COVID-19: the historicity of therapies in the first year of the Pandemic
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/26307 |
Resumo: | The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched. |
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COVID-19: the historicity of therapies in the first year of the PandemicCOVID-19: la historicidad de las terapias en el primer año de la PandemiaCOVID-19: a historicidade das terapêuticas no primeiro ano da Pandemia SARS-CoV-2TerapiasPandemiaCOVID-19.SARS-CoV-2TherapiesPandemicCOVID-19.SARS-CoV-2TerapiasPandemiaCOVID-19.The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched.El objetivo es conocer los constructos terapéuticos de la COVID-19 en su primer año de pandemia. Esta es una revisión narrativa de la literatura, realizada a partir de investigaciones en la Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane con los descriptores estandarizados 'Terapia' Y COVID-19, en el primer año de la pandemia de COVID-19, después la declaración oficial de la OMS. Como resultado se describieron las dianas terapéuticas investigadas (in vivo, in vitro e in silico) y publicadas en el primer año de esta crisis sanitaria. Era evidente que las terapias exploradas se basaban en dianas farmacológicas y no farmacológicas sobre el huésped, el sistema inmunitario y el virus. Los principales agentes probados in vitro e in vivo e in silico pertenecen a las clases farmacológicas de antivirales, antiparasitarios, antiinflamatorios, antibióticos, así como anticuerpos monoclonales, células madre y plasma convaleciente. Según las publicaciones, los fármacos más citados para tratar la COVID-19 fueron la hidroxicloroquina, la cloroquina, la ivermectina, la azitromicina, la vitamina D, la dexametasona u otro glucocorticoide. Se encontró que muchas estrategias terapéuticas contra el COVID-19 han sido refutadas, sin embargo, otras están siendo mejor investigadas.Objetiva-se conhecer os construtos terapêuticos da COVID-19 em seu primeiro ano de pandemia. Trata-se de uma revisão narrativa da literatura, realizada a partir de pesquisas nas bases Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane com os descritores padronizados ‘Therapy’ AND COVID-19, no primeiro ano da pandemia da COVID-19, após a declaração oficial da OMS. Como resultados foram descritos os alvos terapêuticos pesquisados (in vivo, in vitro e in silico) e publicados no primeiro ano dessa crise sanitária. Evidenciou-se que as terapias exploradas se basearam em alvos farmacológicos e não farmacológicos sobre o hospedeiro, sistema imunológico e no vírus. Os principais agentes testados in vitro e in vivo e in silico pertences as classes farmacológicas dos antivirais, antiparasitários, anti-inflamatórios, antibióticos além de anticorpos monoclonais, células-tronco e plasma convalescente. Segundo as publicações, os medicamentos mais citados para tratar a COVID-19 foram a hidroxicloroquina, cloroquina, ivermectina, azitromicina, vitamina D, dexametasona ou outro glicocorticoide. Constatou-se que muitas estratégias terapêuticas contra a COVID-19 foram refutadas, todavia outras estão sendo melhor pesquisadas.Research, Society and Development2022-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2630710.33448/rsd-v11i2.26307Research, Society and Development; Vol. 11 No. 2; e60011226307Research, Society and Development; Vol. 11 Núm. 2; e60011226307Research, Society and Development; v. 11 n. 2; e600112263072525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26307/22908Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferrazhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAndolfatto, DanielZanatta, LeilaFerraz, Lucimare2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/26307Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:22.999667Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
COVID-19: the historicity of therapies in the first year of the Pandemic COVID-19: la historicidad de las terapias en el primer año de la Pandemia COVID-19: a historicidade das terapêuticas no primeiro ano da Pandemia |
title |
COVID-19: the historicity of therapies in the first year of the Pandemic |
spellingShingle |
COVID-19: the historicity of therapies in the first year of the Pandemic Andolfatto, Daniel SARS-CoV-2 Terapias Pandemia COVID-19. SARS-CoV-2 Therapies Pandemic COVID-19. SARS-CoV-2 Terapias Pandemia COVID-19. |
title_short |
COVID-19: the historicity of therapies in the first year of the Pandemic |
title_full |
COVID-19: the historicity of therapies in the first year of the Pandemic |
title_fullStr |
COVID-19: the historicity of therapies in the first year of the Pandemic |
title_full_unstemmed |
COVID-19: the historicity of therapies in the first year of the Pandemic |
title_sort |
COVID-19: the historicity of therapies in the first year of the Pandemic |
author |
Andolfatto, Daniel |
author_facet |
Andolfatto, Daniel Zanatta, Leila Ferraz, Lucimare |
author_role |
author |
author2 |
Zanatta, Leila Ferraz, Lucimare |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Andolfatto, Daniel Zanatta, Leila Ferraz, Lucimare |
dc.subject.por.fl_str_mv |
SARS-CoV-2 Terapias Pandemia COVID-19. SARS-CoV-2 Therapies Pandemic COVID-19. SARS-CoV-2 Terapias Pandemia COVID-19. |
topic |
SARS-CoV-2 Terapias Pandemia COVID-19. SARS-CoV-2 Therapies Pandemic COVID-19. SARS-CoV-2 Terapias Pandemia COVID-19. |
description |
The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26307 10.33448/rsd-v11i2.26307 |
url |
https://rsdjournal.org/index.php/rsd/article/view/26307 |
identifier_str_mv |
10.33448/rsd-v11i2.26307 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26307/22908 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferraz https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferraz https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e60011226307 Research, Society and Development; Vol. 11 Núm. 2; e60011226307 Research, Society and Development; v. 11 n. 2; e60011226307 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052704786219008 |