Biomarkers of renal function in diabetic children and adolescentes

Detalhes bibliográficos
Autor(a) principal: Miranda, Allana Petrúcia Medeiros de
Data de Publicação: 2022
Outros Autores: Canalice, Anajás da Silva Cardoso, Silva, Kaline Oliveira da, Noronha, Juliana Andreia Fernandes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/29063
Resumo: Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of ​​residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium.
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spelling Biomarkers of renal function in diabetic children and adolescentes Biomarcadores de función renal en niños y adolescentes diabéticos Biomarcadores da função renal em crianças e adolescentes diabéticas Diabetes mellitusNefropatia diabéticaCriançasBiomarcadores.Diabetes mellitusEnferedades renalesNiñoBiomarcadores.Diabetes mellitusDoença RenalChildrenBiomarker. Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of ​​residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium.Objetivo: discutir aspectos asociados a los principales biomarcadores utilizados en la rutina de laboratorio para el diagnóstico de disfunción renal en niños y adolescentes con DM1. Metodología: investigación retrospectiva y documental, con procedimientos descriptivos, a través de datos secundarios de las historias clínicas de esta población en un hospital universitario de Paraíba. La recolección de datos se realizó mediante un formulario que contenía variables socioeconómicas, clínicas y de laboratorio, y el análisis se realizó mediante el software SPSS. Resultados y discusión: Se evaluaron 21 historias clínicas, obteniéndose una relación estadísticamente significativa entre los niveles séricos de potasio y urea (p=0,01), la creatinina elevada y el área de residencia (p=0,04). Se encontró que el 5% de los participantes tenían la creatina y la urea elevadas; en el análisis de orina, el 43% tenía glucosuria y el tenía cuerpos cetónicos. Conclusión: Así, se encontró que la población infantil y adolescente con diabetes mellitus tipo 1 presentaba alteraciones en biomarcadores, con un tiempo medio de diagnóstico de 5,29 (±4,17) años, considerándose así una probable lesión renal, como lo han planteado investigaciones previas. demostrado que estos cambios se desarrollan después de 10 años. Además, se demostró que los individuos con alteraciones en la creatinina sérica también tenían promedios más altos de potasio, glucosa, PAS, PAD, FC y sodio.Objetivo: discutir aspectos associados aos principais biomarcadores utilizados na rotina laboratorial para diagnóstico de disfunção renal na população infanto-juvenil com DM1. Metodologia: pesquisa retrospectiva e documental, com procedimentos descritivos, através de dados secundários de prontuários dessa população em um hospital universitário da Paraíba. A coleta de dados foi desenvolvida por meio de um formulário contendo as variáveis socioeconômicas, clínicas e laboratoriais, e análise realizada por meio do software SPSS.  Resultados E discussão: Foram julgados 21 prontuários, obtendo-se relação estatística significativa entre os níveis séricos de potássio e a ureia (p=0,01), e da creatinina elevada e a zona de residência (p=0,04). Verificou-se que 5% dos participantes apresentaram creatina e ureia elevadas; na urinálise, 43% apresentaam glicosúria e corpos cetônicos. Conclusão: Assim, verificou-se que a população infanto-juvenil com diabetes mellitus tipo 1 continham alterações nos biomarcadores, com média  do tempo de diagnóstico de 5,29 (±4,17)  anos, considerando-se, assim, uma provável lesão renal, visto que pesquisas anteriores evideciam que estas alterações são desenvolvidas após 10 anos. Outrossim, demonstrou-se que indivíduos com alterações na creatinina sérica, continham também médias mais elevadas de potássio, glicose, PAS, PAD, FC e sódio.Research, Society and Development2022-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2906310.33448/rsd-v11i6.29063Research, Society and Development; Vol. 11 No. 6; e41011629063Research, Society and Development; Vol. 11 Núm. 6; e41011629063Research, Society and Development; v. 11 n. 6; e410116290632525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/29063/25348Copyright (c) 2022 Allana Petrúcia Medeiros de Miranda; Anajás da Silva Cardoso Canalice; Kaline Oliveira da Silva; Juliana Andreia Fernandes Noronhahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMiranda, Allana Petrúcia Medeiros de Canalice, Anajás da Silva CardosoSilva, Kaline Oliveira da Noronha, Juliana Andreia Fernandes2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/29063Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:14.562854Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Biomarkers of renal function in diabetic children and adolescentes
Biomarcadores de función renal en niños y adolescentes diabéticos
Biomarcadores da função renal em crianças e adolescentes diabéticas
title Biomarkers of renal function in diabetic children and adolescentes
spellingShingle Biomarkers of renal function in diabetic children and adolescentes
Miranda, Allana Petrúcia Medeiros de
Diabetes mellitus
Nefropatia diabética
Crianças
Biomarcadores.
