COVID-19: the historicity of therapies in the first year of the Pandemic

Detalhes bibliográficos
Autor(a) principal: Andolfatto, Daniel
Data de Publicação: 2022
Outros Autores: Zanatta, Leila, Ferraz, Lucimare
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/26307
Resumo: The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched.
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spelling COVID-19: the historicity of therapies in the first year of the PandemicCOVID-19: la historicidad de las terapias en el primer año de la PandemiaCOVID-19: a historicidade das terapêuticas no primeiro ano da Pandemia SARS-CoV-2TerapiasPandemiaCOVID-19.SARS-CoV-2TherapiesPandemicCOVID-19.SARS-CoV-2TerapiasPandemiaCOVID-19.The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched.El objetivo es conocer los constructos terapéuticos de la COVID-19 en su primer año de pandemia. Esta es una revisión narrativa de la literatura, realizada a partir de investigaciones en la Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane con los descriptores estandarizados 'Terapia' Y COVID-19, en el primer año de la pandemia de COVID-19, después la declaración oficial de la OMS. Como resultado se describieron las dianas terapéuticas investigadas (in vivo, in vitro e in silico) y publicadas en el primer año de esta crisis sanitaria. Era evidente que las terapias exploradas se basaban en dianas farmacológicas y no farmacológicas sobre el huésped, el sistema inmunitario y el virus. Los principales agentes probados in vitro e in vivo e in silico pertenecen a las clases farmacológicas de antivirales, antiparasitarios, antiinflamatorios, antibióticos, así como anticuerpos monoclonales, células madre y plasma convaleciente. Según las publicaciones, los fármacos más citados para tratar la COVID-19 fueron la hidroxicloroquina, la cloroquina, la ivermectina, la azitromicina, la vitamina D, la dexametasona u otro glucocorticoide. Se encontró que muchas estrategias terapéuticas contra el COVID-19 han sido refutadas, sin embargo, otras están siendo mejor investigadas.Objetiva-se conhecer os construtos terapêuticos da COVID-19 em seu primeiro ano de pandemia. Trata-se de uma revisão narrativa da literatura, realizada a partir de pesquisas nas bases Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane com os descritores padronizados ‘Therapy’ AND COVID-19, no primeiro ano da pandemia da COVID-19, após a declaração oficial da OMS. Como resultados foram descritos os alvos terapêuticos pesquisados (in vivo, in vitro e in silico) e publicados no primeiro ano dessa crise sanitária. Evidenciou-se que as terapias exploradas se basearam em alvos farmacológicos e não farmacológicos sobre o hospedeiro, sistema imunológico e no vírus. Os principais agentes testados in vitro e in vivo e in silico pertences as classes farmacológicas dos antivirais, antiparasitários, anti-inflamatórios, antibióticos além de anticorpos monoclonais, células-tronco e plasma convalescente. Segundo as publicações, os medicamentos mais citados para tratar a COVID-19 foram a hidroxicloroquina, cloroquina, ivermectina, azitromicina, vitamina D, dexametasona ou outro glicocorticoide. Constatou-se que muitas estratégias terapêuticas contra a COVID-19 foram refutadas, todavia outras estão sendo melhor pesquisadas.Research, Society and Development2022-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2630710.33448/rsd-v11i2.26307Research, Society and Development; Vol. 11 No. 2; e60011226307Research, Society and Development; Vol. 11 Núm. 2; e60011226307Research, Society and Development; v. 11 n. 2; e600112263072525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/26307/22908Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferrazhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAndolfatto, DanielZanatta, LeilaFerraz, Lucimare2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/26307Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:22.999667Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv COVID-19: the historicity of therapies in the first year of the Pandemic
COVID-19: la historicidad de las terapias en el primer año de la Pandemia
COVID-19: a historicidade das terapêuticas no primeiro ano da Pandemia
title COVID-19: the historicity of therapies in the first year of the Pandemic
spellingShingle COVID-19: the historicity of therapies in the first year of the Pandemic
Andolfatto, Daniel
SARS-CoV-2
Terapias
Pandemia
COVID-19.
SARS-CoV-2
Therapies
Pandemic
COVID-19.
SARS-CoV-2
Terapias
Pandemia
COVID-19.
title_short COVID-19: the historicity of therapies in the first year of the Pandemic
title_full COVID-19: the historicity of therapies in the first year of the Pandemic
title_fullStr COVID-19: the historicity of therapies in the first year of the Pandemic
title_full_unstemmed COVID-19: the historicity of therapies in the first year of the Pandemic
title_sort COVID-19: the historicity of therapies in the first year of the Pandemic
author Andolfatto, Daniel
author_facet Andolfatto, Daniel
Zanatta, Leila
Ferraz, Lucimare
author_role author
author2 Zanatta, Leila
Ferraz, Lucimare
author2_role author
author
dc.contributor.author.fl_str_mv Andolfatto, Daniel
Zanatta, Leila
Ferraz, Lucimare
dc.subject.por.fl_str_mv SARS-CoV-2
Terapias
Pandemia
COVID-19.
SARS-CoV-2
Therapies
Pandemic
COVID-19.
SARS-CoV-2
Terapias
Pandemia
COVID-19.
topic SARS-CoV-2
Terapias
Pandemia
COVID-19.
SARS-CoV-2
Therapies
Pandemic
COVID-19.
SARS-CoV-2
Terapias
Pandemia
COVID-19.
description The objective is to know the therapeutic constructs of COVID-19 in its first year of the pandemic. This is a narrative review of the literature, carried out from research in the Biblioteca Virtual de Saúde, Periódicos Capes, PubMed, Cochrane with the standardized descriptors 'Therapy' AND COVID-19, in the first year of the COVID-19 pandemic, after the official declaration of the WHO. As a result, the researched therapeutic targets (in vivo, in vitro, in silico) and published in the first year of this health crisis were described. It was evident that the therapies explored were based on pharmacological and non-pharmacological targets on the host, immune system the virus. The main agents tested in vitro, in vivo, in silico belong to the pharmacological classes of antivirals, antiparasitics, anti-inflammatories, antibiotics as well as monoclonal antibodies, stem cells convalescent plasma. According to the publications, the most cited drugs to treat COVID-19 were hydroxychloroquine, chloroquine, ivermectin, azithromycin, vitamin D, dexamethasone glucocorticoid. It was found that many therapeutic strategies against COVID-19 have been refuted, however, others are being better researched.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26307
10.33448/rsd-v11i2.26307
url https://rsdjournal.org/index.php/rsd/article/view/26307
identifier_str_mv 10.33448/rsd-v11i2.26307
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/26307/22908
dc.rights.driver.fl_str_mv Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferraz
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Daniel Andolfatto; Leila Zanatta; Lucimare Ferraz
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 2; e60011226307
Research, Society and Development; Vol. 11 Núm. 2; e60011226307
Research, Society and Development; v. 11 n. 2; e60011226307
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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