Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19625 |
Resumo: | Introduction: New treatments have been introduced with the objective to increase the survival rate of oncologic patients. As a result of these approaches, there was an increase in the number of cases of toxicity and complications, which can lead to acute respiratory failure (ARF). One of the most frequent ways to treat ARF is non-invasive ventilation (NIV). Despite the proven benefits in several clinical conditions, NIV results in cancer patients are controversial. Objective: To evaluate risk factors associated with NIV failure and hospital mortality in oncologic patients. Methods: Retrospective cohort study including patients with solid tumors and hematological neoplasms admitted for hospitalization at National Cancer Institute between January 1, 2017 and December 31, 2019, who underwent NIV. The association between the variables of exposure and the outcome was performed by gross and adjusted logistic regression. The Kaplan-Meier method was used to analyze the length of hospital stay. Results: Sixty-three patients who underwent NIV in hospitalization were evaluated, and 26 failed NIV. The patients had a mean age of 58.5 years (±15.6), most were male (57.1%), under 60 years old (58.7%) and had comorbidities (55.5%). The patients with pulmonary infection (OR 6.53; 95% CI 1.21-35.12; p=0.02) had a higher risk of failure in NIV. In relation to hospital mortality, patients older than 60 years (OR 6.90; 95% CI, 2.12-22.45; p=0.001) had a higher risk. Conclusion: Patients who presented pulmonary infection were more likely to fail in NIV. Higher hospital mortality was observed among elderly patients. |
id |
UNIFEI_821cff281a773920f14dffa493eadbd3 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/19625 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unitFactores associados com el fracasso de la ventilación no invasiva y la mortalidade em pacientes oncológicos fuera de la unidad de cuidados intensivosFatores associados a falha da ventilação não invasiva e mortalidade em pacientes oncológicos fora da unidade de terapia intensivaVentilación no invasivaCáncerMortalidad.Noninvasive ventilationCancerMortality.Ventilação não invasivaCâncerMortalidade.Introduction: New treatments have been introduced with the objective to increase the survival rate of oncologic patients. As a result of these approaches, there was an increase in the number of cases of toxicity and complications, which can lead to acute respiratory failure (ARF). One of the most frequent ways to treat ARF is non-invasive ventilation (NIV). Despite the proven benefits in several clinical conditions, NIV results in cancer patients are controversial. Objective: To evaluate risk factors associated with NIV failure and hospital mortality in oncologic patients. Methods: Retrospective cohort study including patients with solid tumors and hematological neoplasms admitted for hospitalization at National Cancer Institute between January 1, 2017 and December 31, 2019, who underwent NIV. The association between the variables of exposure and the outcome was performed by gross and adjusted logistic regression. The Kaplan-Meier method was used to analyze the length of hospital stay. Results: Sixty-three patients who underwent NIV in hospitalization were evaluated, and 26 failed NIV. The patients had a mean age of 58.5 years (±15.6), most were male (57.1%), under 60 years old (58.7%) and had comorbidities (55.5%). The patients with pulmonary infection (OR 6.53; 95% CI 1.21-35.12; p=0.02) had a higher risk of failure in NIV. In relation to hospital mortality, patients older than 60 years (OR 6.90; 95% CI, 2.12-22.45; p=0.001) had a higher risk. Conclusion: Patients who presented pulmonary infection were more likely to fail in NIV. Higher hospital mortality was observed among elderly patients.Introducción: Se han introducido nuevos tratamientos con el objetivo de aumentar la supervivencia de los pacientes con cáncer. Por tanto, aumenta el número de casos de complicaciones y toxidades que pueden derivar en insuficiencia respiratoria aguda (IRA). Una de las formas más frecuentes de tratar la IRA es la ventilación no invasiva (VNI). A pesar de los beneficios em varias condiciones clínicas, el uso de VNI em pacientes con cáncer es controvertido. Objetivo: Evaluar los factores asociados con el fracaso de la VNI y la mortalidad. Métodos: Estudio retrospectivo que incluye pacientes con tumores sólidos y neoplasias hematológias ingresados para hospitalización em el Instituto Nacional del Cáncer entre el 1 de enero de 2017 y el 31 de diciembre de 2019 y que se sometieron a VNI. La asociación entre la exposición y las variables de resultado se realizó mediante regresión logística. Se utilizo el método de Kaplan-Meier para analizar la duración de la estancia hospitalaria. Resultados: Se evaluaron 63 pacientes que fueron sometidos a VNI durante la hospitalización y 26 tuvieron falla de VNI. La edad media fue de 58,5 años (±15.6), la mayoría eran hombres (57,1%), menores de 60 años y tenían comorbilidades (55,5%). Los pacientes con infección pulmonar (OR 6,53; IC 95% 1,21-35,12; p=0,02) tenían un mayor riesgo de fracaso de la VNI y, en relación con la mortalidad hospitalaria, los pacientes mayores de 60 años (OR 6,90; IC 95%, 2,12-22,45; p=0,001) tenían un mayor riesgo de muerte. Conclusión: Los pacientes con infección pulmonar tenían más probabilidades de fracasar en la VNI y se observó una mayor mortalidad entre los ancianos.Introdução: Novos tratamentos têm sido introduzidos visando o aumento da sobrevida dos pacientes oncológicos. Com isso, existe um aumento do número de casos de complicações e toxidades que podem levar a insuficiência respiratória aguda (IRA). Um dos caminhos mais frequente para tratamento da IRA é a ventilação não invasiva (VNI). Apesar dos benefícios em diversas condições clínicas, o uso da VNI em pacientes oncológicos é controverso. Objetivo: Avaliar os fatores associados