Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/41692 |
Resumo: | Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the world and has been listed as a global public health priority by the WHO. There is currently no effective treatment for the disease and its cause is still unknown. In recent years, attempts have been made to explain the etiological mechanisms of AD, one proposed hypothesis is the spread of oral microorganisms such as Porphyromonas gingivalis (Pg) to brain tissue in patients with periodontitis. However, this possible causal relationship remains unclear. Objective: to present the role of Pg as a link between periodontitis and Alzheimer's disease based on a literature review of publications from the last 5 years. Materials and methods: search of publications in the following databases: PubMed, SpringerLink, Scientific Direct, Scielo. Results: 19 scientific articles were included of which animal and molecular studies determine that, Pg infection increased the production of inflammatory mediators, thus causing an increase in the production of Aβ (beta amyloid) and subsequently, neurodegeneration compatible with AD; however, no clear relationship has been established in human studies. Conclusion: the effect of Pg on the development of neuroinflammation has been demonstrated; however, further large-scale studies and longitudinal follow-up in humans are needed to better establish the relationship between periodontitis and AD. |
id |
UNIFEI_d5af9ab4a65c1d35211a9e1bf6692324 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/41692 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature reviewLa Porphyromonas gingivalis como vínculo entre la periodontitis y la enfermedad de Alzheimer. Revisión narrativa de literaturaPorphyromonas gingivalis como um elo entre a periodontite e a doença de Alzheimer. Revisão narrativa da literaturaEnfermedad periodontalEnfermedad de AlzheimerPeriodontitisPorphyromonas gingivalis.Doença periodontalDoença de AlzheimerPeriodontitePorphyromonas gingivalis.Alzheimer's diseasePeriodontal diseasePeriodontitisPorphyromonas gingivalis.Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the world and has been listed as a global public health priority by the WHO. There is currently no effective treatment for the disease and its cause is still unknown. In recent years, attempts have been made to explain the etiological mechanisms of AD, one proposed hypothesis is the spread of oral microorganisms such as Porphyromonas gingivalis (Pg) to brain tissue in patients with periodontitis. However, this possible causal relationship remains unclear. Objective: to present the role of Pg as a link between periodontitis and Alzheimer's disease based on a literature review of publications from the last 5 years. Materials and methods: search of publications in the following databases: PubMed, SpringerLink, Scientific Direct, Scielo. Results: 19 scientific articles were included of which animal and molecular studies determine that, Pg infection increased the production of inflammatory mediators, thus causing an increase in the production of Aβ (beta amyloid) and subsequently, neurodegeneration compatible with AD; however, no clear relationship has been established in human studies. Conclusion: the effect of Pg on the development of neuroinflammation has been demonstrated; however, further large-scale studies and longitudinal follow-up in humans are needed to better establish the relationship between periodontitis and AD.La enfermedad de Alzheimer (EA) es uno de los trastornos neurodegenerativos más comunes en el mundo y ha sido catalogada como una prioridad de salud pública mundial por la OMS. Actualmente no existe un tratamiento efectivo para la enfermedad y su causa aún se desconoce. En los últimos años, se ha tratado de explicar los mecanismos etiológicos de la EA y se ha propuesto la hipótesis de la propagación de microorganismos orales como la Porphyromonas gingivalis (Pg) hacia el tejido cerebral en pacientes con periodontitis. Sin embargo, esta posible relación causal sigue sin estar clara. Objetivo: presentar el papel de la Pg como vínculo entre la periodontitis y la enfermedad de Alzheimer a partir de una revisión de literatura de publicaciones de los últimos 5 años. Materiales y métodos: búsqueda de publicaciones en las bases de datos: PubMed, SpringerLink, Scientific Direct, Scielo. Resultados: se incluyeron 19 artículos científicos de los cuales los estudios en animales y moleculares determinan que, la infección por Pg aumentó la producción de los mediadores inflamatorios, provocando así un aumento en la producción de Aβ (beta amiloide) y posteriormente, neurodegeneración compatible con la EA; sin embargo, no se ha establecido una relación clara en los estudios realizados en humanos. Conclusión: se ha demostrado el efecto de la Pg en el desarrollo de neuroinflamación; sin embargo, se necesitan estudios adicionales a gran escala y seguimiento longitudinal en humanos para establecer de mejor manera la relación entre la periodontitis y la EA.A doença de Alzheimer (DA) é um dos distúrbios neurodegenerativos mais comuns no mundo e foi listada como uma prioridade de saúde pública global pela OMS. Atualmente, não há tratamento eficaz para a doença e sua causa ainda é desconhecida. Nos últimos anos, foram feitas tentativas para explicar os mecanismos etiológicos da DA e foi proposta a hipótese da disseminação de microrganismos orais, como a Porphyromonas gingivalis (Pg), para o tecido cerebral em pacientes com periodontite. Entretanto, essa possível relação causal ainda não está clara. Objetivo: apresentar o papel da Pg como um elo