The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly

Detalhes bibliográficos
Autor(a) principal: Ferreira, Flávio José pereira de Almeida
Data de Publicação: 2021
Outros Autores: Cardoso, Fabrizio Antonio Gomide, Pereira , Vandair Gonçalves, Nascentes, Gabriel Antonio Nogueira, Monteiro, Valéria Silva, Espindula , Ana Paula
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/17215
Resumo: The Acquired Human Immunodeficiency Syndrome (AIDS) burdens society and represents one of the greatest challenges of global health due to the severity, dissemination and inequality in access to antiretroviral therapy. Objective: to analyze the thickness of the bone trabeculae and the total collagen density of fragments from bone marrow autopsies with AIDS deficiency. Methodology: retrospective observational, analytical and quantitative study, carried out from 60 bone marrow fragments from autopsied patients, aged between 26 and 71 years, divided into four groups, adults and elderly with and without AIDS. For the histomorphometric analysis, histomorphometric techniques with common light microscopy were used for quantitative analysis of the thickness and microscopy technique with polarized light to evaluate the total collagen in the bone trabeculae. Results: Adult and elderly groups with dissipation AIDS decreased in trabecular bone thickness compared to groups of adults and elderly without AIDS (p<0.001). In the assessment of collagen in groups of adults and elderly people with AIDS, there was a significant increase in total collagen (p<0.001) compared to groups without AIDS. When comparing adults and elderly people with AIDS, there was a significant increase in total collagen in the adult group (p = 0.041). As a complementary result, the body mass index among the groups with AIDS decreased, decreasing in the elderly group (p = 0.040) compared to the adult group. Conclusion: the AIDS factor influences the decrease in the thickness of the bone trabeculae and favors the increase in total collagen in adults and the elderly, being an important factor in the assessment of bone mass, especially in those aged over 50 years who present the greatest loss of organic matrix.
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spelling The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderlyEl síndrome de inmunodeficiencia humana adquirida como factor de reducción del grosor y aumento del colágeno en las trabéculas óseas de adultos y ancianosA síndrome da imunodeficiência humana adquirida como fator na redução da espessura e aumento do colágeno nas trabéculas ósseas de adultos e idososAcquired immunodeficiency syndromeAnatomy e histologyCancellous boneCollagen.Anatomía e histlogiaColágenoHueso esponjosoSíndrome de inmunodeficiencia adquirida.Anatomia e histologiaColágenoOsso trabecularSíndrome de imunodeficiência adquirida.The Acquired Human Immunodeficiency Syndrome (AIDS) burdens society and represents one of the greatest challenges of global health due to the severity, dissemination and inequality in access to antiretroviral therapy. Objective: to analyze the thickness of the bone trabeculae and the total collagen density of fragments from bone marrow autopsies with AIDS deficiency. Methodology: retrospective observational, analytical and quantitative study, carried out from 60 bone marrow fragments from autopsied patients, aged between 26 and 71 years, divided into four groups, adults and elderly with and without AIDS. For the histomorphometric analysis, histomorphometric techniques with common light microscopy were used for quantitative analysis of the thickness and microscopy technique with polarized light to evaluate the total collagen in the bone trabeculae. Results: Adult and elderly groups with dissipation AIDS decreased in trabecular bone thickness compared to groups of adults and elderly without AIDS (p<0.001). In the assessment of collagen in groups of adults and elderly people with AIDS, there was a significant increase in total collagen (p<0.001) compared to groups without AIDS. When comparing adults and elderly people with AIDS, there was a significant increase in total collagen in the adult group (p = 0.041). As a complementary result, the body mass index among the groups with AIDS decreased, decreasing in the elderly group (p = 0.040) compared to the adult group. Conclusion: the AIDS factor influences the decrease in the thickness of the bone trabeculae and favors the increase in total collagen in adults and the elderly, being an important factor in the assessment of bone mass, especially in those aged over 50 years who present the greatest loss of organic matrix.El Síndrome de Inmunodeficiencia Humana Adquirida (SIDA) agobia a la sociedad y representa uno de los mayores desafíos en la salud mundial por la gravedad, difusión y desigualdad en el acceso a la terapia antirretroviral. Objetivo: analizar el grosor de las trabéculas óseas y la densidad de colágeno