Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25144 |
Resumo: | The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review. |
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Leptin and adiponectin: role of these hormones in metabolic processes and its deregulationLeptina y adiponectina: papel de las hormonas en los procesos metabólicos e impactos en su desregulaciónLeptina e adiponectina: papel dos hormônios nos processos metabólicos e impactos na sua desregulaçãoTejido adiposoLeptinaAdiponectinaObesidadDesregulación.Adipose tissueLeptinAdiponectinObesityDeregulation.Tecido adiposoLeptinaAdiponectinaObesidadeDesregulação.The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review.El tejido adiposo es una importante fuente de energía para el cuerpo humano. También es una fuente fundamental de biomoléculas con funciones pro y antiinflamatorias, conocidas como adipocitoquinas, como la leptina y la adiponectina respectivamente. Estas hormonas experimentan variaciones en su actividad, junto con el exceso del tejido adiposo. Concentraciones normales de leptina inhiben el apetito, disminuyen el azúcar en sangre, incrementan la oxidación de ácidos grasos y, por lo tanto, disminuyen la grasa corporal. Los individuos con obesidad muestran altas concentraciones de leptina, pero no actividad receptora ligand. La adiponectina, en concentraciones normales, muestra sensibilidad a la insulina, oxidación de los ácidos grasos musculares, vasculares y de otros órganos, por medio de los receptores de adiponectina 1 y 2 (adipoR1 y adiporR2), cadherina-T, y las vías de señalización. Esta hormona tiene un patrón de expresión opuesto al de la leptina, al estar subexpresada en individuos con obesidad. Ambas hormonas no se encuentran reguladas en individuos obesos, lo que muestra varias señales crónicas de inflamación en el tejido adiposo, como la disfunción mitocondrial, el exceso de ácidos grasos saturados, etc. Todos estos factores se corresponden con una baja calidad del medioambiente sistémico, lo que induce fallos en el sistema endócrino, que contribuyen al desarrollo de enfermedades cardiovasculares, cáncer, diabetes de tipo 2, esteatosis hepática y aterosclerosis. El objetivo de este trabajo es mostrar el impacto de la desregulación de la leptina y la adiponectina en individuos con obesidad, por medio del análisis sistemático de bibliografía.O tecido adiposo é uma fonte importante de energia para o corpo humano, bem como das principais adipocitocinas com ação pró e anti-inflamatória, como leptina e adiponectina, respectivamente. O comportamento destes hormônios são alterados com o excesso de tecido adiposo. Em concentrações normais, a leptina desempenha efeitos de inibir o apetite, aumentar a oxidação dos ácidos graxos, diminuir a glicose e reduzir a gordura corporal. Na obesidade a concentração de leptina aumenta, mas não há ligação com seu receptor, LEPR. A adiponectina em concentrações normais, apresenta atividades como sensibilização à insulina, oxidação dos ácidos graxos presentes nos músculos, órgãos e vasos sanguíneos, ações mediadas pelos receptores AdipoR1, AdipoR2, T- caderina e vias de sinalização. Este hormônio apresenta um padrão de expressão oposto à leptina, estando reduzido em indivíduos obesos. As funções desses dois hormônios são desreguladas em indivíduos obesos, uma vez que, apresentam inflamação crônica no tecido adiposo, decorrente de excesso de citocinas pró-inflamatórias, ceramidas, ácidos graxos saturados, espécies reativas de oxigênio (EROs), disfunção mitocondrial e adipócitos necróticos. Estes fatores, contribuem para um ambiente de baixa qualidade sistêmica, consequentemente, provoca irregularidade no sistema endócrino facilitando o desenvolvimento de doenças associadas, como doenças cardiovasculares, cânceres, diabetes tipo 2, doença hepática gordurosa e aterosclerose. O objetivo deste trabalho é mostrar o impacto da desregulação dos hormônios supracitados em indivíduos obesos, a partir da revisão da literatura atual sobre o assunto.Research, Society and Development2022-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2514410.33448/rsd-v11i2.25144Research, Society and Development; Vol. 11 No. 2; e34711225144Research, Society and Development; Vol. 11 Núm. 2; e34711225144Research, Society and Development; v. 11 n. 2; e347112251442525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25144/22620Copyright (c) 2022 Kaellen Haab dos Santos Pinho; Maria Joseane de Paiva; Raffael Azevedo de Carvalho Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPinho, Kaellen Haab dos SantosPaiva, Maria Joseane deOliveira, Raffael Azevedo de Carvalho2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25144Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:30.148903Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation Leptina y adiponectina: papel de las hormonas en los procesos metabólicos e impactos en su desregulación Leptina e adiponectina: papel dos hormônios nos processos metabólicos e impactos na sua desregulação |
| title |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| spellingShingle |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation Pinho, Kaellen Haab dos Santos Tejido adiposo Leptina Adiponectina Obesidad Desregulación. Adipose tissue Leptin Adiponectin Obesity Deregulation. Tecido adiposo Leptina Adiponectina Obesidade Desregulação. |
| title_short |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| title_full |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| title_fullStr |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| title_full_unstemmed |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| title_sort |
Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation |
| author |
Pinho, Kaellen Haab dos Santos |
| author_facet |
Pinho, Kaellen Haab dos Santos Paiva, Maria Joseane de Oliveira, Raffael Azevedo de Carvalho |
| author_role |
author |
| author2 |
Paiva, Maria Joseane de Oliveira, Raffael Azevedo de Carvalho |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Pinho, Kaellen Haab dos Santos Paiva, Maria Joseane de Oliveira, Raffael Azevedo de Carvalho |
| dc.subject.por.fl_str_mv |
Tejido adiposo Leptina Adiponectina Obesidad Desregulación. Adipose tissue Leptin Adiponectin Obesity Deregulation. Tecido adiposo Leptina Adiponectina Obesidade Desregulação. |
| topic |
Tejido adiposo Leptina Adiponectina Obesidad Desregulación. Adipose tissue Leptin Adiponectin Obesity Deregulation. Tecido adiposo Leptina Adiponectina Obesidade Desregulação. |
| description |
The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-01-27 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/25144 10.33448/rsd-v11i2.25144 |
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https://rsdjournal.org/index.php/rsd/article/view/25144 |
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10.33448/rsd-v11i2.25144 |
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por |
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por |
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https://rsdjournal.org/index.php/rsd/article/view/25144/22620 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 11 No. 2; e34711225144 Research, Society and Development; Vol. 11 Núm. 2; e34711225144 Research, Society and Development; v. 11 n. 2; e34711225144 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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