Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/42188 |
Resumo: | Background: Psychiatric disorders (PD) are prevalent among people living with HIV/AIDS (PLWHA). PD occurrence in PLWHA contributes to higher rates of risky sexual behaviors and non-adherence to Antiretroviral Therapy (ART). Aim: The present study aimed to analyze the influence of PD on ART response of PLWHA. Methods: Retrospective cohort of PLWHA followed at a referral center in northeast Brazil, which was classified into two groups: individuals with and without PD. Demographic, behavioral, follow-up adherence and ART response-related variables were analyzed. Results: Of the 443 patients, 5.4% had a diagnosis of PD. Depression was the most prevalent one (66.6%). Both groups were similar in regard to epidemiological and behavioral variables. Although a higher percentage of patients without PD reported 100% adherence to ART (89.3%), there were no differences when comparing service retention rates, number of ART regimens used, mean CD4 T-lymphocyte levels and presence of undetectable viral load at the last appointment. Patients with PD, however, showed lower CD4 T-lymphocyte increase. Conclusion: The incidence of PD was low, with the most prevalent one being depression. There was no difference regarding ART response when comparing the two groups, except for the magnitude of immune response (CD4 T-lymphocyte increase) of the patients with PD, which was lower. |
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Impact of psychiatric disorders on antiretroviral therapy response of patients with HIVImpacto de los trastornos psiquiátricos en la respuesta a la terapia antirretroviral en pacientes con VIHImpacto dos transtornos psiquiátricos na resposta à terapia antirretroviral de pacientes portadores de HIVMental disordersHIV infectionsAcquired Immunodeficiency Syndrome.Trastornos mentalesinfecciones por VIHSíndrome de inmunodeficiencia adquirida.Transtornos mentaisInfecção pelo HIVSíndrome da imunodeficiência adquirida.Background: Psychiatric disorders (PD) are prevalent among people living with HIV/AIDS (PLWHA). PD occurrence in PLWHA contributes to higher rates of risky sexual behaviors and non-adherence to Antiretroviral Therapy (ART). Aim: The present study aimed to analyze the influence of PD on ART response of PLWHA. Methods: Retrospective cohort of PLWHA followed at a referral center in northeast Brazil, which was classified into two groups: individuals with and without PD. Demographic, behavioral, follow-up adherence and ART response-related variables were analyzed. Results: Of the 443 patients, 5.4% had a diagnosis of PD. Depression was the most prevalent one (66.6%). Both groups were similar in regard to epidemiological and behavioral variables. Although a higher percentage of patients without PD reported 100% adherence to ART (89.3%), there were no differences when comparing service retention rates, number of ART regimens used, mean CD4 T-lymphocyte levels and presence of undetectable viral load at the last appointment. Patients with PD, however, showed lower CD4 T-lymphocyte increase. Conclusion: The incidence of PD was low, with the most prevalent one being depression. There was no difference regarding ART response when comparing the two groups, except for the magnitude of immune response (CD4 T-lymphocyte increase) of the patients with PD, which was lower.Introducción: Los trastornos psiquiátricos (TP) son prevalentes entre las personas que viven con VIH/SIDA (PVVS). La ocurrencia de TP en PVVS contribuye a mayores índices de conductas sexuales de riesgo y falta de adherencia a la Terapia Antirretroviral (TAR). Objetivo: El presente estudio tuvo como objetivo analizar la influencia del TP en la respuesta al TAR en PVVS. Métodos: Cohorte retrospectiva de PVVS seguida en un centro de referencia del Nordeste de Brasil, que fue clasificada en dos grupos: individuos con y sin TP. Se analizaron variables demográficas, conductuales, de adherencia al seguimiento y relacionadas con la respuesta al TARV. Resultados: De los 443 pacientes, el 5,4% fueron diagnosticados de TP. La depresión fue la más prevalente (66,6%). Ambos grupos fueron similares en cuanto a variables epidemiológicas y conductuales. Aunque un mayor porcentaje de pacientes sin TP reportaron 100% de adherencia al TARV (89,3%), no hubo diferencias al comparar tasas de permanencia en el servicio, número de esquemas de TARV utilizados, niveles medios de linfocitos T CD4 y presencia de carga viral indetectable a la última visita. Los pacientes con TP, sin embargo, tenían un menor aumento de linfocitos T CD4. Conclusión: La incidencia de TP fue baja, siendo la depresión la más prevalente. No hubo diferencia en cuanto a la respuesta al TARV al comparar los dos grupos, excepto por la magnitud de la respuesta inmune (aumento de linfocitos T CD4) de los pacientes con TP, que fue menor.Introdução: Os transtornos psiquiátricos (TP) são prevalentes entre pessoas vivendo com HIV/AIDS (PVHA). A ocorrência de TP em PVHA contribui para maiores taxas de comportamentos sexuais de risco e não adesão à Terapia Antirretroviral (TARV). Objetivo: O presente estudo teve como objetivo analisar a influência da TP na resposta à TARV de PVHA. Métodos: Coorte retrospectiva de PVHA acompanhadas em um centro de referência no Nordeste do Brasil, que foi classificada em dois grupos: indivíduos com e sem TP. Variáveis demográficas, comportamentais, adesão ao seguimento e relacionadas à resposta à TARV foram analisadas. Resultados: Dos 443 pacientes, 5,4% tiveram diagnóstico de TP. A depressão foi a mais prevalente (66,6%). Ambos os grupos foram semelhantes em relação às variáveis epidemiológicas e comportamentais. Embora uma porcentagem maior de