg. Carbopol, distilled water, Nebacetin® ointment and extract (gel) were applied topically to the area of the mice lesion as negative control (NC), solvent (SC), positive (PC) and treatment group, respectively, for 21 days. Wounds were recorded on days 0, 7, 14 and 21 days for macroscopic and histological analysis after 21 days. Data were analyzed using the Kruskal-Wallis or Tukey test (p < 0.05). The results showed the presence of tannins, reducing sugars, phenols, flavonoids and alkaloids. In the intergroup, the extract did not show significant difference in the area of the lesion when compared to the PC after the 14th (50 and 75 mg/kg) and 21st days for all doses. In the intragroup, all doses of extract showed a reduction after the 14th and 21st to 100 mg/kg. The extract showed a significant increase in fibroblasts and collagen area at 50 and 100 mg/kg. Thus, the extract has the potential to be explored as an herbal medicine that can be used as a healing gel. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17461 10.33448/rsd-v10i8.17461 |
url |
https://rsdjournal.org/index.php/rsd/article/view/17461 |
identifier_str_mv |
10.33448/rsd-v10i8.17461 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/17461/15505 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 8; e29010817461 Research, Society and Development; Vol. 10 Núm. 8; e29010817461 Research, Society and Development; v. 10 n. 8; e29010817461 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052682463084544 |