Evaluation in silico of eucalipitol monoterpene toxicity

• Autor(a) principal: Gomes, Lucas Linhares
• Data de Publicação: 2020
• Outros Autores: Araújo Neto, Antônio Pereira de, Medeiros, Fabiana Larissa Santos de, Santana, Maria Tays Pereira, Santos, Thallita Alves dos, Oliveira, Heloisa Mara Batista Fernandes de, Guênes, Gymenna Maria Tenório, Alves, Maria Angélica Sátyro Gomes, Penha, Elizandra Silva da, Anjos, Raline Mendonça dos, Oliveira, Vinícius Filgueiras de, Sousa, Aleson Pereira de, Oliveira Filho, Abrahão Alves de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/3092
• topic: Eucalipto; Terpeno; Fitoterapia; Eucalipto; Terpeno; Fitoterapia.; Eucalyptus; Terpene; Phytoterapy

Recent studies related to natural products have shown greater interest in analyzing their toxicological profile, since there are requirements for regulation of safe levels that promote better efficiency of the pharmacological potential of these medicines of natural origin. The present study seeks to analyze through in silico tests the toxicity of eucalyptol monoterpene. For this, the admetSAR® tool was used, a free online database, available at http://lmmd.ecust.edu.cn/admetsar1/, and with this system it was possible to observe toxicity data such as: toxicity AMES, carcinogenicity profile, carcinogenesis and acute oral toxicity. From the in silico analysis, eucalyptol did not show AMES toxicity or degree of carcinogenicity, the carcinogenic profile was considered low and its acute oral toxicity classified as grade III, considered moderate. The research points to a low toxicity of the eucalyptol monoterpene, its silica analysis data suggest that the substance is a good candidate for the development of therapeutic alternatives, however, for a better understanding of the substance's toxicological profile, in vitro and in vitro studies should be performed. alive.