Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence

Detalhes bibliográficos
Autor(a) principal: Macedo, Joyce Lopes
Data de Publicação: 2019
Outros Autores: Oliveira, Amanda Suellenn da Silva Santos, Pereira, Irislene Costa, Assunção, Magnólia de Jesus Sousa Magalhães
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/832
Resumo: The present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed.
id UNIFEI_859238a93256420ba473fbd8d91f6536
oai_identifier_str oai:ojs.pkp.sfu.ca:article/832
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidenceEficacia de la utilización del litio en el tratamiento de la enfermedad de Alzheimer: evidencias científicasEficácia da utilização do lítio no tratamento da doença de Alzheimer: evidências cientificasDemênciaFármacos NeuroprotetoresEficáciaDemenciaFármacos NeuroprotectoreseficienciaInsanityNeuroprotective drugsEfficiencyThe present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed.El presente estudio tuvo como objetivo verificar la efectividad del uso del litio en el tratamiento de la enfermedad de Alzheimer. Se trata de una revisión del tipo integrativa, se utilizó de artículos publicados en los años 2011 a 2014, disponibles en las bases de datos PubMed, ScienceDirect y Scielo. Estudios recientes muestran que la suplementación alimenticia con litio ha prevenido el aumento de mediadores inflamatorios en el cerebro de ratas, llevando a aparentes efectos neuroprotectores terapéuticos del litio. También se produce un aumento de la neurogénesis en el giro dentado del hipocampo y parece aumentar la masa gris, evidenciando que el litio presenta acción neuroprotectora en el tratamiento de los síntomas asociados a la enfermedad de Alzheimer. Se observó que el uso del litio en el tratamiento de la enfermedad de Alzheimer tiene algunos efectos positivos, sin embargo, son necesarios estudios más detallados.O presente estudo teve como objetivo verificar a efetividade do uso do lítio no tratamento da Doença de Alzheimer. Trata-se de uma revisão do tipo integrativa, utilizou-se de artigos publicados nos anos de 2011 a 2014, disponíveis nas bases de dados PubMed, ScienceDirect e Scielo. Estudos recentes mostram que a suplementação alimentar com lítio preveniu o aumento de mediadores inflamatórios no cérebro de ratos, levando a aparentes efeitos neuroprotetores terapêuticos do lítio. Leva também a um aumento de neurogênese no giro denteado do hipocampo e parece aumentar a massa cinzenta, evidenciando que o lítio apresenta ação neuroprotetora no tratamento de sintomas associados a doença de Alzheimer. Observou-se que o uso do lítio no tratamento da doença de Alzheimer possui alguns efeitos positivos, contudo, são necessários estudos mais detalhados.  Research, Society and Development2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/83210.33448/rsd-v8i3.832Research, Society and Development; Vol. 8 No. 3; e4283832Research, Society and Development; Vol. 8 Núm. 3; e4283832Research, Society and Development; v. 8 n. 3; e42838322525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/832/722Copyright (c) 2019 irislene costa pereira, joyce lopes macedo, amanda suellenn da silva santos oliveira, MAGNOLIA de jesus sousa magalhães assunçãoinfo:eu-repo/semantics/openAccessMacedo, Joyce LopesOliveira, Amanda Suellenn da Silva SantosPereira, Irislene CostaAssunção, Magnólia de Jesus Sousa Magalhães2020-03-25T16:07:06Zoai:ojs.pkp.sfu.ca:article/832Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:26:06.995252Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
Eficacia de la utilización del litio en el tratamiento de la enfermedad de Alzheimer: evidencias científicas
Eficácia da utilização do lítio no tratamento da doença de Alzheimer: evidências cientificas
title Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
spellingShingle Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
Macedo, Joyce Lopes
Demência
Fármacos Neuroprotetores
Eficácia
Demencia
Fármacos Neuroprotectores
eficiencia
Insanity
Neuroprotective drugs
Efficiency
title_short Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
title_full Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
title_fullStr Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
title_full_unstemmed Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
title_sort Efficacy of lithium in the treatment of Alzheimer's disease: scientific evidence
author Macedo, Joyce Lopes
author_facet Macedo, Joyce Lopes
Oliveira, Amanda Suellenn da Silva Santos
Pereira, Irislene Costa
Assunção, Magnólia de Jesus Sousa Magalhães
author_role author
author2 Oliveira, Amanda Suellenn da Silva Santos
Pereira, Irislene Costa
Assunção, Magnólia de Jesus Sousa Magalhães
author2_role author
author
author
dc.contributor.author.fl_str_mv Macedo, Joyce Lopes
Oliveira, Amanda Suellenn da Silva Santos
Pereira, Irislene Costa
Assunção, Magnólia de Jesus Sousa Magalhães
dc.subject.por.fl_str_mv Demência
Fármacos Neuroprotetores
Eficácia
Demencia
Fármacos Neuroprotectores
eficiencia
Insanity
Neuroprotective drugs
Efficiency
topic Demência
Fármacos Neuroprotetores
Eficácia
Demencia
Fármacos Neuroprotectores
eficiencia
Insanity
Neuroprotective drugs
Efficiency
description The present study had as objective to verify the effectiveness of the use of lithium in the treatment of Alzheimer's Disease. It is a review of the integrative type, using articles published in the years 2011 to 2014, available in PubMed, ScienceDirect and Scielo databases. Recent studies have shown that dietary supplementation with lithium prevented the increase of inflammatory mediators in the rat brain, leading to apparent therapeutic neuroprotective effects of lithium. It also leads to increased neurogenesis in the hippocampal gyrus and appears to increase gray matter, evidence that lithium has a neuroprotective action in the treatment of symptoms associated with Alzheimer's disease. It was observed that the use of lithium in the treatment of Alzheimer's disease has some positive effects, however, more detailed studies are needed.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/832
10.33448/rsd-v8i3.832
url https://rsdjournal.org/index.php/rsd/article/view/832
identifier_str_mv 10.33448/rsd-v8i3.832
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/832/722
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 8 No. 3; e4283832
Research, Society and Development; Vol. 8 Núm. 3; e4283832
Research, Society and Development; v. 8 n. 3; e4283832
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052776238284800

Registros relacionados