Quality of life in glioblastoma after the introduction of temozolomide: a systematic review

Detalhes bibliográficos
Autor(a) principal: Dias, Thales Augusto Oliveira
Data de Publicação: 2022
Outros Autores: Couto, Dyecika Souza, Cardoso, Edvaldo José Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/37205
Resumo: Introduction: Gliomas are primary tumors of the central nervous system with an aggressive pattern of progression with a poor prognosis in terms of survival and quality of life. The current standard treatment consists of surgery with maximum excision associated with radiotherapy and chemotherapy, based mostly on the use of temozolomide. Since its introduction, the quality of life of patients undergoing this therapy has not been widely targeted and evaluated. Objective: To verify the quality of life of patients with glioblastoma after the introduction of temozolomide in the therapeutic protocols. Methods: A systematic literature review guided by the PICO and PRISMA protocol was conducted; PubMed, Medline and Lilacs databases were consulted. Results: Initially, 77 studies were found, after selection criteria, 35 articles were analyzed. No statistically significant change was found in overall quality of life in studies that analyzed temozolomide therapy versus different control therapies. Conclusion: The association of temozolomide with surgery and radiotherapy proved to be neutral, with no significant negative or positive impacts on the quality of life of patients with glioblastoma.
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spelling Quality of life in glioblastoma after the introduction of temozolomide: a systematic reviewCalidad de vida en glioblastoma después de la introducción de temozolomida: una revisión sistemáticaQualidade de vida no glioblastoma após a introdução da temozolomida: uma revisão sistemáticaQualidade de VidaGlioblastomaTemozolomida.Calidad de VidaGlioblastomaTemozolomida.Quality of LifeGlioblastomaTemozolomide.Introduction: Gliomas are primary tumors of the central nervous system with an aggressive pattern of progression with a poor prognosis in terms of survival and quality of life. The current standard treatment consists of surgery with maximum excision associated with radiotherapy and chemotherapy, based mostly on the use of temozolomide. Since its introduction, the quality of life of patients undergoing this therapy has not been widely targeted and evaluated. Objective: To verify the quality of life of patients with glioblastoma after the introduction of temozolomide in the therapeutic protocols. Methods: A systematic literature review guided by the PICO and PRISMA protocol was conducted; PubMed, Medline and Lilacs databases were consulted. Results: Initially, 77 studies were found, after selection criteria, 35 articles were analyzed. No statistically significant change was found in overall quality of life in studies that analyzed temozolomide therapy versus different control therapies. Conclusion: The association of temozolomide with surgery and radiotherapy proved to be neutral, with no significant negative or positive impacts on the quality of life of patients with glioblastoma.Introducción: Los gliomas son tumores primarios del sistema nervioso central con un patrón agresivo de progresión con mal pronóstico en términos de supervivencia y calidad de vida. El tratamiento estándar actual consiste en cirugía con escisión máxima asociada a radioterapia y quimioterapia, en su mayoría basada en el uso de temozolomida. Desde su introducción, la calidad de vida de los pacientes que se someten a esta terapia no ha sido objeto de una evaluación amplia. Objetivo: verificar la calidad de vida de los pacientes con glioblastoma después de la introducción de temozolomida en los protocolos terapéuticos. Métodos: Se realizó una revisión sistemática de la literatura guiada por el protocolo PICO y PRISMA; Se consultaron las bases de datos PubMed, Medline y Lilacs. Resultados: Inicialmente se encontraron 77 estudios, luego de criterios de selección se analizaron 35 artículos. No se encontraron cambios estadísticamente significativos en la calidad de vida general en los estudios que analizaron la terapia con temozolomida versus diferentes terapias de control. Conclusión: La asociación de temozolomida con cirugía y radioterapia resultó ser neutra, sin impactos negativos o positivos significativos en la calidad de vida de los pacientes con glioblastoma.Introdução: Gliomas são tumores primários do sistema nervoso central com padrão agressivo de progressão com prognóstico ruim quanto a sobrevida e qualidade de vida. O tratamento padrão atual consiste em cirurgia com excisão máxima associado a radioterapia e quimioterapia, pautada majoritariamente pelo uso da temozolomida. Desde sua introdução, a qualidade de vida dos pacientes submetidos a essa terapia não foi amplamente objetivada e