Bibliographic survey of the causal relationship between Neurological disorders and Covid-19
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/41101 |
Resumo: | This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial. |
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Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 Estudio bibliográfico de la relación causal entre trastornos Neurológicos y Covid-19Levantamento bibliográfico da relação causal entre afecções Neurológicas e Covid-19 Lesão NeuronalSARS-CoV-2Covid-19. Lesión NeuronalSARS-CoV-2Covid-19.Neuronal InjurySARS-CoV-2Covid-19. This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial.Este estudio tiene como objetivo realizar una revisión integradora de la literatura para comprender la relación causal entre los trastornos neurológicos y Covid-19 y señalar nuevas actualizaciones sobre el tema. El mundo experimentó la pandemia de la enfermedad por coronavirus 2019, un síndrome respiratorio agudo severo causado por el coronavirus SARS-CoV-2, teniendo como una de las consecuencias patológicas más frecuentes los trastornos neurológicos. El daño al sistema nervioso central (SNC) relacionado con la infección puede ocurrir debido a múltiples razones, que incluyen: Daño por invasión viral directa hay neuronas; Disminución de los niveles de oxígeno debido a la hipoxia; Formación de microtrombos con un estado inflamatorio persistente que induce complicaciones cerebrovasculares. La invasión viral directa conduce a efectos adversos en las neuronas en varios aspectos, como la morfología celular, la electrofisiología, las estructuras subcelulares y la muerte celular. La hipoxemia tiene la capacidad de alterar la integridad de la barrera hematoencefálica, permitiendo la infiltración de células inmunes periféricas y la fuga de proteínas, lo que promueve la disfunción del SNC. Hasta la fecha, los estudios epidemiológicos indican que existe una alta relación patológica entre el Covid-19 y las enfermedades neurológicas. La evidencia acumulada indica que los pacientes que desarrollaron Covid-19 pueden presentar síntomas neurológicos aparentes a largo plazo, como dolor de cabeza, alteración del estado mental, anosmia y mialgia. La relación dañina entre la infección por SARS-CoV-2 y las enfermedades neurológicas es notoria, pero las nuevas búsquedas para comprender mejor su etiología son cruciales.Este trabalho objetiva-se a realizar uma revisão integrativa da literatura para compreender a relação causal entre afecções neurológicas e Covid-19 e apontar novas atualizações sobre o assunto. O mundo vivenciou a pandemia da doença do coronavírus 2019, uma síndrome respiratória aguda grave causada pelo coronavírus SARS-CoV-2, tendo como uma das consequências patológicas mais frequente as afecções neurológicas. Os danos ao sistema nervoso central (SNC) relacionados a infecção podem ocorrer devido a múltiplas razões, incluindo: Danos pela invasão viral direta há neurônios; Diminuição dos níveis de oxigênio devido à hipoxia; Formação de microtrombos com um estado inflamatório persistente que induz a complicações cerebrovasculares. A invasão viral direta leva a efeitos adversos nos neurônios em vários aspectos, como: morfologia celular, eletrofisiologia, estruturas subcelulares e morte celular. A hipoxemia, tem a capacidade de perturbar a integridade da barreira hemato encefálica, permitindo a infiltração de células imunes periféricas e ao vazamento de proteínas, que promove a disfunção do SNC. Até o presente momento, estudos epidemiológicos apontam que a uma alta relação patológica entre Covid-19 e doenças neurológicas. Evidências acumuladas indicam que pacientes que desenvolveram a Covid-19, podem apresentar sintomas neurológicos aparentes a longo prazo, como: dor de cabeça, estado mental alterado, anosmia e mialgia. A relação nociva entre infecção pelo SARS-CoV-2 e doenças neurológicas é notória, porém, é crucial novas buscas para compreender melhor sua etiologia.Research, Society and Development2023-04-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4110110.33448/rsd-v12i4.41101Research, Society and Development; Vol. 12 No. 4; e17412441101Research, Society and Development; Vol. 12 Núm. 4; e17412441101Research, Society and Development; v. 12 n. 4; e174124411012525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/41101/33496Copyright (c) 2023 Felipe dos Santos Carvalho; Jonas Silva Pereira do Amaral; Afonso Henrique de Queiroz Dias; Cristiane Garcia Portolez; Fernanda Marassi; Felipe Napolitano Rodrigues; Eliza Caetano Machado; Gabrielle Coelho