Biomarkers of renal function in diabetic children and adolescentes
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/29063 |
Resumo: | Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium. |
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Biomarkers of renal function in diabetic children and adolescentes Biomarcadores de función renal en niños y adolescentes diabéticos Biomarcadores da função renal em crianças e adolescentes diabéticas Diabetes mellitusNefropatia diabéticaCriançasBiomarcadores.Diabetes mellitusEnferedades renalesNiñoBiomarcadores.Diabetes mellitusDoença RenalChildrenBiomarker. Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium.Objetivo: discutir aspectos asociados a los principales biomarcadores utilizados en la rutina de laboratorio para el diagnóstico de disfunción renal en niños y adolescentes con DM1. Metodología: investigación retrospectiva y documental, con procedimientos descriptivos, a través de datos secundarios de las historias clínicas de esta población en un hospital universitario de Paraíba. La recolección de datos se realizó mediante un formulario que contenía variables socioeconómicas, clínicas y de laboratorio, y el análisis se realizó mediante el software SPSS. Resultados y discusión: Se evaluaron 21 historias clínicas, obteniéndose una relación estadísticamente significativa entre los niveles séricos de potasio y urea (p=0,01), la creatinina elevada y el área de residencia (p=0,04). Se encontró que el 5% de los participantes tenían la creatina y la urea elevadas; en el análisis de orina, el 43% tenía glucosuria y el tenía cuerpos cetónicos. Conclusión: Así, se encontró que la población infantil y adolescente con diabetes mellitus tipo 1 presentaba alteraciones en biomarcadores, con un tiempo medio de diagnóstico de 5,29 (±4,17) años, considerándose así una probable lesión renal, como lo han planteado investigaciones previas. demostrado que estos cambios se desarrollan después de 10 años. Además, se demostró que los individuos con alteraciones en la creatinina sérica también tenían promedios más altos de potasio, glucosa, PAS, PAD, FC y sodio.Objetivo: discutir aspectos associados aos principais biomarcadores utilizados na rotina laboratorial para diagnóstico de disfunção renal na população infanto-juvenil com DM1. Metodologia: pesquisa retrospectiva e documental, com procedimentos descritivos, através de dados secundários de prontuários dessa população em um hospital universitário da Paraíba. A coleta de dados foi desenvolvida por meio de um formulário contendo as variáveis socioeconômicas, clínicas e laboratoriais, e análise realizada por meio do software SPSS. Resultados E discussão: Foram julgados 21 prontuários, obtendo-se relação estatística significativa entre os níveis séricos de potássio e a ureia (p=0,01), e da creatinina elevada e a zona de residência (p=0,04). Verificou-se que 5% dos participantes apresentaram creatina e ureia elevadas; na urinálise, 43% apresentaam glicosúria e corpos cetônicos. Conclusão: Assim, verificou-se que a população infanto-juvenil com diabetes mellitus tipo 1 continham alterações nos biomarcadores, com média do tempo de diagnóstico de 5,29 (±4,17) anos, considerando-se, assim, uma provável lesão renal, visto que pesquisas anteriores evideciam que estas alterações são desenvolvidas após 10 anos. Outrossim, demonstrou-se que indivíduos com alterações na creatinina sérica, continham também médias mais elevadas de potássio, glicose, PAS, PAD, FC e sódio.Research, Society and Development2022-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2906310.33448/rsd-v11i6.29063Research, Society and Development; Vol. 11 No. 6; e41011629063Research, Society and Development; Vol. 11 Núm. 6; e41011629063Research, Society and Development; v. 11 n. 6; e410116290632525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/29063/25348Copyright (c) 2022 Allana Petrúcia Medeiros de Miranda; Anajás da Silva Cardoso Canalice; Kaline Oliveira da Silva; Juliana Andreia Fernandes Noronhahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMiranda, Allana Petrúcia Medeiros de Canalice, Anajás da Silva CardosoSilva, Kaline Oliveira da Noronha, Juliana Andreia Fernandes2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/29063Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:14.562854Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Biomarkers of renal function in diabetic children and adolescentes Biomarcadores de función renal en niños y adolescentes diabéticos Biomarcadores da função renal em crianças e adolescentes diabéticas |
title |
Biomarkers of renal function in diabetic children and adolescentes |
spellingShingle |
Biomarkers of renal function in diabetic children and adolescentes Miranda, Allana Petrúcia Medeiros de Diabetes mellitus Nefropatia diabética Crianças Biomarcadores. Diabetes mellitus Enferedades renales Niño Biomarcadores. Diabetes mellitus Doença Renal Children Biomarker. |
title_short |
Biomarkers of renal function in diabetic children and adolescentes |
title_full |
Biomarkers of renal function in diabetic children and adolescentes |
title_fullStr |
Biomarkers of renal function in diabetic children and adolescentes |
title_full_unstemmed |
Biomarkers of renal function in diabetic children and adolescentes |
title_sort |
Biomarkers of renal function in diabetic children and adolescentes |
author |
Miranda, Allana Petrúcia Medeiros de |
author_facet |
Miranda, Allana Petrúcia Medeiros de Canalice, Anajás da Silva Cardoso Silva, Kaline Oliveira da Noronha, Juliana Andreia Fernandes |
author_role |
author |
author2 |
Canalice, Anajás da Silva Cardoso Silva, Kaline Oliveira da Noronha, Juliana Andreia Fernandes |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Miranda, Allana Petrúcia Medeiros de Canalice, Anajás da Silva Cardoso Silva, Kaline Oliveira da Noronha, Juliana Andreia Fernandes |
dc.subject.por.fl_str_mv |
Diabetes mellitus Nefropatia diabética Crianças Biomarcadores. Diabetes mellitus Enferedades renales Niño Biomarcadores. Diabetes mellitus Doença Renal Children Biomarker. |
topic |
Diabetes mellitus Nefropatia diabética Crianças Biomarcadores. Diabetes mellitus Enferedades renales Niño Biomarcadores. Diabetes mellitus Doença Renal Children Biomarker. |
description |
Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29063 10.33448/rsd-v11i6.29063 |
url |
https://rsdjournal.org/index.php/rsd/article/view/29063 |
identifier_str_mv |
10.33448/rsd-v11i6.29063 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/29063/25348 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 6; e41011629063 Research, Society and Development; Vol. 11 Núm. 6; e41011629063 Research, Society and Development; v. 11 n. 6; e41011629063 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052811797594112 |