Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/11135 |
Resumo: | Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed. |
id |
UNIFEI_c8d001c9ef9844af01e8e707ea2600de |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/11135 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderlyPrecisión de los factores desencadenantes en la identificación de eventos adversos por medicamentos en ancianos hospitalizadosAcurácia de gatilhos na identificação de eventos adversos a medicamento em idosos hospitalizadosIndicadores de Calidad de la Atención de SaludFarmacovigilanciaIndicadores de calidad de la atención de saludEnvejecimiento.Drug-Related Side Effects and Adverse ReactionsPharmacovigilanceQuality indicators, health careAging.Efeitos Colaterais e Reações Adversas Relacionados a MedicamentosFarmacovigilânciaIndicadores de Qualidade em Assistência à SaúdeEnvelhecimento.Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed.Objetivo: Evaluar la precisión del disparador para identificar eventos adversos por medicamentos (AAM) en ancianos hospitalizados. Métodos: Se siguió a 200 pacientes 60 años de una clínica médica de un hospital privado. Para la identificación del ADE, se utilizó la metodología de seguimiento adaptada Global Trigger Tool. La causalidad se determinó mediante el algoritmo de Naranjo. Resultados: De las 200 personas mayores incluidas en el estudio, 106 eran mujeres (53%), la edad promedio fue de 79 años y la estancia hospitalaria promedio fue de aproximadamente ± 10 días. Los desencadenantes seleccionados se identificaron 1.457 veces. El grupo de desencadenantes con mejor desempeño en términos de precisión de análisis fue el desencadenante de evolución, con una sensibilidad del 69% y un valor predictivo positivo del 68%. En el análisis del desempeño individual, la alergia, reacción alérgica y picazón evolutiva logró un desempeño del 100% tanto para la sensibilidad como para el valor predictivo positivo. Se identificaron un total de 165 EA. De estos, el 18% eran flebitis y el 16% hipoglucemiantes. Los medicamentos asociados con ADE incluyeron insulina (15%) y claritromicina (9%). Conclusión: Se ha demostrado que la metodología de activación es eficaz para identificar la IAM. Además, se llevó a cabo la determinación del mejor desencadenante para la construcción de una herramienta de identificación de ADE para ancianos hospitalizados.Objetivo: Avaliar a acurácia dos gatilhos para identificar eventos adversos a medicamentos (EAM) em idosos hospitalizados. Métodos: Duzentos pacientes60 anos de uma clínica médica de um hospital privado foram acompanhados. Para a identificação do EAM, foi usada a metodologia do rastreador da Global Trigger Tool adaptada. A causalidade foi determinada usando o algoritmo de Naranjo. Resultados: Dos 200 idosos incluídos no estudo, 106 eram do sexo feminino (53%), a idade média foi de 79 anos e o tempo médio de internação foi de aproximadamente ± 10 dias. Os gatilhos selecionados foram identificados 1.457 vezes. O grupo de gatilhos com melhor desempenho quanto à acurácia da análise foi presente nas evoluções, com sensibilidade de 69% e valor preditivo positivo de 68%. Na análise de desempenho individual, o gatilho de alergia, reação alérgica e prurido obteve desempenho de 100% tanto para sensibilidade e valor preditivo positivo. Um total de 165 eventos adversos foram identificados. Destes, 18% eram flebite e 16% eram hipoglicemia. Os medicamentos associados ao EAM incluíram insulina (15%) e claritromicina (9%). Conclusão: A metodologia de uso de gatilhos tem se mostrado eficaz na identificação de EAM. Além disso, foi realizada a determinação do melhor gatilho para a construção de uma ferramenta de identificação de EAM para idosos hospitalizados.Research, Society and Development2020-12-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1113510.33448/rsd-v9i12.11135Research, Society and Development; Vol. 9 No. 12; e33491211135Research, Society and Development; Vol. 9 Núm. 12; e33491211135Research, Society and Development; v. 9 n. 12; e334912111352525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11135/9980Copyright (c) 2020 Chriscia Jamilly Pinto de Sousa; Ana Cristina Lo Prete; Carolina Heitmann Mares Azevedo Ribeirohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, Chriscia Jamilly Pinto dePrete, Ana Cristina Lo Ribeiro, Carolina Heitmann Mares Azevedo2020-12-30T23:32:22Zoai:ojs.pkp.sfu.ca:article/11135Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:02.652587Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly Precisión de los factores desencadenantes en la identificación de eventos adversos por medicamentos en ancianos hospitalizados Acurácia de gatilhos na identificação de eventos adversos a medicamento em idosos hospitalizados |
title |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
spellingShingle |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly Sousa, Chriscia Jamilly Pinto de Indicadores de Calidad de la Atención de Salud Farmacovigilancia Indicadores de calidad de la atención de salud Envejecimiento. Drug-Related Side Effects and Adverse Reactions Pharmacovigilance Quality indicators, health care Aging. Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Farmacovigilância Indicadores de Qualidade em Assistência à Saúde Envelhecimento. |
title_short |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
title_full |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
title_fullStr |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
title_full_unstemmed |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
title_sort |
Accuracy of triggers in the identification of adverse drug events in hospitalized elderly |
author |
Sousa, Chriscia Jamilly Pinto de |
author_facet |
Sousa, Chriscia Jamilly Pinto de Prete, Ana Cristina Lo Ribeiro, Carolina Heitmann Mares Azevedo |
author_role |
author |
author2 |
Prete, Ana Cristina Lo Ribeiro, Carolina Heitmann Mares Azevedo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Sousa, Chriscia Jamilly Pinto de Prete, Ana Cristina Lo Ribeiro, Carolina Heitmann Mares Azevedo |
dc.subject.por.fl_str_mv |
Indicadores de Calidad de la Atención de Salud Farmacovigilancia Indicadores de calidad de la atención de salud Envejecimiento. Drug-Related Side Effects and Adverse Reactions Pharmacovigilance Quality indicators, health care Aging. Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Farmacovigilância Indicadores de Qualidade em Assistência à Saúde Envelhecimento. |
topic |
Indicadores de Calidad de la Atención de Salud Farmacovigilancia Indicadores de calidad de la atención de salud Envejecimiento. Drug-Related Side Effects and Adverse Reactions Pharmacovigilance Quality indicators, health care Aging. Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Farmacovigilância Indicadores de Qualidade em Assistência à Saúde Envelhecimento. |
description |
Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11135 10.33448/rsd-v9i12.11135 |
url |
https://rsdjournal.org/index.php/rsd/article/view/11135 |
identifier_str_mv |
10.33448/rsd-v9i12.11135 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11135/9980 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 12; e33491211135 Research, Society and Development; Vol. 9 Núm. 12; e33491211135 Research, Society and Development; v. 9 n. 12; e33491211135 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052666643218432 |