The role of adipocyte in the inflammation and metabolism of the obese

• Autor(a) principal: Sousa, Erica Fernanda Gomes de
• Data de Publicação: 2021
• Outros Autores: Reis , Bruno Gabriel Santos, Nunes Mendes de Brito, Andrea
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18191
• topic: Inflamação; Metabolismo; Adipócitos; Obesidade.; Inflammation; Metabolism; Adipocytes; Obesity.; Inflamación; Metabolismo; Adipocitos; Obesidad.

Objective: To investigate the role of adipocytes in inflammation caused by obesity. Methodology: This is an integrative review, carried out in the LILACS, SCIELO and MEDLINE / PUBMED databases, in the period from September 2020 to May 2021, in English, Spanish and Portuguese language, published between 2015 and May 2021. The following descriptors were used: inflammation, metabolism, adipocytes and obesity, as well as their English versions. Results: The inflammatory state produced by metabolic stress due to obesity is different from classical inflammation, the triggering factor is the excess of nutrients resulting from growth and increase in the number of adipocytes, making it a dysfunctional tissue. Metabolic complications in a state of obesity can be aggravated by an abnormal inflammatory response and it is known to be associated with the formation of toxic reactive oxygen species. Conclusion: It is concluded that adipocytes play an important role in the inflammation and metabolism of the obese, because through adipocytes the main pro-inflammatory cytokines are produced, which can lead to insulin resistance, hypertension, among other metabolic problems.