Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation

Detalhes bibliográficos
Autor(a) principal: Pinho, Kaellen Haab dos Santos
Data de Publicação: 2022
Outros Autores: Paiva, Maria Joseane de, Oliveira, Raffael Azevedo de Carvalho
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/25144
Resumo: The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review.
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spelling Leptin and adiponectin: role of these hormones in metabolic processes and its deregulationLeptina y adiponectina: papel de las hormonas en los procesos metabólicos e impactos en su desregulaciónLeptina e adiponectina: papel dos hormônios nos processos metabólicos e impactos na sua desregulaçãoTejido adiposoLeptinaAdiponectinaObesidadDesregulación.Adipose tissueLeptinAdiponectinObesityDeregulation.Tecido adiposoLeptinaAdiponectinaObesidadeDesregulação.The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review.El tejido adiposo es una importante fuente de energía para el cuerpo humano. También es una fuente fundamental de biomoléculas con funciones pro y antiinflamatorias, conocidas como adipocitoquinas, como la leptina y la adiponectina respectivamente. Estas hormonas experimentan variaciones en su actividad, junto con el exceso del tejido adiposo. Concentraciones normales de leptina inhiben el apetito, disminuyen el azúcar en sangre, incrementan la oxidación de ácidos grasos y, por lo tanto, disminuyen la grasa corporal. Los individuos con obesidad muestran altas concentraciones de leptina, pero no actividad receptora ligand. La adiponectina, en concentraciones normales, muestra sensibilidad a la insulina, oxidación de los ácidos grasos musculares, vasculares y de otros órganos, por medio de los receptores de adiponectina 1 y 2 (adipoR1 y adiporR2), cadherina-T, y las vías de señalización. Esta hormona tiene un patrón de expresión opuesto al de la leptina, al estar subexpresada en individuos con obesidad. Ambas hormonas no se encuentran reguladas en individuos obesos, lo que muestra varias señales crónicas de inflamación en el tejido adiposo, como la disfunción mitocondrial, el exceso de ácidos grasos saturados, etc. Todos estos factores se corresponden con una baja calidad del medioambiente sistémico, lo que induce fallos en el sistema endócrino, que contribuyen al desarrollo de enfermedades cardiovasculares, cáncer, diabetes de tipo 2, esteatosis hepática y aterosclerosis. El objetivo de este trabajo es mostrar el impacto de la desregulación de la leptina y la adiponectina en individuos con obesidad, por medio del análisis sistemático de bibliografía.O tecido adiposo é uma fonte importante de energia para o corpo humano, bem como das principais adipocitocinas com ação pró e anti-inflamatória, como leptina e adiponectina, respectivamente. O comportamento destes hormônios são alterados com o excesso de tecido adiposo. Em concentrações normais, a leptina desempenha efeitos de inibir o apetite, aumentar a oxidação dos ácidos graxos, diminuir a glicose e reduzir a gordura corporal. Na obesidade a concentração de leptina aumenta, mas não há ligação com seu receptor, LEPR. A adiponectina em concentrações normais, apresenta atividades como sensibilização à insulina, oxidação dos ácidos graxos presentes nos músculos, órgãos e vasos sanguíneos, ações mediadas pelos receptores AdipoR1, AdipoR2, T- caderina e vias de sinalização. Este hormônio apresenta um padrão de expressão oposto à leptina, estando reduzido em indivíduos obesos. As funções desses dois hormônios são desreguladas em indivíduos obesos, uma vez que, apresentam inflamação crônica no tecido adiposo, decorrente de excesso de citocinas pró-inflamatórias, ceramidas, ácidos graxos saturados, espécies reativas de oxigênio (EROs), disfunção mitocondrial e adipócitos necróticos. Estes fatores, contribuem para um ambiente de baixa qualidade sistêmica, consequentemente, provoca irregularidade no sistema endócrino facilitando o desenvolvimento de doenças associadas, como doenças cardiovasculares, cânceres, diabetes tipo 2, doença hepática gordurosa e aterosclerose. O objetivo deste trabalho é mostrar o impacto da desregulação dos hormônios supracitados em indivíduos obesos, a partir da revisão da literatura atual sobre o assunto.Research, Society and Development2022-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2514410.33448/rsd-v11i2.25144Research, Society and Development; Vol. 11 No. 2; e34711225144Research, Society and Development; Vol. 11 Núm. 2; e34711225144Research, Society and Development; v. 11 n. 2; e347112251442525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25144/22620Copyright (c) 2022 Kaellen Haab dos Santos Pinho; Maria Joseane de Paiva; Raffael Azevedo de Carvalho Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPinho, Kaellen Haab dos SantosPaiva, Maria Joseane deOliveira, Raffael Azevedo de Carvalho2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25144Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:30.148903Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
Leptina y adiponectina: papel de las hormonas en los procesos metabólicos e impactos en su desregulación
Leptina e adiponectina: papel dos hormônios nos processos metabólicos e impactos na sua desregulação
title Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
spellingShingle Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
Pinho, Kaellen Haab dos Santos
Tejido adiposo
Leptina
Adiponectina
Obesidad
Desregulación.
