Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/19618 |
Resumo: | Introduction: there are reports of a manifestation secondary to infection and viral action in the body: smell disorders and, consequently, taste disorders, which are present even before the molecular confirmation of the infection caused by SARS-CoV-2. Objective: to answer what are the mechanisms of olfactory disorders resulting from Covid-19, as well as risk factors and possible interventions. Methodology: This is a descriptive research of the integrative literature review type. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, August 2021. Results: The mechanisms of olfactory disorders related to SARS-CoV-2 infection are still unknown, but it is probably the result of various patterns, such as nasal mucosa edema, olfactory epithelial damage and even involvement of the central olfactory pathways. It was demonstrated that the expression of angiotensin-converting enzyme (ACE2) was found in the basal layer of the non-keratinizing squamous epithelium in the nasal and oral mucosa and in the nasopharynx. Conclusion: There may be olfactory-gustatory disturbances in variable intensities and prior to the general symptoms of Covid-19, they should be considered as part of the disease's symptoms, even in mild conditions. There is still no scientific evidence of specific treatments for such disorders in Covid-19, and it is important that further studies achieve, through clinical empiricism, better workup for these cases, especially those that manifest as a lasting sequelae of SARS-CoV-2 infection. |
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Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventionsTrastornos olfatorios resultantes de la infección por SARS-CoV-2: fisiopatología, factores de riesgo y posibles intervencionesDistúrbios olfatórios decorrentes de infecção por SARS-CoV-2: fisiopatologia, fatores de risco e possíveis intervençõesCovid-19AnosmiaTrastornos olfatoriosECA2.Covid-19AnosmiaOlfactory disordersACE2.Covid-19AnosmiaDistúrbios olfatóriosACE2.Introduction: there are reports of a manifestation secondary to infection and viral action in the body: smell disorders and, consequently, taste disorders, which are present even before the molecular confirmation of the infection caused by SARS-CoV-2. Objective: to answer what are the mechanisms of olfactory disorders resulting from Covid-19, as well as risk factors and possible interventions. Methodology: This is a descriptive research of the integrative literature review type. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, August 2021. Results: The mechanisms of olfactory disorders related to SARS-CoV-2 infection are still unknown, but it is probably the result of various patterns, such as nasal mucosa edema, olfactory epithelial damage and even involvement of the central olfactory pathways. It was demonstrated that the expression of angiotensin-converting enzyme (ACE2) was found in the basal layer of the non-keratinizing squamous epithelium in the nasal and oral mucosa and in the nasopharynx. Conclusion: There may be olfactory-gustatory disturbances in variable intensities and prior to the general symptoms of Covid-19, they should be considered as part of the disease's symptoms, even in mild conditions. There is still no scientific evidence of specific treatments for such disorders in Covid-19, and it is important that further studies achieve, through clinical empiricism, better workup for these cases, especially those that manifest as a lasting sequelae of SARS-CoV-2 infection.Introducción: existen reportes de una manifestación secundaria a infección y acción viral en el organismo: trastornos del olfato y, en consecuencia, trastornos del gusto, que se presentan incluso antes de la confirmación molecular de la infección por SARS-CoV-2. Objetivo: dar respuesta a cuáles son los mecanismos de los trastornos olfatorios derivados del Covid-19, así como los factores de riesgo y las posibles intervenciones. Metodología: Se trata de una investigación descriptiva del tipo revisión integradora de la literatura. La búsqueda se realizó a través del acceso en línea en la Biblioteca Nacional de Medicina (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) y bases de datos EBSCO Information Services. , Agosto de 2021. Resultados: Aún se desconocen los mecanismos de los trastornos olfatorios relacionados con la infección por SARS-CoV-2, pero probablemente sea el resultado de varios patrones, como edema de la mucosa nasal, daño del epitelio olfatorio e incluso afectación del olfato central. caminos. Se demostró que la expresión de la enzima convertidora de angiotensina (ECA2) se encontraba en la capa basal del epitelio escamoso no queratinizante de la mucosa nasal y oral y en la nasofaringe. Conclusión: Puede haber alteraciones olfatorio-gustativas en intensidades variables y antes de los síntomas generales de Covid-19, deben considerarse como parte de los síntomas de la enfermedad, incluso en condiciones leves. Todavía no hay evidencia científica de tratamientos específicos para tales trastornos en Covid-19, y es importante que estudios adicionales logren, a través del empirismo clínico, un mejor diagnóstico para estos casos, especialmente aquellos que se manifiestan como una secuela duradera de la infección por SARS. -2.Introdução: existem relatos de uma manifestação secundária à infecção e atuação viral no organismo: distúrbios do olfato e, consequentemente, do paladar, e que estão presentes antes mesmo da confirmação molecular da infecção causada por SARS-CoV-2. Objetivo: responder quais são os mecanismos de disfunções olfatórias decorrentes da Covid-19, bem como fatores de risco e possíveis intervenções. Metodologia: Trata-se de uma pesquisa descritiva do tipo revisão integrativa da literatura. