Chitosan-clay nanocomposite as a drug delivery system of ibuprofen
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/24684 |
Resumo: | Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug. |
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Chitosan-clay nanocomposite as a drug delivery system of ibuprofenNanocompuesto de quitosano-arcilla como sistema de liberación controlada de ibuprofenoNanocompósitos de quitosana-argila como sistema de liberação controlada de ibuprofeno NanocompósitosIbuprofenoLiberação controlada de fármacos.NanocompositesIbuprofenoLiberación controlada de fármacos.NanocompositesIbuprofenControlled drug release.Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug.Se prepararon películas de nanocompuestos de quitosano / montmorillonita mediante el método de evaporación de solventes para inmovilizar el fármaco ibuprofeno (IBU) y retrasar su liberación en un medio que simula el ambiente del tracto gastrointestinal. Se estudiaron los efectos de la montmorillonita, en diferentes proporciones de masa (10, 20 y 50%), sobre las propiedades morfológicas y físicas de las películas. Las muestras se caracterizaron por difracción de rayos X (DRX), espectroscopia infrarroja, microscopía electrónica de barrido, grado de hinchamiento, encapsulación del fármaco y eficacia de liberación del fármaco. Según la DRX se evidenció que la incorporación de montmorillonita al quitosano condujo a la formación de nanocompuestos de morfología ordenada. Los espectros infrarrojos confirmaron la buena interacción entre montmorillonita y quitosano mediante la formación de nanocompuestos. Este hecho, que favoreció el encarcelamiento de la IBU, redujo el coeficiente de difusión en los sistemas estudiados. Las micrografías comprobaron la formación de películas densas y uniformes. El perfil de liberación controlada, especialmente para el nanocompuesto con 10% de masa de arcilla, mostró una tasa de liberación de fármaco lenta. La incorporación de montmorillonita en diferentes proporciones produjo diferentes morfologías, con buena eficiencia de encapsulación y un perfil adecuado para la liberación controlada del fármaco.Nanocompósitos de quitosana/montmorilonita na forma de filmes foram preparados pelo método de evaporação de solvente com o intuito de imobilizar o fármaco ibuprofeno (IBU) e retardar sua liberação em um meio que simula o ambiente do trato gastrointestinal. Foram estudados os efeitos da montmorilonita em diferentes proporções de massa (10, 20 e 50%), em função das propriedades morfológicas e físicas dos filmes. As amostras foram caracterizadas por Difração de Raios-X (DRX), Espectroscopia de Infravermelho por Transformada de Fourier, Microscopia Eletrônica de Varredura, Grau de Intumescimento, Encapsulação e Eficiência de Liberação do fármaco. De acordo com o DRX, foi constatado que a incorporação da montmorilonita à quitosana levou à formação de nanocompósitos de morfologia ordenada. Os espectros de infravermelho confirmaram a boa interação entre montmorilonita e quitosana pela formação de nanocompósitos. Esse fato, que favoreceu a prisão do IBU, reduziu o coeficiente de difusão nos sistemas estudados. As micrografias comprovaram a formação de filmes densos e uniformes. O perfil de liberação controlada, especialmente para o nanocompósito com 10% de massa de argila, apresentou uma taxa de liberação lenta do fármaco. Em síntese, A incorporação da montmorilonita em diferentes proporções produziu diferentes morfologias, com boa eficiência de encapsulação e perfil adequado para a liberação controlada do fármaco.Research, Society and Development2022-01-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2468410.33448/rsd-v11i1.24684Research, Society and Development; Vol. 11 No. 1; e25911124684Research, Society and Development; Vol. 11 Núm. 1; e25911124684Research, Society and Development; v. 11 n. 1; e259111246842525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/24684/21857Copyright (c) 2022 Albaniza Alves Tavares; Maria Dennise Medeiros Macêdo; Pedro Henrique Correia de Lima; Rossemberg Cardoso Barbosa; Wladymyr Jefferson Bacalhau Sousa; Cristiano José de Farias Braz; Matheus Ferreira de Souza; Camila Melo Gadelha Pereira Diniz; Marcus Vinícius Lia Fook; Suédina Maria de Lima Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTavares, Albaniza Alves Macêdo, Maria Dennise Medeiros Lima, Pedro Henrique Correia de Barbosa, Rossemberg Cardoso Sousa, Wladymyr Jefferson Bacalhau Braz, Cristiano José de Farias Souza, Matheus Ferreira de Diniz, Camila Melo Gadelha Pereira Fook, Marcus Vinícius Lia Silva, Suédina Maria de Lima 2022-01-16T18:08:18Zoai:ojs.pkp.sfu.ca:article/24684Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:09.699827Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen Nanocompuesto de quitosano-arcilla como sistema de liberación controlada de ibuprofeno Nanocompósitos de quitosana-argila como sistema de liberação controlada de ibuprofeno |
title |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
spellingShingle |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen Tavares, Albaniza Alves Nanocompósitos Ibuprofeno Liberação controlada de fármacos. Nanocomposites Ibuprofeno Liberación controlada de fármacos. Nanocomposites Ibuprofen Controlled drug release. |
title_short |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
title_full |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
title_fullStr |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
title_full_unstemmed |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
title_sort |
Chitosan-clay nanocomposite as a drug delivery system of ibuprofen |
author |
Tavares, Albaniza Alves |
author_facet |
Tavares, Albaniza Alves Macêdo, Maria Dennise Medeiros Lima, Pedro Henrique Correia de Barbosa, Rossemberg Cardoso Sousa, Wladymyr Jefferson Bacalhau Braz, Cristiano José de Farias Souza, Matheus Ferreira de Diniz, Camila Melo Gadelha Pereira Fook, Marcus Vinícius Lia Silva, Suédina Maria de Lima |
author_role |
author |
author2 |
Macêdo, Maria Dennise Medeiros Lima, Pedro Henrique Correia de Barbosa, Rossemberg Cardoso Sousa, Wladymyr Jefferson Bacalhau Braz, Cristiano José de Farias Souza, Matheus Ferreira de Diniz, Camila Melo Gadelha Pereira Fook, Marcus Vinícius Lia Silva, Suédina Maria de Lima |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tavares, Albaniza Alves Macêdo, Maria Dennise Medeiros Lima, Pedro Henrique Correia de Barbosa, Rossemberg Cardoso Sousa, Wladymyr Jefferson Bacalhau Braz, Cristiano José de Farias Souza, Matheus Ferreira de Diniz, Camila Melo Gadelha Pereira Fook, Marcus Vinícius Lia Silva, Suédina Maria de Lima |
dc.subject.por.fl_str_mv |
Nanocompósitos Ibuprofeno Liberação controlada de fármacos. Nanocomposites Ibuprofeno Liberación controlada de fármacos. Nanocomposites Ibuprofen Controlled drug release. |
topic |
Nanocompósitos Ibuprofeno Liberação controlada de fármacos. Nanocomposites Ibuprofeno Liberación controlada de fármacos. Nanocomposites Ibuprofen Controlled drug release. |
description |
Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/24684 10.33448/rsd-v11i1.24684 |
url |
https://rsdjournal.org/index.php/rsd/article/view/24684 |
identifier_str_mv |
10.33448/rsd-v11i1.24684 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/24684/21857 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 1; e25911124684 Research, Society and Development; Vol. 11 Núm. 1; e25911124684 Research, Society and Development; v. 11 n. 1; e25911124684 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052700957868032 |