Adipose tissue
Leptin
Adiponectin
Obesity
Deregulation.
Tecido adiposo
Leptina
Adiponectina
Obesidade
Desregulação.
title_short Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
title_full Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
title_fullStr Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
title_full_unstemmed Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
title_sort Leptin and adiponectin: role of these hormones in metabolic processes and its deregulation
author Pinho, Kaellen Haab dos Santos
author_facet Pinho, Kaellen Haab dos Santos
Paiva, Maria Joseane de
Oliveira, Raffael Azevedo de Carvalho
author_role author
author2 Paiva, Maria Joseane de
Oliveira, Raffael Azevedo de Carvalho
author2_role author
author
dc.contributor.author.fl_str_mv Pinho, Kaellen Haab dos Santos
Paiva, Maria Joseane de
Oliveira, Raffael Azevedo de Carvalho
dc.subject.por.fl_str_mv Tejido adiposo
Leptina
Adiponectina
Obesidad
Desregulación.
Adipose tissue
Leptin
Adiponectin
Obesity
Deregulation.
Tecido adiposo
Leptina
Adiponectina
Obesidade
Desregulação.
topic Tejido adiposo
Leptina
Adiponectina
Obesidad
Desregulación.
Adipose tissue
Leptin
Adiponectin
Obesity
Deregulation.
Tecido adiposo
Leptina
Adiponectina
Obesidade
Desregulação.
description The adipose tissue is an important energy source for the human body. It is also a critical source of biomolecules with pro and anti-inflammatory functions, known as adipocytokines, such as leptin and adiponectin, respectively. These hormones suffer variations in activity along with adipose tissue excess. Normal concentrations of leptin inhibits appetite, decreases blood sugar, increases fatty acid oxidation, and therefore, decreases body fat. Obese individuals shows high leptin concentration, but no ligand-receptor activity. Adiponectin, in normal concentrations, shows insulin sensibilization, oxidation of muscular, vascular and other organs fatty acids, by the adiponectin receptors 1 and 2 (adipoR1 and adipoR2), cadherin-T and signalling pathways. This hormone has an opposite expression pattern than leptin, being underexpressed in obese individuals. Both hormones are deregulated in obese individuals, showing several chronic inflammation signals on adipose tissue, such as mitochondrial dysfunction, excess of saturated fatty acids, etc. All these factors corroborate to a low quality systemic environment, inducing endocrine system failures, which contributes development of cardiovascular diseases, cancer, type 2 diabetes, hepatic steatosis, and atherosclerosis. The objective of this work is to show the impact of leptin and adiponectin deregulation in obese individuals through systematic literature review.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/25144
10.33448/rsd-v11i2.25144
url https://rsdjournal.org/index.php/rsd/article/view/25144
identifier_str_mv 10.33448/rsd-v11i2.25144
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/25144/22620
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 2; e34711225144
Research, Society and Development; Vol. 11 Núm. 2; e34711225144
Research, Society and Development; v. 11 n. 2; e34711225144
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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