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services, no mês de agosto de 2021. Resultados: Os mecanismos dos distúrbios olfatórios relacionados à infecção por SARS-CoV-2 ainda são desconhecidos, mas é provavelmente o resultado de vários padrões, como edema da mucosa nasal, dano epitelial olfatório e até mesmo envolvimento da região central vias olfativas. Foi demonstrado que a expressão de enzima conversora de angiotensina (ACE2) foi encontrada na camada basal do epitélio escamoso não queratinizante na mucosa nasal e oral e na nasofaringe. Conclusão: Podem ocorrer distúrbios olfativo-gustativos em intensidades variáveis e prévios aos sintomas gerais da Covid-19, devem ser considerados como parte dos sintomas da doença, mesmo em quadros leves. Não há ainda evidências científicas de tratamentos específicos para tais distúrbios na Covid-19, sendo de importância que estudos posteriores consigam, por meio de empirismo clínico, melhor propedêutica para esses casos, principalmente aqueles que manifestam-se como sequela duradoura da infecção por SARS-CoV-2.Research, Society and Development2021-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1961810.33448/rsd-v10i11.19618Research, Society and Development; Vol. 10 No. 11; e180101119618Research, Society and Development; Vol. 10 Núm. 11; e180101119618Research, Society and Development; v. 10 n. 11; e1801011196182525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19618/17409Copyright (c) 2021 Júlia Fernandes Nogueira; Bárbara Queiroz de Figueiredo; Ana Luísa de Castro Melo; Ana Paula Ferreira Araújo; Isabella Barata Linces Alves; João Pedro de Miranda Carvalho; Luana Damaceno Miranda; Sabrina Siqueira Porto; Marcelo Gomes de Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessNogueira, Júlia FernandesFigueiredo, Bárbara Queiroz de Melo, Ana Luísa de CastroAraújo, Ana Paula FerreiraAlves, Isabella Barata LincesCarvalho, João Pedro de MirandaMiranda, Luana DamacenoPorto, Sabrina SiqueiraAlmeida, Marcelo Gomes de 2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19618Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:29.195394Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions Trastornos olfatorios resultantes de la infección por SARS-CoV-2: fisiopatología, factores de riesgo y posibles intervenciones Distúrbios olfatórios decorrentes de infecção por SARS-CoV-2: fisiopatologia, fatores de risco e possíveis intervenções |
title |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
spellingShingle |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions Nogueira, Júlia Fernandes Covid-19 Anosmia Trastornos olfatorios ECA2. Covid-19 Anosmia Olfactory disorders ACE2. Covid-19 Anosmia Distúrbios olfatórios ACE2. |
title_short |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
title_full |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
title_fullStr |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
title_full_unstemmed |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
title_sort |
Olfactory disorders resulting from SARS-CoV-2 infection: pathophysiology, risk factors and possible interventions |
author |
Nogueira, Júlia Fernandes |
author_facet |
Nogueira, Júlia Fernandes Figueiredo, Bárbara Queiroz de Melo, Ana Luísa de Castro Araújo, Ana Paula Ferreira Alves, Isabella Barata Linces Carvalho, João Pedro de Miranda Miranda, Luana Damaceno Porto, Sabrina Siqueira Almeida, Marcelo Gomes de |
author_role |
author |
author2 |
Figueiredo, Bárbara Queiroz de Melo, Ana Luísa de Castro Araújo, Ana Paula Ferreira Alves, Isabella Barata Linces Carvalho, João Pedro de Miranda Miranda, Luana Damaceno Porto, Sabrina Siqueira Almeida, Marcelo Gomes de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nogueira, Júlia Fernandes Figueiredo, Bárbara Queiroz de Melo, Ana Luísa de Castro Araújo, Ana Paula Ferreira Alves, Isabella Barata Linces Carvalho, João Pedro de Miranda Miranda, Luana Damaceno Porto, Sabrina Siqueira Almeida, Marcelo Gomes de |
dc.subject.por.fl_str_mv |
Covid-19 Anosmia Trastornos olfatorios ECA2. Covid-19 Anosmia Olfactory disorders ACE2. Covid-19 Anosmia Distúrbios olfatórios ACE2. |
topic |
Covid-19 Anosmia Trastornos olfatorios ECA2. Covid-19 Anosmia Olfactory disorders ACE2. Covid-19 Anosmia Distúrbios olfatórios ACE2. |
description |
Introduction: there are reports of a manifestation secondary to infection and viral action in the body: smell disorders and, consequently, taste disorders, which are present even before the molecular confirmation of the infection caused by SARS-CoV-2. Objective: to answer what are the mechanisms of olfactory disorders resulting from Covid-19, as well as risk factors and possible interventions. Methodology: This is a descriptive research of the integrative literature review type. The search was carried out through online access in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Virtual Health Library (BVS) and EBSCO databases Information Services, August 2021. Results: The mechanisms of olfactory disorders related to SARS-CoV-2 infection are still unknown, but it is probably the result of various patterns, such as nasal mucosa edema, olfactory epithelial damage and even involvement of the central olfactory pathways. It was demonstrated that the expression of angiotensin-converting enzyme (ACE2) was found in the basal layer of the non-keratinizing squamous epithelium in the nasal and oral mucosa and in the nasopharynx. Conclusion: There may be olfactory-gustatory disturbances in variable intensities and prior to the general symptoms of Covid-19, they should be considered as part of the disease's symptoms, even in mild conditions. There is still no scientific evidence of specific treatments for such disorders in Covid-19, and it is important that further studies achieve, through clinical empiricism, better workup for these cases, especially those that manifest as a lasting sequelae of SARS-CoV-2 infection. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19618 10.33448/rsd-v10i11.19618 |
url |
https://rsdjournal.org/index.php/rsd/article/view/19618 |
identifier_str_mv |
10.33448/rsd-v10i11.19618 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/19618/17409 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 11; e180101119618 Research, Society and Development; Vol. 10 Núm. 11; e180101119618 Research, Society and Development; v. 10 n. 11; e180101119618 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052641919893504 |