a falha da VNI e a mortalidade hospitalar em pacientes oncológicos. Métodos: Trata-se de um estudo de coorte retrospectivo incluindo pacientes com tumores sólidos e neoplasias hematológicas admitidos para internação hospitalar no Instituto Nacional de Câncer entre 1 de Janeiro de 2017 e 31 de dezembro de 2019 e que realizaram VNI. A associação entre as variáveis de exposição e de desfecho foram realizadas através da regressão logística. O método de Kaplan-Meier foi usado para análise do tempo de internação hospitalar. Resultados: Sessenta e três pacientes que realizaram VNI durante a internação foram avaliados e 26 apresentaram falha na VNI. A média de idade era de 58,5 anos (±15.6), a maioria eram homens (57,1%), menos de 60 anos (58,7%) e tinha comorbidades (55,5%). Os pacientes com infecção pulmonar (OR 6,53; IC 95% 1,21-35,12; p=0,02) tinham maior risco de falha na VNI e em relação a mortalidade hospitalar, pacientes com mais de 60 anos (OR 6,90; IC 95%, 2,12-22,45; p=0,001) tinham maior risco de morte. Conclusão: Pacientes com infecção pulmonar tinham mais chance de falhar na VNI e uma maior mortalidade foi observada entre os idosos.Research, Society and Development2021-08-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1962510.33448/rsd-v10i11.19625Research, Society and Development; Vol. 10 No. 11; e211101119625Research, Society and Development; Vol. 10 Núm. 11; e211101119625Research, Society and Development; v. 10 n. 11; e2111011196252525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/19625/17437Copyright (c) 2021 Gustavo Telles Silva; Bianca Paraiso Araujo; Eduarda Martins Faria; Camila Martins de Bessa; Anke Bergmann; Luiz Claudio Santos Thulerhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Gustavo Telles Araujo, Bianca Paraiso Faria, Eduarda Martins Bessa, Camila Martins deBergmann, AnkeThuler, Luiz Claudio Santos 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19625Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:29.525943Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit Factores associados com el fracasso de la ventilación no invasiva y la mortalidade em pacientes oncológicos fuera de la unidad de cuidados intensivos Fatores associados a falha da ventilação não invasiva e mortalidade em pacientes oncológicos fora da unidade de terapia intensiva |
title |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
spellingShingle |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit Silva, Gustavo Telles Ventilación no invasiva Cáncer Mortalidad. Noninvasive ventilation Cancer Mortality. Ventilação não invasiva Câncer Mortalidade. |
title_short |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
title_full |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
title_fullStr |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
title_full_unstemmed |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
title_sort |
Factors associated with non-invasive ventilation failure and mortality in oncologic patients outside the intensive care unit |
author |
Silva, Gustavo Telles |
author_facet |
Silva, Gustavo Telles Araujo, Bianca Paraiso Faria, Eduarda Martins Bessa, Camila Martins de Bergmann, Anke Thuler, Luiz Claudio Santos |
author_role |
author |
author2 |
Araujo, Bianca Paraiso Faria, Eduarda Martins Bessa, Camila Martins de Bergmann, Anke Thuler, Luiz Claudio Santos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Gustavo Telles Araujo, Bianca Paraiso Faria, Eduarda Martins Bessa, Camila Martins de Bergmann, Anke Thuler, Luiz Claudio Santos |
dc.subject.por.fl_str_mv |
Ventilación no invasiva Cáncer Mortalidad. Noninvasive ventilation Cancer Mortality. Ventilação não invasiva Câncer Mortalidade. |
topic |
Ventilación no invasiva Cáncer Mortalidad. Noninvasive ventilation Cancer Mortality. Ventilação não invasiva Câncer Mortalidade. |
description |
Introduction: New treatments have been introduced with the objective to increase the survival rate of oncologic patients. As a result of these approaches, there was an increase in the number of cases of toxicity and complications, which can lead to acute respiratory failure (ARF). One of the most frequent ways to treat ARF is non-invasive ventilation (NIV). Despite the proven benefits in several clinical conditions, NIV results in cancer patients are controversial. Objective: To evaluate risk factors associated with NIV failure and hospital mortality in oncologic patients. Methods: Retrospective cohort study including patients with solid tumors and hematological neoplasms admitted for hospitalization at National Cancer Institute between January 1, 2017 and December 31, 2019, who underwent NIV. The association between the variables of exposure and the outcome was performed by gross and adjusted logistic regression. The Kaplan-Meier method was used to analyze the length of hospital stay. Results: Sixty-three patients who underwent NIV in hospitalization were evaluated, and 26 failed NIV. The patients had a mean age of 58.5 years (±15.6), most were male (57.1%), under 60 years old (58.7%) and had comorbidities (55.5%). The patients with pulmonary infection (OR 6.53; 95% CI 1.21-35.12; p=0.02) had a higher risk of failure in NIV. In relation to hospital mortality, patients older than 60 years (OR 6.90; 95% CI, 2.12-22.45; p=0.001) had a higher risk. Conclusion: Patients who presented pulmonary infection were more likely to fail in NIV. Higher hospital mortality was observed among elderly patients. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19625 10.33448/rsd-v10i11.19625 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19625 |
identifier_str_mv |
10.33448/rsd-v10i11.19625 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19625/17437 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e211101119625 Research, Society and Development; Vol. 10 Núm. 11; e211101119625 Research, Society and Development; v. 10 n. 11; e211101119625 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052825770917888 |