Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40859 |
Resumo: | Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response. |
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Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic reviewDisfunción endotelial y complicaciones trombóticas asociadas al SARS-CoV-2 en adultos: una revisión sistemáticaDisfunção endotelial e complicações trombóticas associada a SARS-CoV-2 em adultos: uma revisão sistemáticaSARS-CoV-2AdultEndothelial dysfunctionThrombotic complications.SARS-CoV-2AdultoDisfunción endotelialComplicaciones trombóticas.SARS-CoV-2AdultoDisfunção endotelialComplicações trombóticas.Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response.Introducción: Durante la pandemia se observaron ocurrencias de complicaciones tromboembólicas y disfunciones endoteliales asociadas a la COVID-19. Sin embargo, la fisiopatología de los mecanismos de acción no está completamente dilucidada. Métodos: Con el objetivo de una mejor comprensión de los mecanismos asociados de la función endotelial debido a COVID-19, se realizó una revisión sistemática utilizando bases de datos índice y un proceso de selección en el que los criterios de inclusión fueron artículos que abordan el mecanismo de eventos trombóticos por disfunción endotelial. y publicaciones que asocian COVID-19 con complicaciones trombóticas en adultos de hasta 59 años. Conclusión: el SARS-CoV-2 está asociado con una función endotelial alterada por mecanismos endoteliales inducidos por infección y lesión viral directa, lo que lleva a cambios en el eje angiotensina II/AT1 y respuesta inflamatoria.Introdução: Durante a pandemia, foram constatadas ocorrências de complicações tromboembólicas e disfunções endoteliais associadas ao COVID-19. Entretanto, a fisiopatologia dos mecanismos de ação não estão totalmente elucidados. Métodos: visando melhor entendimento dos mecanismos associados da função endotelial devido ao COVID-19 foi realizada uma revisão sistemática desenvolvida por meio de bases de dados de indexadores e processo de seleção no qual os critérios de inclusão foram artigos que abordassem o mecanismo dos eventos trombóticos por meio da disfunção do endotélio e publicações que associam a COVID-19 as complicações trombóticas em adultos até 59 anos. Conclusão: a SARS-CoV-2 está associada a alteração função endotelial por mecanismos endoteliais induzida por infecção viral direta e por lesão, levando a mudanças no eixo angiotensina II/AT1 e resposta inflamatória.Research, Society and Development2023-03-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4085910.33448/rsd-v12i4.40859Research, Society and Development; Vol. 12 No. 4; e3312440859Research, Society and Development; Vol. 12 Núm. 4; e3312440859Research, Society and Development; v. 12 n. 4; e33124408592525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/40859/33338Copyright (c) 2023 Mariane Arakawa Pamplona; José Hittalo Taveira; Karina Magalhães da Mata; Kleber Silva Moraes; Ana Beatriz de Assis Ribeiro; Maria Clara Mendonça França; Cleverson Rodrigues Fernandeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPamplona, Mariane Arakawa Taveira, José Hittalo Mata, Karina Magalhães da Moraes, Kleber Silva Ribeiro, Ana Beatriz de AssisFrança, Maria Clara Mendonça Fernandes, Cleverson Rodrigues 2023-04-21T18:13:32Zoai:ojs.pkp.sfu.ca:article/40859Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-04-21T18:13:32Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review Disfunción endotelial y complicaciones trombóticas asociadas al SARS-CoV-2 en adultos: una revisión sistemática Disfunção endotelial e complicações trombóticas associada a SARS-CoV-2 em adultos: uma revisão sistemática |
title |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
spellingShingle |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review Pamplona, Mariane Arakawa SARS-CoV-2 Adult Endothelial dysfunction Thrombotic complications. SARS-CoV-2 Adulto Disfunción endotelial Complicaciones trombóticas. SARS-CoV-2 Adulto Disfunção endotelial Complicações trombóticas. |
title_short |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
title_full |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
title_fullStr |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
title_full_unstemmed |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
title_sort |
Endothelial dysfunction and thrombotic complications associated with SARS-CoV-2 in adults: a systematic review |
author |
Pamplona, Mariane Arakawa |
author_facet |
Pamplona, Mariane Arakawa Taveira, José Hittalo Mata, Karina Magalhães da Moraes, Kleber Silva Ribeiro, Ana Beatriz de Assis França, Maria Clara Mendonça Fernandes, Cleverson Rodrigues |
author_role |
author |
author2 |
Taveira, José Hittalo Mata, Karina Magalhães da Moraes, Kleber Silva Ribeiro, Ana Beatriz de Assis França, Maria Clara Mendonça Fernandes, Cleverson Rodrigues |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pamplona, Mariane Arakawa Taveira, José Hittalo Mata, Karina Magalhães da Moraes, Kleber Silva Ribeiro, Ana Beatriz de Assis França, Maria Clara Mendonça Fernandes, Cleverson Rodrigues |
dc.subject.por.fl_str_mv |
SARS-CoV-2 Adult Endothelial dysfunction Thrombotic complications. SARS-CoV-2 Adulto Disfunción endotelial Complicaciones trombóticas. SARS-CoV-2 Adulto Disfunção endotelial Complicações trombóticas. |
topic |
SARS-CoV-2 Adult Endothelial dysfunction Thrombotic complications. SARS-CoV-2 Adulto Disfunción endotelial Complicaciones trombóticas. SARS-CoV-2 Adulto Disfunção endotelial Complicações trombóticas. |
description |
Introduction: During the pandemic, occurrences of thromboembolic complications and endothelial dysfunctions associated with COVID-19 were observed. Thus, the pathophysiology of the mechanisms of action are not fully elucidated. Methods: Aiming at a better understanding of the associated mechanisms of endothelial function due to COVID-19, a systematic review was developeded out using index databases and a selection process in which the inclusion criteria were articles that addressed the mechanism of thrombotic events by endothelium dysfunction and publications that associate COVID-19 with thrombotic complications in adults up to 59 years of age. Conclusion: SARS-CoV-2 is associated with altered endothelial function by endothelial mechanisms induced by direct viral infection and injury, leading to changes in the angiotensin II/AT1 axis and inflammatory response. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40859 10.33448/rsd-v12i4.40859 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40859 |
identifier_str_mv |
10.33448/rsd-v12i4.40859 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40859/33338 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 4; e3312440859 Research, Society and Development; Vol. 12 Núm. 4; e3312440859 Research, Society and Development; v. 12 n. 4; e3312440859 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052621197934592 |