Diabetes mellitus
Enferedades renales
Niño
Biomarcadores.
Diabetes mellitus
Doença Renal
Children
Biomarker.
title_short Biomarkers of renal function in diabetic children and adolescentes
title_full Biomarkers of renal function in diabetic children and adolescentes
title_fullStr Biomarkers of renal function in diabetic children and adolescentes
title_full_unstemmed Biomarkers of renal function in diabetic children and adolescentes
title_sort Biomarkers of renal function in diabetic children and adolescentes
author Miranda, Allana Petrúcia Medeiros de
author_facet Miranda, Allana Petrúcia Medeiros de
Canalice, Anajás da Silva Cardoso
Silva, Kaline Oliveira da
Noronha, Juliana Andreia Fernandes
author_role author
author2 Canalice, Anajás da Silva Cardoso
Silva, Kaline Oliveira da
Noronha, Juliana Andreia Fernandes
author2_role author
author
author
dc.contributor.author.fl_str_mv Miranda, Allana Petrúcia Medeiros de
Canalice, Anajás da Silva Cardoso
Silva, Kaline Oliveira da
Noronha, Juliana Andreia Fernandes
dc.subject.por.fl_str_mv Diabetes mellitus
Nefropatia diabética
Crianças
Biomarcadores.
Diabetes mellitus
Enferedades renales
Niño
Biomarcadores.
Diabetes mellitus
Doença Renal
Children
Biomarker.
topic Diabetes mellitus
Nefropatia diabética
Crianças
Biomarcadores.
Diabetes mellitus
Enferedades renales
Niño
Biomarcadores.
Diabetes mellitus
Doença Renal
Children
Biomarker.
description Objective: to discuss aspects associated with the main biomarkers used in the laboratory routine for the diagnosis of renal dysfunction in children and adolescents with DM1. Methodology: retrospective and documentary research, with descriptive procedures, through secondary data from medical records of this population in a university hospital in Paraíba. Data collection was carried out using a form containing socioeconomic, clinical and laboratory variables, and analysis was performed using SPSS software. Results and discussion: Twenty-one medical records were evaluated, obtaining a statistically significant relationship between serum potassium and urea levels (p=0.01), and high creatinine and the area of ​​residence (p=0.04). It was found that 5% of the participants had elevated creatine and urea; on urinalysis, 43% had glycosuria and had ketone bodies. Conclusion: Thus, it was found that the child and adolescent population with type 1 diabetes mellitus had alterations in biomarkers, with a mean time of diagnosis of 5.29 (±4.17) years, thus considering a probable lesion. kidney disease, as previous research has shown that these changes develop after 10 years. Furthermore, it was shown that individuals with alterations in serum creatinine also contained higher averages of potassium, glucose, SBP, DBP, HR and sodium.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29063
10.33448/rsd-v11i6.29063
url https://rsdjournal.org/index.php/rsd/article/view/29063
identifier_str_mv 10.33448/rsd-v11i6.29063
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/29063/25348
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 6; e41011629063
Research, Society and Development; Vol. 11 Núm. 6; e41011629063
Research, Society and Development; v. 11 n. 6; e41011629063
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
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instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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