Accuracy of triggers in the identification of adverse drug events in hospitalized elderly

Detalhes bibliográficos
Autor(a) principal: Sousa, Chriscia Jamilly Pinto de
Data de Publicação: 2020
Outros Autores: Prete, Ana Cristina Lo, Ribeiro, Carolina Heitmann Mares Azevedo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11135
Resumo: Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed.
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spelling Accuracy of triggers in the identification of adverse drug events in hospitalized elderlyPrecisión de los factores desencadenantes en la identificación de eventos adversos por medicamentos en ancianos hospitalizadosAcurácia de gatilhos na identificação de eventos adversos a medicamento em idosos hospitalizadosIndicadores de Calidad de la Atención de SaludFarmacovigilanciaIndicadores de calidad de la atención de saludEnvejecimiento.Drug-Related Side Effects and Adverse ReactionsPharmacovigilanceQuality indicators, health careAging.Efeitos Colaterais e Reações Adversas Relacionados a MedicamentosFarmacovigilânciaIndicadores de Qualidade em Assistência à SaúdeEnvelhecimento.Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed.Objetivo: Evaluar la precisión del disparador para identificar eventos adversos por medicamentos (AAM) en ancianos hospitalizados. Métodos: Se siguió a 200 pacientes 60 años de una clínica médica de un hospital privado. Para la identificación del ADE, se utilizó la metodología de seguimiento adaptada Global Trigger Tool. La causalidad se determinó mediante el algoritmo de Naranjo. Resultados: De las 200 personas mayores incluidas en el estudio, 106 eran mujeres (53%), la edad promedio fue de 79 años y la estancia hospitalaria promedio fue de aproximadamente ± 10 días. Los desencadenantes seleccionados se identificaron 1.457 veces. El grupo de desencadenantes con mejor desempeño en términos de precisión de análisis fue el desencadenante de evolución, con una sensibilidad del 69% y un valor predictivo positivo del 68%. En el análisis del desempeño individual, la alergia, reacción alérgica y picazón evolutiva logró un desempeño del 100% tanto para la sensibilidad como para el valor predictivo positivo. Se identificaron un total de 165 EA. De estos, el 18% eran flebitis y el 16% hipoglucemiantes. Los medicamentos asociados con ADE incluyeron insulina (15%) y claritromicina (9%). Conclusión: Se ha demostrado que la metodología de activación es eficaz para identificar la IAM. Además, se llevó a cabo la determinación del mejor desencadenante para la construcción de una herramienta de identificación de ADE para ancianos hospitalizados.Objetivo: Avaliar a acurácia dos gatilhos para identificar eventos adversos a medicamentos (EAM) em idosos hospitalizados. Métodos: Duzentos pacientes60 anos de uma clínica médica de um hospital privado foram acompanhados. Para a identificação do EAM, foi usada a metodologia do rastreador da Global Trigger Tool adaptada. A causalidade foi determinada usando o algoritmo de Naranjo. Resultados: Dos 200 idosos incluídos no estudo, 106 eram do sexo feminino (53%), a idade média foi de 79 anos e o tempo médio de internação foi de aproximadamente ± 10 dias. Os gatilhos selecionados foram identificados 1.457 vezes. O grupo de gatilhos com melhor desempenho quanto à acurácia da análise foi presente nas evoluções, com sensibilidade de 69% e valor preditivo positivo de 68%. Na análise de desempenho individual, o gatilho de alergia, reação alérgica e prurido obteve desempenho de 100% tanto para sensibilidade e valor preditivo positivo. Um total de 165 eventos adversos foram identificados. Destes, 18% eram flebite e 16% eram hipoglicemia. Os medicamentos associados ao EAM incluíram insulina (15%) e claritromicina (9%). Conclusão: A metodologia de uso de gatilhos tem se mostrado eficaz na identificação de EAM. Além disso, foi realizada a determinação do melhor gatilho para a construção de uma ferramenta de identificação de EAM para idosos hospitalizados.Research, Society and Development2020-12-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1113510.33448/rsd-v9i12.11135Research, Society and Development; Vol. 9 No. 12; e33491211135Research, Society and Development; Vol. 9 Núm. 12; e33491211135Research, Society and Development; v. 9 n. 12; e334912111352525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11135/9980Copyright (c) 2020 Chriscia Jamilly Pinto de Sousa; Ana Cristina Lo Prete; Carolina Heitmann Mares Azevedo Ribeirohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSousa, Chriscia Jamilly Pinto dePrete, Ana Cristina Lo Ribeiro, Carolina Heitmann Mares Azevedo2020-12-30T23:32:22Zoai:ojs.pkp.sfu.ca:article/11135Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:02.652587Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
Precisión de los factores desencadenantes en la identificación de eventos adversos por medicamentos en ancianos hospitalizados
Acurácia de gatilhos na identificação de eventos adversos a medicamento em idosos hospitalizados
title Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
spellingShingle Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
Sousa, Chriscia Jamilly Pinto de
Indicadores de Calidad de la Atención de Salud
Farmacovigilancia
Indicadores de calidad de la atención de salud
Envejecimiento.
