Bibliographic survey of the causal relationship between Neurological disorders and Covid-19

Detalhes bibliográficos
Autor(a) principal: Carvalho, Felipe dos Santos
Data de Publicação: 2023
Outros Autores: Amaral, Jonas Silva Pereira do, Dias, Afonso Henrique de Queiroz, Portolez, Cristiane Garcia, Marassi, Fernanda, Rodrigues, Felipe Napolitano, Machado, Eliza Caetano, Zambrin, Gabrielle Coelho, Bianchi, Caroline Scalabrini, Oliveira, Caio Ferreira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/41101
Resumo: This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.
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spelling Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 Estudio bibliográfico de la relación causal entre trastornos Neurológicos y Covid-19Levantamento bibliográfico da relação causal entre afecções Neurológicas e Covid-19 Lesão NeuronalSARS-CoV-2Covid-19. Lesión NeuronalSARS-CoV-2Covid-19.Neuronal InjurySARS-CoV-2Covid-19. This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.Este estudio tiene como objetivo realizar una revisión integradora de la literatura para comprender la relación causal entre los trastornos neurológicos y Covid-19 y señalar nuevas actualizaciones sobre el tema. El mundo experimentó la pandemia de la enfermedad por coronavirus 2019, un síndrome respiratorio agudo severo causado por el coronavirus SARS-CoV-2, teniendo como una de las consecuencias patológicas más frecuentes los trastornos neurológicos. El daño al sistema nervioso central (SNC) relacionado con la infección puede ocurrir debido a múltiples razones, que incluyen: Daño por invasión viral directa hay neuronas; Disminución de los niveles de oxígeno debido a la hipoxia; Formación de microtrombos con un estado inflamatorio persistente que induce complicaciones cerebrovasculares. La invasión viral directa conduce a efectos adversos en las neuronas en varios aspectos, como la morfología celular, la electrofisiología, las estructuras subcelulares y la muerte celular. La hipoxemia tiene la capacidad de alterar la integridad de la barrera hematoencefálica, permitiendo la infiltración de células inmunes periféricas y la fuga de proteínas, lo que promueve la disfunción del SNC. Hasta la fecha, los estudios epidemiológicos indican que existe una alta relación patológica entre el Covid-19 y las enfermedades neurológicas. La evidencia acumulada indica que los pacientes que desarrollaron Covid-19 pueden presentar síntomas neurológicos aparentes a largo plazo, como dolor de cabeza, alteración del estado mental, anosmia y mialgia. La relación dañina entre la infección por SARS-CoV-2 y las enfermedades neurológicas es notoria, pero las nuevas búsquedas para comprender mejor su etiología son cruciales.Este trabalho objetiva-se a realizar uma revisão integrativa da literatura para compreender a relação causal entre afecções neurológicas e Covid-19 e apontar novas atualizações sobre o assunto. O mundo vivenciou a pandemia da doença do coronavírus 2019, uma síndrome respiratória aguda grave causada pelo coronavírus SARS-CoV-2, tendo como uma das consequências patológicas mais frequente as afecções neurológicas. Os danos ao sistema nervoso central (SNC) relacionados a infecção podem ocorrer devido a múltiplas razões, incluindo: Danos pela invasão viral direta há neurônios; Diminuição dos níveis de oxigênio devido à hipoxia; Formação de microtrombos com um estado inflamatório persistente que induz a complicações cerebrovasculares. A invasão viral direta leva a efeitos adversos nos neurônios em vários aspectos, como: morfologia celular, eletrofisiologia, estruturas subcelulares e morte celular. A hipoxemia, tem a capacidade de perturbar a integridade da barreira hemato encefálica, permitindo a infiltração de células imunes periféricas e ao vazamento de proteínas, que promove a disfunção do SNC. Até o presente momento, estudos epidemiológicos apontam que a uma alta relação patológica entre Covid-19 e doenças