pacientes sem TP tenha relatado 100% de adesão à TARV (89,3%), não houve diferenças ao comparar as taxas de permanência no serviço, número de esquemas de TARV utilizados, níveis médios de linfócitos T CD4 e presença de carga viral indetectável na última consulta. Pacientes com TP, no entanto, apresentaram menor aumento de linfócitos T CD4. Conclusão: A incidência de TP foi baixa, sendo a depressão a mais prevalente. Não houve diferença em relação à resposta à TARV na comparação dos dois grupos, exceto na magnitude da resposta imune (aumento de linfócitos T CD4) dos pacientes com TP, que foi menor.Research, Society and Development2023-06-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4218810.33448/rsd-v12i6.42188Research, Society and Development; Vol. 12 No. 6; e18912642188Research, Society and Development; Vol. 12 Núm. 6; e18912642188Research, Society and Development; v. 12 n. 6; e189126421882525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/42188/34162Copyright (c) 2023 Lara Gurgel Fernandes Távora; Geysa Maria Nogueira Farias; Bianca Carneiro de Melo Jorge ; Ingrid Fernandes Vasconcelos; Laila Maria Teixeira Amorim ; Maria Gabriela Vegini ; Robysom Alves Camelo Dantashttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTávora, Lara Gurgel Fernandes Farias, Geysa Maria Nogueira Jorge , Bianca Carneiro de Melo Vasconcelos, Ingrid Fernandes Amorim , Laila Maria Teixeira Vegini , Maria GabrielaDantas, Robysom Alves Camelo 2023-07-06T11:16:27Zoai:ojs.pkp.sfu.ca:article/42188Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-07-06T11:16:27Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV Impacto de los trastornos psiquiátricos en la respuesta a la terapia antirretroviral en pacientes con VIH Impacto dos transtornos psiquiátricos na resposta à terapia antirretroviral de pacientes portadores de HIV |
title |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
spellingShingle |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV Távora, Lara Gurgel Fernandes Mental disorders HIV infections Acquired Immunodeficiency Syndrome. Trastornos mentales infecciones por VIH Síndrome de inmunodeficiencia adquirida. Transtornos mentais Infecção pelo HIV Síndrome da imunodeficiência adquirida. |
title_short |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
title_full |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
title_fullStr |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
title_full_unstemmed |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
title_sort |
Impact of psychiatric disorders on antiretroviral therapy response of patients with HIV |
author |
Távora, Lara Gurgel Fernandes |
author_facet |
Távora, Lara Gurgel Fernandes Farias, Geysa Maria Nogueira Jorge , Bianca Carneiro de Melo Vasconcelos, Ingrid Fernandes Amorim , Laila Maria Teixeira Vegini , Maria Gabriela Dantas, Robysom Alves Camelo |
author_role |
author |
author2 |
Farias, Geysa Maria Nogueira Jorge , Bianca Carneiro de Melo Vasconcelos, Ingrid Fernandes Amorim , Laila Maria Teixeira Vegini , Maria Gabriela Dantas, Robysom Alves Camelo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Távora, Lara Gurgel Fernandes Farias, Geysa Maria Nogueira Jorge , Bianca Carneiro de Melo Vasconcelos, Ingrid Fernandes Amorim , Laila Maria Teixeira Vegini , Maria Gabriela Dantas, Robysom Alves Camelo |
dc.subject.por.fl_str_mv |
Mental disorders HIV infections Acquired Immunodeficiency Syndrome. Trastornos mentales infecciones por VIH Síndrome de inmunodeficiencia adquirida. Transtornos mentais Infecção pelo HIV Síndrome da imunodeficiência adquirida. |
topic |
Mental disorders HIV infections Acquired Immunodeficiency Syndrome. Trastornos mentales infecciones por VIH Síndrome de inmunodeficiencia adquirida. Transtornos mentais Infecção pelo HIV Síndrome da imunodeficiência adquirida. |
description |
Background: Psychiatric disorders (PD) are prevalent among people living with HIV/AIDS (PLWHA). PD occurrence in PLWHA contributes to higher rates of risky sexual behaviors and non-adherence to Antiretroviral Therapy (ART). Aim: The present study aimed to analyze the influence of PD on ART response of PLWHA. Methods: Retrospective cohort of PLWHA followed at a referral center in northeast Brazil, which was classified into two groups: individuals with and without PD. Demographic, behavioral, follow-up adherence and ART response-related variables were analyzed. Results: Of the 443 patients, 5.4% had a diagnosis of PD. Depression was the most prevalent one (66.6%). Both groups were similar in regard to epidemiological and behavioral variables. Although a higher percentage of patients without PD reported 100% adherence to ART (89.3%), there were no differences when comparing service retention rates, number of ART regimens used, mean CD4 T-lymphocyte levels and presence of undetectable viral load at the last appointment. Patients with PD, however, showed lower CD4 T-lymphocyte increase. Conclusion: The incidence of PD was low, with the most prevalent one being depression. There was no difference regarding ART response when comparing the two groups, except for the magnitude of immune response (CD4 T-lymphocyte increase) of the patients with PD, which was lower. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/42188 10.33448/rsd-v12i6.42188 |
url |
https://rsdjournal.org/index.php/rsd/article/view/42188 |
identifier_str_mv |
10.33448/rsd-v12i6.42188 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/42188/34162 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 6; e18912642188 Research, Society and Development; Vol. 12 Núm. 6; e18912642188 Research, Society and Development; v. 12 n. 6; e18912642188 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052626379997184 |