Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18193 |
Resumo: | Pesticides or agrochemicals are groups of substances where they act in the agricultural environment, in order to control different elements that hinder the cultivation of plantations, they are generally used by occupational workers at rural level in order to increase production in the fields and eradicate diseases and pests there existing, such improper use can cause damage to human health, animals and even the environment. This research has as a general objective to identify the use of pesticides as possible pathophysiological guides from a detailed approach to the action of the chemicals involved and the biomolecular signals at the level of the central nervous system. As a methodology, it is an integrative review study in which it was adopted for the collection of data for the survey by review of journals, using the following electronic databases of indexed data: Scientific Eletronic Library, Latin American and Caribbean Literature in Health Sciences and US National Library of Medicine National Institutes of Health. The results presented reveal classes of pesticides induces an increase in cytochrome P-450 (CYP), elevation in reactive oxygen species (ROS), in addition to altered reaction of the antioxidant enzyme (SOD and catalase), changes in thyroid stimulating hormone parameters (TSH), accompanied by low activities of SOD, CAT and glutathione S-transferase (GST), synthesis of cytokines such as interferon gamma γ and tumor necrosis factor α. TNFα resulting from neurotoxicity. Thus, agrochemicals are cholinesterase inhibitors and are of primary nature for signaling changes in other pathophysiological processes. |
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Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptorsExposición a defensores agrícolas: Guías fisiopatológicas sistémicas de los receptores colinérgicos muscarínicos y nicotínicosExposição aos defensores agrícolas: Norteadores fisiopatológicos sistêmicos a partir dos receptores colinérgicos muscarínicos e nicotínicosPesticidesPathophysiologyCholinergic receptors.PlaguicidasFisiopatologíaReceptores colinérgicos.AgrotóxicosFisiopatologicaReceptores colinérgicos.Pesticides or agrochemicals are groups of substances where they act in the agricultural environment, in order to control different elements that hinder the cultivation of plantations, they are generally used by occupational workers at rural level in order to increase production in the fields and eradicate diseases and pests there existing, such improper use can cause damage to human health, animals and even the environment. This research has as a general objective to identify the use of pesticides as possible pathophysiological guides from a detailed approach to the action of the chemicals involved and the biomolecular signals at the level of the central nervous system. As a methodology, it is an integrative review study in which it was adopted for the collection of data for the survey by review of journals, using the following electronic databases of indexed data: Scientific Eletronic Library, Latin American and Caribbean Literature in Health Sciences and US National Library of Medicine National Institutes of Health. The results presented reveal classes of pesticides induces an increase in cytochrome P-450 (CYP), elevation in reactive oxygen species (ROS), in addition to altered reaction of the antioxidant enzyme (SOD and catalase), changes in thyroid stimulating hormone parameters (TSH), accompanied by low activities of SOD, CAT and glutathione S-transferase (GST), synthesis of cytokines such as interferon gamma γ and tumor necrosis factor α. TNFα resulting from neurotoxicity. Thus, agrochemicals are cholinesterase inhibitors and are of primary nature for signaling changes in other pathophysiological processes.Los plaguicidas os agroquímicos son grupos de sustancias donde actúan en el medio agrícola, con el fin de controlar diferentes elementos que dañan el cultivo de las plantaciones, generalmente son utilizados por trabajadores ocupacionales a nivel rural con el fin de incrementar la producción en los campos y erradicar enfermedades. y plagas allí, tal uso indebido puede causar daños a la salud humana, a los animales e incluso al medio ambiente. Esta investigación tiene como objetivo general identificar el uso de plaguicidas como posibles guías fisiopatológicas a partir de un enfoque detallado de la acción de las sustancias químicas involucradas y las señales biomoleculares a nivel del sistema nervioso central. Como metodología, es un estudio de revisión integradora en el cual se adoptó para la recolección de datos a través de la encuesta por revisión de revistas, utilizando 50 revistas, siguiendo las bases de datos electrónicas indexadas: Biblioteca Electrónica Científica, Literatura Latinoamericana y Caribeña en Ciencias de la Salud y Biblioteca Nacional de Medicina de EE. UU. Institutos Nacionales de Salud. Los resultados presentados revelan clases de plaguicidas que inducen aumento del citocromo P-450 (CYP), cambio de especies reactivas de oxígeno (ROS), además de una reacción alterada de la enzima antioxidante (SOD y catalasa), cambios en los parámetros de hormona estimulante del tiroides (TSH), acompañada de bajas actividades de la enzima SOD, CAT y glutatión S-transferasa (GST), síntesis de citocinas como el interferón gamma γ y el factor de necrosis tumoral α. TNFα resultante de neurotoxicidad. Por tanto, los inhibidores agroquímicos de la acción colinérgica enximática provocan una alteración de las proteínas intracelulares que resulta en un proceso fisiopatológico.Os agrotóxicos ou agroquímicos são grupos de substância onde agem no meio ambiente agrícola, no sentido de controlar distintos elementos que prejudiquem o cultivo das plantações, geralmente são utilizados por trabalhadores ocupacional a nível rural no intuito de maior produção na lavoura e erradicação de doenças e pragas ali exitentes, tal utilização indevida pode gerar danos a saúde humana, de animais e até mesmo do meio