Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/22159 |
Resumo: | Bisphosphonates (BIS) are indicated for several clinical disorders (e.g., osteoporosis). However, BIS has been associated with osteonecrosis and alterations in osteoclastogenesis and skeletal development. This study aimed to evaluate the effects of BIS (zoledronic acid - ZA and alendronate sodium - AS) on zones of the growth plate of rat femur. Animals (Wistar rats, n = 19) were divided into groups: 1) AS Group: animals received alendronate sodium orally (3 mg/kg per day); 2) ZA Group: ZA was administered intraperitoneally (0.2 mg/kg per week); and 3) Control Group (CG): a vehicle was administered. Animals were euthanized 21 days after the treatment, and femurs were collected for histological analysis. The images of all zones (resting, proliferative, hypertrophic, and calcified) were processed by the Qcapture® software providing a 40 and 400-fold increase. ZA decreased epiphyseal growth plate cell zones (ZA Group vs. CG) in most cases. Likewise, AS diminished the proliferative zone (AS Group vs. CG). Furthermore, ZA increased the calcified zone (ZA Group vs. CG). Previous works demonstrated that BIS decrease the epiphyseal disc. This reduction is probably due to the shortening of the cellular zones that undergoes calcification/ossification. The present results suggest that BIS should be carefully indicated because these drugs might accelerate epiphyseal closure. |
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Effects of bisphosphonates on different zones of the epiphyseal growth plate of ratsEfectos de los bisfosfonatos en diferentes áreas de la placa de crecimiento epifisario de ratasEfeitos dos bisfosfonatos em diferentes zonas da placa de crescimento epifisária de ratosAlendronateZoledronic acidGrowth plateAnimal modelsEpiphyses.AlendronatoÁcido zoledrónicoPlaca de crecimientoModelos animalesEpífisis.AlendronatoÁcido zoledrônicoPlaca de crescimentoModelos animaisEpífises.Bisphosphonates (BIS) are indicated for several clinical disorders (e.g., osteoporosis). However, BIS has been associated with osteonecrosis and alterations in osteoclastogenesis and skeletal development. This study aimed to evaluate the effects of BIS (zoledronic acid - ZA and alendronate sodium - AS) on zones of the growth plate of rat femur. Animals (Wistar rats, n = 19) were divided into groups: 1) AS Group: animals received alendronate sodium orally (3 mg/kg per day); 2) ZA Group: ZA was administered intraperitoneally (0.2 mg/kg per week); and 3) Control Group (CG): a vehicle was administered. Animals were euthanized 21 days after the treatment, and femurs were collected for histological analysis. The images of all zones (resting, proliferative, hypertrophic, and calcified) were processed by the Qcapture® software providing a 40 and 400-fold increase. ZA decreased epiphyseal growth plate cell zones (ZA Group vs. CG) in most cases. Likewise, AS diminished the proliferative zone (AS Group vs. CG). Furthermore, ZA increased the calcified zone (ZA Group vs. CG). Previous works demonstrated that BIS decrease the epiphyseal disc. This reduction is probably due to the shortening of the cellular zones that undergoes calcification/ossification. The present results suggest that BIS should be carefully indicated because these drugs might accelerate epiphyseal closure.Los bisfosfonatos (BIS) están indicados para varias afecciones clínicas, como la osteoporosis. Sin embargo, los BIS se han asociado con osteonecrosis, alteraciones en la osteoclastogénesis y desarrollo esquelético. El presente estudio probó la hipótesis de que BIS (alendronato sódico - AS y ácido zoledrónico - ZA) modifica el grosor de las zonas de la placa de crecimiento del fémur de rata. Las ratas Wistar (n = 19) se dividieron en: 1) Grupo AS: alendronato sódico oral (3 mg / kg / día); 2) Grupo ZA: administración intraperitoneal de ácido zoledrónico (0,2 mg / kg / semana); y 3) Grupo Control (GC): sin administración de medicación. Después de 21 días de tratamiento, se sacrificó a los animales y se recogieron los fémures para análisis histológico. Se capturaron imágenes de diferentes zonas de la placa de crecimiento (zonas de reposo, proliferativas, hipertróficas y calcificadas) utilizando el software Qcapture® (aumento 40 y 400 veces). ZA disminuyó las zonas de células de placa (Grupo ZA frente a CG) en la mayoría de los casos. Asimismo, AS provocó una disminución en la zona proliferativa (Grupo AS vs. GC). Además, las ratas tratadas con ZA mostraron un mayor grosor de la zona calcificada (Grupo ZA frente a GC). Estudios anteriores han demostrado el efecto de BIS en la reducción del grosor del disco epifisario. Esta reducción de la placa de crecimiento probablemente se deba al acortamiento de las zonas celulares que sufren calcificación y osificación. Nuestros resultados sugieren que los BIS deben indicarse con precaución, ya que pueden acelerar el cierre epifisario.Os bisfosfonatos (BIS) são indicados para diversas condições clínicas, como a osteoporose. No entanto, os BIS têm sido associado a osteonecrose, alterações na osteoclastogênese e no desenvolvimento esquelético. O presente estudo testou a hipótese de que os BIS (alendronato de sódio - AS e ácido zoledrônico - ZA) modificam a espessura das zonas da placa de crescimento do fêmur de ratos. Ratos Wistar (n = 19) foram divididos em: 1) Grupo AS: alendronato de sódio por via oral (3 mg / kg / dia); 2) Grupo ZA: administração de ácido zoledrônico por via intraperitoneal (0,2 mg / kg / semana); e 3) Grupo Controle (GC): sem administração de medicamentos. Após 21 dias de tratamento, os animais foram