total de fragmentos de autopsias de médula ósea con deficiencia de SIDA. Metodología: estudio retrospectivo observacional, analítico y cuantitativo, realizado a partir de 60 fragmentos de médula ósea de pacientes autopsiados, con edades entre 26 y 71 años, divididos en cuatro grupos, adultos y ancianos con y sin sida. Para los análisis histomorfométricos se utilizaron técnicas histomorfométricas con microscopía óptica común para el análisis cuantitativo del espesor y técnica de microscopía con luz polarizada para evaluar el colágeno total en las trabéculas óseas. Resultados: Los grupos de adultos y ancianos con SIDA de disipación disminuyeron en el grosor del hueso trabecular en comparación con los grupos de adultos y ancianos sin SIDA (p <0,001). En la evaluación del colágeno en grupos de adultos y ancianos con sida, hubo un aumento significativo del colágeno total (p <0,001) en comparación con los grupos sin sida. Al comparar adultos y ancianos con SIDA, hubo un aumento significativo en el colágeno total en el grupo de adultos (p = 0.041). Como resultado complementario, el índice de masa corporal entre los grupos con sida disminuyó, disminuyendo en el grupo de ancianos (p = 0.040) en comparación con el grupo de adultos. Conclusión: el factor SIDA influye en la disminución del grosor de las trabéculas óseas y favorece el aumento del colágeno total en adultos y ancianos, siendo un factor importante en la valoración de la masa ósea, especialmente en los mayores de 50 años que presentan la mayor Pérdida de matriz orgánica.              A Síndrome da Imunodeficiência Humana Adquirida (SIDA) onera a sociedade e representa um dos maiores desafios da saúde mundial em decorrência da sua gravidade, disseminação e desigualdade ao acesso a terapia antirretroviral. Objetivo: analisar a espessura das trabéculas ósseas e a densidade de colágeno total de fragmentos de autópsias da medula óssea de indivíduos com SIDA. Metodologia: estudo observacional retrospectivo, analítico e quantitativo, realizado a partir de 60 fragmentos da medula óssea de indivíduos autopsiados, com idade entre 26 e 71 anos, divididos em quatro grupos, adultos e idosos com e sem SIDA. Para as análises histomorfométricas foram utilizadas as técnicas de histomorfometria com microscopia de luz comum para análise quantitativa da espessura e técnica de microscopia com luz polarizada para avaliação do colágeno total nas trabéculas ósseas. Resultados: os grupos de adultos e de idosos com SIDA apresentaram diminuição significativa na espessura das trabéculas ósseas em comparação aos grupos de adultos e de idosos sem SIDA (p<0,001). Na avaliação do colágeno os grupos de adultos e de idosos com SIDA apresentaram aumento significativo do colágeno total (p<0,001) em comparação aos grupos sem SIDA. Na comparação entre os indivíduos adultos e idosos com SIDA houve aumento significativo do colágeno total no grupo de adultos (p=0,041). Como resultado complementar, o índice de massa corporal entre os grupos com a SIDA apresentou diminuição significativa no grupo de idosos (p=0,040) em comparação ao grupo de adultos. Conclusão: o fator SIDA influencia a diminuição da espessura das trabéculas ósseas e favorece o aumento do colágeno total em adultos e idosos sendo fator importante na avaliação da massa óssea, principalmente em indivíduos com mais de 50 anos que apresentam maior perda da matriz orgânica.Research, Society and Development2021-07-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1721510.33448/rsd-v10i8.17215Research, Society and Development; Vol. 10 No. 8; e22510817215Research, Society and Development; Vol. 10 Núm. 8; e22510817215Research, Society and Development; v. 10 n. 8; e225108172152525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/17215/15434Copyright (c) 2021 Flávio José pereira de Almeida Ferreira; Fabrizio Antonio Gomide Cardoso; Vandair Gonçalves Pereira ; Gabriel Antonio Nogueira Nascentes; Valéria Silva Monteiro; Ana Paula Espindula https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFerreira, Flávio José pereira de AlmeidaCardoso, Fabrizio Antonio Gomide Pereira , Vandair GonçalvesNascentes, Gabriel Antonio NogueiraMonteiro, Valéria Silva Espindula , Ana Paula2021-08-21T18:46:59Zoai:ojs.pkp.sfu.ca:article/17215Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:36.055870Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
El síndrome de inmunodeficiencia humana adquirida como factor de reducción del grosor y aumento del colágeno en las trabéculas óseas de adultos y ancianos
A síndrome da imunodeficiência humana adquirida como fator na redução da espessura e aumento do colágeno nas trabéculas ósseas de adultos e idosos
title The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
spellingShingle The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
Ferreira, Flávio José pereira de Almeida
Acquired immunodeficiency syndrome
Anatomy e histology
Cancellous bone
Collagen.