entre a periodontite e a doença de Alzheimer com base em uma revisão da literatura de publicações dos últimos 5 anos. Materiais e métodos: pesquisa de publicações nos seguintes bancos de dados: PubMed, SpringerLink, Scientific Direct, Scielo. Resultados: foram incluídos 19 artigos científicos dos quais os estudos em animais e moleculares determinaram que a infecção por Pg aumentava a produção de mediadores inflamatórios, causando assim, um aumento na produção de Aβ (beta amiloide) e, subsequentemente, neurodegeneração compatível com a DA; no entanto, nenhuma relação clara foi estabelecida em estudos em humanos. Conclusão: o efeito da Pg no desenvolvimento da neuroinflamação foi demonstrado; entretanto, são necessários mais estudos em larga escala e com o acompanhamento longitudinal em humanos.Research, Society and Development2023-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4169210.33448/rsd-v12i5.41692Research, Society and Development; Vol. 12 No. 5; e17212541692Research, Society and Development; Vol. 12 Núm. 5; e17212541692Research, Society and Development; v. 12 n. 5; e172125416922525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIspahttps://rsdjournal.org/index.php/rsd/article/view/41692/33820Copyright (c) 2023 Andrea Nicole Peralta Avila; Andrea Soledad Carvajal Endarahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPeralta Avila, Andrea Nicole Carvajal Endara, Andrea Soledad 2023-05-30T13:24:21Zoai:ojs.pkp.sfu.ca:article/41692Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-05-30T13:24:21Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review La Porphyromonas gingivalis como vínculo entre la periodontitis y la enfermedad de Alzheimer. Revisión narrativa de literatura Porphyromonas gingivalis como um elo entre a periodontite e a doença de Alzheimer. Revisão narrativa da literatura |
title |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
spellingShingle |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review Peralta Avila, Andrea Nicole Enfermedad periodontal Enfermedad de Alzheimer Periodontitis Porphyromonas gingivalis. Doença periodontal Doença de Alzheimer Periodontite Porphyromonas gingivalis. Alzheimer's disease Periodontal disease Periodontitis Porphyromonas gingivalis. |
title_short |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
title_full |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
title_fullStr |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
title_full_unstemmed |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
title_sort |
Porphyromonas gingivalis as a link between periodontitis and Alzheimer's disease. Narrative literature review |
author |
Peralta Avila, Andrea Nicole |
author_facet |
Peralta Avila, Andrea Nicole Carvajal Endara, Andrea Soledad |
author_role |
author |
author2 |
Carvajal Endara, Andrea Soledad |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Peralta Avila, Andrea Nicole Carvajal Endara, Andrea Soledad |
dc.subject.por.fl_str_mv |
Enfermedad periodontal Enfermedad de Alzheimer Periodontitis Porphyromonas gingivalis. Doença periodontal Doença de Alzheimer Periodontite Porphyromonas gingivalis. Alzheimer's disease Periodontal disease Periodontitis Porphyromonas gingivalis. |
topic |
Enfermedad periodontal Enfermedad de Alzheimer Periodontitis Porphyromonas gingivalis. Doença periodontal Doença de Alzheimer Periodontite Porphyromonas gingivalis. Alzheimer's disease Periodontal disease Periodontitis Porphyromonas gingivalis. |
description |
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the world and has been listed as a global public health priority by the WHO. There is currently no effective treatment for the disease and its cause is still unknown. In recent years, attempts have been made to explain the etiological mechanisms of AD, one proposed hypothesis is the spread of oral microorganisms such as Porphyromonas gingivalis (Pg) to brain tissue in patients with periodontitis. However, this possible causal relationship remains unclear. Objective: to present the role of Pg as a link between periodontitis and Alzheimer's disease based on a literature review of publications from the last 5 years. Materials and methods: search of publications in the following databases: PubMed, SpringerLink, Scientific Direct, Scielo. Results: 19 scientific articles were included of which animal and molecular studies determine that, Pg infection increased the production of inflammatory mediators, thus causing an increase in the production of Aβ (beta amyloid) and subsequently, neurodegeneration compatible with AD; however, no clear relationship has been established in human studies. Conclusion: the effect of Pg on the development of neuroinflammation has been demonstrated; however, further large-scale studies and longitudinal follow-up in humans are needed to better establish the relationship between periodontitis and AD. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/41692 10.33448/rsd-v12i5.41692 |
url |
https://rsdjournal.org/index.php/rsd/article/view/41692 |
identifier_str_mv |
10.33448/rsd-v12i5.41692 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/41692/33820 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Andrea Nicole Peralta Avila; Andrea Soledad Carvajal Endara https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Andrea Nicole Peralta Avila; Andrea Soledad Carvajal Endara https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 5; e17212541692 Research, Society and Development; Vol. 12 Núm. 5; e17212541692 Research, Society and Development; v. 12 n. 5; e17212541692 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052624292282368 |