Drug-Related Side Effects and Adverse Reactions
Pharmacovigilance
Quality indicators, health care
Aging.
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Farmacovigilância
Indicadores de Qualidade em Assistência à Saúde
Envelhecimento.
title_short Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
title_full Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
title_fullStr Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
title_full_unstemmed Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
title_sort Accuracy of triggers in the identification of adverse drug events in hospitalized elderly
author Sousa, Chriscia Jamilly Pinto de
author_facet Sousa, Chriscia Jamilly Pinto de
Prete, Ana Cristina Lo
Ribeiro, Carolina Heitmann Mares Azevedo
author_role author
author2 Prete, Ana Cristina Lo
Ribeiro, Carolina Heitmann Mares Azevedo
author2_role author
author
dc.contributor.author.fl_str_mv Sousa, Chriscia Jamilly Pinto de
Prete, Ana Cristina Lo
Ribeiro, Carolina Heitmann Mares Azevedo
dc.subject.por.fl_str_mv Indicadores de Calidad de la Atención de Salud
Farmacovigilancia
Indicadores de calidad de la atención de salud
Envejecimiento.
Drug-Related Side Effects and Adverse Reactions
Pharmacovigilance
Quality indicators, health care
Aging.
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Farmacovigilância
Indicadores de Qualidade em Assistência à Saúde
Envelhecimento.
topic Indicadores de Calidad de la Atención de Salud
Farmacovigilancia
Indicadores de calidad de la atención de salud
Envejecimiento.
Drug-Related Side Effects and Adverse Reactions
Pharmacovigilance
Quality indicators, health care
Aging.
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Farmacovigilância
Indicadores de Qualidade em Assistência à Saúde
Envelhecimento.
description Objective: Evaluate trigger accuracy for identifying adverse drug events (ADEs) in hospitalised elderly. Methods: Two hundred patients 60 years old from a medical clinic within a private hospital were followed-up. For ADE identification the adapted Global Trigger Tool tracker methodology was used. Causality was determined using the Naranjo Algorithm. Results: Of the 200 elderly patients included in the study, 106 were females (53%), the average age was 79 years, and the average length of hospital stay was approximately ± 10 days. Selected triggers were identified 1,457 times. The group of triggers with the best performance regarding its analysis accuracy was evolution triggers, with sensitivity of 69% and positive predictive value of 68%. In the individual performance analysis, the evolution tracker allergy, allergic reaction, pruritus achieved 100% performance for both sensitivity and positive predictive value. A total of 165 ADs were identified. Of these, 18% were phlebitis and 16% were hypoglycaemia. Drugs associated with ADE included insulin (15%) and Clarithromycin (9%). Conclusion: The triggering methodology has been effective for identifying ADEs. In addition, determination best trigger for constructing an ADE identification tool for hospitalised elderly was performed.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11135
10.33448/rsd-v9i12.11135
url https://rsdjournal.org/index.php/rsd/article/view/11135
identifier_str_mv 10.33448/rsd-v9i12.11135
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11135/9980
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 12; e33491211135
Research, Society and Development; Vol. 9 Núm. 12; e33491211135
Research, Society and Development; v. 9 n. 12; e33491211135
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052666643218432

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