ambiente. Esta pesquisa tem como objetivo geral identificar o uso dos agrotóxicos como possíveis norteadores fisiopatológicos a partir de uma abordagem detalhada da ação das substâncias químicas envolvidas e os sinais biomoleculares a nível do sistema nervoso central. Como metodologia, trata-se de um estudo de revisão integrativa no qual foi adotada para a coleta de dados para através do levantamento por revisão de periódicos, sendo utilizado 50 periodicos, seguindo as bases eletrônicas de dados indexadas: Scientific Eletronic Library, Literatura Latino-Americano e do Caribe em Ciências da Saúde e US National Library of Medicine National Institutes of Health. Os resultados apresentandos revelam classes de agrotóxicos induz aumento do citocromo P-450 (CYP), alteação nas espécies reativas de oxigênio (ERO), além de reação alterada da enzima antioxidante (SOD e catalase), mudanças no paramentros de hormônio estimulante da tireoide (TSH), acompanhados de baixas atividades de SOD, CAT e enzima glutationa S-transferase (GST), síntese de citocinas como interferon gama γ e fator de necrose tumoral α. TNFα resultante de neurotoxicidade. Assim, os agroquímicos inibidores de ação enximatica colinérgica, ocasionam alteração proteína intracelular resutando em processo fisiopatológico.Research, Society and Development2021-07-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1819310.33448/rsd-v10i9.18193Research, Society and Development; Vol. 10 No. 9; e20410918193Research, Society and Development; Vol. 10 Núm. 9; e20410918193Research, Society and Development; v. 10 n. 9; e204109181932525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18193/15835Copyright (c) 2021 Murilo de Jesus Porto; Marisol Porto Rocha; Jaciara Pinheiro de Souza; Graziella Cecilio Credidio; André Lacerda Braga Teleshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPorto, Murilo de Jesus Rocha, Marisol Porto Souza, Jaciara Pinheiro deCredidio, Graziella CecilioTeles, André Lacerda Braga 2021-09-12T14:28:06Zoai:ojs.pkp.sfu.ca:article/18193Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:22.639513Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors Exposición a defensores agrícolas: Guías fisiopatológicas sistémicas de los receptores colinérgicos muscarínicos y nicotínicos Exposição aos defensores agrícolas: Norteadores fisiopatológicos sistêmicos a partir dos receptores colinérgicos muscarínicos e nicotínicos |
title |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
spellingShingle |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors Porto, Murilo de Jesus Pesticides Pathophysiology Cholinergic receptors. Plaguicidas Fisiopatología Receptores colinérgicos. Agrotóxicos Fisiopatologica Receptores colinérgicos. |
title_short |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
title_full |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
title_fullStr |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
title_full_unstemmed |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
title_sort |
Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors |
author |
Porto, Murilo de Jesus |
author_facet |
Porto, Murilo de Jesus Rocha, Marisol Porto Souza, Jaciara Pinheiro de Credidio, Graziella Cecilio Teles, André Lacerda Braga |
author_role |
author |
author2 |
Rocha, Marisol Porto Souza, Jaciara Pinheiro de Credidio, Graziella Cecilio Teles, André Lacerda Braga |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Porto, Murilo de Jesus Rocha, Marisol Porto Souza, Jaciara Pinheiro de Credidio, Graziella Cecilio Teles, André Lacerda Braga |
dc.subject.por.fl_str_mv |
Pesticides Pathophysiology Cholinergic receptors. Plaguicidas Fisiopatología Receptores colinérgicos. Agrotóxicos Fisiopatologica Receptores colinérgicos. |
topic |
Pesticides Pathophysiology Cholinergic receptors. Plaguicidas Fisiopatología Receptores colinérgicos. Agrotóxicos Fisiopatologica Receptores colinérgicos. |
description |
Pesticides or agrochemicals are groups of substances where they act in the agricultural environment, in order to control different elements that hinder the cultivation of plantations, they are generally used by occupational workers at rural level in order to increase production in the fields and eradicate diseases and pests there existing, such improper use can cause damage to human health, animals and even the environment. This research has as a general objective to identify the use of pesticides as possible pathophysiological guides from a detailed approach to the action of the chemicals involved and the biomolecular signals at the level of the central nervous system. As a methodology, it is an integrative review study in which it was adopted for the collection of data for the survey by review of journals, using the following electronic databases of indexed data: Scientific Eletronic Library, Latin American and Caribbean Literature in Health Sciences and US National Library of Medicine National Institutes of Health. The results presented reveal classes of pesticides induces an increase in cytochrome P-450 (CYP), elevation in reactive oxygen species (ROS), in addition to altered reaction of the antioxidant enzyme (SOD and catalase), changes in thyroid stimulating hormone parameters (TSH), accompanied by low activities of SOD, CAT and glutathione S-transferase (GST), synthesis of cytokines such as interferon gamma γ and tumor necrosis factor α. TNFα resulting from neurotoxicity. Thus, agrochemicals are cholinesterase inhibitors and are of primary nature for signaling changes in other pathophysiological processes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18193 10.33448/rsd-v10i9.18193 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18193 |
identifier_str_mv |
10.33448/rsd-v10i9.18193 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18193/15835 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 9; e20410918193 Research, Society and Development; Vol. 10 Núm. 9; e20410918193 Research, Society and Development; v. 10 n. 9; e20410918193 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052752900128768 |