Zambrin; Caroline Scalabrini Bianchi; Caio Ferreira Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho, Felipe dos Santos Amaral, Jonas Silva Pereira doDias, Afonso Henrique de Queiroz Portolez, Cristiane Garcia Marassi, Fernanda Rodrigues, Felipe Napolitano Machado, Eliza Caetano Zambrin, Gabrielle Coelho Bianchi, Caroline Scalabrini Oliveira, Caio Ferreira 2023-04-21T18:13:32Zoai:ojs.pkp.sfu.ca:article/41101Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-04-21T18:13:32Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 Estudio bibliográfico de la relación causal entre trastornos Neurológicos y Covid-19 Levantamento bibliográfico da relação causal entre afecções Neurológicas e Covid-19 |
title |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
spellingShingle |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 Carvalho, Felipe dos Santos Lesão Neuronal SARS-CoV-2 Covid-19. Lesión Neuronal SARS-CoV-2 Covid-19. Neuronal Injury SARS-CoV-2 Covid-19. |
title_short |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
title_full |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
title_fullStr |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
title_full_unstemmed |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
title_sort |
Bibliographic survey of the causal relationship between Neurological disorders and Covid-19 |
author |
Carvalho, Felipe dos Santos |
author_facet |
Carvalho, Felipe dos Santos Amaral, Jonas Silva Pereira do Dias, Afonso Henrique de Queiroz Portolez, Cristiane Garcia Marassi, Fernanda Rodrigues, Felipe Napolitano Machado, Eliza Caetano Zambrin, Gabrielle Coelho Bianchi, Caroline Scalabrini Oliveira, Caio Ferreira |
author_role |
author |
author2 |
Amaral, Jonas Silva Pereira do Dias, Afonso Henrique de Queiroz Portolez, Cristiane Garcia Marassi, Fernanda Rodrigues, Felipe Napolitano Machado, Eliza Caetano Zambrin, Gabrielle Coelho Bianchi, Caroline Scalabrini Oliveira, Caio Ferreira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Felipe dos Santos Amaral, Jonas Silva Pereira do Dias, Afonso Henrique de Queiroz Portolez, Cristiane Garcia Marassi, Fernanda Rodrigues, Felipe Napolitano Machado, Eliza Caetano Zambrin, Gabrielle Coelho Bianchi, Caroline Scalabrini Oliveira, Caio Ferreira |
dc.subject.por.fl_str_mv |
Lesão Neuronal SARS-CoV-2 Covid-19. Lesión Neuronal SARS-CoV-2 Covid-19. Neuronal Injury SARS-CoV-2 Covid-19. |
topic |
Lesão Neuronal SARS-CoV-2 Covid-19. Lesión Neuronal SARS-CoV-2 Covid-19. Neuronal Injury SARS-CoV-2 Covid-19. |
description |
This study aims to perform an integrative literature review to understand the causal relationship between neurological disorders and Covid-19 and to point out new updates on the subject. The world experienced the pandemic of coronavirus disease 2019, a severe acute respiratory syndrome caused by the coronavirus SARS-CoV-2, having as one of the most frequent pathological consequences neurological disorders. Damage to the central nervous system (CNS) related to infection can occur due to multiple reasons, including: Damage by direct viral invasion there are neurons; Decreased oxygen levels due to hypoxia; Formation of microthrombi with a persistent inflammatory state that induces cerebrovascular complications. Direct viral invasion leads to adverse effects on neurons in several aspects, such as cell morphology, electrophysiology, subcellular structures, and cell death. Hypoxemia has the ability to disturb the integrity of the blood brain barrier, allowing the infiltration of peripheral immune cells and protein leakage, which promotes CNS dysfunction. To date, epidemiological studies indicate that a high pathological relationship between Covid-19 and neurological diseases. Accumulated evidence indicates that patients who developed Covid-19 may present with long-term apparent neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. The harmful relationship between SARS-CoV-2 infection and neurological diseases is notorious, but new searches to better understand its etiology are crucial. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/41101 10.33448/rsd-v12i4.41101 |
url |
https://rsdjournal.org/index.php/rsd/article/view/41101 |
identifier_str_mv |
10.33448/rsd-v12i4.41101 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/41101/33496 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 4; e17412441101 Research, Society and Development; Vol. 12 Núm. 4; e17412441101 Research, Society and Development; v. 12 n. 4; e17412441101 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052622108098560 |