Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18521 |
Resumo: | Objective: the aim of this work was to explain the implications of the genetic profile (TNF-α polymorphisms in the region-308) in the outcome of different pathologies; and explain how this profile is obtained in the laboratory. Methodology: The salting out technique, according to Miller et al. (1988) was used to explain the reader how the genetic profile of TNF-α is obtained to foresee the outcome of pathologies that are modulated by this cytokine. Results: the product of the amplified digestion of TNF-α genes was obtained, photographed and explained for the reader. Conclusions: the genetic profile may be useful as a predictor for the outcome of different pathologies, so that doctors and dentists may choose the best therapy for each patient. |
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Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases Polimorfismo Genético del TNF-α y sus implicaciones en la visión previa del curso de las patologías, incluidas las enfermedades orales Polimorfismo Genético do TNF-α e suas implicações na visualização do curso de patologias, incluindo doenças bucais Cell-free nucleic acidsPolimorfismo genéticoPolimorfismo de nucleotídeo únicoPeriodontite.Ácidos nucleicos libres de célulasPolymorphisme génétiquePolimorfismo de nucleótido simplePeriodontitis.Cell-free nucleic acidsPolymorphism geneticPolymorphism single nucleotidePeriodontitis.Objective: the aim of this work was to explain the implications of the genetic profile (TNF-α polymorphisms in the region-308) in the outcome of different pathologies; and explain how this profile is obtained in the laboratory. Methodology: The salting out technique, according to Miller et al. (1988) was used to explain the reader how the genetic profile of TNF-α is obtained to foresee the outcome of pathologies that are modulated by this cytokine. Results: the product of the amplified digestion of TNF-α genes was obtained, photographed and explained for the reader. Conclusions: the genetic profile may be useful as a predictor for the outcome of different pathologies, so that doctors and dentists may choose the best therapy for each patient.Objetivo: el objetivo de este trabajo fue explicar las implicaciones del perfil genético (polimorfismos en la región-308 del TNF-α) en la evolución de diferentes patologías; y explicar cómo se obtiene este perfil en el laboratorio. Metodología: La técnica de salting out, según Miller et al. (1988) se utilizó para explicar al lector cómo se obtiene el perfil genético de TNF-α para prever el resultado de patologías que son moduladas por esta citoquina. Resultados: Se obtuvo, fotografió y explicó al lector el producto de la digestión amplificada de los genes TNF-α. Conclusiones: el perfil genético puede ser útil como predictor del desenlace de diferentes patologías, de modo que médicos y odontólogos puedan elegir la mejor terapia para cada paciente.Objetivo: o objetivo deste trabalho foi explicar as implicações do perfil genético (polimorfismos do TNF-α na região 308) no desfecho de diferentes patologias; e explicar como esse perfil é obtido em laboratório. Metodologia: A técnica de salting out, segundo Miller et al. (1988) foi utilizado para explicar ao leitor como o perfil genético do TNF-α é obtido para prever o desfecho de patologias que são moduladas por essa citocina. Resultados: o produto da digestão amplificada dos genes do TNF-α foi obtido, fotografado e explicado ao leitor. Conclusões: o perfil genético pode ser útil como preditor de desfecho de diferentes patologias, para que médicos e dentistas possam escolher a melhor terapia para cada paciente.Research, Society and Development2021-08-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1852110.33448/rsd-v10i11.18521Research, Society and Development; Vol. 10 No. 11; e61101118521Research, Society and Development; Vol. 10 Núm. 11; e61101118521Research, Society and Development; v. 10 n. 11; e611011185212525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/18521/17292Copyright (c) 2021 Luciano Barreto Silva; Rodolfo Scavuzzi Carneiro da Cunha; Gabriel Henrique De Oliveira Queiroz; Guilherme Marinho Sampaio ; Hadassa Fonsêca da Silva ; Sandra Sayão Maia; Paulo Melo Júnior; Edleine Dellalibera ; Ana Paula Veras Sobralhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Luciano Barreto Cunha, Rodolfo Scavuzzi Caneiro daQueiroz, Gabriel Henrique De Oliveira Sampaio , Guilherme Marinho Silva, Hadassa Fonsêca da Maia, Sandra Sayão Melo Júnior , PauloDellalibera, EdleineSobral, Ana Paula Veras 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/18521Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:38.768955Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases Polimorfismo Genético del TNF-α y sus implicaciones en la visión previa del curso de las patologías, incluidas las enfermedades orales Polimorfismo Genético do TNF-α e suas implicações na visualização do curso de patologias, incluindo doenças bucais |
