Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/832 |
Resumo: | The present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed. |
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Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidenceEficacia de la utilización del litio en el tratamiento de la enfermedad de Alzheimer: evidencias científicasEficácia da utilização do lítio no tratamento da doença de Alzheimer: evidências cientificasDemênciaFármacos NeuroprotetoresEficáciaDemenciaFármacos NeuroprotectoreseficienciaInsanityNeuroprotective drugsEfficiencyThe present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed.El presente estudio tuvo como objetivo verificar la efectividad del uso del litio en el tratamiento de la enfermedad de Alzheimer. Se trata de una revisión del tipo integrativa, se utilizó de artículos publicados en los años 2011 a 2014, disponibles en las bases de datos PubMed, ScienceDirect y Scielo. Estudios recientes muestran que la suplementación alimenticia con litio ha prevenido el aumento de mediadores inflamatorios en el cerebro de ratas, llevando a aparentes efectos neuroprotectores terapéuticos del litio. También se produce un aumento de la neurogénesis en el giro dentado del hipocampo y parece aumentar la masa gris, evidenciando que el litio presenta acción neuroprotectora en el tratamiento de los síntomas asociados a la enfermedad de Alzheimer. Se observó que el uso del litio en el tratamiento de la enfermedad de Alzheimer tiene algunos efectos positivos, sin embargo, son necesarios estudios más detallados.O presente estudo teve como objetivo verificar a efetividade do uso do lítio no tratamento da Doença de Alzheimer. Trata-se de uma revisão do tipo integrativa, utilizou-se de artigos publicados nos anos de 2011 a 2014, disponíveis nas bases de dados PubMed, ScienceDirect e Scielo. Estudos recentes mostram que a suplementação alimentar com lítio preveniu o aumento de mediadores inflamatórios no cérebro de ratos, levando a aparentes efeitos neuroprotetores terapêuticos do lítio. Leva também a um aumento de neurogênese no giro denteado do hipocampo e parece aumentar a massa cinzenta, evidenciando que o lítio apresenta ação neuroprotetora no tratamento de sintomas associados a doença de Alzheimer. Observou-se que o uso do lítio no tratamento da doença de Alzheimer possui alguns efeitos positivos, contudo, são necessários estudos mais detalhados. Research, Society and Development2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/83210.33448/rsd-v8i3.832Research, Society and Development; Vol. 8 No. 3; e4283832Research, Society and Development; Vol. 8 Núm. 3; e4283832Research, Society and Development; v. 8 n. 3; e42838322525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/832/722Copyright (c) 2019 irislene costa pereira, joyce lopes macedo, amanda suellenn da silva santos oliveira, MAGNOLIA de jesus sousa magalhães assunçãoinfo:eu-repo/semantics/openAccessMacedo, Joyce LopesOliveira, Amanda Suellenn da Silva SantosPereira, Irislene CostaAssunção, Magnólia de Jesus Sousa Magalhães2020-03-25T16:07:06Zoai:ojs.pkp.sfu.ca:article/832Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:26:06.995252Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence Eficacia de la utilización del litio en el tratamiento de la enfermedad de Alzheimer: evidencias científicas Eficácia da utilização do lítio no tratamento da doença de Alzheimer: evidências cientificas |
title |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
spellingShingle |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence Macedo, Joyce Lopes Demência Fármacos Neuroprotetores Eficácia Demencia Fármacos Neuroprotectores eficiencia Insanity Neuroprotective drugs Efficiency |
title_short |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
title_full |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
title_fullStr |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
title_full_unstemmed |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
title_sort |
Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence |
author |
Macedo, Joyce Lopes |
author_facet |
Macedo, Joyce Lopes Oliveira, Amanda Suellenn da Silva Santos Pereira, Irislene Costa Assunção, Magnólia de Jesus Sousa Magalhães |
author_role |
author |
author2 |
Oliveira, Amanda Suellenn da Silva Santos Pereira, Irislene Costa Assunção, Magnólia de Jesus Sousa Magalhães |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Macedo, Joyce Lopes Oliveira, Amanda Suellenn da Silva Santos Pereira, Irislene Costa Assunção, Magnólia de Jesus Sousa Magalhães |
dc.subject.por.fl_str_mv |
Demência Fármacos Neuroprotetores Eficácia Demencia Fármacos Neuroprotectores eficiencia Insanity Neuroprotective drugs Efficiency |
topic |
Demência Fármacos Neuroprotetores Eficácia Demencia Fármacos Neuroprotectores eficiencia Insanity Neuroprotective drugs Efficiency |
description |
The present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/832 10.33448/rsd-v8i3.832 |
url |
https://rsdjournal.org/index.php/rsd/article/view/832 |
identifier_str_mv |
10.33448/rsd-v8i3.832 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/832/722 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 8 No. 3; e4283832 Research, Society and Development; Vol. 8 Núm. 3; e4283832 Research, Society and Development; v. 8 n. 3; e4283832 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052776238284800 |