The Genetic Polymorphism of TNF-α Associated with the Anti-TNF-α Therapy Used for COVID-19 Patients – Another Possible Approach

• Autor(a) principal: Silva, Luciano Barreto
• Data de Publicação: 2022
• Outros Autores: Sampaio, Guilherme Marinho, Cunha, Rodolfo Scavuzzi Carneiro, Muniz, Caroline Isabele Félix, Santos Neto, Alexandrino Pereira, Anjos, Hemanuelly Albuquerque dos, Fonseca, Felipe Leonardo de Melo Almeida, Ataíde Filho, Ailton Coelho de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/21576
• topic: Cell-free nucleic acids; Genetic polymorphism; Polymorphism, single nucleotide; DNA.; Ácidos nucleicos livres; Polimorfismo genético; Polimorfismo de nucleotídeo único; DNA.; Ácidos nucleicos Libres de células; Polimorfismo genético; Polimorfismo de nucleótide simple; ADN.

Objective: This work aimed of to review the implications of anti-TNF-α therapy in COVID-19 patients associated with the genetic polymorphism (TNF-α polymorphisms in the region-308) of this pertinent cytokine  Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Twenty-six articles were collected. Anti-TNF-α therapy was interpreted and evaluated. Conclusions: Although scarce information is available in the current literature, anti- TNF-α therapy seems to be a viable clinical approach for hospitalized COVID-19 patients who do not need oxygen supply. The genetic polymorphisms, although relevant, may be useful for further researched to assess the clinical response in different research groups.