Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.

Detalhes bibliográficos
Autor(a) principal: Januário , Bruna Miranda
Data de Publicação: 2022
Outros Autores: Diniz, Vânia Maria de Carvalho, Barros , Pedro Erian de Andrade, Lima , Viviane da Silva, Guerra Júnior , José Israel, Silva, Gabriela Cavalcante da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/24595
Resumo: Introduction: Over time, treatments with plant species have become more effective for the vast majority of the population, even with a vague collection of scientific research that proves their safety and effectiveness. Among these different species is the arboreal Crescentia cujete L., which is widely distributed in Northeastern Brazil. It is applied with various therapeutic purposes, from antihypertensive, analgesic, antispasmodic and some gynecological disorders. Objective: To analyze the possible cytotoxicity of the hydroalcoholic extract of the fruit. Methodology: The extract was obtained through dynamic maceration in a hydroalcoholic solution. A cytotoxicity analysis was carried out based on the methodologies of osmotic fragility and lethality against Artemia salina L. 45.32%. Conclusion: Therefore, further research aimed at safety and possible applicability of the extract in question is encouraged.
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spelling Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.Análisis de los efectos citotóxicos del extracto de fruto de Crescentia cujete L.Análise dos efeitos citotóxicos do extrato do fruto de Crescentia cujete L.Crescentia cujeteHemolysisBrine shrimp.Crescentia cujeteHemólisisArtemia salina.Crescentia cujeteHemóliseArtemia salina.Introduction: Over time, treatments with plant species have become more effective for the vast majority of the population, even with a vague collection of scientific research that proves their safety and effectiveness. Among these different species is the arboreal Crescentia cujete L., which is widely distributed in Northeastern Brazil. It is applied with various therapeutic purposes, from antihypertensive, analgesic, antispasmodic and some gynecological disorders. Objective: To analyze the possible cytotoxicity of the hydroalcoholic extract of the fruit. Methodology: The extract was obtained through dynamic maceration in a hydroalcoholic solution. A cytotoxicity analysis was carried out based on the methodologies of osmotic fragility and lethality against Artemia salina L. 45.32%. Conclusion: Therefore, further research aimed at safety and possible applicability of the extract in question is encouraged.Introducción: Con el tiempo, los tratamientos con especies vegetales se han vuelto más efectivos para la gran mayoría de la población, incluso con una vaga colección de investigaciones científicas que prueban su seguridad y efectividad. Entre estas diferentes especies se encuentra la arbórea Crescentia cujete L., que se distribuye ampliamente en el noreste de Brasil. Se aplica con diversas finalidades terapéuticas, desde antihipertensivo, analgésico, antiespasmódico y algunos trastornos ginecológicos. Objetivo: Analizar la posible citotoxicidad del extracto hidroalcohólico del fruto. Metodología: El extracto se obtuvo mediante maceración dinámica en solución hidroalcohólica. El análisis de citotoxicidad se basó en las metodologías de fragilidad osmótica y letalidad frente a Artemia Salina L. Resultados: Los ensayos citotóxicos arrojaron CL50 28,75, considerando alto potencial citotóxico frente a Artemia Salina L., con respecto al porcentaje hemolítico, el extracto obtuvo 45,32%. Conclusión: Por lo tanto, se recomienda realizar más investigaciones destinadas a la seguridad y la posible aplicabilidad del extracto en cuestión.Introdução: Ao decorrer dos tempos os tratamentos com espécies vegetais se tornaram mais vigentes para a grande maioria populacional, mesmo com um vago acervo de pesquisas científicas que comprovem a segurança e eficácia dos mesmos. Entre essas diversas espécies está a Crescentia cujete L., do tipo arbóreo, detentora de grande distribuição no Nordeste brasileiro. É aplicada com várias finalidades terapêuticas desde anti-hipertensiva, analgésica, antiespasmódica e alguns distúrbios ginecológicos. Objetivo: Analisar a possível citotoxicidade do extrato hidroalcoólico do fruto. Metodologia: A obtenção do extrato se deu através de maceração dinâmica em solução hidroalcoólica. A análise de citotoxicidade ocorreu com base nas metodologias de fragilidade