Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals

Detalhes bibliográficos
Autor(a) principal: Silva, Shellygton Lima
Data de Publicação: 2020
Outros Autores: Lima, Maísa Evangelista de, Santos, Raissa Daniel Trajano dos, Neto, Hermes Diniz, Silva, Daniele de Figueredo, Lima, Edeltrudes de Oliveira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/5775
Resumo: Onychomycosis are fungal infections of nails caused by pathogenic fungi, dermatophytes, non-dermatophytes and especially by species of the genus Candida. Yeast fungi cause infections in nails, due to their ability to invade the hyponychium, proximal border and by vascular or lymphatic dissemination, representing an important worldwide public health problem. In order to understand the low efficacy of treatment for onychomycosis and phenotypic changes caused by resistance mechanisms this study was to evaluate the susceptibility profile of onychomycosis clinical isolates of Candida to conventional antifungal. The antifungal sensitivity test for different strains and clinical isolates obtained from the Micoteca of the Laboratory of Antibacterial and Antifungal Activity of Natural and Synthetic Bioactive Products was carried out by the disk diffusion test. In view of the observed results, it can be inferred that the isolates had a high degree of resistance to azole drugs, considered to be drugs of first choice in the treatment of onychomycosis. Therefore, prior knowledge of in vitro tests can help in the pharmacotherapy of onychomycosis and monitoring prevalence of susceptibility profile to conventional antifungal and how perspective should use other susceptibility test to antifungal drugs and molecular techniques for a better understanding of phenotypes resistance.
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spelling Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungalsPerfil de sensibilidad antifúngica de aislados clínicos obtenidos de onicomicosis a antifúngicos convencionalesPerfil de sensibilidade antifúngica de isolados clínicos obtidos de onicomicose aos antifúngicos convencionaisCandidaDifusão em discoOnicomicoseResistência a antifúngica.CandidaDifusión en discoOnicomicosisResistencia antifúngica.CandidaDisk diffusionOnychomycosisResistance antifungals.Onychomycosis are fungal infections of nails caused by pathogenic fungi, dermatophytes, non-dermatophytes and especially by species of the genus Candida. Yeast fungi cause infections in nails, due to their ability to invade the hyponychium, proximal border and by vascular or lymphatic dissemination, representing an important worldwide public health problem. In order to understand the low efficacy of treatment for onychomycosis and phenotypic changes caused by resistance mechanisms this study was to evaluate the susceptibility profile of onychomycosis clinical isolates of Candida to conventional antifungal. The antifungal sensitivity test for different strains and clinical isolates obtained from the Micoteca of the Laboratory of Antibacterial and Antifungal Activity of Natural and Synthetic Bioactive Products was carried out by the disk diffusion test. In view of the observed results, it can be inferred that the isolates had a high degree of resistance to azole drugs, considered to be drugs of first choice in the treatment of onychomycosis. Therefore, prior knowledge of in vitro tests can help in the pharmacotherapy of onychomycosis and monitoring prevalence of susceptibility profile to conventional antifungal and how perspective should use other susceptibility test to antifungal drugs and molecular techniques for a better understanding of phenotypes resistance.La onicomicosis son infecciones fúngicas de las uñas causadas por hongos patógenos, dermatofitos, no dermatofitos y especialmente por especies del género Candida. Los hongos de levadura causan infecciones en las uñas, debido a su capacidad de invadir el hiponiquio, el borde proximal y la diseminación vascular o linfática, lo que representa un importante problema de salud pública en todo el mundo. Con el fin de comprender la baja eficacia del tratamiento para la onicomicosis y los cambios fenotípicos causados por los mecanismos de resistencia, este estudio tuvo como objetivo evaluar el perfil de susceptibilidad de los aislados clínicos de onicomicosis por Candida a los antifúngicos convencionales. La prueba de difusión de disco llevó a cabo la prueba de sensibilidad antifúngica para diferentes cepas y aislados clínicos obtenidos de la micoteca del Laboratorio de actividad antibacteriana y antifúngica de productos bioactivos naturales y sintéticos. En vista de los resultados observados, se puede inferir que los aislamientos tenían un alto grado de resistencia a los fármacos azólicos, considerados medicamentos de primera elección en el tratamiento de la onicomicosis. Por lo tanto, el conocimiento previo de los análisis in vitro puede ayudar en la farmacoterapia de la onicomicosis y en el monitoreo de la prevalencia del perfil de susceptibilidad a los antifúngicos convencionales y, como perspectiva, se deben usar otras pruebas de susceptibilidad a los antifúngicos y las técnicas moleculares para una mejor comprensión de los fenotipos de resistencia.Onicomicoses são afecções micóticas de unhas ocasionadas por fungos patogênicos, dermatófitos, não-dermatófitos e principalmente por espécies do gênero Candida. Fungos leveduriformes causam infecções em unhas, devido à sua capacidade de invasão ao hiponíquio, borda proximal e por disseminação vascular ou linfática, representando um importante problema de saúde pública mundial. Com o propósito de compreender a baixa eficácia de tratamento para onicomicoses e modificações fenotípicas causadas por mecanismos de resistência esse