Anatomía e histlogia
Colágeno
Hueso esponjoso
Síndrome de inmunodeficiencia adquirida.
Anatomia e histologia
Colágeno
Osso trabecular
Síndrome de imunodeficiência adquirida.
title_short The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
title_full The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
title_fullStr The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
title_full_unstemmed The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
title_sort The acquired human immunodeficiency syndrome as a factor in reducing the thickness and increasing collagen in bone trabeculae of adults and the elderly
author Ferreira, Flávio José pereira de Almeida
author_facet Ferreira, Flávio José pereira de Almeida
Cardoso, Fabrizio Antonio Gomide
Pereira , Vandair Gonçalves
Nascentes, Gabriel Antonio Nogueira
Monteiro, Valéria Silva
Espindula , Ana Paula
author_role author
author2 Cardoso, Fabrizio Antonio Gomide
Pereira , Vandair Gonçalves
Nascentes, Gabriel Antonio Nogueira
Monteiro, Valéria Silva
Espindula , Ana Paula
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Flávio José pereira de Almeida
Cardoso, Fabrizio Antonio Gomide
Pereira , Vandair Gonçalves
Nascentes, Gabriel Antonio Nogueira
Monteiro, Valéria Silva
Espindula , Ana Paula
dc.subject.por.fl_str_mv Acquired immunodeficiency syndrome
Anatomy e histology
Cancellous bone
Collagen.
Anatomía e histlogia
Colágeno
Hueso esponjoso
Síndrome de inmunodeficiencia adquirida.
Anatomia e histologia
Colágeno
Osso trabecular
Síndrome de imunodeficiência adquirida.
topic Acquired immunodeficiency syndrome
Anatomy e histology
Cancellous bone
Collagen.
Anatomía e histlogia
Colágeno
Hueso esponjoso
Síndrome de inmunodeficiencia adquirida.
Anatomia e histologia
Colágeno
Osso trabecular
Síndrome de imunodeficiência adquirida.
description The Acquired Human Immunodeficiency Syndrome (AIDS) burdens society and represents one of the greatest challenges of global health due to the severity, dissemination and inequality in access to antiretroviral therapy. Objective: to analyze the thickness of the bone trabeculae and the total collagen density of fragments from bone marrow autopsies with AIDS deficiency. Methodology: retrospective observational, analytical and quantitative study, carried out from 60 bone marrow fragments from autopsied patients, aged between 26 and 71 years, divided into four groups, adults and elderly with and without AIDS. For the histomorphometric analysis, histomorphometric techniques with common light microscopy were used for quantitative analysis of the thickness and microscopy technique with polarized light to evaluate the total collagen in the bone trabeculae. Results: Adult and elderly groups with dissipation AIDS decreased in trabecular bone thickness compared to groups of adults and elderly without AIDS (p<0.001). In the assessment of collagen in groups of adults and elderly people with AIDS, there was a significant increase in total collagen (p<0.001) compared to groups without AIDS. When comparing adults and elderly people with AIDS, there was a significant increase in total collagen in the adult group (p = 0.041). As a complementary result, the body mass index among the groups with AIDS decreased, decreasing in the elderly group (p = 0.040) compared to the adult group. Conclusion: the AIDS factor influences the decrease in the thickness of the bone trabeculae and favors the increase in total collagen in adults and the elderly, being an important factor in the assessment of bone mass, especially in those aged over 50 years who present the greatest loss of organic matrix.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/17215
10.33448/rsd-v10i8.17215
url https://rsdjournal.org/index.php/rsd/article/view/17215
identifier_str_mv 10.33448/rsd-v10i8.17215
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/17215/15434
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 8; e22510817215
Research, Society and Development; Vol. 10 Núm. 8; e22510817215
Research, Society and Development; v. 10 n. 8; e22510817215
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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