osmótica e letalidade frente à Artemia Salina L. Resultados: Os ensaios citotóxicos apresentaram CL50 28,75, considerando alto potencial citotóxico frente à Artemia Salina L., quanto ao percentual hemolítico, o extrato obteve 45,32 %. Conclusão: Portanto, impulsiona-se a realização de mais pesquisas voltadas a segurança e possível aplicabilidade do extrato em questão.Research, Society and Development2022-01-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2459510.33448/rsd-v11i1.24595Research, Society and Development; Vol. 11 No. 1; e38511124595Research, Society and Development; Vol. 11 Núm. 1; e38511124595Research, Society and Development; v. 11 n. 1; e385111245952525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/24595/22150Copyright (c) 2022 Bruna Miranda Januário ; Vânia Maria de Carvalho Diniz; Pedro Erian de Andrade Barros ; Viviane da Silva Lima ; José Israel Guerra Júnior ; Gabriela Cavalcante da Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessJanuário , Bruna Miranda Diniz, Vânia Maria de Carvalho Barros , Pedro Erian de Andrade Lima , Viviane da Silva Guerra Júnior , José Israel Silva, Gabriela Cavalcante da 2022-01-16T18:08:18Zoai:ojs.pkp.sfu.ca:article/24595Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:05.796406Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
Análisis de los efectos citotóxicos del extracto de fruto de Crescentia cujete L.
Análise dos efeitos citotóxicos do extrato do fruto de Crescentia cujete L.
title Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
spellingShingle Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
Januário , Bruna Miranda
Crescentia cujete
Hemolysis
Brine shrimp.
Crescentia cujete
Hemólisis
Artemia salina.
Crescentia cujete
Hemólise
Artemia salina.
title_short Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
title_full Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
title_fullStr Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
title_full_unstemmed Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
title_sort Analysis of the cytotoxic effects of the fruit extract of Crescentia cujete L.
author Januário , Bruna Miranda
author_facet Januário , Bruna Miranda
Diniz, Vânia Maria de Carvalho
Barros , Pedro Erian de Andrade
Lima , Viviane da Silva
Guerra Júnior , José Israel
Silva, Gabriela Cavalcante da
author_role author
author2 Diniz, Vânia Maria de Carvalho
Barros , Pedro Erian de Andrade
Lima , Viviane da Silva
Guerra Júnior , José Israel
Silva, Gabriela Cavalcante da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Januário , Bruna Miranda
Diniz, Vânia Maria de Carvalho
Barros , Pedro Erian de Andrade
Lima , Viviane da Silva
Guerra Júnior , José Israel
Silva, Gabriela Cavalcante da
dc.subject.por.fl_str_mv Crescentia cujete
Hemolysis
Brine shrimp.
Crescentia cujete
Hemólisis
Artemia salina.
Crescentia cujete
Hemólise
Artemia salina.
topic Crescentia cujete
Hemolysis
Brine shrimp.
Crescentia cujete
Hemólisis
Artemia salina.
Crescentia cujete
Hemólise
Artemia salina.
description Introduction: Over time, treatments with plant species have become more effective for the vast majority of the population, even with a vague collection of scientific research that proves their safety and effectiveness. Among these different species is the arboreal Crescentia cujete L., which is widely distributed in Northeastern Brazil. It is applied with various therapeutic purposes, from antihypertensive, analgesic, antispasmodic and some gynecological disorders. Objective: To analyze the possible cytotoxicity of the hydroalcoholic extract of the fruit. Methodology: The extract was obtained through dynamic maceration in a hydroalcoholic solution. A cytotoxicity analysis was carried out based on the methodologies of osmotic fragility and lethality against Artemia salina L. 45.32%. Conclusion: Therefore, further research aimed at safety and possible applicability of the extract in question is encouraged.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24595
10.33448/rsd-v11i1.24595
url https://rsdjournal.org/index.php/rsd/article/view/24595
identifier_str_mv 10.33448/rsd-v11i1.24595
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24595/22150
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 1; e38511124595
Research, Society and Development; Vol. 11 Núm. 1; e38511124595
Research, Society and Development; v. 11 n. 1; e38511124595
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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