Exposure to agricultural defenders: Systemic pathophysiological guides from muscarinic and nicotinic cholinergic receptors

• Autor(a) principal: Porto, Murilo de Jesus
• Data de Publicação: 2021
• Outros Autores: Rocha, Marisol Porto, Souza, Jaciara Pinheiro de, Credidio, Graziella Cecilio, Teles, André Lacerda Braga
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/18193
• topic: Pesticides; Pathophysiology; Cholinergic receptors.; Plaguicidas; Fisiopatología; Receptores colinérgicos.; Agrotóxicos; Fisiopatologica; Receptores colinérgicos.

Pesticides or agrochemicals are groups of substances where they act in the agricultural environment, in order to control different elements that hinder the cultivation of plantations, they are generally used by occupational workers at rural level in order to increase production in the fields and eradicate diseases and pests there existing, such improper use can cause damage to human health, animals and even the environment. This research has as a general objective to identify the use of pesticides as possible pathophysiological guides from a detailed approach to the action of the chemicals involved and the biomolecular signals at the level of the central nervous system. As a methodology, it is an integrative review study in which it was adopted for the collection of data for the survey by review of journals, using the following electronic databases of indexed data: Scientific Eletronic Library, Latin American and Caribbean Literature in Health Sciences and US National Library of Medicine National Institutes of Health. The results presented reveal classes of pesticides induces an increase in cytochrome P-450 (CYP), elevation in reactive oxygen species (ROS), in addition to altered reaction of the antioxidant enzyme (SOD and catalase), changes in thyroid stimulating hormone parameters (TSH), accompanied by low activities of SOD, CAT and glutathione S-transferase (GST), synthesis of cytokines such as interferon gamma γ and tumor necrosis factor α. TNFα resulting from neurotoxicity. Thus, agrochemicals are cholinesterase inhibitors and are of primary nature for signaling changes in other pathophysiological processes.