Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal

Detalhes bibliográficos
Autor(a) principal: Morais, Maria Franncielly Simões de
Data de Publicação: 2020
Outros Autores: Medeiros, Herbert Igor Rodrigues de, Jorge, Maria Thaynara, Costa, Érick Caique Santos, Freitas, Juliano Carlo Rufino, Carmo, Egberto dos Santos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/4523
Resumo: In recent years, mycoses have become a serious public health problem, mainly due to the increase in the number of people with immunodeficiency, innate or acquired, and the appearance of multiresistant microorganisms due to the indiscriminate use of antibiotics. In order to minimize these problems, compounds containing the 1,2,4-oxadiazolic ring are the target of numerous pharmacological and toxicological studies aimed at developing new, more potent and selective antimicrobials. Thus, the present study aimed to evaluate the toxicological and antifungal potential of the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol. The synthesis of compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was carried out from the reaction between benzamidoxime and ethyl salicylate. Toxicological potential was evaluated using the microcustacean Artemia salina Leach.   The evaluation of the antifungal potential was carried out against different strains of potentially pathogenic fungi, using the serial microdilution technique. After 24h of reaction, the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was obtained with 72% yield, had a melting point of 159-160ºC and the 1H and 13C NMR data corroborate its structure. The compound showed low toxicity against the brine shrimp, with an LC50 of 565,100 μg/mL, while the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration showed equal values of 4000 μg/mL for the fungus Rhizopus orizae. These results encourage other studies, since compound showed low toxicity and reduced spectrum of action, which favours the treatment of specific fungal infections.
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spelling Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungalSíntesis del 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol y evaluación de su potencial toxicológico y antifúngicoSíntese do 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol e avaliação do seu potencial toxicológico e antifúngico124-oxadiazolPotencial toxicológicoPotencial antifúngico.124-oxadiazolPotencial toxicológicoPotencial antifúngico.124-oxadizoleToxicological potentialAntifungal potential.In recent years, mycoses have become a serious public health problem, mainly due to the increase in the number of people with immunodeficiency, innate or acquired, and the appearance of multiresistant microorganisms due to the indiscriminate use of antibiotics. In order to minimize these problems, compounds containing the 1,2,4-oxadiazolic ring are the target of numerous pharmacological and toxicological studies aimed at developing new, more potent and selective antimicrobials. Thus, the present study aimed to evaluate the toxicological and antifungal potential of the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol. The synthesis of compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was carried out from the reaction between benzamidoxime and ethyl salicylate. Toxicological potential was evaluated using the microcustacean Artemia salina Leach.   The evaluation of the antifungal potential was carried out against different strains of potentially pathogenic fungi, using the serial microdilution technique. After 24h of reaction, the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was obtained with 72% yield, had a melting point of 159-160ºC and the 1H and 13C NMR data corroborate its structure. The compound showed low toxicity against the brine shrimp, with an LC50 of 565,100 μg/mL, while the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration showed equal values of 4000 μg/mL for the fungus Rhizopus orizae. These results encourage other studies, since compound showed low toxicity and reduced spectrum of action, which favours the treatment of specific fungal infections.En los últimos años, las micosis se han convertido en un grave problema de salud pública, principalmente debido al aumento en el número de personas con inmunodeficiencia, innata o adquirida, y la aparición de microorganismos multirresistentes debido al uso indiscriminado de antibióticos. Para minimizar estos problemas, los compuestos que contienen el anillo 1,2,4-oxadiazólico son el objetivo de numerosos estudios farmacológicos y toxicológicos destinados a desarrollar nuevos antimicrobianos más potentes y selectivos. Por lo tanto, el presente estudio tuvo como objetivo evaluar el potencial toxicológico y antifúngico del compuesto 2- (3-fenil-1,2,4-oxadiazol-5-il) fenol. La síntesis del compuesto 2- (3-fenil-1,2,4-oxadiazol-5-il) fenol se realizó a partir de la reacción entre benzamidoxima y salicilato de etilo. La evaluación del potencial toxicológico se realizó utilizando el microcrustáceo Artemia salina Leach. La evaluación del potencial antifúngico se realizó contra diferentes cepas de hongos potencialmente patógenos, utilizando la técnica de microdilución en serie. Después de 24 h de reacción, se obtuvo el compuesto 2- (3-fenil-1,2,4-oxadiazol-5-il) fenol con un rendimiento del 72%, presentando un punto de fusión de 159-160ºC y los datos de 1H NMR y 13C corroboran su estructura. El compuesto mostró baja toxicidad contra los camarones de salmuera, con una CL50 de 565,100 μg / ml, mientras que la concentración inhibitoria mínima y la concentración fungicida mínima mostraron valores iguales de 4000 μg / ml para el hongo Rhizopus orizae. Estos resultados alientan otros estudios, ya que el compuesto mostró baja toxicidad y espectro de acción reducido, lo que favorece el tratamiento de infecciones fúngicas específicas.Nos últimos anos, as micoses têm se tornado um grave problema de saúde pública, principalmente, devido ao aumento do número de pessoas com imunodeficiência, inata ou adquirida, e pelo surgimento de microrganismos multiresistentes decorrente do uso indiscriminado de antibióticos. A fim de minimizar esses problemas, compostos contendo o anel 1,2,4-oxadiazólico são alvo de