Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/20673 |
Resumo: | Introduction: Flavonoids have received an increasing attention from the scientific community in the last decade due to its antioxidant and anti-inflammatory effects, showing benefits in various conditions, including major depression in animal models. The aim of this study was to review the evidence produced in the last 10 years regarding the antidepressant, antioxidant and anti-inflammatory effect of flavonoids in rodent models of depression. Material and methods: It was performed a systematic review to gather articles published between 2009 and 2019 that evaluate those effects of flavonoids in rodent models of depression. Results: 43 studies were included in the review. The most frequently studied flavonoids were hesperidin (14%) and baicalin (9%). The major natural source of flavonoids were citrus fruits (19%) and Scutellaria baicalensis Georgi (9%). Mice were used in the majority of the studies (86%). The majority of the studies did not use a specific model of depression (40%), and the most frequently used one was Chronic Unpredictable Mild Stress (21%). The most frequently used behavioral tests were forced swim test (81%), tail suspension test (56%) and open field test (51%). Discussion: Considering total tests, 93% of them presented an antidepressant activity, and all the studies that evaluated oxidative stress (37%) and inflammation (39%) found a significant antioxidant and anti-inflammatory result, respectively. Conclusions: Those findings demonstrate that the antidepressant, antioxidant and anti-inflammatory effects of flavonoids that were already evidenced in the study of other pathological conditions are also present in rodent depression models. |
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Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodentsRevisión sistemática de la actividad antidepresiva y los efectos antioxidantes y antiinflamatorios asociados de los flavonoides en roedoresRevisão sistemática da atividade antidepressiva e dos efeitos antioxidantes e anti-inflamatórios dos flavonóides em roedoresDepressãoAntidepressivoFlavonoidesModelo animal.DepresiónAntidepresivoFlavonoidesModelo animal.DepressionAntidepressantFlavonoidsAnimal model.Introduction: Flavonoids have received an increasing attention from the scientific community in the last decade due to its antioxidant and anti-inflammatory effects, showing benefits in various conditions, including major depression in animal models. The aim of this study was to review the evidence produced in the last 10 years regarding the antidepressant, antioxidant and anti-inflammatory effect of flavonoids in rodent models of depression. Material and methods: It was performed a systematic review to gather articles published between 2009 and 2019 that evaluate those effects of flavonoids in rodent models of depression. Results: 43 studies were included in the review. The most frequently studied flavonoids were hesperidin (14%) and baicalin (9%). The major natural source of flavonoids were citrus fruits (19%) and Scutellaria baicalensis Georgi (9%). Mice were used in the majority of the studies (86%). The majority of the studies did not use a specific model of depression (40%), and the most frequently used one was Chronic Unpredictable Mild Stress (21%). The most frequently used behavioral tests were forced swim test (81%), tail suspension test (56%) and open field test (51%). Discussion: Considering total tests, 93% of them presented an antidepressant activity, and all the studies that evaluated oxidative stress (37%) and inflammation (39%) found a significant antioxidant and anti-inflammatory result, respectively. Conclusions: Those findings demonstrate that the antidepressant, antioxidant and anti-inflammatory effects of flavonoids that were already evidenced in the study of other pathological conditions are also present in rodent depression models.Introducción: Los flavonoides han recibido una atención creciente por parte de la comunidad científica en la última década debido a sus efectos antioxidantes y antiinflamatorios, mostrando beneficios en diversas afecciones, incluida la depresión mayor en modelos animales. El objetivo de este estudio fue revisar la evidencia producida en los últimos 10 años sobre el efecto antidepresivo, antioxidante y antiinflamatorio de los flavonoides en modelos de depresión en roedores. Material y métodos: Se realizó una revisión sistemática para recopilar artículos publicados entre 2009 y 2019 que evalúan los efectos de los flavonoides en modelos de depresión en roedores. Resultados: Se incluyeron 43 estudios en la revisión. Los flavonoides más estudiados fueron la hesperidina (14%) y la baicalina (9%). La principal fuente natural de flavonoides fueron los cítricos (19%) y Scutellaria baicalensis Georgi (9%). Se utilizaron ratones en la mayoría de los estudios (86%). La mayoría de los estudios no utilizaron un modelo específico de depresión (40%), y el más utilizado fue el estrés leve crónico impredecible (21%). Las pruebas de comportamiento más utilizadas fueron la prueba de natación forzada (81%), la prueba de suspensión de la cola (56%) y la prueba de campo abierto (51%). Discusión: Considerando el total de pruebas, el 93% de ellas presentó actividad antidepresiva, y todos los estudios que evaluaron estrés oxidativo (37%) e inflamación (39%) encontraron un resultado antioxidante y antiinflamatorio significativo, respectivamente. Conclusiones: Estos hallazgos demuestran que los efectos antidepresivos, antioxidantes y antiinflamatorios de los flavonoides que ya se evidenciaron en el estudio de otras condiciones patológicas también están presentes en modelos de depresión en roedores.Introdução: Os flavonóides têm recebido cada vez mais atenção da comunidade científica na última década devido aos seus efeitos antioxidantes e antiinflamatórios, apresentando benefícios em diversas condições, incluindo depressão maior em modelos animais. O objetivo deste estudo foi revisar as evidências produzidas nos últimos 10 anos sobre o efeito antidepressivo, antioxidante e anti-inflamatório dos flavonóides em modelos de depressão em roedores. Material e métodos: foi