Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

Detalhes bibliográficos
Autor(a) principal: Santos, Beatriz da Silva
Data de Publicação: 2021
Outros Autores: Silva, Manoela Santos da, Pereira, Isadora Oliveira e, Lemos, Lucas Brasileiro, Lemos, Gisele da Silveira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/14250
Resumo: This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.
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spelling Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of BahiaPosibles interacciones farmacológicas y perfil de antimicrobianos prescritos para uso ambulatorio en el interior de BahíaInterações medicamentosas potenciais e perfil de antimicrobianos prescritos para uso ambulatorial no interior da BahiaInteracciones FarmacológicasPrescripciones de MedicamentosAntiinfecciosos.Interações medicamentosasPrescrições de medicamentosAnti-infecciosos.Drug interactionsDrug prescriptionsAnti-infective agents.This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.Este estudio tuvo como objetivo analizar el perfil de los antimicrobianos y las posibles interacciones farmacológicas, que involucran a estos fármacos, prescritos para uso ambulatorio en el interior de Bahía. Se trata de un estudio transversal, realizado a partir del análisis de 404 prescripciones antimicrobianas enumeradas en la DRC nº 20/2011, puestas a disposición por la tienda de una cadena de farmacias, referidas al período de mayo de 2018. El análisis de interacciones medicamentosas (MI) se realizó utilizando la base de datos MICROMEDEX® versión 2.0 (2011). La clase de antimicrobianos más prescrita fue la de los β-lactámicos (27,7%), seguida de los macrólidos (25,3%) y las fluoroquinolonas (18,3%). En cuanto a los fármacos prescritos en combinación, predominaron los antiinflamatorios no esteroideos (23,3%) y los analgésicos (19,8%). Se observaron un total de 20 interacciones medicamentosas diferentes, que incluían antimicrobianos, con mayor frecuencia para ciprofloxacino. Luego de analizar las interacciones, fue posible verificar los riesgos relacionados con las asociaciones de medicamentos que se pueden minimizar con el análisis de la prescripción por parte de un profesional farmacéutico y los sistemas de alerta en la prescripción electrónica.Este trabalho teve como objetivo analisar o perfil de antimicrobianos e as interações medicamentosas potenciais, envolvendo esses fármacos, prescritos para uso ambulatorial no interior da Bahia.  Trata-se de um estudo transversal, executado a partir da análise de 404 prescrições de antimicrobianos listados na RDC no 20/2011, disponibilizadas pela loja Matriz de uma rede de Farmácias, referente ao período de maio de 2018. A análise das interações medicamentosas (IM) foi feita através da base de dados MICROMEDEX® versão 2.0 (2011).   A classe de antimicrobianos mais prescrita foi a dos β-lactâmicos (27,7%), seguido dos macrolídeos (25,3%) e fluorquinolonas (18,3%). Quanto aos fármacos prescritos em associação, houve predomínio dos antiinflamatórios não esteroidais (23,3%) e analgésicos (19,8%). Observou-se um total de 20 interações medicamentosas diferentes, envolvendo antimicrobianos, com maior frequência para o ciprofloxacino. Após análise das interações pôde-se verificar os riscos relacionados a associações de medicamentos que podem ser minimizados com a análise da prescrição por profissional farmacêutico e sistemas de alertas em prescrição eletrônica.Research, Society and Development2021-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1425010.33448/rsd-v10i4.14250Research, Society and Development; Vol. 10 No. 4; e44210414250Research, Society and Development; Vol. 10 Núm. 4; e44210414250Research, Society and Development; v. 10 n. 4; e442104142502525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/14250/12869Copyright (c) 2021 Beatriz da Silva Santos; Manoela Santos da Silva; Isadora Oliveira e Pereira; Lucas Brasileiro Lemos; Gisele da Silveira Lemoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Beatriz da SilvaSilva, Manoela Santos da Pereira, Isadora Oliveira eLemos, Lucas BrasileiroLemos, Gisele da Silveira 2021-04-25T11:21:26Zoai:ojs.pkp.sfu.ca:article/14250Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:35:25.135779Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
Posibles interacciones farmacológicas y perfil de antimicrobianos prescritos para uso ambulatorio en el interior de Bahía
Interações medicamentosas potenciais e perfil de antimicrobianos prescritos para uso ambulatorial no interior da Bahia
title Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
spellingShingle Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
Santos, Beatriz da Silva
Interacciones Farmacológicas
Prescripciones de Medicamentos
Antiinfecciosos.
Interações medicamentosas
Prescrições de medicamentos
Anti-infecciosos.
Drug interactions
Drug prescriptions
Anti-infective agents.
title_short Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
title_full Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
title_fullStr Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
title_full_unstemmed Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
title_sort Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia
author Santos, Beatriz da Silva
author_facet Santos, Beatriz da Silva
Silva, Manoela Santos da
Pereira, Isadora Oliveira e
Lemos, Lucas Brasileiro
Lemos, Gisele da Silveira
author_role author
author2 Silva, Manoela Santos da
Pereira, Isadora Oliveira e
Lemos, Lucas Brasileiro
Lemos, Gisele da Silveira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Beatriz da Silva
Silva, Manoela Santos da
Pereira, Isadora Oliveira e
Lemos, Lucas Brasileiro
Lemos, Gisele da Silveira
dc.subject.por.fl_str_mv Interacciones Farmacológicas
Prescripciones de Medicamentos
Antiinfecciosos.
Interações medicamentosas
Prescrições de medicamentos
Anti-infecciosos.
Drug interactions
Drug prescriptions
Anti-infective agents.
topic Interacciones Farmacológicas
Prescripciones de Medicamentos
Antiinfecciosos.
Interações medicamentosas
Prescrições de medicamentos
Anti-infecciosos.
Drug interactions
Drug prescriptions
Anti-infective agents.
description This study aimed to analyze the profile of antimicrobials and potential drug interactions, involving these drugs, prescribed for outpatient use in the interior of Bahia. This is a cross-sectional study, carried out based on the analysis of 404 antimicrobial prescriptions listed in the DRC no. 20/2011, made available by the store of a chain of pharmacies, referring to the period of May 2018. The analysis of drug interactions (IM) was made using the MICROMEDEX® version 2.0 database (2011). The most prescribed class of antimicrobials was that of β-lactams (27.7%), followed by macrolides (25.3%) and fluoroquinolones (18.3%). As for the drugs prescribed in combination, there was a predominance of non-steroidal anti-inflammatory drugs (23.3%) and analgesics (19.8%). A total of 20 different drug interactions were observed, involving antimicrobials, most frequently for ciprofloxacin. After analyzing the interactions, it was possible to verify the risks related to drug associations that can be minimized with the analysis of the prescription by a pharmaceutical professional and alert systems in electronic prescription.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14250
10.33448/rsd-v10i4.14250
url https://rsdjournal.org/index.php/rsd/article/view/14250
identifier_str_mv 10.33448/rsd-v10i4.14250
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/14250/12869
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 4; e44210414250
Research, Society and Development; Vol. 10 Núm. 4; e44210414250
Research, Society and Development; v. 10 n. 4; e44210414250
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052747883741184

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