neurológicas. Evidências acumuladas indicam que pacientes que desenvolveram a Covid-19, podem apresentar sintomas neurológicos aparentes a longo prazo, como: dor de cabeça, estado mental alterado, anosmia e mialgia. A relação nociva entre infecção pelo SARS-CoV-2 e doenças neurológicas é notória, porém, é crucial novas buscas para compreender melhor sua etiologia.Research, Society and Development2023-04-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4110110.33448/rsd-v12i4.41101Research, Society and Development; Vol. 12 No. 4; e17412441101Research, Society and Development; Vol. 12 Núm. 4; e17412441101Research, Society and Development; v. 12 n. 4; e174124411012525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/41101/33496Copyright (c) 2023 Felipe dos Santos Carvalho; Jonas Silva Pereira do Amaral; Afonso Henrique de Queiroz Dias; Cristiane Garcia Portolez; Fernanda Marassi; Felipe Napolitano Rodrigues; Eliza Caetano Machado; Gabrielle Coelho Zambrin; Caroline Scalabrini Bianchi; Caio Ferreira Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho, Felipe dos Santos Amaral, Jonas Silva Pereira doDias, Afonso Henrique de Queiroz Portolez, Cristiane Garcia Marassi, Fernanda Rodrigues, Felipe Napolitano Machado, Eliza Caetano Zambrin, Gabrielle Coelho Bianchi, Caroline Scalabrini Oliveira, Caio Ferreira 2023-04-21T18:13:32Zoai:ojs.pkp.sfu.ca:article/41101Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-04-21T18:13:32Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
Estudio bibliográfico de la relación causal entre trastornos Neurológicos y Covid-19
Levantamento bibliográfico da relação causal entre afecções Neurológicas e Covid-19
title Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
spellingShingle Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
Carvalho, Felipe dos Santos
Lesão Neuronal
SARS-CoV-2
Covid-19.
Lesión Neuronal
SARS-CoV-2
Covid-19.
Neuronal Injury
SARS-CoV-2
Covid-19.
title_short Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
title_full Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
title_fullStr Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
title_full_unstemmed Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
title_sort Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
author Carvalho, Felipe dos Santos
author_facet Carvalho, Felipe dos Santos
Amaral, Jonas Silva Pereira do
Dias, Afonso Henrique de Queiroz
Portolez, Cristiane Garcia
Marassi, Fernanda
Rodrigues, Felipe Napolitano
Machado, Eliza Caetano
Zambrin, Gabrielle Coelho
Bianchi, Caroline Scalabrini
Oliveira, Caio Ferreira
author_role author
author2 Amaral, Jonas Silva Pereira do
Dias, Afonso Henrique de Queiroz
Portolez, Cristiane Garcia
Marassi, Fernanda
Rodrigues, Felipe Napolitano
Machado, Eliza Caetano
Zambrin, Gabrielle Coelho
Bianchi, Caroline Scalabrini
Oliveira, Caio Ferreira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Felipe dos Santos
Amaral, Jonas Silva Pereira do
Dias, Afonso Henrique de Queiroz
Portolez, Cristiane Garcia
Marassi, Fernanda
Rodrigues, Felipe Napolitano
Machado, Eliza Caetano
Zambrin, Gabrielle Coelho
Bianchi, Caroline Scalabrini
Oliveira, Caio Ferreira
dc.subject.por.fl_str_mv Lesão Neuronal
SARS-CoV-2
Covid-19.
Lesión Neuronal
SARS-CoV-2
Covid-19.
Neuronal Injury
SARS-CoV-2
Covid-19.
topic Lesão Neuronal
SARS-CoV-2
Covid-19.
Lesión Neuronal
SARS-CoV-2
Covid-19.
Neuronal Injury
SARS-CoV-2
Covid-19.
description This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/41101
10.33448/rsd-v12i4.41101
url https://rsdjournal.org/index.php/rsd/article/view/41101
identifier_str_mv 10.33448/rsd-v12i4.41101
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/41101/33496
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 12 No. 4; e17412441101
Research, Society and Development; Vol. 12 Núm. 4; e17412441101
Research, Society and Development; v. 12 n. 4; e17412441101
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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