| title |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| spellingShingle |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases Silva, Luciano Barreto Cell-free nucleic acids Polimorfismo genético Polimorfismo de nucleotídeo único Periodontite. Ácidos nucleicos libres de células Polymorphisme génétique Polimorfismo de nucleótido simple Periodontitis. Cell-free nucleic acids Polymorphism genetic Polymorphism single nucleotide Periodontitis. |
| title_short |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| title_full |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| title_fullStr |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| title_full_unstemmed |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| title_sort |
Genetic polymorphism of TNF-α and its implications in previewing the course of pathologies, including oral diseases |
| author |
Silva, Luciano Barreto |
| author_facet |
Silva, Luciano Barreto Cunha, Rodolfo Scavuzzi Caneiro da Queiroz, Gabriel Henrique De Oliveira Sampaio , Guilherme Marinho Silva, Hadassa Fonsêca da Maia, Sandra Sayão Melo Júnior , Paulo Dellalibera, Edleine Sobral, Ana Paula Veras |
| author_role |
author |
| author2 |
Cunha, Rodolfo Scavuzzi Caneiro da Queiroz, Gabriel Henrique De Oliveira Sampaio , Guilherme Marinho Silva, Hadassa Fonsêca da Maia, Sandra Sayão Melo Júnior , Paulo Dellalibera, Edleine Sobral, Ana Paula Veras |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Luciano Barreto Cunha, Rodolfo Scavuzzi Caneiro da Queiroz, Gabriel Henrique De Oliveira Sampaio , Guilherme Marinho Silva, Hadassa Fonsêca da Maia, Sandra Sayão Melo Júnior , Paulo Dellalibera, Edleine Sobral, Ana Paula Veras |
| dc.subject.por.fl_str_mv |
Cell-free nucleic acids Polimorfismo genético Polimorfismo de nucleotídeo único Periodontite. Ácidos nucleicos libres de células Polymorphisme génétique Polimorfismo de nucleótido simple Periodontitis. Cell-free nucleic acids Polymorphism genetic Polymorphism single nucleotide Periodontitis. |
| topic |
Cell-free nucleic acids Polimorfismo genético Polimorfismo de nucleotídeo único Periodontite. Ácidos nucleicos libres de células Polymorphisme génétique Polimorfismo de nucleótido simple Periodontitis. Cell-free nucleic acids Polymorphism genetic Polymorphism single nucleotide Periodontitis. |
| description |
Objective: the aim of this work was to explain the implications of the genetic profile (TNF-α polymorphisms in the region-308) in the outcome of different pathologies; and explain how this profile is obtained in the laboratory. Methodology: The salting out technique, according to Miller et al. (1988) was used to explain the reader how the genetic profile of TNF-α is obtained to foresee the outcome of pathologies that are modulated by this cytokine. Results: the product of the amplified digestion of TNF-α genes was obtained, photographed and explained for the reader. Conclusions: the genetic profile may be useful as a predictor for the outcome of different pathologies, so that doctors and dentists may choose the best therapy for each patient. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-08-22 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18521 10.33448/rsd-v10i11.18521 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/18521 |
| identifier_str_mv |
10.33448/rsd-v10i11.18521 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18521/17292 |
| dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
| publisher.none.fl_str_mv |
Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e61101118521 Research, Society and Development; Vol. 10 Núm. 11; e61101118521 Research, Society and Development; v. 10 n. 11; e61101118521 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052818626969600 |