avaliada. Objetivo: Verificar a qualidade de vida dos pacientes portadores de glioblastoma após a introdução da temozolomida nos protocolos terapêuticos. Métodos: Foi conduzida revisão sistemática da literatura guiada pelo protocolo PICO e PRISMA; consultadas as bases de dados do PubMed, Medline e Lilacs. Resultados: Inicialmente encontrados 77 estudos, após critérios de seleção foram analisados 35 artigos. Não foi encontrada alteração estatisticamente significativa na qualidade de vida global nos estudos que analisaram a terapia com temozolomida frente às diferentes terapias controle. Conclusão: A associação da temozolomida à cirurgia e radioterapia se mostrou neutra, sem impactos negativos ou positivos consideráveis na qualidade de vida dos pacientes portadores de glioblastoma.Research, Society and Development2022-11-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3720510.33448/rsd-v11i15.37205Research, Society and Development; Vol. 11 No. 15; e311111537205Research, Society and Development; Vol. 11 Núm. 15; e311111537205Research, Society and Development; v. 11 n. 15; e3111115372052525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/37205/31037Copyright (c) 2022 Thales Augusto Oliveira Dias; Dyecika Souza Couto; Edvaldo José Rodrigues Cardosohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDias, Thales Augusto Oliveira Couto, Dyecika Souza Cardoso, Edvaldo José Rodrigues 2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/37205Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:28.030696Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
Calidad de vida en glioblastoma después de la introducción de temozolomida: una revisión sistemática
Qualidade de vida no glioblastoma após a introdução da temozolomida: uma revisão sistemática
title Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
spellingShingle Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
Dias, Thales Augusto Oliveira
Qualidade de Vida
Glioblastoma
Temozolomida.
Calidad de Vida
Glioblastoma
Temozolomida.
Quality of Life
Glioblastoma
Temozolomide.
title_short Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
title_full Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
title_fullStr Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
title_full_unstemmed Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
title_sort Quality of life in glioblastoma after the introduction of temozolomide: a systematic review
author Dias, Thales Augusto Oliveira
author_facet Dias, Thales Augusto Oliveira
Couto, Dyecika Souza
Cardoso, Edvaldo José Rodrigues
author_role author
author2 Couto, Dyecika Souza
Cardoso, Edvaldo José Rodrigues
author2_role author
author
dc.contributor.author.fl_str_mv Dias, Thales Augusto Oliveira
Couto, Dyecika Souza
Cardoso, Edvaldo José Rodrigues
dc.subject.por.fl_str_mv Qualidade de Vida
Glioblastoma
Temozolomida.
Calidad de Vida
Glioblastoma
Temozolomida.
Quality of Life
Glioblastoma
Temozolomide.
topic Qualidade de Vida
Glioblastoma
Temozolomida.
Calidad de Vida
Glioblastoma
Temozolomida.
Quality of Life
Glioblastoma
Temozolomide.
description Introduction: Gliomas are primary tumors of the central nervous system with an aggressive pattern of progression with a poor prognosis in terms of survival and quality of life. The current standard treatment consists of surgery with maximum excision associated with radiotherapy and chemotherapy, based mostly on the use of temozolomide. Since its introduction, the quality of life of patients undergoing this therapy has not been widely targeted and evaluated. Objective: To verify the quality of life of patients with glioblastoma after the introduction of temozolomide in the therapeutic protocols. Methods: A systematic literature review guided by the PICO and PRISMA protocol was conducted; PubMed, Medline and Lilacs databases were consulted. Results: Initially, 77 studies were found, after selection criteria, 35 articles were analyzed. No statistically significant change was found in overall quality of life in studies that analyzed temozolomide therapy versus different control therapies. Conclusion: The association of temozolomide with surgery and radiotherapy proved to be neutral, with no significant negative or positive impacts on the quality of life of patients with glioblastoma.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-18
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37205
10.33448/rsd-v11i15.37205
url https://rsdjournal.org/index.php/rsd/article/view/37205
identifier_str_mv 10.33448/rsd-v11i15.37205
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37205/31037
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e311111537205
Research, Society and Development; Vol. 11 Núm. 15; e311111537205
Research, Society and Development; v. 11 n. 15; e311111537205
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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