estudo teve por objetivo avaliar o perfil de susceptibilidade de isolados clínicos de onicomicoses do gênero Candida a antifúngicos convencionais. O ensaio de sensibilidade aos antifúngicos para diferentes cepas e isolados clínicos obtidos da micoteca do Laboratório de Atividade Antibacteriana e Antifúngica de Produtos Naturais e Sintéticos Bioativos foi realizado pelo teste de difusão em disco. Diante dos resultados observados pode-se inferir que os isolados apresentaram alto grau de resistência aos fármacos azólicos, considerados medicamentos de primeira escolha no tratamento de onicomisose. Portanto, o conhecimento prévio de análises in vitro pode auxiliar na farmacoterapia de onicomicose e no monitoramento de prevalência do perfil de suscetibilidade aos antifúngicos convencionais e como perspectiva deve-se utilizar outros testes de susceptibilidade aos antifúngicos e técnicas moleculares para uma melhor compreensão de fenótipos de resistência.Research, Society and Development2020-07-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/577510.33448/rsd-v9i8.5775Research, Society and Development; Vol. 9 No. 8; e561985775Research, Society and Development; Vol. 9 Núm. 8; e561985775Research, Society and Development; v. 9 n. 8; e5619857752525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/5775/5159Copyright (c) 2020 Shellygton Lima Silvahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Shellygton LimaLima, Maísa Evangelista deSantos, Raissa Daniel Trajano dosNeto, Hermes DinizSilva, Daniele de FigueredoLima, Edeltrudes de Oliveira2020-08-20T18:00:17Zoai:ojs.pkp.sfu.ca:article/5775Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:11.150069Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
Perfil de sensibilidad antifúngica de aislados clínicos obtenidos de onicomicosis a antifúngicos convencionales
Perfil de sensibilidade antifúngica de isolados clínicos obtidos de onicomicose aos antifúngicos convencionais
title Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
spellingShingle Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
Silva, Shellygton Lima
Candida
Difusão em disco
Onicomicose
Resistência a antifúngica.
Candida
Difusión en disco
Onicomicosis
Resistencia antifúngica.
Candida
Disk diffusion
Onychomycosis
Resistance antifungals.
title_short Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
title_full Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
title_fullStr Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
title_full_unstemmed Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
title_sort Antifungal sensitivity profile of clinical isolates obtained from onychomycosis to conventional antifungals
author Silva, Shellygton Lima
author_facet Silva, Shellygton Lima
Lima, Maísa Evangelista de
Santos, Raissa Daniel Trajano dos
Neto, Hermes Diniz
Silva, Daniele de Figueredo
Lima, Edeltrudes de Oliveira
author_role author
author2 Lima, Maísa Evangelista de
Santos, Raissa Daniel Trajano dos
Neto, Hermes Diniz
Silva, Daniele de Figueredo
Lima, Edeltrudes de Oliveira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Shellygton Lima
Lima, Maísa Evangelista de
Santos, Raissa Daniel Trajano dos
Neto, Hermes Diniz
Silva, Daniele de Figueredo
Lima, Edeltrudes de Oliveira
dc.subject.por.fl_str_mv Candida
Difusão em disco
Onicomicose
Resistência a antifúngica.
Candida
Difusión en disco
Onicomicosis
Resistencia antifúngica.
Candida
Disk diffusion
Onychomycosis
Resistance antifungals.
topic Candida
Difusão em disco
Onicomicose
Resistência a antifúngica.
Candida
Difusión en disco
Onicomicosis
Resistencia antifúngica.
Candida
Disk diffusion
Onychomycosis
Resistance antifungals.
description Onychomycosis are fungal infections of nails caused by pathogenic fungi, dermatophytes, non-dermatophytes and especially by species of the genus Candida. Yeast fungi cause infections in nails, due to their ability to invade the hyponychium, proximal border and by vascular or lymphatic dissemination, representing an important worldwide public health problem. In order to understand the low efficacy of treatment for onychomycosis and phenotypic changes caused by resistance mechanisms this study was to evaluate the susceptibility profile of onychomycosis clinical isolates of Candida to conventional antifungal. The antifungal sensitivity test for different strains and clinical isolates obtained from the Micoteca of the Laboratory of Antibacterial and Antifungal Activity of Natural and Synthetic Bioactive Products was carried out by the disk diffusion test. In view of the observed results, it can be inferred that the isolates had a high degree of resistance to azole drugs, considered to be drugs of first choice in the treatment of onychomycosis. Therefore, prior knowledge of in vitro tests can help in the pharmacotherapy of onychomycosis and monitoring prevalence of susceptibility profile to conventional antifungal and how perspective should use other susceptibility test to antifungal drugs and molecular techniques for a better understanding of phenotypes resistance.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/5775
10.33448/rsd-v9i8.5775
url https://rsdjournal.org/index.php/rsd/article/view/5775
identifier_str_mv 10.33448/rsd-v9i8.5775
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/5775/5159
dc.rights.driver.fl_str_mv Copyright (c) 2020 Shellygton Lima Silva
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Shellygton Lima Silva
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 8; e561985775
Research, Society and Development; Vol. 9 Núm. 8; e561985775
Research, Society and Development; v. 9 n. 8; e561985775
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052779203657728

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