eutanasiados e os fêmures coletados para análise histológica. As imagens de diferentes zonas da placa de crescimento (zonas de repouso, proliferativas, hipertróficas e calcificadas) foram capturadas usando o software Qcapture® (aumento de 40 e 400 vezes). ZA diminuiu as zonas de células da placa (Grupo ZA vs. CG) na maioria dos casos. Da mesma forma, o AS causou uma diminuição da zona proliferativa (Grupo AS vs. GC). Além disso, ratos tratados com ZA apresentaram aumento da espessura da zona calcificada (Grupo ZA vs. GC). Estudos anteriores mostraram efeito dos BIS na redução da espessura do disco epifisário. Essa redução da placa de crescimento provavelmente deve-se ao encurtamento das zonas celulares que sofrem calcificação e ossificação. Nossos resultados sugerem que os BIS devem ser indicados com cautela, pois podem acelerar o fechamento epifisário.Research, Society and Development2021-11-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2215910.33448/rsd-v10i14.22159Research, Society and Development; Vol. 10 No. 14; e518101422159Research, Society and Development; Vol. 10 Núm. 14; e518101422159Research, Society and Development; v. 10 n. 14; e5181014221592525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/22159/19849Copyright (c) 2021 Deise Ponzoni; Elissa Kerli Fernandes; Mateus Muller da Silva; Izabel Cristina Custódio de Souza; John Kim Neubert; Alexandre Silva Quevedohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPonzoni, DeiseFernandes, Elissa Kerli Silva, Mateus Muller da Souza, Izabel Cristina Custódio de Neubert, John Kim Quevedo, Alexandre Silva 2021-12-04T11:48:39Zoai:ojs.pkp.sfu.ca:article/22159Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:41:23.826237Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats Efectos de los bisfosfonatos en diferentes áreas de la placa de crecimiento epifisario de ratas Efeitos dos bisfosfonatos em diferentes zonas da placa de crescimento epifisária de ratos |
title |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
spellingShingle |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats Ponzoni, Deise Alendronate Zoledronic acid Growth plate Animal models Epiphyses. Alendronato Ácido zoledrónico Placa de crecimiento Modelos animales Epífisis. Alendronato Ácido zoledrônico Placa de crescimento Modelos animais Epífises. |
title_short |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
title_full |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
title_fullStr |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
title_full_unstemmed |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
title_sort |
Effects of bisphosphonates on different zones of the epiphyseal growth plate of rats |
author |
Ponzoni, Deise |
author_facet |
Ponzoni, Deise Fernandes, Elissa Kerli Silva, Mateus Muller da Souza, Izabel Cristina Custódio de Neubert, John Kim Quevedo, Alexandre Silva |
author_role |
author |
author2 |
Fernandes, Elissa Kerli Silva, Mateus Muller da Souza, Izabel Cristina Custódio de Neubert, John Kim Quevedo, Alexandre Silva |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ponzoni, Deise Fernandes, Elissa Kerli Silva, Mateus Muller da Souza, Izabel Cristina Custódio de Neubert, John Kim Quevedo, Alexandre Silva |
dc.subject.por.fl_str_mv |
Alendronate Zoledronic acid Growth plate Animal models Epiphyses. Alendronato Ácido zoledrónico Placa de crecimiento Modelos animales Epífisis. Alendronato Ácido zoledrônico Placa de crescimento Modelos animais Epífises. |
topic |
Alendronate Zoledronic acid Growth plate Animal models Epiphyses. Alendronato Ácido zoledrónico Placa de crecimiento Modelos animales Epífisis. Alendronato Ácido zoledrônico Placa de crescimento Modelos animais Epífises. |
description |
Bisphosphonates (BIS) are indicated for several clinical disorders (e.g., osteoporosis). However, BIS has been associated with osteonecrosis and alterations in osteoclastogenesis and skeletal development. This study aimed to evaluate the effects of BIS (zoledronic acid - ZA and alendronate sodium - AS) on zones of the growth plate of rat femur. Animals (Wistar rats, n = 19) were divided into groups: 1) AS Group: animals received alendronate sodium orally (3 mg/kg per day); 2) ZA Group: ZA was administered intraperitoneally (0.2 mg/kg per week); and 3) Control Group (CG): a vehicle was administered. Animals were euthanized 21 days after the treatment, and femurs were collected for histological analysis. The images of all zones (resting, proliferative, hypertrophic, and calcified) were processed by the Qcapture® software providing a 40 and 400-fold increase. ZA decreased epiphyseal growth plate cell zones (ZA Group vs. CG) in most cases. Likewise, AS diminished the proliferative zone (AS Group vs. CG). Furthermore, ZA increased the calcified zone (ZA Group vs. CG). Previous works demonstrated that BIS decrease the epiphyseal disc. This reduction is probably due to the shortening of the cellular zones that undergoes calcification/ossification. The present results suggest that BIS should be carefully indicated because these drugs might accelerate epiphyseal closure. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22159 10.33448/rsd-v10i14.22159 |
url |
https://rsdjournal.org/index.php/rsd/article/view/22159 |
identifier_str_mv |
10.33448/rsd-v10i14.22159 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/22159/19849 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 14; e518101422159 Research, Society and Development; Vol. 10 Núm. 14; e518101422159 Research, Society and Development; v. 10 n. 14; e518101422159 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052694468231168 |