realizada uma revisão sistemática para reunir artigos publicados entre 2009 e 2019 que avaliam os efeitos dos flavonóides em modelos de depressão em roedores. Resultados: 43 estudos foram incluídos na revisão. Os flavonóides mais frequentemente estudados foram hesperidina (14%) e baicalina (9%). A principal fonte natural de flavonóides foram frutas cítricas (19%) e Scutellaria baicalensis Georgi (9%). Camundongos foram usados na maioria dos estudos (86%). A maioria dos estudos não usou um modelo específico de depressão (40%), e o mais usado foi o Estresse Leve Imprevisível Crônico (21%). Os testes comportamentais mais usados foram o teste de natação forçada (81%), o teste de suspensão da cauda (56%) e o teste de campo aberto (51%). Discussão: Considerando o total de testes, 93% deles apresentaram atividade antidepressiva, e todos os estudos que avaliaram estresse oxidativo (37%) e inflamação (39%) encontraram resultado antioxidante e anti-inflamatório significativo, respectivamente. Conclusões: Esses achados demonstram que os efeitos antidepressivos, antioxidantes e anti-inflamatórios dos flavonóides já evidenciados no estudo de outras patologias também estão presentes em modelos de depressão em roedores.Research, Society and Development2021-09-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2067310.33448/rsd-v10i12.20673Research, Society and Development; Vol. 10 No. 12; e410101220673Research, Society and Development; Vol. 10 Núm. 12; e410101220673Research, Society and Development; v. 10 n. 12; e4101012206732525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/20673/18396Copyright (c) 2021 Lysrayane Kerullen David Barroso; Mateus Aragão Esmeraldo; Isaac Carioca de Oliveira; Miguel Costa Rodrigues Junior; Nickolas Souza Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarroso, Lysrayane Kerullen DavidEsmeraldo, Mateus Aragãode Oliveira, Isaac CariocaRodrigues Junior, Miguel CostaSilva, Nickolas Souza2021-11-14T20:26:51Zoai:ojs.pkp.sfu.ca:article/20673Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:40:14.876574Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents Revisión sistemática de la actividad antidepresiva y los efectos antioxidantes y antiinflamatorios asociados de los flavonoides en roedores Revisão sistemática da atividade antidepressiva e dos efeitos antioxidantes e anti-inflamatórios dos flavonóides em roedores |
title |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
spellingShingle |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents Barroso, Lysrayane Kerullen David Depressão Antidepressivo Flavonoides Modelo animal. Depresión Antidepresivo Flavonoides Modelo animal. Depression Antidepressant Flavonoids Animal model. |
title_short |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
title_full |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
title_fullStr |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
title_full_unstemmed |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
title_sort |
Systematic review of the antidepressant activity and associated antioxidant and anti-inflammatory effects of flavonoids in rodents |
author |
Barroso, Lysrayane Kerullen David |
author_facet |
Barroso, Lysrayane Kerullen David Esmeraldo, Mateus Aragão de Oliveira, Isaac Carioca Rodrigues Junior, Miguel Costa Silva, Nickolas Souza |
author_role |
author |
author2 |
Esmeraldo, Mateus Aragão de Oliveira, Isaac Carioca Rodrigues Junior, Miguel Costa Silva, Nickolas Souza |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barroso, Lysrayane Kerullen David Esmeraldo, Mateus Aragão de Oliveira, Isaac Carioca Rodrigues Junior, Miguel Costa Silva, Nickolas Souza |
dc.subject.por.fl_str_mv |
Depressão Antidepressivo Flavonoides Modelo animal. Depresión Antidepresivo Flavonoides Modelo animal. Depression Antidepressant Flavonoids Animal model. |
topic |
Depressão Antidepressivo Flavonoides Modelo animal. Depresión Antidepresivo Flavonoides Modelo animal. Depression Antidepressant Flavonoids Animal model. |
description |
Introduction: Flavonoids have received an increasing attention from the scientific community in the last decade due to its antioxidant and anti-inflammatory effects, showing benefits in various conditions, including major depression in animal models. The aim of this study was to review the evidence produced in the last 10 years regarding the antidepressant, antioxidant and anti-inflammatory effect of flavonoids in rodent models of depression. Material and methods: It was performed a systematic review to gather articles published between 2009 and 2019 that evaluate those effects of flavonoids in rodent models of depression. Results: 43 studies were included in the review. The most frequently studied flavonoids were hesperidin (14%) and baicalin (9%). The major natural source of flavonoids were citrus fruits (19%) and Scutellaria baicalensis Georgi (9%). Mice were used in the majority of the studies (86%). The majority of the studies did not use a specific model of depression (40%), and the most frequently used one was Chronic Unpredictable Mild Stress (21%). The most frequently used behavioral tests were forced swim test (81%), tail suspension test (56%) and open field test (51%). Discussion: Considering total tests, 93% of them presented an antidepressant activity, and all the studies that evaluated oxidative stress (37%) and inflammation (39%) found a significant antioxidant and anti-inflammatory result, respectively. Conclusions: Those findings demonstrate that the antidepressant, antioxidant and anti-inflammatory effects of flavonoids that were already evidenced in the study of other pathological conditions are also present in rodent depression models. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/20673 10.33448/rsd-v10i12.20673 |
url |
https://rsdjournal.org/index.php/rsd/article/view/20673 |
identifier_str_mv |
10.33448/rsd-v10i12.20673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/20673/18396 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 12; e410101220673 Research, Society and Development; Vol. 10 Núm. 12; e410101220673 Research, Society and Development; v. 10 n. 12; e410101220673 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052756041662464 |