inúmeros estudos farmacológicos e toxicológicos visando desenvolver novos antimicrobianos mais potentes e seletivos. Deste modo, o presente estudo objetivou avaliar o potencial toxicológico e antifúngico do composto 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol. A síntese do composto 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol foi realizada a partir da reação entre a benzamidoxima e o salicilato de etila. A avaliação do potencial toxicológico foi realizado utilizando o microcrustáceo Artemia salina Leach. A avaliação do potencial antifúngico foi realizada frente a diferentes cepas de fungos potencialmente patogênicos, por meio da técnica de microdiluição seriada. Após 24h de reação, o composto 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol foi obtido com 72% de rendimento, apresentando um ponto de fusão de 159-160ºC e os dados de RMN 1H e 13C corroboram a sua estrutura. O composto apresentou baixa toxicidade frente as artêmias, com uma CL50 de 565,100 μg/mL, enquanto que a Concentração Inibitória Mínima e a Concentração Fungicida Mínima apresentaram valores iguais de 4000 μg/mL para o fungo Rhizopus orizae. Estes resultados estimulam outros estudos, uma vez que o composto apresentou baixa toxicidade e espectro de ação reduzido, o que favorece o tratamento de infecções fúngicas específicas.Research, Society and Development2020-05-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/452310.33448/rsd-v9i7.4523Research, Society and Development; Vol. 9 No. 7; e601974523Research, Society and Development; Vol. 9 Núm. 7; e601974523Research, Society and Development; v. 9 n. 7; e6019745232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/4523/3987Copyright (c) 2020 Maria Franncielly Silva Morais, Herbert Igor Rodrigues de Medeiros, Maria Thaynara Jorge, Juliano Carlo Rufino Freitas, Egberto dos Santos Carmoinfo:eu-repo/semantics/openAccessMorais, Maria Franncielly Simões deMedeiros, Herbert Igor Rodrigues deJorge, Maria ThaynaraCosta, Érick Caique SantosFreitas, Juliano Carlo RufinoCarmo, Egberto dos Santos2020-08-20T18:05:03Zoai:ojs.pkp.sfu.ca:article/4523Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:28:20.986468Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
Síntesis del 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol y evaluación de su potencial toxicológico y antifúngico
Síntese do 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol e avaliação do seu potencial toxicológico e antifúngico
title Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
spellingShingle Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
Morais, Maria Franncielly Simões de
1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadizole
Toxicological potential
Antifungal potential.
title_short Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
title_full Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
title_fullStr Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
title_full_unstemmed Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
title_sort Synthesis of 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol and evaluation of its potential the toxicological and antifungal
author Morais, Maria Franncielly Simões de
author_facet Morais, Maria Franncielly Simões de
Medeiros, Herbert Igor Rodrigues de
Jorge, Maria Thaynara
Costa, Érick Caique Santos
Freitas, Juliano Carlo Rufino
Carmo, Egberto dos Santos
author_role author
author2 Medeiros, Herbert Igor Rodrigues de
Jorge, Maria Thaynara
Costa, Érick Caique Santos
Freitas, Juliano Carlo Rufino
Carmo, Egberto dos Santos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Morais, Maria Franncielly Simões de
Medeiros, Herbert Igor Rodrigues de
Jorge, Maria Thaynara
Costa, Érick Caique Santos
Freitas, Juliano Carlo Rufino
Carmo, Egberto dos Santos
dc.subject.por.fl_str_mv 1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadizole
Toxicological potential
Antifungal potential.
topic 1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadiazol
Potencial toxicológico
Potencial antifúngico.
1
2
4-oxadizole
Toxicological potential
Antifungal potential.
description In recent years, mycoses have become a serious public health problem, mainly due to the increase in the number of people with immunodeficiency, innate or acquired, and the appearance of multiresistant microorganisms due to the indiscriminate use of antibiotics. In order to minimize these problems, compounds containing the 1,2,4-oxadiazolic ring are the target of numerous pharmacological and toxicological studies aimed at developing new, more potent and selective antimicrobials. Thus, the present study aimed to evaluate the toxicological and antifungal potential of the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol. The synthesis of compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was carried out from the reaction between benzamidoxime and ethyl salicylate. Toxicological potential was evaluated using the microcustacean Artemia salina Leach.   The evaluation of the antifungal potential was carried out against different strains of potentially pathogenic fungi, using the serial microdilution technique. After 24h of reaction, the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was obtained with 72% yield, had a melting point of 159-160ºC and the 1H and 13C NMR data corroborate its structure. The compound showed low toxicity against the brine shrimp, with an LC50 of 565,100 μg/mL, while the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration showed equal values of 4000 μg/mL for the fungus Rhizopus orizae. These results encourage other studies, since compound showed low toxicity and reduced spectrum of action, which favours the treatment of specific fungal infections.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4523
10.33448/rsd-v9i7.4523
url https://rsdjournal.org/index.php/rsd/article/view/4523
identifier_str_mv 10.33448/rsd-v9i7.4523
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/4523/3987
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 7; e601974523
Research, Society and Development; Vol. 9 Núm. 7; e601974523
Research, Society and Development; v. 9 n. 7; e601974523
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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